CN113599400A - Liquid composition for preventing battery foreign matter from damaging esophagus and application thereof - Google Patents
Liquid composition for preventing battery foreign matter from damaging esophagus and application thereof Download PDFInfo
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- CN113599400A CN113599400A CN202110820962.1A CN202110820962A CN113599400A CN 113599400 A CN113599400 A CN 113599400A CN 202110820962 A CN202110820962 A CN 202110820962A CN 113599400 A CN113599400 A CN 113599400A
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- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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Abstract
The invention discloses a liquid composition for preventing a battery foreign body from damaging an esophagus, which comprises the following raw material components in percentage by volume: 40-60% of edible oil and 40-60% of honey. The invention also discloses application of the liquid composition for preventing the battery foreign matter from damaging the esophagus in preventing the damage of the battery foreign matter on the esophagus. The liquid composition for preventing the esophagus from being damaged by the foreign matters of the battery can radically block the discharge of the battery by mixing the edible oil and the honey to form the edible viscous insulating liquid, so that the generation of alkaline substances in tissues is reduced, the esophagus damage can be more effectively prevented, the damaged area of the esophagus is reduced, the discharge of the battery is reduced, the necrosis range and depth of the mucosa of the esophagus are reduced, and the infiltration range and depth of neutrophils are reduced; the liquid composition provided by the invention has the characteristics of low price, simple raw materials and easy acquisition, and is suitable for wide popularization and use.
Description
Technical Field
The invention belongs to the technical field of preparation and application of liquid compositions, and particularly relates to a liquid composition for preventing a battery foreign body from damaging an esophagus and application thereof.
Background
In real life, an event that a child swallows a battery by mistake happens occasionally, and particularly the occurrence probability of the event that the child swallows a button battery by mistake is high. Insertion of the battery into the esophagus can quickly corrode the esophagus and cause serious complications and even death. Button cell intake classification and treatment guidelines set forth in the U.S. national center for toxicants, early administration of a pH-neutralized viscous liquid in the event of a mistaken ingestion of a button cell may alleviate esophageal injury. However, the fundamental reason why the battery corrodes and damages the esophagus is that the battery discharges, which causes a great amount of alkaline substances to be generated in the esophageal tissue to cause tissue coagulative necrosis, while the above-mentioned pH-neutralized viscous liquid, which is usually referred to as honey or sucralfate, is administered as pH-neutralized viscous liquid, which is a method for neutralizing the alkaline substances already generated in the tissue, but has no measures for preventing the battery from discharging, and thus, even if the pH-neutralized viscous liquid is used, the damage of the esophagus caused by the battery discharge cannot be completely avoided, and thus, the therapeutic effect is limited. Therefore, there is a need for an edible liquid composition to block the discharge of the battery so as to better prevent the damage of the esophagus caused by the foreign materials in the battery.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a liquid composition for preventing a foreign body of a battery from damaging an esophagus and application thereof.
The invention aims to provide a liquid composition for preventing a battery foreign body from damaging an esophagus, which consists of the following raw material components in percentage by volume:
40-60% of edible oil and 40-60% of honey.
Preferably, the liquid composition for preventing the battery foreign matter from damaging the esophagus provided by the invention comprises the following raw material components in percentage by volume:
50% of edible oil and 50% of honey.
The second object of the present invention is to provide a use of the above liquid composition for preventing the damage of the battery foreign matter to the esophagus in preventing the damage of the battery foreign matter to the esophagus.
Compared with the prior art, the invention has the beneficial effects that:
(1) the liquid composition for preventing the esophagus from being damaged by the foreign matters of the battery can radically block the discharge of the battery by mixing the edible oil and the honey to form the edible viscous insulating liquid, so that the generation of alkaline substances in tissues is reduced, the esophagus damage can be more effectively prevented, the damaged area of the esophagus is reduced, the discharge of the battery is reduced, the necrosis range and depth of the mucosa of the esophagus are reduced, and the infiltration range and depth of neutrophils are reduced;
(2) the liquid composition provided by the invention has the characteristics of low price, simple raw materials and easy acquisition, and is suitable for wide popularization and use;
(3) the liquid composition provided by the invention provides an effective measure for clinically treating the esophagus battery foreign matter, so as to prevent the esophagus battery foreign matter from being damaged;
(4) the liquid composition provided by the invention is beneficial to improving the prognosis of patients with esophageal battery foreign body, preventing complications and reducing the medical cost and the patient expense.
Drawings
FIG. 1 is a diagram illustrating the effect of a liquid composition for preventing a foreign object from damaging an esophagus of a battery according to an embodiment of the present invention on substantially damaging esophageal tissue by the battery;
FIG. 2 is a diagram illustrating the effect of a liquid composition for preventing a foreign object from damaging an esophagus of a battery according to an embodiment of the present invention on reducing the discharge of the battery in the esophagus;
FIG. 3 is a graph showing the effect of a liquid composition for preventing damage to the esophagus by a foreign object in a battery according to an embodiment of the present invention on reducing the necrosis depth of esophageal tissue;
FIG. 4 is a diagram illustrating the effect of the liquid composition for preventing the battery foreign object from damaging the esophagus to reduce the infiltration depth of the esophageal granulocytes according to the embodiment of the present invention.
Detailed Description
In order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.
The test methods not specifically described in the following examples were carried out according to conventional methods and conditions in the art, and the starting materials were commercially available.
Example 1
A liquid composition for preventing a battery from damaging an esophagus by foreign matters comprises the following raw material components in percentage by volume:
50% of edible oil and 50% of honey.
Example 2
A liquid composition for preventing a battery from damaging an esophagus by foreign matters comprises the following raw material components in percentage by volume:
40% of edible oil and 60% of honey.
Example 3
A liquid composition for preventing a battery from damaging an esophagus by foreign matters comprises the following raw material components in percentage by volume:
60% of edible oil and 40% of honey.
The liquid composition for preventing the battery foreign matter from damaging the esophagus provided in embodiments 1 to 3 of the present invention has substantially the same effect of preventing the battery foreign matter from damaging the esophagus, and therefore, only the liquid composition for preventing the battery foreign matter from damaging the esophagus provided in embodiment 1 of the present invention has been studied on the effect of preventing the battery foreign matter from damaging the esophagus.
First, experimental design
1. Laboratory apparatus
Anesthesia machine, endotracheal tube, laryngoscope, 20mL syringe, big animal surgical instrument, voltmeter, laminar flow operating room.
2. Laboratory animals and materials
2.1 Experimental animals
Bama miniature pigs, clean grade, male, 10 + -0.5 kg in weight, available from WUDOU Biotech.
2.2 materials of the experiment
Button cell (Song brand, diameter 20mm, voltage 3mV), normal saline, edible oil (Luhua), honey, isoflurane, neutral formaldehyde, etc.
3. Experimental methods
Three experimental animals were anesthetized systemically (surgical depth), placed supine, supported with their heads 30 ° high, and exposed to the hypopharynx using an anesthetic laryngoscope (Miller laryngoscope), and then the anodes of three coin cells were placed facing the posterior wall of the esophagus, respectively, in the proximal esophagus (near the hypopharynx) of the three experimental animals, and from 5 minutes after the placement of the cells, they were inserted into the location of the cells by connecting a catheter through a syringe, and 10mL of physiological saline, 10mL of honey, and 10mL of the liquid composition prepared in example 1 of the present invention were injected, once every 10 minutes, until 55 minutes, and then the coin cells were removed at 60 minutes. The method comprises the steps of measuring the voltage of a battery respectively before the battery is placed and after the battery is taken out, appropriately easing pain before anesthesia recovery for three experimental animals, enabling piglets to eat normally after anesthesia recovery, appropriately supplementing wet dog food, vegetables, fruits and the like, killing the piglets on the 7 th day, dissecting a near-end esophagus, taking a picture (with a scale) and measuring the size of mucosal ulcer, taking the esophagus out after the damage diffusion of a muscle layer is performed, fixing and manufacturing a pathological section, measuring the damage length and width of the mucosa visible to the naked eye again after the fixing is performed for 24 hours, taking a picture (with the scale), analyzing the necrosis depth of the damaged part by HE (with the scale), analyzing the granulation depth of tissues, the damage diffusion of the muscle layer, the fracture number of the intrinsic muscle layer, the fracture length of the intrinsic muscle layer and the average fracture length, and taking a fixed section of the normal esophagus at the far end as a normal control.
4. Results of the experiment
As shown in FIG. 1, the injured surface area of the esophagus of the experimental animal injected with physiological saline was 2.70. + -. 0.37cm2The esophagus injury surface area of the experimental animal injected with honey is 1.10 +/-0.15 cm2The surface area of the injured esophagus of the experimental animal injected with the liquid composition provided in example 1 of the present invention was 0.43. + -. 0.17cm2. Although both honey injections and the liquid composition provided in example 1 of the present invention reduced the esophageal injury surface area (P) compared to the saline control group<0.01), but the liquid composition provided in example 1 of the present invention can significantly reduce the esophageal injury surface area (P) as compared with injected honey<0.05)。
As shown in FIG. 2, the residual voltage of the battery placed in the body of the experimental animal injected with physiological saline was 2.77. + -. 0.03mV, the residual voltage of the battery placed in the body of the experimental animal injected with honey was 2.84. + -. 0.04mV, and the residual voltage of the battery placed in the body of the experimental animal injected with the liquid composition provided in example 1 of the present invention was 2.96. + -. 0.01 mV. Although both the injection of honey and the liquid composition provided in example 1 of the present invention increased the residual voltage of the battery (P <0.05) compared to the saline control group, the liquid composition provided in example 1 of the present invention significantly increased the residual voltage of the battery (P <0.01) compared to the injection of honey.
As shown in fig. 3, the esophageal necrosis depth of the experimental animals injected with physiological saline was 53.9 ± 11.6%, the esophageal necrosis depth of the experimental animals injected with honey was 19.6 ± 13.0%, and the esophageal necrosis depth of the experimental animals injected with the liquid composition provided in example 1 of the present invention was 4.3 ± 7.5%. Compared with saline control group, although the injection of honey and the liquid composition provided by the invention in the example 1 can reduce the necrosis depth of esophagus (P < 0.01); however, the liquid composition provided in example 1 of the present invention tended to reduce the depth of esophageal necrosis compared to honey injections, but did not show any statistical difference (P ═ 0.27).
As shown in fig. 4, the esophageal necrosis depth of the experimental animals injected with physiological saline was 83.0 ± 7.9%, the esophageal necrosis depth of the experimental animals injected with honey was 54.3 ± 8.3%, and the esophageal necrosis depth of the experimental animals injected with the liquid composition provided in example 1 of the present invention was 13.3 ± 14.6%. Compared with saline control group, although the injection of honey and the liquid composition provided by the invention in the example 1 can reduce the necrosis depth of esophagus (P < 0.05); however, the liquid composition provided in example 1 of the present invention significantly reduced the depth of esophageal necrosis (P <0.01) compared to honey injection, and the effect thereof was also studied by using edible oil alone in the course of practical experiments, and it was found that although the use of edible oil alone reduced the area of injury, it resulted in perforation of the esophagus, which was reduced because of perforation of the esophagus, resulting in reduction of lateral spread of injury.
In summary, the experimental determination results of the embodiments of the present invention show that: for piglets with esophageal injuries caused by button cells, compared with honey or normal saline, the liquid composition provided by the embodiment 1 of the invention can obviously reduce the general injury area of the esophagus, prevent battery discharge and reduce the pathological injury of esophageal tissues, thereby verifying the effectiveness of the liquid composition provided by the embodiment 1 of the invention in preventing the injury of the esophageal batteries by foreign matters.
In summary, the liquid composition for preventing the esophagus from being damaged by the foreign matter in the battery provided by the embodiment of the invention can fundamentally block the discharge of the battery by mixing the edible oil and the honey to form the edible viscous insulating liquid, so that the generation of alkaline substances in tissues is reduced, the esophagus can be more effectively prevented from being damaged, and the damage range and degree are reduced; the liquid composition provided by the invention has the characteristics of low price, simple raw materials and easy acquisition, and is suitable for wide popularization and use.
It should be noted that when the following claims refer to numerical ranges, it should be understood that both endpoints of each numerical range and any numerical value between the two endpoints can be selected, and since the steps and methods adopted are the same as those in embodiments 1 to 3, the present invention describes preferred embodiments in order to prevent redundant description, but once a person skilled in the art knows the basic inventive concept, other changes and modifications can be made to these embodiments. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (3)
1. The liquid composition for preventing the battery foreign matter from damaging the esophagus is characterized by comprising the following raw material components in percentage by volume:
40-60% of edible oil and 40-60% of honey.
2. The liquid composition for preventing the foreign matter in the battery from damaging the esophagus according to claim 1, which comprises the following raw material components by volume percent:
50% of edible oil and 50% of honey.
3. Use of the liquid composition for preventing damage to the esophagus by battery foreign matter according to claim 1 for preventing damage to the esophagus by battery foreign matter.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110820962.1A CN113599400A (en) | 2021-07-20 | 2021-07-20 | Liquid composition for preventing battery foreign matter from damaging esophagus and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110820962.1A CN113599400A (en) | 2021-07-20 | 2021-07-20 | Liquid composition for preventing battery foreign matter from damaging esophagus and application thereof |
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| CN113599400A true CN113599400A (en) | 2021-11-05 |
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| CN202110820962.1A Pending CN113599400A (en) | 2021-07-20 | 2021-07-20 | Liquid composition for preventing battery foreign matter from damaging esophagus and application thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112055594A (en) * | 2018-04-09 | 2020-12-08 | 索法尔瑞士有限公司 | Liquid composition for treating mucosa of oropharyngeal laryngeal tract |
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- 2021-07-20 CN CN202110820962.1A patent/CN113599400A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112055594A (en) * | 2018-04-09 | 2020-12-08 | 索法尔瑞士有限公司 | Liquid composition for treating mucosa of oropharyngeal laryngeal tract |
Non-Patent Citations (2)
| Title |
|---|
| 史含生等: "《百物另类妙用小辞典》", 28 February 2005 * |
| 高玉芳: "《中医养生智慧》", 31 May 2016 * |
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