CN113577026A - Aerosol and preparation method thereof - Google Patents

Aerosol and preparation method thereof Download PDF

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Publication number
CN113577026A
CN113577026A CN202110895720.9A CN202110895720A CN113577026A CN 113577026 A CN113577026 A CN 113577026A CN 202110895720 A CN202110895720 A CN 202110895720A CN 113577026 A CN113577026 A CN 113577026A
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hfc
aerosol
parts
butane
propane
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Chinese (zh)
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章子隽
陈冠斌
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Zhongshan Weixi Daily Chemical Technology Co ltd
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Zhongshan Weixi Daily Chemical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses an aerosol, which comprises the following raw materials: hydrofluorocarbons, liquefied hydrocarbons and inert gases. The aerosol can stay on skin for a long time after being sprayed on the skin, and can produce a more lasting analgesic effect on the pain part.

Description

Aerosol and preparation method thereof
Technical Field
The invention belongs to the technical field of aerosol, and particularly relates to aerosol and a preparation method thereof.
Background
On the stadium, sportsman when violent motion, the sports injury appears more easily, and medical staff can use motion aerosol to spray in sportsman's wound position to reach the purpose of alleviating pain fast, but current motion aerosol generally stays on human skin for a short time (within 2 seconds), and is shorter to the time of acting on the wound position, and in order to persist the analgesia, medical staff need continuously press the shower nozzle of aerosol canister, makes aerosol persist spraying in sportsman's wound position, sometimes need spout complete jar aerosol.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides an aerosol and a preparation method thereof, and the aerosol can stay on the skin for a long time after being sprayed on the skin and can generate a more lasting analgesic effect on the pain part.
The technical purpose of the invention is realized by the following technical scheme:
an aerosol comprises the following raw materials: hydrofluorocarbons, liquefied hydrocarbons and inert gases.
Preferably, the hydrofluorocarbons comprise HFC-245fa, HFC-152a and HFC-134a, and the aerosol comprises the following raw materials in parts by mass: HFC-245 fa: 10-25 parts; HFC-152 a: 3-5 parts; HFC-134 a: 4-6 parts; liquefied hydrocarbon: 30-70 parts; inert gas: 0.5-3 parts.
Preferably, the mass ratio of HFC-245fa, HFC-152a and HFC-134a is (15-19): (3.5-4.5): (4-5).
Preferably, the liquefied hydrocarbon is propane and butane, and the mass ratio of propane to butane in the propane and butane is (2-4): (6-8).
Preferably, the inert gas is at least one of nitrogen and carbon dioxide.
Preferably, the mass ratio of the inert gas to the liquefied hydrocarbon is (1.2-2): (52-55).
Another object of the present invention is to provide a method for preparing the above aerosol:
a method of preparing an aerosol formulation as described above, comprising the steps of:
(1) filling hydrofluorocarbon into the aerosol can;
(2) filling liquefied hydrocarbon;
(3) and (3) filling inert gas at a certain temperature, and then installing an aerosol valve.
Preferably, the temperature in step (5) is 22-28 ℃.
The invention has the beneficial effects that:
(1) the aerosol adopts HFC-245fa, HFC-152a and HFC-134a with specific proportion to form an azeotropic mixture with specific liquefied hydrocarbon and inert gas in the aerosol, so that the boiling point of the aerosol solution can be obviously improved, the aerosol can be combined with moisture on the surface of skin to form a film after being sprayed on the pain part of an athlete, the film can be retained for a longer time, and the moisturizing and cooling feeling can be brought for a longer time, thereby being capable of easing pain more durably;
(2) the aerosol of the invention adopts specific liquefied hydrocarbon and inert gas, controls the proportion of the liquefied hydrocarbon and the inert gas, and is matched with other liquefied gases with different saturated vapor pressure gradients in the aerosol to form a gas-liquid system, so that the product is ensured to maintain relatively stable internal pressure from the initial use to the final use, the content is ensured to be fully sprayed, the spraying rate of the product under the conditions of normal temperature (25 ℃), lower temperature (5 ℃) and higher temperature (35 ℃) is stabilized to be more than 95 percent, and the using requirements of people under different temperatures are met.
Detailed Description
The present invention will be further described with reference to the following specific examples.
Example 1:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 10 parts of (A); HFC-152 a: 3 parts of a mixture; HFC-134 a: 4 parts of a mixture; propane and butane: 70 parts of (B); carbon dioxide: 0.5 part of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 2: 8.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane; (5) charging carbon dioxide at 22 deg.C, and installing aerosol valve.
Example 2:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 25 parts of (1); HFC-152 a: 5 parts of a mixture; HFC-134 a: 6 parts of (1); propane and butane: 30 parts of (1); nitrogen gas: 3 parts of propane and butane in the propane and butane, wherein the mass ratio of propane to butane is 4: 6.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane; (5) charging nitrogen at 28 deg.C, and installing aerosol valve.
Example 3:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 12 parts of (1); HFC-152 a: 3.5 parts; HFC-134 a: 5 parts of a mixture; propane and butane: 42 parts of (A); nitrogen gas: 1 part of propane and butane in the propane and butane, wherein the mass ratio of propane to butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane; (5) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Example 4:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 20 parts of (1); HFC-152 a: 4.5 parts; HFC-134 a: 5.5 parts; propane and butane: 60 parts; nitrogen gas: 2.5 parts of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane; (5) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Example 5:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 17 parts of (1); HFC-152 a: 4 parts of a mixture; HFC-134 a: 4.5 parts; propane and butane: 53 parts of a mixture; nitrogen gas: 1.5 parts of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane; (5) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Example 6:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 15 parts of (1); HFC-152 a: 4.5 parts; HFC-134 a: 5 parts of a mixture; propane and butane: 55 parts of (1); nitrogen gas: 1.2 parts of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane; (5) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Example 7:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 19 parts of a mixture; HFC-152 a: 3.5 parts; HFC-134 a: 4 parts of a mixture; propane and butane: 52 parts of (1); nitrogen gas: 2 parts of propane and butane in the propane and butane, wherein the mass ratio of propane to butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane; (5) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Comparative example 1:
the aerosol comprises the following raw materials in parts by weight: HFC-152 a: 4 parts of a mixture; HFC-134 a: 4.5 parts; propane and butane: 53 parts of a mixture; nitrogen gas: 1.5 parts of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) charging HFC-152 a; (2) charging HFC-134 a; (3) filling propane and butane; (4) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Comparative example 2:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 17 parts of (1); HFC-134 a: 4.5 parts; propane and butane: 53 parts of a mixture; nitrogen gas: 1.5 parts of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-134 a; (3) filling propane and butane; (4) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Comparative example 3:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 17 parts of (1); HFC-152 a: 4 parts of a mixture; propane and butane: 53 parts of a mixture; nitrogen gas: 1.5 parts of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) filling propane and butane; (4) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Comparative example 4:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 17 parts of (1); HFC-152 a: 4 parts of a mixture; HFC-134 a: 4.5 parts; nitrogen gas: 1.5 parts.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) and (3) filling nitrogen at 25 ℃, and then installing an aerosol valve to obtain the product.
Comparative example 5:
the aerosol comprises the following raw materials in parts by weight: HFC-245 fa: 17 parts of (1); HFC-152 a: 4 parts of a mixture; HFC-134 a: 4.5 parts; propane and butane: 53 parts of propane and butane, wherein the mass ratio of propane to butane in the propane and butane is 3: 7.
The preparation method of the aerosol comprises the following steps: (1) HFC-245fa is filled into the aerosol tank; (2) charging HFC-152 a; (3) charging HFC-134 a; (4) filling propane and butane, and installing an aerosol valve.
Test example:
the aerosol formulations of examples 1 to 7 and comparative examples 1 to 5 were sprayed on the skin of the arm of the subject in such a manner that the distance from the skin of the arm was 10cm, the spraying was carried out for 3 seconds, the time was counted after the spraying, the time was stopped when the skin wetness of the subject disappeared, and the residence time was recorded, while the ejection rates of the aerosol formulations of examples 1 to 7 and comparative examples 1 to 5 were measured at normal temperature (25 ℃), lower temperature (5 ℃) and higher temperature (35 ℃), respectively, and the results of the tests are shown in Table 1.
Table 1: aerosol test results for examples 1-7 and comparative examples 1-5
Figure BDA0003197815300000051
As can be seen from Table 1, the aerosol of the present application can stay on human skin for more than 7s, and when the proportion of HFC-245fa, HFC-152a and HFC-134a in the aerosol is (15-19): (3.5-4.5): (4-5), the residence time of the aerosol on the skin of a human body can reach more than 10s, so that after the aerosol is sprayed on the pain part of an athlete, the aerosol can bring a relatively long moist feeling and a cool feeling, and can relieve pain for a relatively long time, and medical staff do not need to continuously press a spray head of an aerosol can for continuous spraying.
The spraying rate of the aerosol is stabilized to be more than 95% under the conditions of normal temperature (25 ℃), lower temperature (5 ℃) and higher temperature (35 ℃), and when the ratio of propane and butane to inert gas in the aerosol is (1.2-2): (52-55), the spraying rate of the aerosol is stabilized to be more than 96% at normal temperature (25 ℃), at lower temperature (5 ℃) and at higher temperature (35 ℃), and can reach 99.5% at most, thereby meeting the use requirements of people at different temperatures.
Meanwhile, comparing example 5 with comparative examples 1-3, it can be seen that the residence time on human skin is significantly reduced when one of HFC-245fa, HFC-152a and HFC-134a is absent in the aerosol, without changing other components and preparation methods in the aerosol; as is clear from comparison of example 5 with comparative examples 4 to 5, the ejection rate of the aerosol at normal temperature (25 ℃ C.), lower temperature (5 ℃ C.) and higher temperature (35 ℃ C.) was greatly reduced when one of propane and butane and an inert gas was absent from the aerosol, while the other components and the preparation method were not changed.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (8)

1. An aerosol formulation, characterized by: comprises the following raw materials:
hydrofluorocarbons, liquefied hydrocarbons and inert gases.
2. An aerosol formulation as claimed in claim 1, wherein: the hydrofluorocarbon comprises HFC-245fa, HFC-152a and HFC-134a, and the aerosol comprises the following raw materials in parts by mass:
HFC-245 fa: 10-25 parts;
HFC-152 a: 3-5 parts;
HFC-134 a: 4-6 parts;
liquefied hydrocarbon: 30-70 parts;
inert gas: 0.5-3 parts.
3. An aerosol formulation as claimed in claim 1, wherein: the mass ratio of HFC-245fa, HFC-152a and HFC-134a is (15-19): (3.5-4.5): (4-5).
4. An aerosol formulation as claimed in claim 1, wherein: the liquefied hydrocarbon is propane and butane, and the mass ratio of propane to butane in the propane and butane is (2-4): (6-8).
5. An aerosol formulation as claimed in claim 1, wherein: the inert gas is at least one of nitrogen and carbon dioxide.
6. An aerosol formulation as claimed in claim 2, wherein: the mass ratio of the inert gas to the liquefied hydrocarbon is (1.2-2): (52-55).
7. A method of producing an aerosol formulation as claimed in any one of claims 1 to 6, wherein: the method comprises the following steps:
(1) filling hydrofluorocarbon into the aerosol can;
(2) filling liquefied hydrocarbon;
(3) and (3) filling inert gas at a certain temperature, and then installing an aerosol valve.
8. The method for producing an aerosol according to claim 7, wherein: the temperature in the step (5) is 22-28 ℃.
CN202110895720.9A 2021-08-05 2021-08-05 Aerosol and preparation method thereof Pending CN113577026A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2365621A1 (en) * 1976-09-15 1978-04-21 Johnson & Son Inc S C IMPROVED PROPULSIVE SYSTEM FOR AEROSOL, AND COMPOSITION IN CONTAINER
CN2832720Y (en) * 2005-06-16 2006-11-01 徐州汉哲机械科技有限公司 Aerosol can for binary package of liquefied gas
CN106821588A (en) * 2017-02-24 2017-06-13 中山威习日化科技有限公司 A kind of analgesia cryospray agent with specific aerosol valve Yu actuator
US20210052495A1 (en) * 2018-03-09 2021-02-25 Animal Ethics Pty Ltd Cooling Composition and Method of Use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2365621A1 (en) * 1976-09-15 1978-04-21 Johnson & Son Inc S C IMPROVED PROPULSIVE SYSTEM FOR AEROSOL, AND COMPOSITION IN CONTAINER
CN2832720Y (en) * 2005-06-16 2006-11-01 徐州汉哲机械科技有限公司 Aerosol can for binary package of liquefied gas
CN106821588A (en) * 2017-02-24 2017-06-13 中山威习日化科技有限公司 A kind of analgesia cryospray agent with specific aerosol valve Yu actuator
US20210052495A1 (en) * 2018-03-09 2021-02-25 Animal Ethics Pty Ltd Cooling Composition and Method of Use

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Application publication date: 20211102