CN113607866A - Apparatus for controlling temperature of chromatographic column and method for manufacturing the same - Google Patents
Apparatus for controlling temperature of chromatographic column and method for manufacturing the same Download PDFInfo
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- CN113607866A CN113607866A CN202110794717.8A CN202110794717A CN113607866A CN 113607866 A CN113607866 A CN 113607866A CN 202110794717 A CN202110794717 A CN 202110794717A CN 113607866 A CN113607866 A CN 113607866A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 92
- 230000017525 heat dissipation Effects 0.000 claims abstract description 12
- 238000005057 refrigeration Methods 0.000 claims abstract description 8
- 230000001681 protective effect Effects 0.000 claims description 31
- 238000004587 chromatography analysis Methods 0.000 claims description 14
- 238000007789 sealing Methods 0.000 claims description 14
- 239000011810 insulating material Substances 0.000 claims description 8
- 239000012774 insulation material Substances 0.000 claims description 5
- 238000005265 energy consumption Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
Abstract
The invention provides a device for controlling the temperature of a chromatographic column and a manufacturing method thereof, wherein the device for controlling the temperature of the chromatographic column comprises the chromatographic column, a bottom plate, a cavity and a top plate; further comprising: the heat conduction unit is provided with heat dissipation teeth and is arranged on the inner side of the bottom plate; the refrigeration unit is arranged on the outer side of the bottom plate and is in contact with the heat conduction unit; the circuit board is arranged on the outer side of the cavity; the heating module is wound on the chromatographic column, and the spiral chromatographic column is arranged on the upper side of the heat conducting unit; the electric wire connected with the heating module is connected with the circuit board; the temperature sensor is arranged in the cavity, and an electric wire connected with the temperature sensor is connected with the circuit board; the heating seat is provided with an opening and is arranged outside the cavity; the joint is arranged in the heating seat and is communicated with the opening; two ends of the chromatographic column respectively penetrate through the through holes of the cavity and are connected with the joints; the heater and the temperature measuring element are respectively arranged in the heating seat. The invention has the advantages of small volume, low energy consumption and the like.
Description
Technical Field
The invention relates to the field of chromatographic analysis, in particular to a device for controlling the temperature of a chromatographic column and a manufacturing method thereof.
Background
At present, a gas bath heating scheme is mostly adopted in a column oven temperature control technology, specifically, a heating wire is heated in a gas bath manner to realize temperature programming of a chromatographic column, the power required by heating is high (about 2000W), the temperature control range is usually about room temperature plus 10-400 ℃, some low-boiling-point substances can be effectively separated at a low temperature, and the common column oven cannot realize effective separation of the low-boiling-point substances.
In order to solve the problem of high power of the column oven, a small column oven is released by some companies, but the gas bath heating mode is still adopted for chromatographic column heating, and the defect of the mode is that the problem of heat loss of the gas bath heating cannot be solved;
aiming at the problem of low-temperature separation, the prior art adopts the method of introducing liquid nitrogen or liquid CO into a column box2The mode of (2) provides lower initial temperature for the column box, and the disadvantage of this kind of mode lies in can't realizing the accurate control to microthermal.
Disclosure of Invention
In order to solve the defects in the prior art, the invention provides a device for controlling the temperature of a chromatographic column.
The purpose of the invention is realized by the following technical scheme:
the device for controlling the temperature of the chromatographic column comprises the chromatographic column, a bottom plate, a cavity and a top plate, wherein a closed space is enclosed by the bottom plate, the cavity and the top plate, and the chromatographic column is arranged in the closed space; the apparatus for controlling the temperature of a chromatography column further comprises:
the heat conduction unit is provided with heat dissipation teeth and is arranged on the inner side of the bottom plate;
the refrigeration unit is arranged on the outer side of the bottom plate and is in contact with the heat conduction unit;
the circuit board is arranged on the outer side of the cavity;
the heating module is wound on the chromatographic column, and the spiral chromatographic column is arranged on the upper side of the heat conducting unit; the electric wire connected with the heating module is connected with the circuit board;
the temperature sensor is arranged in the cavity, and an electric wire connected with the temperature sensor is connected with the circuit board;
the heating seat is provided with an opening and is arranged outside the cavity; the joint is arranged in the heating seat and is communicated with the opening; two ends of the chromatographic column respectively penetrate through the through holes of the cavity and are connected with the joints;
the heater and the temperature measuring element are respectively arranged in the heating seat.
The invention also aims to provide a manufacturing method of the device for controlling the temperature of the chromatographic column, and the aim is realized by the following technical scheme:
a method of manufacturing a device for controlling the temperature of a chromatography column, said method comprising the steps of:
(A1) fixing a heat conduction unit on the inner side of the bottom plate, wherein the heat conduction unit is provided with heat dissipation teeth;
(A2) fixing a spiral chromatographic column on the upper side of the heat conducting unit, wherein a heating module is wound on the outer side of the chromatographic column; the temperature sensor is arranged on the upper side of the bottom plate;
(A3) installing a cavity, arranging the cavity on the upper side of the bottom plate, arranging a first connector at the through hole of the cavity, and sealing the through hole;
fixing a heating seat on the outer side of the cavity, wherein the heating seat is provided with an opening, and a cylindrical component on the lower side of the heating seat penetrates through the through hole of the cavity; arranging a joint in the heating seat and communicating with the opening; two ends of the chromatographic column respectively penetrate through the cylindrical component and are connected with the joint;
(A4) connecting a circuit; the heating module and the temperature sensor are respectively inserted into the part of the first connector assembly, which is positioned at the inner side of the cavity;
the heater and the temperature measuring element are respectively arranged in the heating seat;
(A5) fixing a top plate on the upper side of the cavity;
(A6) the circuit board is inserted in the part of the first connector assembly, which is positioned outside the cavity;
(A7) wrapping heat-insulating materials on the outer sides of the cavity, the bottom plate and the top plate;
(A8) and a protective shell is arranged on the outer side of the heat-insulating material, and the second connector on the circuit board is exposed.
Compared with the prior art, the invention has the beneficial effects that:
1. the temperature control efficiency is high;
the heating module wound on the chromatographic column is used for realizing the direct heating of the chromatographic column, while the heating module not wound (in and out of the cavity part) is realized through the body and the cylindrical part outside the chromatographic column, so that the rapid temperature rise of the whole chromatographic column is realized;
the refrigeration unit arranged outside the cavity is connected with the heat conduction unit, so that the temperature in the cavity is quickly reduced; due to the arrangement of the fan, the cooling time is further reduced;
by means of the arrangement of the sealing elements and the heat insulation materials, the space where the chromatographic column is located is sealed, heat exchange with the outside (a non-refrigeration unit) is reduced, and the temperature control efficiency is further improved;
2. the temperature control precision is high;
the temperature sensor is arranged in the closed space, and the temperature obtained in real time is utilized to accurately control the heating module and the refrigerating unit, so that the temperature control precision of the chromatographic column part in the cavity is improved;
the temperature sensor suspended between the radiating teeth accurately obtains the real temperature and improves the subsequent temperature control precision;
the heating of the chromatographic column without winding the heating module is independently realized by using the heater and the temperature measuring element, so that the temperature control precision of the chromatographic column part entering and exiting the cavity is realized;
3. the power consumption is low;
due to the adoption of the scheme of direct heating, the heat insulation by the protective material and the formed closed space, the power consumption of heating is reduced, and the overall heating power is less than 100W and is obviously lower than 2000W in the prior art.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only for illustrating the technical solutions of the present invention and are not intended to limit the scope of the present invention. In the figure:
FIG. 1 is a schematic flow diagram of a method of manufacturing an apparatus for controlling the temperature of a chromatography column according to an embodiment of the invention.
Detailed Description
Fig. 1 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. Some conventional aspects have been simplified or omitted for the purpose of explaining the technical solution of the present invention. Those skilled in the art will appreciate that variations or substitutions from these embodiments will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
the device for controlling the temperature of the chromatographic column comprises:
the device comprises a chromatographic column, a bottom plate, a cavity and a top plate, wherein a closed space is enclosed by the bottom plate, the cavity and the top plate, and the chromatographic column is arranged in the closed space;
the heat conduction unit is provided with heat dissipation teeth and is arranged on the inner side of the bottom plate;
a refrigeration unit, such as a TEC, disposed at an outer side of the base plate and in contact with the heat conduction unit;
the circuit board is arranged on the outer side of the cavity;
a heating module such as an insulated heating wire, the heating module being wound around the chromatographic column, the spiral chromatographic column being disposed on an upper side of the heat conducting unit; the electric wire connected with the heating module is connected with the circuit board, for example, the electric wire penetrates through a through hole of the cavity to be connected with the circuit board, or a connector arranged at the through hole of the cavity is used for switching;
the temperature sensor is arranged in the cavity, and an electric wire connected with the temperature sensor is connected with the circuit board, for example, the electric wire penetrates through a through hole of the cavity to be connected with the circuit board, or a connector arranged at the through hole of the cavity is used for switching;
the heating seat is provided with an opening and is arranged outside the cavity; the joint is arranged in the heating seat and is communicated with the opening; two ends of the chromatographic column respectively penetrate through the through holes of the cavity and are connected with the joints; that is, heating of the portion of the chromatography column not wrapped by the heating module (i.e., the portion entering and exiting the chamber) is achieved;
the heater and the temperature measuring element are respectively arranged in the heating seat.
In order to heat a chromatography column entering and exiting the chamber by means of a heating seat outside the chamber, further, the heating seat comprises:
the body is provided with the opening and is arranged on the outer side of the cavity, and a first sealing element is arranged between the body and the outer wall of the cavity; the heater and the temperature measuring element are arranged in the body;
one end of the cylindrical component is fixed at the bottom side of the body, and the other end of the cylindrical component penetrates through the through hole of the cavity and enters the cavity; the chromatographic column passes through the cylindrical part and is connected with the joint.
In order to prevent the heating seat with high temperature from being touched by mistake and form a closed space, further, the heating seat further comprises:
the two ends of the protective cover are opened and are arranged outside the body; a second sealing element is arranged between the bottom end of the protective cover and the body, and a third sealing element is arranged between the outer wall of the body on the upper side of the joint and the protective cover;
the screw penetrates through the through hole surrounding the opening at the top end of the protective cover and is fixed in the screw hole at the top end of the body; the second and third seals are compressed between the boot and the body, respectively, with the opening of the body exposed.
In order to stably fix the chromatographic column, further, a support column is disposed on an inner wall of the bottom plate, the support column is disposed around the heat conducting unit, the chromatographic column is fixed on the support column, and a gap is formed between the heat conducting unit and the chromatographic column.
In order to increase the cooling rate, further, the device for controlling the temperature of the chromatographic column further comprises:
the fan is arranged on the upper side of the heat conduction unit and is positioned in the area enclosed by the chromatographic column; and the electric wire connected with the fan passes through the cavity and is connected with the circuit board.
In order to form a closed space to improve the efficiency of temperature control, further, the device for controlling the temperature of the chromatographic column further comprises:
the first connector is arranged at the through hole of the cavity and seals the through hole; the heating module, the temperature sensor and the electric wire of the fan are respectively inserted in the part, located on the inner side of the cavity, of the first connector, and the circuit board is inserted in the part, located on the outer side of the cavity, of the first connector.
In order to improve the temperature efficiency and the protection effect of the chromatographic column, further, the device for controlling the temperature of the chromatographic column further comprises:
the shell is arranged on the outer sides of the cavity, the bottom plate and the top plate;
the heat insulation material is arranged in a space between the shell and the cavity, and the second connector on the circuit board is exposed.
In order to accurately obtain the temperature of the chromatographic column, the temperature sensor is further arranged between the radiating teeth in a suspended manner.
Fig. 1 schematically shows a flow chart of a method for manufacturing an apparatus for controlling a temperature of a chromatography column according to an embodiment of the present invention, as shown in fig. 1, the method comprising the steps of:
(A1) fixing a heat conduction unit on the inner side of the bottom plate, wherein the heat conduction unit is provided with heat dissipation teeth, for example, by screws;
(A2) fixing a spiral chromatographic column on the upper side of the heat conducting unit, wherein a heating module is wound on the outer side of the chromatographic column; the temperature sensor is arranged on the upper side of the bottom plate;
(A3) installing a cavity, arranging the cavity on the upper side of the bottom plate, arranging a first connector at the through hole of the cavity, and sealing the through hole;
fixing a heating seat on the outer side of the cavity, wherein the heating seat is provided with an opening, and a cylindrical component on the lower side of the heating seat penetrates through the through hole of the cavity; arranging a joint in the heating seat and communicating with the opening; two ends of the chromatographic column respectively penetrate through the cylindrical component and are connected with the joint;
(A4) connecting a circuit; the heating module and the temperature sensor are respectively inserted into the part of the first connector assembly, which is positioned at the inner side of the cavity;
the heater and the temperature measuring element are respectively arranged in the heating seat;
(A5) fixing a top plate on the upper side of the cavity;
(A6) the circuit board is inserted in the part of the first connector assembly, which is positioned outside the cavity;
(A7) wrapping heat-insulating materials on the outer sides of the cavity, the bottom plate and the top plate;
(A8) and a protective shell is arranged on the outer side of the heat-insulating material, and the second connector on the circuit board is exposed.
In order to prevent the heating base with high temperature from being touched by mistake and form a closed space, further, in the step (A3), a protective cover is sleeved outside the heating base, and the opening of the heating base is exposed;
a screw penetrates through the through hole surrounding the opening at the top end of the protective cover and is fixed in the screw hole at the top end of the heating seat; a second sealing element between the bottom end of the protective cover and the heating seat is extruded, and a third sealing element arranged between the outer wall of the heating seat on the upper side of the joint and the protective cover is extruded;
the first seal between the heating seat and the cavity is compressed.
Example 2:
an application example of the apparatus for controlling a column and the method for manufacturing the same according to embodiment 1 of the present invention.
In the application example, a sixth annular groove is formed in the inner wall of the rectangular bottom plate, a sixth O-shaped ring is arranged in the sixth annular groove, a rectangular through hole is formed in the surrounding area of the sixth annular groove, and a mounting hole is formed between the rectangular through hole and the sixth annular groove;
one side of the heat conduction unit, which faces the rectangular through hole, is a plane, and the other side, which is back to the rectangular through hole, is provided with heat dissipation teeth distributed in an array manner, and screws penetrate through the heat conduction unit and are fixed on the mounting holes, so that the heat conduction unit is fixed on the inner side of the rectangular through hole, namely the inner side of the bottom plate; the plurality of support columns are fixed on the inner side of the bottom plate and surround the heat conducting unit; the refrigeration unit arranged on the outer side of the bottom plate adopts a TEC, and the cold end of the refrigeration unit passes through the rectangular through hole and is in contact with the plane of the heat conduction unit;
the heating module adopts a heating wire and is directly wound on a chromatographic column, the chromatographic column is spiral, and the inlet end and the outlet end are linear; a heat conducting film is wound outside the chromatographic column of the spiral part, the chromatographic column of the spiral part is fixed on the supporting column, and a gap is formed between the chromatographic column and the heat radiating teeth (without contact);
the temperature sensor is arranged between the heat dissipation teeth in a suspended manner, and the fan is arranged on the upper side of the heat dissipation teeth and is positioned in the region surrounded by the spiral chromatographic column;
the cavity is rectangular, and the hollow part is cylindrical; the upper side of the cavity is provided with a first through hole and a second through hole, and the lower side of the cavity is provided with a third through hole; the outer wall of the cavity is provided with a fifth annular groove surrounding the third through hole, a fifth O-shaped ring is arranged in the groove, the first connector is fixed at the third through hole and extrudes the fifth O-shaped ring, and therefore the third through hole is sealed; the outer side of the cavity is provided with a first annular groove surrounding the first through hole and a fourth annular groove surrounding the second through hole, the first O-shaped ring is arranged in the first annular groove, and the fourth O-shaped ring is arranged in the fourth annular groove;
the first heating seat and the second heating seat are of the same structure, the first joint and the second joint are the same, the first heating seat comprises a body and a cylindrical component which are made of metal materials, the top end of the body is provided with an opening communicated with the first joint and a hole surrounding the opening, the body is fixed outside the first through hole and extrudes a first O-shaped ring, the cylindrical component is fixed on the lower side of the body, penetrates through the first through hole and surrounds a linear chromatographic column, and the first joint is located between the bodies and connected with the chromatographic column penetrating through the cylindrical component; the outer wall of the body on the upper side of the first joint is provided with a third annular groove, and a third O-shaped ring is arranged in the third annular groove; the first protective cover and the second protective cover are the same and both ends are open; the bottom end of the first protective cover is provided with a second annular groove, the second O-shaped ring is arranged in the second annular groove, and the top end of the first protective cover is provided with a plurality of through holes surrounding the opening; the screw penetrates through the through hole at the top end of the first protective cover and is fixed in the hole at the top end of the body, and the second O-shaped ring and the third O-shaped ring are extruded; the installation mode between the second protective cover and the second heating seat is the same as that of the first protective cover;
the circuit board is arranged outside the cavity and is spliced with the part of the first connector assembly, which is positioned outside the cavity, and the second connector assembly is fixed on the circuit board; the heating module, the fan and the wires of the temperature sensor are inserted into the part, located in the cavity, of the first connector;
the heat insulation material is arranged on the outer sides of the cavity, the bottom plate and the top plate, the shell is arranged on the outer side of the heat insulation material, and the second connector on the circuit board is exposed and is convenient to connect with external electrical components.
As shown in fig. 1, the method for manufacturing the apparatus for controlling a chromatography column of the present embodiment includes the steps of:
(A1) fixing a heat conduction unit on the inner side of the bottom plate, namely the inner side of the rectangular through hole, wherein one side of the heat conduction unit, which is back to the rectangular through hole, is provided with heat dissipation teeth, and one side of the heat conduction unit, which faces the rectangular through hole, is a plane;
(A2) fixing a spiral chromatographic column on the upper side of the heat conducting unit, wherein a heating module and a heat conducting film are sequentially wound on the outer side of the chromatographic column; the temperature sensor is arranged on the upper side of the bottom plate and suspended between the heat dissipation teeth;
(A3) a cavity is installed, the cavity is arranged on the upper side of the bottom plate, and a sixth O-shaped ring is arranged between the cavity and the bottom plate; arranging the first connector at a third through hole of the cavity, and extruding the fifth O-shaped ring so as to close the third through hole;
the linear parts of the chromatographic column respectively pass through the first through hole and the second through hole;
the screw penetrates through the bottom plate and is connected with the cavity, and the sixth O-shaped ring is extruded;
fixing a body of a first heating seat at a first through hole on the outer side of the cavity, extruding a first O-shaped ring by the body, enabling a cylindrical component to penetrate through the first through hole to enter the cavity, enabling a linear chromatographic column to penetrate through the cylindrical component and be connected with a first joint, and enabling the first joint to be communicated with an opening of the body;
the first protective cover is arranged on the outer side of the body, the screw penetrates through the through hole in the top end of the first protective cover and is fixed in the hole in the top end of the body, and the second O-shaped ring and the third O-shaped ring are extruded;
similarly, a second heating seat and a second protective cover are installed;
(A4) connecting a circuit; the heating module, the fan and the wires of the temperature sensor are respectively inserted into the part, located on the inner side of the cavity, of the first connector;
the heater and the temperature measuring element are respectively arranged in the first heating seat and the second heating seat;
(A5) fixing a top plate on the upper side of the cavity, wherein a seventh annular groove is formed in the lower side of the top plate, and a seventh O-shaped ring is arranged in the seventh annular groove;
the screw penetrates through the top plate and is connected with the cavity, and the seventh O-shaped ring is extruded;
(A6) the circuit board is inserted in the part of the first connector assembly, which is positioned outside the cavity;
(A7) wrapping heat-insulating materials on the outer sides of the cavity, the bottom plate and the top plate;
(A8) and a protective shell is arranged on the outer side of the heat-insulating material, and the second connector on the circuit board is exposed.
Claims (10)
1. The device for controlling the temperature of the chromatographic column comprises the chromatographic column, a bottom plate, a cavity and a top plate, wherein a closed space is enclosed by the bottom plate, the cavity and the top plate, and the chromatographic column is arranged in the closed space; characterized in that the device for controlling the temperature of the chromatographic column further comprises:
the heat conduction unit is provided with heat dissipation teeth and is arranged on the inner side of the bottom plate;
the refrigeration unit is arranged on the outer side of the bottom plate and is in contact with the heat conduction unit;
the circuit board is arranged on the outer side of the cavity;
the heating module is wound on the chromatographic column, and the spiral chromatographic column is arranged on the upper side of the heat conducting unit; the electric wire connected with the heating module is connected with the circuit board;
the temperature sensor is arranged in the cavity, and an electric wire connected with the temperature sensor is connected with the circuit board;
the heating seat is provided with an opening and is arranged outside the cavity; the joint is arranged in the heating seat and is communicated with the opening; two ends of the chromatographic column respectively penetrate through the through holes of the cavity and are connected with the joints;
the heater and the temperature measuring element are respectively arranged in the heating seat.
2. The apparatus for controlling the temperature of a chromatography column of claim 1, wherein the heated seat comprises:
the body is provided with the opening and is arranged on the outer side of the cavity, and a first sealing element is arranged between the body and the outer wall of the cavity; the heater and the temperature measuring element are arranged in the body;
one end of the cylindrical component is fixed at the bottom side of the body, and the other end of the cylindrical component penetrates through the through hole of the cavity and enters the cavity; the chromatographic column passes through the cylindrical part and is connected with the joint.
3. The apparatus for controlling the temperature of a chromatography column of claim 2, wherein the heated seat further comprises:
the two ends of the protective cover are opened and are arranged outside the body; a second sealing element is arranged between the bottom end of the protective cover and the body, and a third sealing element is arranged between the outer wall of the body on the upper side of the joint and the protective cover;
the screw penetrates through the through hole surrounding the opening at the top end of the protective cover and is fixed in the screw hole at the top end of the body; the second and third seals are compressed between the boot and the body, respectively, with the opening of the body exposed.
4. The apparatus of claim 1, wherein the inner wall of the base plate is provided with a support column, the support column is disposed around the heat conducting unit, the chromatographic column is fixed on the support column, and a gap is formed between the heat conducting unit and the chromatographic column.
5. The apparatus for controlling the temperature of a chromatography column according to claim 1, further comprising:
the fan is arranged on the upper side of the heat conduction unit and is positioned in the area enclosed by the chromatographic column; and the electric wire connected with the fan passes through the cavity and is connected with the circuit board.
6. The apparatus for controlling the temperature of a chromatography column according to claim 5, further comprising:
the first connector is arranged at the through hole of the cavity and seals the through hole; the heating module, the temperature sensor and the electric wire of the fan are respectively inserted in the part, located on the inner side of the cavity, of the first connector, and the circuit board is inserted in the part, located on the outer side of the cavity, of the first connector.
7. The apparatus for controlling the temperature of a chromatography column according to claim 1, further comprising:
the shell is arranged on the outer sides of the cavity, the bottom plate and the top plate;
the heat insulation material is arranged in a space between the shell and the cavity, and the second connector on the circuit board is exposed.
8. The apparatus of claim 1, wherein the temperature sensor is suspended between heat sink teeth.
9. A method of manufacturing a device for controlling the temperature of a chromatography column, said method comprising the steps of:
(A1) fixing a heat conduction unit on the inner side of the bottom plate, wherein the heat conduction unit is provided with heat dissipation teeth;
(A2) fixing a spiral chromatographic column on the upper side of the heat conducting unit, wherein a heating module is wound on the outer side of the chromatographic column; the temperature sensor is arranged on the upper side of the bottom plate;
(A3) installing a cavity, arranging the cavity on the upper side of the bottom plate, arranging a first connector at the through hole of the cavity, and sealing the through hole;
fixing a heating seat on the outer side of the cavity, wherein the heating seat is provided with an opening, and a cylindrical component on the lower side of the heating seat penetrates through the through hole of the cavity; arranging a joint in the heating seat and communicating with the opening; two ends of the chromatographic column respectively penetrate through the cylindrical component and are connected with the joint;
(A4) connecting a circuit; the heating module and the temperature sensor are respectively inserted into the part of the first connector assembly, which is positioned at the inner side of the cavity;
the heater and the temperature measuring element are respectively arranged in the heating seat;
(A5) fixing a top plate on the upper side of the cavity;
(A6) the circuit board is inserted in the part of the first connector assembly, which is positioned outside the cavity;
(A7) wrapping heat-insulating materials on the outer sides of the cavity, the bottom plate and the top plate;
(A8) and a protective shell is arranged on the outer side of the heat-insulating material, and the second connector on the circuit board is exposed.
10. The method of claim 9, wherein in step (a3), the protective cover is fitted over the outside of the heating base, the opening of the heating base being exposed;
a screw penetrates through the through hole surrounding the opening at the top end of the protective cover and is fixed in the screw hole at the top end of the heating seat; a second sealing element between the bottom end of the protective cover and the heating seat is extruded, and a third sealing element arranged between the outer wall of the heating seat on the upper side of the joint and the protective cover is extruded;
the first seal between the heating seat and the cavity is compressed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110794717.8A CN113607866A (en) | 2021-07-14 | 2021-07-14 | Apparatus for controlling temperature of chromatographic column and method for manufacturing the same |
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| CN202110794717.8A CN113607866A (en) | 2021-07-14 | 2021-07-14 | Apparatus for controlling temperature of chromatographic column and method for manufacturing the same |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009236584A (en) * | 2008-03-26 | 2009-10-15 | Yazaki Corp | Column unit and gas chromatograph device |
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