CN113559321A - Light-cured degradable polyester composite guided bone regeneration membrane - Google Patents
Light-cured degradable polyester composite guided bone regeneration membrane Download PDFInfo
- Publication number
- CN113559321A CN113559321A CN202111125646.9A CN202111125646A CN113559321A CN 113559321 A CN113559321 A CN 113559321A CN 202111125646 A CN202111125646 A CN 202111125646A CN 113559321 A CN113559321 A CN 113559321A
- Authority
- CN
- China
- Prior art keywords
- bone regeneration
- collagen
- membrane
- guided bone
- regeneration membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
Abstract
The invention discloses a light-cured degradable composite guided bone regeneration membrane and a preparation method and application thereof, wherein the guided bone regeneration membrane consists of biodegradable polyester, collagen, magnesium powder or zinc powder and a photoinitiator, the collagen and the degradable polyester are fully infiltrated into collagen to form an interpenetrating network structure, and the guided bone regeneration membrane has good shaping property before light curing and can adapt to the shape of bone defect; after photocuring, the degradable composite guided bone regeneration membrane has certain supporting performance and can maintain the space required by bone regeneration; meanwhile, the collagen membrane is wrapped by the biodegradable polyester, so that the degradation speed of the collagen is reduced, the action time of the guided bone regeneration membrane is prolonged, and sufficient time is provided for bone repair. The guided bone regeneration membrane is a novel guided bone regeneration membrane which has the functions of supporting and shielding and can promote the regeneration of bone tissues.
Description
Technical Field
The invention relates to a preparation technology of a guided bone regeneration membrane, in particular to a photocuring degradable polyester composite guided bone regeneration membrane and a preparation method and application thereof.
Background
Periodontal and implant surgery in the mouth often need to apply guided bone regeneration technology, wherein the key material is guided bone regeneration membrane, and collagen membrane is widely applied in guided bone regeneration technology. The collagen membrane has extracellular matrix as main component, high biocompatibility and certain capacity of promoting the proliferation, adhesion and differentiation of osteoblast. The collagen membrane can prevent fibroblasts and epithelial cells which are proliferated quickly from invading the bone defect area to generate competitive inhibition with osteoblasts, and is beneficial to the proliferation of the osteoblasts. However, the collagen membrane used at present has the problems of too fast degradation, insufficient supporting strength and the like.
In order to increase the supporting performance of the guided bone regeneration membrane, a titanium net, a polytetrafluoroethylene membrane or a combination of the titanium net and the polytetrafluoroethylene membrane are used, and although the guided bone regeneration membrane has the supporting and barrier effects, the guided bone regeneration membrane is not degradable, and the guided bone regeneration membrane must be taken out after a secondary operation, so that the risk of infection of an operation area and the pain of a patient are increased. In addition, some degradable guided bone regeneration membranes such as polylactic acid and biodegradable polyester are used, but at present, these high molecular guided bone regeneration membranes have no plasticity, cannot be completely matched with the bone defect shape, are difficult to fix and difficult to operate, usually require membrane nails to provide mechanical retention in the operation, prolong the operation time, increase the risk of infection, increase the pain and economic burden of patients, and limit the wide application of such guided bone regeneration membranes.
Therefore, it is of great importance to develop a guided bone regeneration membrane having barrier function, moldability, support strength and capable of promoting bone regeneration.
Disclosure of Invention
The invention aims to provide a photocuring degradable polyester composite guided bone regeneration membrane, a preparation method and application thereof, so as to solve the problems.
In order to achieve the purpose, the invention provides the following technical scheme:
the light-cured degradable polyester composite guided bone regeneration membrane is made of biodegradable polyester, collagen, magnesium powder or zinc powder and a photoinitiator, wherein the mass ratio of the magnesium powder or the zinc powder to the biodegradable polyester is 0.1-1: 20, and the mass ratio of the biodegradable polyester to the collagen is 15-10: 4, the mass ratio of the photoinitiator to the biodegradable polyester is 0.1-1: 100, the thickness of the biodegradable polyester composite guided bone regeneration membrane is 0.30-0.60 mm, and the elastic modulus is more than or equal to 200 MPa.
Preferably, the biodegradable polyester is a homopolymer or copolymer of glycolide, lactide, caprolactone having a polymerizable double bond structure. One of the methyl acryloyl polycaprolactone, the methyl acryloyl polylactic acid and the methyl acryloyl polyethylene glycol introduces a double bond functional group through methyl acryloyl acylation of the hydroxyl at the end of the three-arm biodegradable polyester molecule, the functionality is 3, the molecular weight Mw is about 2000Da, and the curing can be realized through blue light or ultraviolet light illumination by matching with a photoinitiator.
Preferably, the photoinitiator is at least one of 2-hydroxy-methylphenylpropane-1-one, benzophenone, 2,4, 6-trimethylbenzoyl-diphenylphosphine oxide or ethyl 2,4, 6-trimethylbenzoyl phenylphosphonate.
Preferably, the collagen is type I collagen or type II collagen.
Preferably, the diameter of the magnesium powder is 1-100 μm, and the diameter of the zinc powder is 1-100 μm.
The invention also discloses a preparation method of the light-cured biodegradable polyester composite guided bone regeneration membrane, which comprises the following steps:
firstly, heating biodegradable polyester to a molten state, adding a proper amount of photoinitiator, and fully mixing to obtain a mixed solution; secondly, adding a proper amount of magnesium powder or zinc powder into the solution obtained in the first step, and fully mixing to obtain a mixed solution; thirdly, the solution obtained in the second step is coated on the front surface of the collagen membrane, and after the solution is fully soaked, the solution is frozen and stored. And fourthly, in use, the degradable polyester leads the bone regeneration membrane to be shaped, and then the shape is formed through photocuring.
Preferably, the heating operation in the step I comprises water bath heating or thermostat heating, and the heating temperature is 30-70 ℃; the mixing operation includes oscillator oscillation and ultrasonic oscillation; the oscillation speed of the oscillator is 1000rmp, and the time is 15 minutes; the ultrasonic vibration was 60Hz for 20 minutes.
Preferably, the mixing operation in the second step comprises oscillator oscillation and ultrasonic oscillation; the oscillation speed of the oscillator is 1000rmp, and the time is 15 minutes; the ultrasonic vibration was 60Hz for 20 minutes.
Preferably, the step III is carried out under the condition of fully soaking, namely heating in a constant temperature box at the temperature of 30-45 ℃.
Preferably, the heating and freezing conditions in the step III are that the freezing temperature is-20-4 ℃.
Preferably, the photocuring condition in the step (iv) is blue light or ultraviolet light curing.
The preferred preparation method comprises the following steps: heating the biodegradable polyester to a molten state at a constant temperature of 37 ℃, adding a proper amount of photoinitiator, wherein the mass ratio of the photoinitiator to the biodegradable polyester is 0.1:100, oscillating by an oscillator at a rotating speed of 1000rmp for 15 minutes; ultrasonic oscillation is 60Hz, the time is 20 minutes, and the mixture is fully mixed to obtain a mixed solution;
secondly, adding a proper amount of magnesium powder or zinc powder into the solution obtained in the first step, wherein the mass ratio of the magnesium powder or the zinc powder to the biodegradable polyester is 1:20, oscillating by an oscillator at the rotating speed of 1000rmp for 15 minutes; ultrasonic oscillation is 60Hz, the time is 20 minutes, and the mixture is fully mixed to obtain a mixed solution;
③ leading the solution obtained in the step two to be 50mg/cm2The components are uniformly coated on the front surface of a collagen membrane, heated in a constant temperature box at 37 ℃ and fully soaked, and then frozen at 4 ℃ and stored.
And fourthly, in use, the biodegradable polyester guided bone regeneration membrane is shaped, and is cured and formed by blue light or ultraviolet light to obtain the biodegradable polyester composite guided bone regeneration membrane.
The invention also comprises the application of the biodegradable polyester composite membrane, which is used as a protective membrane for implants and periodontal bone defects, a nasal septum repair membrane, a guided bone regeneration membrane for guided bone regeneration and guided tissue regeneration.
Compared with the prior art, the invention has the following advantages:
the invention provides a light-cured degradable polyester composite guided bone regeneration membrane and a preparation method and application thereof. The light-cured degradable polyester composite guided bone regeneration membrane consists of biodegradable polyester, collagen, magnesium powder or zinc powder and a photoinitiator, wherein the biodegradable polyester fully infiltrates the collagen membrane and then forms an interpenetrating network structure with the collagen, and has good shaping property before light curing and can well adapt to the shape of bone defect; after photocuring, the biodegradable polyester composite guided bone regeneration membrane has certain supporting performance and maintains the space required by bone regeneration; meanwhile, the collagen is wrapped by the biodegradable polyester, so that the degradation speed of the collagen is reduced, the action time of guiding the bone regeneration membrane is prolonged, and sufficient time is provided for bone repair; the addition of magnesium powder or zinc powder can promote the increase of biocompatibility and improve the bone regeneration capability. The membrane is a novel bone regeneration guiding membrane which has the functions of shaping, supporting and shielding and can promote the regeneration of bone tissues.
The biodegradable polyester composite guided bone regeneration membrane has the advantages of biodegradable polyester and collagen, has good biocompatibility and controllable degradation time, can be completely absorbed by degradation products, has no residues in vivo, and does not need to be taken out for the second time in an operation. The solidified biodegradable polyester has good support performance, and can maintain the time and space required by bone regeneration, thereby promoting the bone regeneration.
The preparation method adopts a coating infiltration method, can design the biodegradable polyester composite guided bone regeneration membranes with different thicknesses, has an interpenetrating network structure with good mechanical property, and can provide different support strengths and degradation times through the preparation of the composite guided bone regeneration membranes with different thicknesses so as to be suitable for different clinical requirements. Meanwhile, the use of various reagents is reduced in the preparation process, the preparation method is green and environment-friendly, and the high biological safety of the implant can be ensured.
Drawings
Fig. 1 is a manufacturing process of the photo-curable degradable polycaprolactone composite guided bone regeneration membrane of example 1.
Fig. 2 is a scanning electron microscope observation of the photo-curable degradable polycaprolactone composite guided bone regeneration membrane of example 1, from left to right, respectively observing front, back and cross-sectional views of the biodegradable polyester composite guided bone regeneration membrane at 200 times magnification, wherein the protruding part of the front is a protrusion wrapping magnesium powder, the filament of the back is collagen fiber wrapping biodegradable polyester, and the cross-section can observe an interpenetrating network structure formed by the biodegradable polyester and collagen.
FIG. 3 shows gross and Micro-CT results of the photocurable polycaprolactone composite guided bone regeneration membrane of example 1 implanted 8 weeks after implantation into a skull defect of a rat, the left side is a control group, and the right side is an experimental group. The upper image is a real image of skull defect, the lower image is a Micro-CT image, it can be seen that the control group bone defect area is wrapped by soft tissue, and no new bone is generated; the bone defect area of the experimental group is obviously generated by new bone, and the bone defect area is obviously reduced compared with the control group.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without any creative work based on the embodiments of the present invention belong to the protection scope of the present invention.
Example 1
A photocuring polycaprolactone composite guided bone regeneration membrane, wherein the mass ratio of magnesium powder to methacryloylated polycaprolactone is 1:20, the mass ratio of photoinitiator to 2,4, 6-trimethyl benzoyl phenyl ethyl phosphonate is 0.1:100, and the coating proportion of methacryloylated polycaprolactone to collagen is 50mg/cm2The thickness of the polycaprolactone composite guided bone regeneration membrane is 0.50mm, the surface is compact and has no pores, and the elastic modulusIs 241.33 +/-27.01 MPa.
The preparation method is shown in figure 1 and comprises the following steps:
heating methacryloylated polycaprolactone to a molten state in a constant-temperature water bath kettle at 37 ℃, adding a photoinitiator 2,4, 6-trimethyl benzoyl phenyl ethyl phosphonate, wherein the mass ratio of the photoinitiator to the biodegradable polyester is 0.1:100, oscillating by an oscillator, rotating at 1000rmp, and keeping for 15 minutes; ultrasonic oscillation is 60Hz, the time is 20 minutes, and the mixture is fully mixed to obtain a mixed solution;
adding 50mg of magnesium powder into the solution obtained in the step 1ml, oscillating by using an oscillator at the rotating speed of 1000rmp for 15 minutes; ultrasonic oscillation is 60Hz, the time is 20 minutes, and the mixture is fully mixed to obtain a mixed solution;
③ leading the solution obtained in the step two to be 50mg/cm2The components are uniformly coated on the front surface of a collagen membrane, heated in a constant temperature box at 37 ℃ and fully soaked, and then frozen at 4 ℃ and stored.
Before or during use, the light-cured polycaprolactone guided bone regeneration membrane is firstly shaped, and is formed by blue light curing, so that the polycaprolactone composite guided bone regeneration membrane is obtained.
Example 2 Performance test method of Photocurable polycaprolactone composite guided bone regeneration Membrane
Size: the thickness is measured by a general measuring tool or a special measuring tool according to the method specified in GB/T6672-2001.
Mechanical strength: measured according to the method specified in GB/T130221991.
An electron micrograph of the photo-cured polycaprolactone composite guided bone regeneration membrane is shown in fig. 2.
The thickness of the photocuring polycaprolactone composite guided bone regeneration membrane can be adjusted according to the coating proportion, the thickness is 0.30-0.60 mm, and the elastic modulus is 241.33 +/-27.01 MPa.
Example 3 animal experiments
The sample obtained in example 1 was used for rat skull defect test
Healthy 8-week-old SD rats, male, 6, were randomly assigned 2 groups of 3 animals each. All SD rats are bred in an SPF-level laboratory, normally eat food, freely drink water, adopt preoperative adaptive breeding,
after intravenous injection and anesthesia of experimental animals, disinfection, skin incision and skull exposure are carried out, basically consistent bone defects (diameter is 6 mm) are prepared on the skull by using a bone drill, a light-cured polycaprolactone composite guide bone regeneration film is covered on a bone defect area (smooth surface is upward, rough surface is downward), appropriate shaping, light curing, suture and disinfection are carried out.
One of the two groups of animals is an experimental group, a skull defect part is covered with a light-cured polycaprolactone composite guided bone regeneration membrane, and blue light or ultraviolet light is cured; the other group was used as a blank group, and prepared for direct suturing after bone defect.
The experimental results are as follows:
1. all wounds are well healed and no infection, hematoma or necrosis occurs.
2. In the experimental group, after 8 weeks of operation, the bone regeneration membrane is guided to be thinned, and most of the defect area is filled with new bone tissues; the blank control is formed by a small amount of new bone tissue at the bottom of the defect area after 8 weeks of operation, and fibrous connective tissue wraps the defect area; the light-cured polycaprolactone composite guided bone regeneration membrane plays a role in supporting and blocking soft tissue from growing into a defect area, and is favorable for promoting the growth of new bone tissues, and the figure 3 shows that the light-cured polycaprolactone composite guided bone regeneration membrane has the function of supporting and blocking the soft tissue from growing into the defect area.
Claims (10)
1. The light-cured degradable polyester composite guided bone regeneration membrane is characterized in that: the light-cured biodegradable polyester composite guided bone regeneration membrane consists of biodegradable polyester, collagen, magnesium powder or zinc powder and a photoinitiator, wherein the mass ratio of the magnesium powder or the zinc powder to the biodegradable polyester is 0.1-1: 20, the mass ratio of the biodegradable polyester to the collagen is 15-10: 4, the mass ratio of the photoinitiator to the biodegradable polyester is 0.1-1: 100, the thickness of the biodegradable composite guided bone regeneration membrane is 0.30-0.60 mm, and the elastic modulus is more than or equal to 200 MPa.
2. The photo-curable degradable polyester composite guided bone regeneration membrane according to claim 1, wherein the biodegradable polyester is a homopolymer or copolymer of glycolide, lactide, and caprolactone having a polymerizable double bond structure, and the photo-initiator is at least one of 2-hydroxy-methylphenylpropane-1-one, benzophenone, 2,4, 6-trimethylbenzoyl-diphenylphosphine oxide, or ethyl 2,4, 6-trimethylbenzoyl phenylphosphinate, and is cured by irradiation with blue light or ultraviolet light.
3. The photo-curable degradable polyester composite guided bone regeneration membrane according to claim 1, wherein the collagen is type I collagen or type II collagen, and the front surface is a smooth surface and the back surface is a rough surface.
4. The photo-curable degradable polyester composite guided bone regeneration membrane as claimed in claim 1, wherein the diameter of the magnesium powder or zinc powder is 1-100 μm.
5. The preparation method of the photo-curing degradable composite guided bone regeneration membrane of claim 1, which is characterized in that: comprises the following steps:
firstly, heating biodegradable polyester to a molten state, adding a proper amount of photoinitiator, and fully and uniformly mixing to obtain a mixed solution;
secondly, adding a proper amount of magnesium powder or zinc powder into the solution obtained in the first step, and fully mixing to obtain a mixed solution;
thirdly, coating the solution obtained in the second step on the front surface of the collagen membrane, fully soaking, freezing and storing;
and fourthly, in use, the biodegradable composite guided bone regeneration membrane is shaped and photocured to form the composite guided bone regeneration membrane.
6. The method of claim 5, wherein: heating operation in the step I comprises water bath heating or thermostat heating, wherein the heating temperature is 30-70 ℃; the mixing operation includes oscillator oscillation and ultrasonic oscillation; the oscillation speed of the oscillator is 1000rmp, and the time is 15 minutes; ultrasonic oscillation is 60Hz, and the time is 20 minutes; mixing operation comprises oscillator oscillation and ultrasonic oscillation; the oscillation speed of the oscillator is 1000rmp, and the time is 15 minutes; the ultrasonic vibration was 60Hz for 20 minutes.
7. The method of claim 5, wherein: in the third step, the condition of adding sufficient infiltration is that the incubator is heated, the heating temperature is 30-45 ℃, and in the fourth step, the light curing condition is blue light or ultraviolet light curing.
8. The use of the light-cured degradable composite guided bone regeneration membrane of claim 1 in biomedicine.
9. The use of claim 8, wherein: the degradable polyester fully infiltrates the collagen membrane and then forms an interpenetrating network structure with the collagen, has good shaping property before photocuring and can be well adapted to the shape of bone defect; after photocuring, the degradable polyester composite guided bone regeneration membrane has certain supporting performance and maintains the space required by bone regeneration; meanwhile, the degradable polyester wraps the collagen, so that the degradation speed of the collagen is reduced, the action time of guiding the bone regeneration membrane is prolonged, sufficient time is provided for bone repair, and the addition of magnesium powder or zinc powder can promote the increase of biocompatibility and improve the bone regeneration capacity.
10. The use of claim 8, wherein: the light-cured degradable polyester composite guided bone regeneration membrane is used as a barrier membrane for guided bone regeneration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111125646.9A CN113559321B (en) | 2021-09-26 | 2021-09-26 | Light-cured degradable polyester composite guided bone regeneration membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111125646.9A CN113559321B (en) | 2021-09-26 | 2021-09-26 | Light-cured degradable polyester composite guided bone regeneration membrane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113559321A true CN113559321A (en) | 2021-10-29 |
| CN113559321B CN113559321B (en) | 2021-12-14 |
Family
ID=78174517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111125646.9A Active CN113559321B (en) | 2021-09-26 | 2021-09-26 | Light-cured degradable polyester composite guided bone regeneration membrane |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113559321B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114306733A (en) * | 2022-03-02 | 2022-04-12 | 北京大学口腔医学院 | Degradable composite guided bone regeneration membrane with shaping support performance |
| CN114732962A (en) * | 2022-05-20 | 2022-07-12 | 武汉理工大学 | Degradable antibacterial guided bone regeneration membrane and preparation method and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120253470A1 (en) * | 2011-03-30 | 2012-10-04 | President And Fellows Of Harvard College | Compositions for bone tissue repair and uses thereof |
| US20150266225A1 (en) * | 2014-03-19 | 2015-09-24 | Cas In Bio Co., Lid. | Facile Methods for Fabricating a Uniformly Patterned and Porous Nanofibrous Scaffold |
| CN107335101A (en) * | 2017-08-07 | 2017-11-10 | 北京湃生生物科技有限公司 | A kind of composite collagen tissue regeneration membrane and preparation method thereof |
| CN109847108A (en) * | 2019-03-13 | 2019-06-07 | 北京大学口腔医学院 | A kind of zinc-containing alloy guided bone bone tissue regeneration film |
| CN111330083A (en) * | 2018-12-18 | 2020-06-26 | 诺一迈尔（苏州）医学科技有限公司 | Barrier membrane for guided bone regeneration and preparation method thereof |
| CN112190771A (en) * | 2020-10-23 | 2021-01-08 | 扬子江药业集团广州海瑞药业有限公司 | Bone tissue regeneration guide membrane and preparation method thereof |
-
2021
- 2021-09-26 CN CN202111125646.9A patent/CN113559321B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120253470A1 (en) * | 2011-03-30 | 2012-10-04 | President And Fellows Of Harvard College | Compositions for bone tissue repair and uses thereof |
| US20150266225A1 (en) * | 2014-03-19 | 2015-09-24 | Cas In Bio Co., Lid. | Facile Methods for Fabricating a Uniformly Patterned and Porous Nanofibrous Scaffold |
| CN107335101A (en) * | 2017-08-07 | 2017-11-10 | 北京湃生生物科技有限公司 | A kind of composite collagen tissue regeneration membrane and preparation method thereof |
| CN111330083A (en) * | 2018-12-18 | 2020-06-26 | 诺一迈尔（苏州）医学科技有限公司 | Barrier membrane for guided bone regeneration and preparation method thereof |
| CN109847108A (en) * | 2019-03-13 | 2019-06-07 | 北京大学口腔医学院 | A kind of zinc-containing alloy guided bone bone tissue regeneration film |
| CN112190771A (en) * | 2020-10-23 | 2021-01-08 | 扬子江药业集团广州海瑞药业有限公司 | Bone tissue regeneration guide membrane and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 金光柱等: "rhBMP-2/Co/PLGA复合生物膜对腭裂骨缺损修复的实验研究", 《实用口腔医学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114306733A (en) * | 2022-03-02 | 2022-04-12 | 北京大学口腔医学院 | Degradable composite guided bone regeneration membrane with shaping support performance |
| CN114732962A (en) * | 2022-05-20 | 2022-07-12 | 武汉理工大学 | Degradable antibacterial guided bone regeneration membrane and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113559321B (en) | 2021-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5356629A (en) | Composition for effecting bone repair | |
| Peter et al. | Polymer concepts in tissue engineering | |
| Yaszemski et al. | The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold | |
| US4843112A (en) | Bioerodable implant composition | |
| Dupoirieux et al. | Comparative study of three different membranes for guided bone regeneration of rat cranial defects | |
| CN113559321B (en) | Light-cured degradable polyester composite guided bone regeneration membrane | |
| US5085861A (en) | Bioerodable implant composition comprising crosslinked biodegradable polyesters | |
| US20040115240A1 (en) | Composite for attaching, growing and/or repairing of living tissues and use of said composite | |
| TWI436779B (en) | Biodegradable filler for restoration of alveolar bones | |
| WO2010081408A1 (en) | Bioactive tissue regeneration film and preparation method thereof | |
| CN104474589A (en) | Guided tissue regeneration membrane as well as preparation method and application thereof | |
| Kretlow et al. | Evaluation of soft tissue coverage over porous polymethylmethacrylate space maintainers within nonhealing alveolar bone defects | |
| JP2005521440A (en) | Bioresorbable osteoconductive composition for bone regeneration | |
| Hokugo et al. | Prefabrication of vascularized bone graft using guided bone regeneration | |
| Yang et al. | Characteristics and biocompatibility of a biodegradable genipin‐cross‐linked gelatin/β‐tricalcium phosphate reinforced nerve guide conduit | |
| CN109966552A (en) | Tissue engineering bracket material and preparation method thereof, application, application method | |
| CN100540069C (en) | Biodegradable active medical tissue adhesive and preparation method thereof | |
| Cheng et al. | Ovine model for engineering bone segments | |
| Yan et al. | An interference screw made using a silk fibroin-based bulk material with high content of hydroxyapatite for anterior cruciate ligament reconstruction in a rabbit model | |
| Chen et al. | Reconstruction of calvarial defect using a tricalcium phosphate-oligomeric proanthocyanidins cross-linked gelatin composite | |
| Luczyszyn et al. | Histologic analysis of the acellular dermal matrix graft incorporation process: a pilot study in dogs. | |
| Sa et al. | Bone response to porous poly (methyl methacrylate) cement loaded with hydroxyapatite particles in a rabbit mandibular model | |
| Dean et al. | Effect of transforming growth factor β2 on marrow-infused foam poly (propylene fumarate) tissue-engineered constructs for the repair of critical-size cranial defects in rabbits | |
| CN111973797B (en) | Non-invasive implantation high-viscosity adhesive material for orthopedics department and preparation method and application thereof | |
| Song et al. | Biomimetic characteristics of mussel adhesive protein-loaded collagen membrane in guided bone regeneration of rabbit calvarial defects |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |