CN113616354B - Detection method and device for liquid perfusion - Google Patents
Detection method and device for liquid perfusion Download PDFInfo
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- CN113616354B CN113616354B CN202111091295.4A CN202111091295A CN113616354B CN 113616354 B CN113616354 B CN 113616354B CN 202111091295 A CN202111091295 A CN 202111091295A CN 113616354 B CN113616354 B CN 113616354B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D7/00—Control of flow
- G05D7/06—Control of flow characterised by the use of electric means
- G05D7/0617—Control of flow characterised by the use of electric means specially adapted for fluid materials
- G05D7/0629—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means
- G05D7/0635—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means by action on throttling means
Abstract
The invention discloses a detection method and equipment for liquid perfusion, wherein when first lactic acid data received by a control terminal exceeds a first lactic acid threshold value configured at the control terminal, a perfusion trigger instruction is sent to a perfusion device; when the first lactic acid data exceed a first lactic acid threshold value, the control terminal records the temperature of the current target perfusion area as first temperature data, and records the maximum value of the current first lactic acid data after the first lactic acid data exceed the first lactic acid threshold value as first correction data; and the control terminal corrects the first lactic acid threshold after calculating the first temperature data and the first correction data. The detection method and the detection equipment for liquid perfusion realize automatic control of the liquid perfusion device, liberate manpower, improve the precision of perfusion control, and improve the accuracy of perfusion time by dynamically adjusting the trigger perfusion threshold.
Description
Technical Field
The invention relates to an intelligent control technology, in particular to a detection method and equipment for liquid perfusion.
Background
When the liquid is filled into the target filling area, in the prior art, the liquid filling time and the liquid filling time are controlled according to the experience of a user, so that the filling result is inaccurate, and the normal operation is influenced.
Disclosure of Invention
The invention aims to solve the technical problems that in the prior art, the control of a perfusion device depends on manual experience, and the perfusion result is not accurate enough, and aims to provide a detection method and equipment for liquid perfusion to solve the problems.
The invention is realized by the following technical scheme:
in one aspect, a detection method for liquid perfusion includes:
acquiring the lactic acid content of a target perfusion area as first lactic acid data, and acquiring the temperature of the target perfusion area;
perfusing the target perfusion region with a liquid when the first lactate data exceeds a first lactate threshold;
when the first lactic acid data exceed the first lactic acid threshold, recording the temperature of the current target perfusion area as first temperature data, and recording the maximum value of the current first lactic acid data after the first lactic acid data exceed the first lactic acid threshold as first correction data;
and correcting the first lactic acid threshold value after calculating the first temperature data and the first correction data.
Further, the correcting the first threshold value after the first temperature data and the first correction data are calculated includes:
calculating a difference value between the first correction data and a preset second lactic acid threshold value to serve as second correction data, and correcting the second correction data through the first temperature data to serve as third correction data;
and calculating the difference value of the first lactic acid threshold value and the third correction data as a corrected first lactic acid threshold value.
Further, the method also comprises the following steps:
initializing the first lactate threshold at turn-on; the initializing is accomplished by assigning the second threshold value of lactic acid to the first threshold value of lactic acid.
Further, the correcting the second correction data by the first temperature data as third correction data includes:
calculating a ratio of the first temperature data to preset second temperature data to serve as fourth correction data; the first temperature data and the second temperature data both adopt Kelvin temperature;
and calculating a product of the second correction data and the fourth correction data as third correction data.
Further, the method also comprises the following steps:
acquiring the moment when the first lactic acid data exceeds the first lactic acid threshold as a first moment, and acquiring the moment when the first lactic acid data reaches the maximum value after exceeding the first lactic acid threshold as a second moment;
calculating a difference value between the second time and the first time as a correction time, and calculating a difference value between the maximum value and the first lactic acid threshold value as corrected lactic acid data;
calculating the ratio of the corrected lactic acid data to the corrected time as rising speed data;
generating perfusion flow data from the rise speed data;
and correcting the flow rate of the next perfusion according to the perfusion flow rate data.
Further, generating perfusion flow data from the rise rate data comprises:
and calculating the ratio of the rising speed data to a preset reference speed to be multiplied by a preset reference flow to generate perfusion flow data.
Further, the preset dosage of the liquid for filling the target filling area is 10-15 ml/kg of body weight.
Further, the method also comprises the following steps:
acquiring a bioelectrical signal of a target perfusion area;
filtering and denoising the bioelectric signal, performing frequency domain analysis to obtain power spectral density in a preset frequency band, and taking the power spectral density as electric signal discrimination data;
and when the electrical signal discrimination data exceeds a threshold value, filling liquid into the target filling area.
In one aspect, a detection apparatus for perfusion, comprises:
a control terminal communicatively coupled to a perfusion apparatus that perfuses a target perfusion area with a liquid and issues a perfusion trigger instruction to the perfusion apparatus;
a first sensor configured to be communicatively coupled to the control terminal and to acquire the lactate content of the target perfusion region as first lactate data to be sent to the control terminal;
the second sensor is configured to be communicatively coupled to the control terminal and acquire the temperature of the target perfusion area and send the temperature to the control terminal;
the control terminal is configured to send the perfusion trigger instruction to the perfusion device when the received first lactic acid data exceeds a first lactic acid threshold configured to the control terminal;
when the first lactic acid data exceed the first lactic acid threshold, the control terminal records the temperature of the current target perfusion area as first temperature data, and records the maximum value of the current first lactic acid data after the first lactic acid data exceed the first lactic acid threshold as first correction data;
and the control terminal corrects the first lactic acid threshold after calculating the first temperature data and the first correction data.
Systems and methods using lactic acid as an indicator are disclosed in the prior art, and in particular, systems, devices and methods relating to ex vivo organ care are provided. Lactate measurements in arterial and venous vascular lines of an organ care system cardiac perfusion apparatus were used to assess: 1) global perfusion status of the ex vivo heart, and 2) metabolic status of the ex vivo heart, and 3) global vascular patency of the ex vivo donor heart. This aspect of the invention takes advantage of the unique ability of cardiomyocytes to produce/produce lactate in the absence of oxygen and metabolize/utilize lactate to produce energy when perfused well with oxygen.
It can be seen from the prior art that the detection of oxygen deficiency of myocardial cells by lactic acid already exists in the prior art, but in practice, the inventor found that when the liquid perfusion area is subjected to liquid perfusion, because the oxygen supply and the jump stopping function of the jump stopping liquid need time to function, if the jump stopping liquid is perfused only when the lactic acid content reaches a certain degree, the lactic acid content can continuously rise for a period of time, so that the perfusion monitoring is not accurate enough.
In the implementation of the present embodiment, the fluid used for perfusion to the target perfusion area is a beating-stopping fluid, which has the functions of stopping the heart activity and providing nutrition to the heart, and the beating-stopping fluid itself belongs to the prior art, and will not be described in detail herein. The present embodiment is used as a set of equipment for detecting and controlling a perfusion device, and the present embodiment has a control terminal communicating with the perfusion device, where the control terminal may be a desktop computer, a tablet computer, a notebook computer, a mobile phone, or other control terminals capable of implementing data processing and data communication, and is not limited herein. The sensor also comprises two sensors, and the two sensors can adopt an integrated probe type sensor or an independent detection sensor, such as a clamping type sensor.
The control terminal sends the perfusion trigger instruction to the perfusion device when the first lactic acid data exceeds a first lactic acid threshold value, the perfusion device executes perfusion operation after receiving the perfusion trigger instruction, the perfusion dosage can adopt 10-15 ml/kg of body weight, the dosage belongs to the prior art, and the method is not repeated here.
In order to solve the problem of the continuous increase of lactate after perfusion in the prior art, the inventor continuously corrects the first lactate data in the present embodiment, and it should be understood that the correction process in the present application is a dynamic correction process, and the result of each correction affects the first lactate threshold of the next perfusion. Meanwhile, in order to ensure the accuracy of data correction, the inventor extracts first temperature data and first correction data through a sensor, and the main correction principle is that the maximum value of the first lactic acid threshold corresponding to the next perfusion is corrected to be in accordance with the current first lactic acid threshold when the first lactic acid threshold is perfused, and further correction is carried out by combining with a temperature factor, so that the purpose of correcting the temperature is achieved, and the final correction value is more and more close to the true value because the correction is dynamic. According to the embodiment of the invention, by arranging the device, the automatic control of the liquid-stopping filling device is realized, the manpower is liberated, the accuracy of filling control is improved, and the accuracy of filling time is improved by dynamically adjusting the trigger filling threshold value.
Further, the control terminal is also provided with a second lactic acid threshold, the difference value between the first correction data and the second lactic acid threshold is calculated to be used as second correction data, and the second correction data is corrected to be used as third correction data through the first temperature data;
and the control terminal calculates the difference value between the first lactic acid threshold and the third correction data as a corrected first lactic acid threshold.
Further, the control terminal initializes the first lactic acid threshold when being turned on;
and the control terminal assigns the second lactic acid threshold value to the first lactic acid threshold value to complete the initialization.
Further, the control terminal is also configured with second temperature data, and a ratio of the first temperature data to the second temperature data is calculated to serve as fourth correction data; the first temperature data and the second temperature data both adopt Kelvin temperature;
the control terminal calculates a product of the second correction data and the fourth correction data as third correction data.
Further, the control terminal is further configured to acquire, as a first time, a time when the first lactate data exceeds the first lactate threshold, and acquire, as a second time, a time when the first lactate data reaches a maximum value after exceeding the first lactate threshold at this time;
the control terminal calculates the difference between the second moment and the first moment as correction time, and calculates the difference between the maximum value and the first lactic acid threshold value as corrected lactic acid data;
the control terminal calculates the ratio of the corrected lactic acid data to the corrected time as rising speed data;
the control terminal generates perfusion flow data according to the rising speed data;
and the control terminal sends the perfusion flow data to the perfusion device and is used for correcting the flow of the perfusion device in the next time.
Further, the control terminal is configured with a reference speed and a reference flow;
and the control terminal calculates the ratio of the rising speed data to the reference speed and multiplies the reference flow to generate perfusion flow data.
Further, the perfusion device perfuses a preset dose of liquid to the target perfusion area when receiving the perfusion trigger instruction, wherein the preset dose is 10-15 ml/kg of body weight.
Further, the method also comprises the following steps:
a third sensor configured to be communicatively coupled to the control terminal and to acquire a bioelectric signal of a target perfusion region;
the control terminal generates electric signal judging data after processing the bioelectric signal and sends a perfusion trigger instruction to the perfusion device when the electric signal judging data exceeds a threshold value.
Further, after filtering and denoising the bioelectric signal, the control terminal performs frequency domain analysis to obtain a power spectral density in a preset frequency band, and uses the power spectral density as electric signal discrimination data.
Further, the control terminal is further configured to generate a perfusion temperature instruction according to the temperature of the target perfusion area, send the perfusion temperature instruction to the perfusion device, and use the perfusion temperature instruction for temperature correction of the next perfusion of the perfusion device.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the detection method and the detection equipment for liquid perfusion realize automatic control of the liquid perfusion device, liberate manpower, improve the precision of perfusion control, and improve the accuracy of perfusion time by dynamically adjusting the trigger perfusion threshold.
Drawings
The accompanying drawings, which are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principles of the invention. In the drawings:
FIG. 1 is a schematic view of the structure of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples and accompanying drawings, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not meant to limit the present invention.
Example (b):
a detection method for liquid perfusion, comprising:
acquiring the lactic acid content of the target perfusion area as first lactic acid data, and acquiring the temperature of the target perfusion area;
perfusing a liquid into the target perfusion region when the first lactate data exceeds a first lactate threshold configured;
when the first lactic acid data exceed the first lactic acid threshold, recording the temperature of the current target perfusion area as first temperature data, and recording the maximum value of the current first lactic acid data after the first lactic acid data exceed the first lactic acid threshold as first correction data;
and correcting the first lactic acid threshold value after calculating the first temperature data and the first correction data.
In order to facilitate the explanation of the above-mentioned detection apparatus for perfusion, please refer to fig. 1, which is a schematic diagram of a communication architecture of the detection apparatus for perfusion disclosed in the embodiment of the present invention. Wherein, the detection device for perfusion can comprise a control terminal 100, a first sensor 201 and a second sensor 202, and the control terminal 100 is communicatively connected to the first sensor 201 and the second sensor 202.
A detection apparatus for perfusion, comprising:
a control terminal 100 communicatively coupled to a perfusion apparatus 300 for perfusing a target perfusion area 200 with a liquid, and issuing a perfusion trigger instruction to the perfusion apparatus 300;
a first sensor 201, configured to be communicatively coupled to the control terminal 100, and acquire the lactate content of the target perfusion area 200 as first lactate data to be sent to the control terminal 100;
a second sensor 202 configured to be communicatively coupled to the control terminal 100 and acquire the temperature of the target perfusion area 200 and transmit the temperature to the control terminal 100;
the control terminal 100 is configured to send the perfusion trigger instruction to the perfusion device 300 when the received first lactate data exceeds a first lactate threshold configured in the control terminal 100;
when the first lactic acid data exceeds the first lactic acid threshold, the control terminal 100 records the temperature of the current target perfusion area 200 as first temperature data, and records the maximum value of the current first lactic acid data after the first lactic acid data exceeds the first lactic acid threshold as first correction data;
the control terminal 100 calculates the first temperature data and the first correction data, and corrects the first lactate threshold.
It can be seen from the prior art that the detection of oxygen deficiency of myocardial cells by lactic acid already exists in the prior art, but in practice, the inventor found that when the target perfusion area 200 is perfused with the arrest liquid, the oxygen supply and the arrest function of the arrest liquid take time to function, so if the arrest liquid is perfused only when the lactic acid content reaches a certain degree, the lactic acid content also continuously rises for a period of time, and the perfusion monitoring is not accurate enough.
In this embodiment, as a set of equipment for detecting and controlling the perfusion apparatus 300, the embodiment has a control terminal 100 communicating with the perfusion apparatus 300, and the control terminal 100 may be a desktop computer, a tablet computer, a notebook computer, a mobile phone, or other control terminals 100 capable of implementing data processing and data communication, which is not limited herein. The sensor also comprises two sensors, and the two sensors can adopt an integrated probe type sensor or an independent detection sensor, such as a clamping type sensor.
When the first lactic acid data exceeds the first lactic acid threshold, the control terminal 100 sends the perfusion trigger instruction to the perfusion device 300, and the perfusion device 300 executes perfusion operation after receiving the perfusion trigger instruction, wherein the perfusion dose can be 10-15 ml/kg of body weight, and the dose belongs to the prior art, and is not repeated here.
In order to solve the problem of the continuous increase of lactate after perfusion in the prior art, the inventor continuously corrects the first lactate data in the present embodiment, and it should be understood that the correction process in the present application is a dynamic correction process, and the result of each correction affects the first lactate threshold of the next perfusion. Meanwhile, in order to ensure the accuracy of data correction, the inventor extracts first temperature data and first correction data of the target perfusion region 200 through a sensor, and the main correction principle is that a first lactic acid threshold corresponding to the next perfusion is corrected to a maximum value in the perfusion process to be consistent with the current first lactic acid threshold, and further correction is performed by combining a temperature factor, so that the purpose of correcting the temperature is achieved, and the final correction value is more and more close to the true value because the correction is dynamic. It should be understood that the target perfusion area 200 may be a reservoir of the heart after extracorporeal circulation or other area requiring perfusion. By arranging the devices, the embodiment of the invention realizes the automatic control of the liquid filling device 300, liberates manpower, improves the accuracy of filling control, and can improve the accuracy of filling time by dynamically adjusting the trigger filling threshold.
In one embodiment, the control terminal 100 is further configured with a second lactate threshold, calculates a difference between the first correction data and the second lactate threshold as second correction data, and corrects the second correction data by the first temperature data as third correction data;
the control terminal 100 calculates a difference between the first lactate threshold and the third correction data as a corrected first lactate threshold.
In this embodiment, in order to further realize the precise control of the first lactate threshold, the control terminal 100 is further configured with a second lactate threshold, which is a fixed value for characterizing the lactate state that should be subjected to the perfusion operation. By calculating the difference between the first correction data and the second lactate threshold, the difference between the maximum lactate content after the infusion and the second lactate threshold can be determined, which is a positive value, typically during the first few infusions, and then the effect on lactate production is corrected based on the different temperature conditions.
In specific practice, the inventor finds that the temperature of the target perfusion region 200 varies in the surgical environment, and the main factors of the variation are the heat generation of various devices, the variation of the ambient temperature of the operating room and the influence of the temperature of the surgical lamp, which are difficult to control from the source, so in the embodiment, the inventor adopts a mode of directly performing temperature correction on the second correction data, and it should be understood that the temperature correction can be performed by using a temperature-corresponding lactic acid variation curve, or by using a difference technology, and the like, which is not repeated herein.
The third correction data generated by correcting the second correction data is directly subtracted from the first lactate threshold in this embodiment as a new first lactate threshold for the next perfusion test. The first lactic acid threshold value is changed every time, so that the first correction data are continuously close to the second lactic acid threshold value, the detection accuracy is ensured, and when the first correction data are lower than the second lactic acid threshold value, the difference value can be calculated to be timely recalled.
In one embodiment, the control terminal 100 initializes the first lactate threshold when being turned on;
the control terminal 100 assigns the second lactate threshold to the first lactate threshold to complete the initialization.
In this embodiment, the whole adjustment process of the first lactate threshold is regarded as an iterative approach process, so that initialization is required at the initial iteration, and from the safety point of view, the second lactate threshold is assigned to the first lactate threshold, that is, when the first perfusion is performed, the perfusion is performed based on the second lactate threshold.
In one embodiment, the control terminal 100 is further configured with second temperature data, and calculates a ratio of the first temperature data and the second temperature data as fourth correction data; the first temperature data and the second temperature data both adopt Kelvin temperature;
the control terminal 100 calculates a product of the second correction data and the fourth correction data as third correction data.
In this embodiment, in order to implement the temperature correction on the second correction data, the second temperature data is preset as a standardized data in this embodiment, it should be understood that the second temperature data generally uses a common room temperature, that is, 293.15K, and after the second correction data is corrected by the generated fourth correction data, the third correction data for directly performing the correction calculation can be obtained.
In one embodiment, the control terminal 100 is further configured to acquire a time when the first lactate data exceeds the first lactate threshold as a first time, and acquire a time when the first lactate data reaches a maximum value after exceeding the first lactate threshold at this time as a second time;
the control terminal 100 calculates a difference between the second time and the first time as a correction time, and calculates a difference between the maximum value and the first lactate threshold as corrected lactate data;
the control terminal 100 calculates a ratio of the corrected lactic acid data to the corrected time as rising speed data;
the control terminal 100 generates perfusion flow data according to the rising speed data;
the control terminal 100 sends the perfusion flow data to the perfusion device 300, and the perfusion flow data is used for correcting the flow of the next perfusion of the perfusion device 300.
In the present embodiment, referring to fig. 1, the conventional perfusion apparatus 300 generally includes several main components: according to the operation mode of the conventional perfusion apparatus 300, the liquid in the liquid storage tank 301 should be pumped into the thermostat 303 by the pump 302, and the thermostat 303 completes heating or cooling, and then is output into the pipeline to reach the target perfusion area 200 through the solenoid valve 304, and the corresponding output flow rate is usually fixed, it should be understood that the preset dose of the liquid and the perfusion flow rate set forth in this embodiment are different, the preset dose indicates the volume of the liquid in one perfusion, and the unit is generally ml, and the perfusion flow rate indicates the speed of the liquid in one perfusion, and the unit is generally ml/s.
On the basis of the above-mentioned prior art, the inventor found that although accurate detection of the lactic acid content and accurate control of the perfusion apparatus 300 can be achieved by the above-mentioned embodiments, it is disadvantageous to suppress the lactic acid content if perfusion is performed on the basis of the same flow rate each time, for example, after reaching the first lactic acid threshold, the lactic acid content still rises at a fast speed, which may cause the maximum value of the lactic acid content to reach a dangerous value, especially for different people with corresponding great differences in physical conditions, and the lactic acid content rises at a fast speed, so that in this embodiment, a way adaptive to the lactic acid content rising speed is adopted to control the liquid perfusion flow rate.
In this example, the flow rate control was mainly performed using the rate at which the start of perfusion until the lactic acid rises to the maximum value as the rising rate data. Specifically, the flow control can be performed through linear interpolation, or the flow control can be performed through data fitting, and by means of the embodiment, adaptive control can be performed on different lactic acid rise conditions well.
In one embodiment, the control terminal 100 is configured with a reference speed and a reference flow rate;
the control terminal 100 calculates the ratio of the rise speed data to the reference speed multiplied by the reference flow to generate perfusion flow data.
In the implementation of this embodiment, a linear manner is adopted to generate perfusion flow data, and the flow is specifically controlled by a preset reference speed and a preset reference flow.
In one embodiment, the perfusion device 300 perfuses a preset dose of liquid to the target perfusion area 200 when receiving the perfusion trigger command, wherein the preset dose is 10-15 ml/kg body weight.
In one embodiment, please refer to fig. 1, which further includes:
a third sensor 203 configured to be communicatively coupled to the control terminal 100 and acquire a bioelectric signal of the target perfusion area 200;
the control terminal 100 processes the bioelectric signal to generate an electrical signal determination data, and sends a perfusion trigger instruction to the perfusion device 300 when the electrical signal determination data exceeds a threshold value.
In the implementation of this embodiment, in practice, the inventor finds that the heart is prone to have a rebound phenomenon with the increase of the lactic acid content, which is very dangerous during the operation, and in scientific practice, the inventor finds that the activity degree of the bioelectric signal can be well detected and predicted for the rebound of the heart, so in this embodiment, the bioelectric signal is used for emergency judgment, when the judgment data of the bioelectric signal exceeds a threshold value, it indicates that the heart is going to rebound, at this time, a perfusion trigger instruction is sent to the perfusion device 300, and the perfusion device 300 starts perfusion to inhibit the rebound.
In an embodiment, after filtering and denoising the bioelectric signal, the control terminal 100 performs frequency domain analysis to obtain a power spectral density within a preset frequency band, and uses the power spectral density as electrical signal discrimination data.
In the implementation of this embodiment, since the noise ratio of the bioelectric signal itself is relatively large and is easily affected by the surrounding environment, and meanwhile, the inventor also finds that the complex hopping condition represented by the bioelectric signal is different in different frequency bands, in this embodiment, a criterion of extracting the power spectral density in a preset frequency band and performing the complex hopping with the power spectral density is adopted.
In one embodiment, referring to fig. 1, the control terminal 100 is further configured to generate a perfusion temperature command according to the temperature of the target perfusion area 200, send the perfusion temperature command to the perfusion apparatus 300, and use the perfusion temperature command for temperature correction of the next perfusion of the perfusion apparatus 300.
In the embodiment, the temperature of the target perfusion region 200 is controlled, the higher the temperature, the faster the lactic acid increases, but each perfusion is time-consuming, and if the lactic acid increases rapidly, the more times of perfusion are needed, which prolongs the operation time and is disadvantageous to the operation itself, so that the perfusion temperature control can be realized by sending a perfusion temperature command to the perfusion device 300 in the embodiment.
Those of ordinary skill in the art will appreciate that the elements and algorithm steps of the examples described in connection with the embodiments disclosed herein may be embodied in electronic hardware, computer software, or combinations of both, and that the components and steps of the examples have been described in a functional general in the foregoing description for the purpose of illustrating clearly the interchangeability of hardware and software. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the implementation. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention.
In the several embodiments provided in the present application, it should be understood that the disclosed apparatus and method may be implemented in other ways. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may also be an electric, mechanical or other form of connection.
The elements described as separate parts may or may not be physically separate, as one of ordinary skill in the art would appreciate that the elements and algorithm steps of the examples described in connection with the embodiments disclosed herein may be embodied in electronic hardware, computer software, or combinations of both, and that the components and steps of the examples have been described in a functional general sense in the foregoing description for clarity of explanation of the interchangeability of hardware and software. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the implementation. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention.
In addition, functional units in the embodiments of the present invention may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.
The integrated unit, if implemented in the form of a software functional unit and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention essentially or partially contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product stored in a storage medium and including instructions for causing a computer device (which may be a personal computer, a server, or a grid device) to execute all or part of the steps of the method according to the embodiments of the present invention. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (9)
1. A method for detecting perfusion of a liquid, comprising: acquiring the lactic acid content of a target perfusion area as first lactic acid data, and acquiring the temperature of the target perfusion area; perfusing the target perfusion region with a liquid when the first lactate data exceeds a first lactate threshold; when the first lactic acid data exceed the first lactic acid threshold, recording the temperature of the current target perfusion area as first temperature data, and recording the maximum value of the current first lactic acid data after the first lactic acid data exceed the first lactic acid threshold as first correction data; correcting the first lactic acid threshold value after calculating the first temperature data and the first correction data;
further comprising: acquiring the moment when the first lactic acid data exceeds the first lactic acid threshold as a first moment, and acquiring the moment when the first lactic acid data reaches the maximum value after exceeding the first lactic acid threshold as a second moment; calculating a difference value between the second time and the first time as a correction time, and calculating a difference value between the maximum value and the first lactic acid threshold value as corrected lactic acid data; calculating the ratio of the corrected lactic acid data to the corrected time as rising speed data; generating perfusion flow data from the rise speed data; and correcting the flow rate of the next perfusion according to the perfusion flow rate data.
2. The detection method for liquid perfusion according to claim 1, wherein the correcting the first lactate threshold after operating the first temperature data and the first correction data comprises: calculating a difference value between the first correction data and a preset second lactic acid threshold value to serve as second correction data, and correcting the second correction data through the first temperature data to serve as third correction data; and calculating the difference value of the first lactic acid threshold value and the third correction data as a corrected first lactic acid threshold value.
3. The detection method for liquid perfusion of claim 2, further comprising: initializing the first lactate threshold at turn-on; the initializing is accomplished by assigning the second threshold value of lactic acid to the first threshold value of lactic acid.
4. The detection method for liquid perfusion according to claim 2, wherein correcting the second correction data by the first temperature data as third correction data includes: calculating a ratio of the first temperature data to preset second temperature data to serve as fourth correction data; the first temperature data and the second temperature data both adopt Kelvin temperature; and calculating a product of the second correction data and the fourth correction data as third correction data.
5. The detection method for liquid perfusion of claim 1, wherein generating perfusion flow data from the rise rate data comprises: and calculating the ratio of the rising speed data to a preset reference speed to be multiplied by a preset reference flow to generate perfusion flow data.
6. The method for detecting perfusion of liquid according to claim 1, wherein the preset dosage of the liquid for perfusion in the target perfusion area is 10-15 ml/kg of body weight.
7. The detection method for liquid perfusion according to claim 1, further comprising: acquiring a bioelectrical signal of a target perfusion area; filtering and denoising the bioelectric signal, performing frequency domain analysis to obtain power spectral density in a preset frequency band, and taking the power spectral density as electric signal discrimination data; and when the electrical signal discrimination data exceeds a threshold value, filling liquid into the target filling area.
8. A test device for perfusion of a liquid according to any of claims 1 to 7, comprising:
a control terminal communicatively coupled to a perfusion apparatus that perfuses a target perfusion area with a liquid and issues a perfusion trigger instruction to the perfusion apparatus; a first sensor configured to be communicatively coupled to the control terminal and to acquire the lactate content of the target perfusion region as first lactate data to be sent to the control terminal; the second sensor is configured to be communicatively coupled to the control terminal and acquire the temperature of the target perfusion area and send the temperature to the control terminal; the control terminal is configured to send the perfusion trigger instruction to the perfusion device when the received first lactic acid data exceeds a first lactic acid threshold configured to the control terminal; when the first lactic acid data exceed the first lactic acid threshold, the control terminal records the temperature of the current target perfusion area as first temperature data, and records the maximum value of the current first lactic acid data after the first lactic acid data exceed the first lactic acid threshold as first correction data; and the control terminal corrects the first lactic acid threshold after calculating the first temperature data and the first correction data.
9. The detection apparatus for liquid perfusion according to claim 8, further comprising: a third sensor configured to be communicatively coupled to the control terminal and to acquire a bioelectric signal of a target perfusion region; the control terminal generates electric signal judging data after processing the bioelectric signal and sends a perfusion trigger instruction to the perfusion device when the electric signal judging data exceeds a threshold value.
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| US6803227B2 (en) * | 2001-10-16 | 2004-10-12 | Supachill Technologies Pty. Ltd. | Organ preservation system including articles comprising a super-coolable composition having long-duration phase change capability |
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