CN113576408A - PH capsule, PH capsule wireless detection system and esophagus pH monitoring method - Google Patents
PH capsule, PH capsule wireless detection system and esophagus pH monitoring method Download PDFInfo
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- CN113576408A CN113576408A CN202110808556.3A CN202110808556A CN113576408A CN 113576408 A CN113576408 A CN 113576408A CN 202110808556 A CN202110808556 A CN 202110808556A CN 113576408 A CN113576408 A CN 113576408A
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- 239000002775 capsule Substances 0.000 title claims abstract description 69
- 238000012544 monitoring process Methods 0.000 title claims abstract description 14
- 238000001514 detection method Methods 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims abstract description 12
- 210000003238 esophagus Anatomy 0.000 title claims abstract description 11
- 238000012545 processing Methods 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 238000004806 packaging method and process Methods 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 238000007405 data analysis Methods 0.000 claims description 4
- 230000004913 activation Effects 0.000 abstract description 4
- 230000004044 response Effects 0.000 abstract description 4
- 230000000191 radiation effect Effects 0.000 abstract description 3
- 239000011347 resin Substances 0.000 description 7
- 229920005989 resin Polymers 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000024798 heartburn Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6861—Capsules, e.g. for swallowing or implanting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4211—Diagnosing or evaluating reflux
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4233—Evaluating particular parts, e.g. particular organs oesophagus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4238—Evaluating particular parts, e.g. particular organs stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0295—Operational features adapted for recording user messages or annotations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
Abstract
The invention discloses a pH capsule, a pH capsule wireless detection system and an esophagus pH monitoring method, wherein the pH capsule comprises a pH sensor, the pH sensor comprises a sensor main body and a circuit connecting part which are connected, and the sensor main body is arranged outside a shell. The invention obviously reduces the volume of the pH capsule, improves the radiation effect of the pH capsule antenna, reduces the activation time of the pH sensor and improves the response speed of the sensor.
Description
Technical Field
The invention relates to the technical field of gastroesophageal pH monitoring, in particular to a pH capsule, a pH capsule wireless detection system and an esophagus pH monitoring method.
Background
Gastroesophageal reflux disease (GERD) is a clinically common disorder of digestive motility, generally refers to the reflux of gastric or duodenal contents to the esophagus, causing a variety of malaise or symptoms, the most common clinical symptoms being heartburn, chest pain, and acid regurgitation. The current method commonly used for gastroesophageal reflux disease examination is to pass a pH capsule through the mouth and fix it in the esophagus, and monitor the pH value in the esophagus for 96 hours continuously. The pH capsule is integrally provided with a pair of pH electrodes (sensors), the pH capsule realizes the collection of pH values through the pH electrodes, then the collected pH data is sent to a data recorder outside a human body through a radio frequency circuit and an antenna, the data recorder stores the received data, and after the monitoring is finished, the recorder uploads the stored data to the software of an upper computer for analysis and finally outputs an analysis report.
At present, pH data acquired by a pH capsule mainly detects signals through a pH reference electrode and an indication Ti electrode, the signals are subjected to AD conversion after passing through an operational amplifier, then the processed data are processed and packaged, the processed data are sent to a radio frequency circuit for driving, wireless signals are transmitted outwards through a capsule antenna, and finally the wireless signals are received and stored by an external data recorder. However, the following defects mainly exist in the technology: 1) the capsule antenna is encapsulated inside the capsule, and the encapsulated substance (colloid) has certain attenuation (6-9 dBm) on wireless signals, so that the communication effect is influenced;
2) the pH sensor is packaged in the resin shell, and only the end face of the pH sensor is exposed to the outside and contacts with a measured substance, so that the sensor has longer activation time, slow response and inconvenient use; 3) the pH sensor and the capsule antenna are independent, the occupied space is large, the miniaturization of the MEMS system of the pH capsule is not facilitated, and the clinical use of the pH capsule is also influenced.
Therefore, those skilled in the art are dedicated to develop a pH capsule with good communication effect and small volume, a pH capsule wireless detection system and an esophageal pH monitoring method.
Disclosure of Invention
In view of the above-mentioned defects in the prior art, the technical problem to be solved by the present invention is to provide a pH capsule, a pH capsule wireless detection system and an esophageal pH monitoring method with good communication effect and small volume.
In order to achieve the above object, the present invention provides a pH capsule comprising a pH sensor including a sensor body and a circuit connection part connected, wherein the sensor body is disposed outside a housing.
Preferably, the sensor main body is of a spiral structure, so that the length of the pH sensor can be increased, and the sensor main body can be fully exposed outside the whole pH capsule, so that the pH value of a detected substance can be better sensed, and a better radiation space environment can be provided during signal emission.
Preferably, the pH sensor is connected to a switching circuit, and of course, the pH sensor is connected to the switching circuit through a circuit connecting portion thereof, the circuit connecting portion is disposed inside the resin housing, and the switching circuit is connected to the amplifying circuit and the radio frequency driving circuit, respectively.
Preferably, the output end of the amplifying circuit is connected with an AD conversion circuit, the output end of the AD conversion circuit is connected with a data processing unit, and the signal output end of the data processing unit is connected with the radio frequency driving circuit.
Preferably, a first input end of the switching circuit is connected with the pH sensor, and a second input end of the switching circuit is connected with the radio frequency driving circuit; and the first output end of the switching circuit is connected with the amplifying circuit, and the second output end of the switching circuit is connected with the pH sensor.
The invention also provides a wireless detection system for the pH capsule, which comprises the pH capsule and further comprises:
the pH capsule monitoring system comprises a data recorder for establishing a communication link with the pH capsule and a data analysis device connected with the data recorder.
Preferably, the pH capsules are fixed to a capsule conveyor.
The invention also provides an esophagus pH monitoring method, which comprises the following steps:
1) connecting the pH sensor to an amplifying circuit;
2) the pH sensor senses the pH value of surrounding substances and amplifies a sensing signal by an amplifying circuit;
3) performing analog-to-digital conversion on the amplified signal, and performing packaging, packaging and encoding processing;
4) connecting the pH sensor to a radio frequency drive circuit;
5) and the processed data is transmitted out by the pH sensor after being driven by radio frequency.
Preferably, step 1) is entered after step 5) is completed.
Preferably, the step 1) and the step 4) are completed by connecting a switching circuit.
The invention has the beneficial effects that: the invention obviously reduces the volume of the pH capsule, improves the radiation effect of the pH capsule antenna, reduces the activation time of the pH sensor and improves the response speed of the sensor.
Drawings
FIG. 1 is a schematic diagram of the structure of a pH capsule according to an embodiment of the present invention.
FIG. 2 is a schematic structural diagram of a pH capsule according to an embodiment of the present invention.
FIG. 3 is a schematic structural diagram of a pH capsule wireless detection system according to an embodiment of the present invention
Detailed Description
The present invention will be further described with reference to the accompanying drawings and examples, wherein the terms "upper", "lower", "left", "right", "inner", "outer", and the like, as used herein, refer to an orientation or positional relationship indicated in the drawings, which is for convenience and simplicity of description, and does not indicate or imply that the referenced devices or components must be in a particular orientation, constructed and operated in a particular manner, and thus should not be construed as limiting the present invention.
As shown in fig. 1, a pH capsule includes a pH sensor 101, and the pH sensor 101 includes a sensor body 11 and a circuit connection portion connected, wherein the sensor body 11 is disposed outside a resin case 2. In this embodiment, the sensor body 11 is a spiral structure, the pH sensor 101 is made of titanium, and the sensor body 11 and the circuit connection portion are integrally formed.
As shown in fig. 2, the pH sensor 101 is connected to the switching circuit 102, but of course, the pH sensor 101 is connected to the switching circuit 102 through a circuit connection portion provided inside the resin case. The switching circuit 102 is connected to an amplifying circuit 103 and a radio frequency driving circuit 106, respectively. In this embodiment, a first input terminal of the switching circuit 102 is connected to the pH sensor 101, a second input terminal thereof is connected to the rf driving circuit 106, a first output terminal of the switching circuit 102 is connected to the amplifying circuit 103, and a second output terminal thereof is connected to the pH sensor 101.
The output end of the amplifying circuit 103 is connected with an AD conversion circuit 104, the output end of the AD conversion circuit 104 is connected with a data processing unit 105, and the signal output end of the data processing unit 105 is connected with a radio frequency driving circuit 106.
In this embodiment, after the pH sensor 101 and the circuits inside the pH capsule are installed, the resin casing 2 is filled with resin, so that the pH sensor 101, the internal circuits, and the resin casing 2 have good stability.
The working principle of the pH capsule of the invention is as follows: when the pH capsule 1 is in operation, the pH sensor 101 is switched to the amplifying circuit 103 by the switching circuit 102, the sensor body 11 of the pH sensor 101 senses the pH value of the surrounding substance, then a weak sensing signal is sent to the amplifying circuit 103 through the circuit connecting part, the amplifying circuit 103 filters and amplifies the signal and then performs AD conversion (analog-to-digital conversion) by the AD conversion circuit 104, the data processing unit 105 performs packaging and encoding processing on the data after the AD conversion, and then sends the processed data to the radio frequency driving circuit 106. Before the data is sent to the rf driving circuit 106, the data processing unit 105 needs to control 102 the switching circuit to switch the pH sensor to be connected to the rf driving circuit 106, and finally, the data processing unit 105 sends the processed data to the rf driving circuit 106, and the processed data is transmitted by the pH sensor 101 after being driven. After the transmission is completed, the data processing unit 105 needs to control 102 the switching circuit to switch the pH sensor 101 to the amplifying circuit 103 in preparation for the next working cycle.
The invention also provides a pH capsule wireless detection system, which comprises the pH capsule 1, wherein the pH capsule 1 is fixed on the capsule conveyor 5, and the pH capsule wireless detection system further comprises: a data recorder 3 establishing a communication link with the pH capsule 1, and a data analysis device 4 connected to said data recorder 3. When the pH capsule is used, the power supply of the pH capsule 1 and the power supply of the data recorder 3 are switched on, so that the pH capsule 1 and the data recorder 3 are in a working state, ID matching is carried out on the pH capsule 1 and the data recorder 3, and a normal communication link is established after the matching is finished. After calibration, the pH capsule 1 is secured to the patient's esophageal LES 5cm by the capsule transporter 5 for at least 48h of pH detection. After the recording is finished, the data recorder 3 guides the data into the data analysis device 4 provided with data analysis software for analysis, and finally, a data patient diagnosis report is obtained.
The invention also provides an esophagus pH monitoring method which can be completed by adopting the esophagus pH capsule and comprises the following steps:
1) the pH sensor is connected to an amplification circuit.
2) The pH sensor senses the pH value of the surrounding substances and amplifies the sensing signal by an amplifying circuit.
3) And performing analog-to-digital conversion on the amplified signal, and performing packaging, packaging and encoding processing.
4) The pH sensor is connected to a radio frequency drive circuit.
5) And the processed data is transmitted out by the pH sensor after being driven by radio frequency.
Step 1) is entered after step 5) is completed.
In the present invention, the steps 1) and 4) can be implemented by using the switching circuit 102, and the circuit connection of the pH sensor can be switched to the amplifying circuit 103 or connected to the rf driving circuit 106 under the control of the data processing unit 105.
Before data acquisition, the switching circuit 102 switches the pH sensor 101 to the connection amplifying circuit 103, the amplifying circuit 103 filters and amplifies the signal acquired by the pH sensor 101, the AD conversion circuit 104 performs AD conversion, namely analog-to-digital conversion, and the data processing unit 105 performs packaging, packaging and encoding processing. At this time, the data processing unit 105 controls the switching circuit 102 to switch the pH sensor to be connected to the radio frequency driving circuit 106, so that the processed data can be transmitted by the pH sensor after being radio frequency driven. And returning to the step 1) for the next work.
The invention combines the functions of the pH sensor and the pH capsule antenna into a whole, can not only detect the pH value, but also be used as an antenna of a radio frequency circuit to transmit the pH data. The volume of the pH capsule is reduced, the attenuation of wireless signals can be reduced by the exposed antenna, the radiation effect of the pH capsule antenna is improved, the activation time of the pH sensor is shortened, and the response speed of the sensor is improved.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (10)
1. A pH capsule is characterized in that: the pH sensor comprises a pH sensor (101), wherein the pH sensor (101) comprises a sensor main body (11) and a circuit connecting part which are connected, and the sensor main body (11) is arranged outside a shell (2).
2. The pH capsule of claim 1, wherein: the sensor body (11) is of a spiral structure.
3. The pH capsule of claim 1, wherein: the pH sensor (101) is connected with a switching circuit (102), and the switching circuit (102) is respectively connected with an amplifying circuit (103) and a radio frequency driving circuit (106).
4. The pH capsule of claim 3, wherein: the output end of the amplifying circuit (103) is connected with an AD conversion circuit (104), the output end of the AD conversion circuit (104) is connected with a data processing unit (105), and the signal output end of the data processing unit (105) is connected with the radio frequency driving circuit (106).
5. The pH capsule of claim 4, wherein: the first input end of the switching circuit (102) is connected with the pH sensor (101), and the second input end is connected with the radio frequency driving circuit (106); the first output end of the switching circuit (102) is connected with the amplifying circuit (103), and the second output end is connected with the pH sensor (101).
6. A wireless pH capsule detection system, comprising a pH capsule (1) according to any one of claims 1 to 6, further comprising:
a data recorder (3) establishing a communication link with the pH capsule (1), and a data analysis device (4) connected with the data recorder (3).
7. The pH capsule wireless detection system according to claim 6, wherein the pH capsule (1) is fixed on a capsule conveyor (5).
8. The esophagus pH monitoring method is characterized by comprising the following steps:
1) connecting the pH sensor to an amplifying circuit;
2) the pH sensor senses the pH value of surrounding substances and amplifies a sensing signal by an amplifying circuit;
3) performing analog-to-digital conversion on the amplified signal, and performing packaging, packaging and encoding processing;
4) connecting the pH sensor to a radio frequency drive circuit;
5) and the processed data is transmitted out by the pH sensor after being driven by radio frequency.
9. The esophageal pH monitoring method according to claim 8, wherein: step 1) is entered after step 5) is completed.
10. The esophageal pH monitoring method according to claim 8 or 9, wherein: and the step 1) and the step 4) are completed by connecting a switching circuit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110808556.3A CN113576408A (en) | 2021-07-16 | 2021-07-16 | PH capsule, PH capsule wireless detection system and esophagus pH monitoring method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110808556.3A CN113576408A (en) | 2021-07-16 | 2021-07-16 | PH capsule, PH capsule wireless detection system and esophagus pH monitoring method |
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| Publication Number | Publication Date |
|---|---|
| CN113576408A true CN113576408A (en) | 2021-11-02 |
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| CN202110808556.3A Pending CN113576408A (en) | 2021-07-16 | 2021-07-16 | PH capsule, PH capsule wireless detection system and esophagus pH monitoring method |
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|---|---|---|---|---|
| CN201275065Y (en) * | 2008-10-28 | 2009-07-22 | 重庆金山科技（集团）有限公司 | Wireless esophageal pH monitoring system |
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| CN108134652A (en) * | 2017-12-22 | 2018-06-08 | 重庆金山医疗器械有限公司 | A kind of method and system for reducing PH capsule wireless detecting system loss of data |
| CN208598378U (en) * | 2017-12-28 | 2019-03-15 | 重庆金山医疗器械有限公司 | A kind of pH capsule |
| CN111541003A (en) * | 2020-06-18 | 2020-08-14 | 天津理工大学 | Flexible antenna sensor for wearable equipment |
| CN111839440A (en) * | 2020-08-18 | 2020-10-30 | 重庆金山医疗技术研究院有限公司 | PH capsule operating means and detection device |
| CN212592087U (en) * | 2020-08-18 | 2021-02-26 | 重庆金山医疗技术研究院有限公司 | PH capsule operating means and detecting instrument |
| CN213345594U (en) * | 2020-05-22 | 2021-06-04 | 重庆金山医疗技术研究院有限公司 | Pneumatic type PH capsule device and detection apparatus |
| CN112964936A (en) * | 2021-01-30 | 2021-06-15 | 天津理工大学 | Miniature antenna sensor sensitive to dielectric constant of surrounding environment |
-
2021
- 2021-07-16 CN CN202110808556.3A patent/CN113576408A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201275065Y (en) * | 2008-10-28 | 2009-07-22 | 重庆金山科技（集团）有限公司 | Wireless esophageal pH monitoring system |
| CN105342543A (en) * | 2015-09-25 | 2016-02-24 | 重庆金山科技（集团）有限公司 | Multi-parameter wireless esophagus detection capsule and detection control system |
| CN108134652A (en) * | 2017-12-22 | 2018-06-08 | 重庆金山医疗器械有限公司 | A kind of method and system for reducing PH capsule wireless detecting system loss of data |
| CN208598378U (en) * | 2017-12-28 | 2019-03-15 | 重庆金山医疗器械有限公司 | A kind of pH capsule |
| CN213345594U (en) * | 2020-05-22 | 2021-06-04 | 重庆金山医疗技术研究院有限公司 | Pneumatic type PH capsule device and detection apparatus |
| CN111541003A (en) * | 2020-06-18 | 2020-08-14 | 天津理工大学 | Flexible antenna sensor for wearable equipment |
| CN111839440A (en) * | 2020-08-18 | 2020-10-30 | 重庆金山医疗技术研究院有限公司 | PH capsule operating means and detection device |
| CN212592087U (en) * | 2020-08-18 | 2021-02-26 | 重庆金山医疗技术研究院有限公司 | PH capsule operating means and detecting instrument |
| CN112964936A (en) * | 2021-01-30 | 2021-06-15 | 天津理工大学 | Miniature antenna sensor sensitive to dielectric constant of surrounding environment |
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