CN113545778A - Porous blood sugar electrode material and preparation method thereof - Google Patents
Porous blood sugar electrode material and preparation method thereof Download PDFInfo
- Publication number
- CN113545778A CN113545778A CN202110758334.5A CN202110758334A CN113545778A CN 113545778 A CN113545778 A CN 113545778A CN 202110758334 A CN202110758334 A CN 202110758334A CN 113545778 A CN113545778 A CN 113545778A
- Authority
- CN
- China
- Prior art keywords
- blood sugar
- electrode material
- carbon cloth
- current collector
- porous blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008280 blood Substances 0.000 title claims abstract description 65
- 210000004369 blood Anatomy 0.000 title claims abstract description 65
- 239000007772 electrode material Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000010949 copper Substances 0.000 claims abstract description 71
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 57
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 57
- 239000004744 fabric Substances 0.000 claims abstract description 57
- 239000002131 composite material Substances 0.000 claims abstract description 40
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000005751 Copper oxide Substances 0.000 claims abstract description 39
- 229910000431 copper oxide Inorganic materials 0.000 claims abstract description 39
- 229910052802 copper Inorganic materials 0.000 claims abstract description 18
- 238000010438 heat treatment Methods 0.000 claims abstract description 18
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 17
- 238000011065 in-situ storage Methods 0.000 claims abstract description 16
- 238000002791 soaking Methods 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 11
- BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 claims description 10
- KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 claims description 10
- 229940112669 cuprous oxide Drugs 0.000 claims description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 3
- 230000035945 sensitivity Effects 0.000 description 15
- 238000001514 detection method Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G3/00—Compounds of copper
- C01G3/02—Oxides; Hydroxides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Electrodes For Compound Or Non-Metal Manufacture (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Inert Electrodes (AREA)
Abstract
The invention discloses a porous blood sugar electrode material, which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the current collector in situ, and the preparation process comprises the following steps: firstly, preparing self-reduction copper conductive ink; secondly, soaking the carbon cloth into self-reduction conductive ink; thirdly, taking out the carbon cloth and drying; and fourthly, placing the carbon cloth in a muffle furnace for heat treatment to obtain the porous blood sugar electrode. The current collector has a net-shaped hollow structure, so that the contact area between the current collector and a sample to be detected in a unit space can be increased, and the flower-shaped copper oxide generated in situ not only is firmly combined, but also has the advantages of multiple active sites and rapid signal response.
Description
Technical Field
The invention is applied to the field of biosensors, and relates to a porous blood glucose electrode material with high specific surface, multiple active sites, high sensitivity and flexibility and a preparation method thereof.
Background
With the increase of national economic strength and the improvement of living standard of people, more and more patients with diabetes (called as 'rich disease') exist. According to the international diabetes union (IDF) survey, it is estimated that from 1.51 hundred million in 2000 to date, there has been a dramatic increase, reaching 4.63 hundred million in 2019. However, the method for detecting the blood sugar content is still simple, the current household blood sugar meter usually detects the blood sugar content by extracting fingertip blood, and the extracted venous blood adopted by hospitals is blood which is more dependent on high-content glucose, and the extracted blood has certain harm and pain to human bodies. Therefore, the traditional blood glucose meter is difficult to meet the increasing concern of people on self health nowadays no matter from the aspects of non-invasive detection, sensitivity and the like. Glucose in sweat is closely related to blood sugar, and noninvasive detection can be well realized by combining analysis of body temperature, heart rate and other physical signs. However, the concentration of sweat is usually only a few tens to a few hundredths of the blood glucose concentration, which is well below the detection limit of conventional blood glucose electrodes, and becomes a key limiting the application of such technologies.
The invention discloses a porous blood sugar electrode material and a preparation method thereof, which can obviously reduce the detection limit of an electrode and realize accurate detection of sweat by improving the specific surface area of the electrode and the associativity of a current collector and a functional semiconductor.
Disclosure of Invention
The invention aims to solve the technical problem of insufficient sensitivity of the existing blood sugar electrode and provides a porous blood sugar electrode material and a preparation method thereof.
In order to solve the technical problems, the functional electrode material of the porous blood sugar electrode material consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ.
In a possible embodiment, the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 0.1-1000 μm, the central pore diameter of the mesh wire is 0.01-500 μm, and the flower-shaped copper oxide is composed of flake copper oxide and/or cuprous oxide with the thickness of 10-100 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink;
secondly, soaking the carbon cloth into self-reduction conductive ink;
thirdly, taking out the carbon cloth and drying;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment to obtain the porous blood sugar electrode.
As a possible implementation manner, further, the self-reduced copper conductive ink in the first step contains 2 to 40% by mass of Cu, and the solvent includes but is not limited to one or a mixture of several of ethanol, water, ethylene glycol, acetone, and glycerol.
As a possible implementation manner, further, the carbon cloth in the second step is soaked for 1 to 60 minutes at a temperature of 20 to 60 ℃.
As a possible implementation manner, further, the drying temperature in the third step is 40 to 200 ℃ and the time is 1 to 48 hours.
As a possible implementation manner, further, the heat treatment temperature in the first step is 400 to 500 ℃, the atmosphere is air or oxygen atmosphere, and the time is 1 to 6 hours
By adopting the technical scheme, the invention has the following beneficial effects:
(1) compared with the existing commercial blood sugar electrode, the invention does not use biological enzyme, but adopts inorganic material as catalyst, so that the dependence of sensitivity on temperature and humidity is obviously reduced, and the requirement on storage environment is obviously reduced.
(2) The Cu/C current collector and the flower-shaped copper oxide are generated in situ by the self-reduction conductive ink, and the interface between the current collector and the copper oxide catalyst layer is fresh, so that the electronic transmission is facilitated, and the sensitivity is improved.
(3) According to the invention, the carbon cloth is used as a carrier to prepare the electrode, and in the heat treatment process, the carbon cloth is removed by thermal decomposition to form a porous network wire, so that the weight of the electrode is reduced, the specific surface area of the electrode can be increased, more active sites are provided, and the sensitivity of the electrode is improved.
Drawings
The invention is described in further detail below with reference to the following figures and embodiments:
fig. 1 is a schematic structural diagram of a porous blood glucose electrode material of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described in detail and completely with reference to the accompanying drawings.
The invention provides a porous blood sugar electrode material, wherein the functional electrode material consists of a reticular hollow Cu/C composite current collector and a flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ.
In a possible embodiment, the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 0.1-1000 μm, the central pore diameter of the mesh wire is 0.01-500 μm, and the flower-shaped copper oxide is composed of flake copper oxide and/or cuprous oxide with the thickness of 10-100 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink;
secondly, soaking the carbon cloth into self-reduction conductive ink;
thirdly, taking out the carbon cloth and drying;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment to obtain the porous blood sugar electrode.
As a possible implementation manner, further, the self-reducing copper conductive ink in the first step contains 2 to 40% by mass of Cu, and the solvent includes but is not limited to one or a mixture of several of ethanol, water, ethylene glycol, acetone, glycerol, and erythritol.
As a possible implementation manner, further, the carbon cloth in the second step is soaked for 1 to 60 minutes at a temperature of 20 to 60 ℃.
As a possible implementation manner, further, the drying temperature in the third step is 40 to 200 ℃ and the time is 1 to 48 hours.
As a possible implementation mode, further, the heat treatment temperature in the first step is 400-500 ℃, the atmosphere is air or oxygen atmosphere, and the time is 1-6 hours.
Example 1
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 0.1 mu m, the central aperture of the mesh wire is 0.01 mu m, and the flower-shaped copper oxide is composed of flaky copper oxide with the thickness of 10 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 40% of Cu by mass and ethanol as a solvent;
secondly, soaking the carbon cloth in the self-reduction conductive ink for 60 minutes at the temperature of 60 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 120 ℃ for 6 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at 400 ℃, wherein the atmosphere is an oxygen atmosphere for 1 hour, and obtaining the porous blood sugar electrode.
The detection limit of the electrode was 0.5. mu. mol/L.
Example 2
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 20 mu m, the central aperture of the mesh wire is 10 mu m, and the flower-shaped copper oxide is composed of flaky cuprous oxide with the thickness of 40 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 20% of Cu by mass and 20% of ethanol as a solvent;
secondly, soaking the carbon cloth in the self-reduction conductive ink for 10 minutes at the temperature of 40 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at 40 ℃ for 48 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at the temperature of 420 ℃, wherein the atmosphere is air atmosphere and the time is 26 hours, and obtaining the porous blood sugar electrode.
The electrode sensitivity was 1.2. mu. mol/L.
Example 3
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 800 mu m, the central aperture of the mesh wire is 200 mu m, and the flower-shaped copper oxide is formed by mixing 20 percent of flake copper oxide with the thickness of 100 nm and 80 percent of cuprous oxide with the thickness of 80 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 5% of Cu by mass and ethylene glycol as a solvent;
secondly, soaking the carbon cloth in self-reduction conductive ink for 30 minutes at 50 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 200 ℃ for 25 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at 4500 ℃ in an air atmosphere for 3 hours to obtain the porous blood sugar electrode.
The electrode sensitivity was 3.0. mu. mol/L.
Example 4
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 1000 mu m, the central aperture of the mesh wire is 500 mu m, and the flower-shaped copper oxide is formed by mixing 20 percent of flake copper oxide with the thickness of 70 nm and 80 percent of cuprous oxide with the thickness of 30 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 15% of Cu by mass and acetone as a solvent;
secondly, soaking the carbon cloth in the self-reduction conductive ink for 40 minutes at the temperature of 20 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 60 ℃ for 32 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at 460 ℃ for 2 hours in an oxygen atmosphere to obtain the porous blood sugar electrode.
The electrode sensitivity was 3.5. mu. mol/L.
Example 5
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 90 mu m, the central aperture of the mesh wire is 50 mu m, and the flower-shaped copper oxide is composed of flaky cuprous oxide with the thickness of 50 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 2% of Cu by mass and 40% of ethanol in acetone solution;
secondly, soaking the carbon cloth in the self-reduction conductive ink for 1 minute at the temperature of 30 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 150 ℃ for 2 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at 400 ℃, wherein the atmosphere is an oxygen atmosphere and the time is 4 hours, and obtaining the porous blood sugar electrode.
The electrode sensitivity was 1.5. mu. mol/L.
Example 6
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 400 mu m, the central aperture of the mesh wire is 200 mu m, and the flower-shaped copper oxide is composed of flaky copper oxide with the thickness of 60 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 35% of Cu by mass and ethanol as a solvent;
secondly, soaking the carbon cloth in the self-reduction conductive ink for 20 minutes at the temperature of 20 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 150 ℃ for 1 hour;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at 400 ℃, wherein the atmosphere is air atmosphere and the time is 5 hours, and obtaining the porous blood sugar electrode.
The electrode sensitivity was 1.8. mu. mol/L.
Example 7
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 2 mu m, the central aperture of the mesh wire is 0.8 mu m, and the flower-shaped copper oxide is composed of flaky copper oxide with the thickness of 50 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 2% of Cu by mass and acetone as a solvent;
secondly, soaking the carbon cloth in the self-reduction conductive ink for 10 minutes at the temperature of 20 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 50 ℃ for 1 hour;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at 480 ℃, wherein the atmosphere is air atmosphere and the time is 3 hours, and obtaining the porous blood sugar electrode.
The electrode sensitivity was 0.2. mu. mol/L.
Example 8
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 8 mu m, the central aperture of the mesh wire is 0.01 mu m, and the flower-shaped copper oxide is composed of flaky cuprous oxide with the thickness of 30 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 5% of Cu by mass and water as a solvent;
secondly, soaking the carbon cloth in the self-reduction conductive ink for 10 minutes at the temperature of 60 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 200 ℃ for 48 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at the temperature of 500 ℃, wherein the atmosphere is an oxygen atmosphere and the time is 6 hours, and obtaining the porous blood sugar electrode.
The electrode sensitivity was 1.8. mu. mol/L.
Example 9
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 0.5 mu m, the central aperture of the mesh wire is 0.01 mu m, and the flower-shaped copper oxide is formed by mixing 90 percent of sheet-shaped copper oxide with the thickness of 10nm and 10 percent of cuprous oxide with the thickness of 30 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 8 mass percent of Cu and 40 percent of glycerol in ethanol solution;
secondly, soaking the carbon cloth in self-reduction conductive ink for 50 minutes at 40 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at 160 ℃ for 12 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at the temperature of 500 ℃, wherein the atmosphere is air atmosphere and the time is 3 hours, and obtaining the porous blood sugar electrode.
The electrode sensitivity was 0.8. mu. mol/L.
Example 10
Preparing a porous blood sugar electrode material which consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ. Wherein the diameter of a mesh wire in the reticular hollow Cu/C composite current collector is 300 mu m, the central aperture of the mesh wire is 100 mu m, and the flower-shaped copper oxide is composed of flaky cuprous oxide with the thickness of 90 nm.
A preparation method of a porous blood sugar electrode material comprises the following steps:
firstly, preparing self-reduction copper conductive ink containing 15% of Cu by mass and ethanol as a solvent;
secondly, soaking the carbon cloth in self-reduction conductive ink for 5 minutes at 50 ℃;
thirdly, taking out the carbon cloth and drying the carbon cloth at the temperature of 150 ℃ for 40 hours;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment at the temperature of 500 ℃, wherein the atmosphere is an oxygen atmosphere and the time is 5 hours, and obtaining the porous blood sugar electrode.
The electrode sensitivity was 2.8. mu. mol/L.
Claims (8)
1. A porous blood sugar electrode material is characterized in that the functional electrode material consists of a reticular hollow Cu/C composite current collector and flower-shaped copper oxide growing on the reticular hollow Cu/C composite current collector in situ.
2. The porous blood glucose electrode material of claim 1, wherein the diameter of the mesh wire in the mesh-shaped hollow Cu/C composite current collector is 0.1-1000 μm, and the central pore diameter of the mesh wire is 0.01-500 μm.
3. The porous blood glucose electrode material of claim 1, wherein the flower-like copper oxide is composed of flake copper oxide and/or cuprous oxide with a thickness of 10-100 nm.
4. A preparation method of a porous blood sugar electrode material is characterized by comprising the following steps:
firstly, preparing self-reduction copper conductive ink;
secondly, soaking the carbon cloth into self-reduction conductive ink;
thirdly, taking out the carbon cloth and drying;
and fourthly, placing the carbon cloth in a muffle furnace for heat treatment to obtain the porous blood sugar electrode.
5. The method according to claim 4, wherein the self-reduced copper conductive ink in the first step contains Cu in an amount of 2-40% by mass, and the solvent includes but is not limited to one or more selected from ethanol, water, ethylene glycol, acetone, and glycerol.
6. The method for preparing the porous blood sugar electrode material according to claim 4, wherein the carbon cloth in the second step is soaked for 1-60 minutes at a temperature of 20-60 ℃.
7. The method for preparing a porous blood sugar electrode material according to claim 4, wherein the drying temperature in the third step is 40-200 ℃ for 1-48 hours.
8. The method for preparing a porous blood sugar electrode material according to claim 4, wherein the heat treatment temperature in the fourth step is 400 to 500 ℃, the atmosphere is air or oxygen atmosphere, and the time is 1 to 6 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110758334.5A CN113545778A (en) | 2021-07-05 | 2021-07-05 | Porous blood sugar electrode material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110758334.5A CN113545778A (en) | 2021-07-05 | 2021-07-05 | Porous blood sugar electrode material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113545778A true CN113545778A (en) | 2021-10-26 |
Family
ID=78102737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110758334.5A Pending CN113545778A (en) | 2021-07-05 | 2021-07-05 | Porous blood sugar electrode material and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113545778A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105462365A (en) * | 2014-09-11 | 2016-04-06 | 中国科学院苏州纳米技术与纳米仿生研究所 | Electric conduction nanometer copper ink preparation method |
| CN106450590A (en) * | 2016-11-04 | 2017-02-22 | 中南大学 | Copper/nitrogen double-doped porous fibrous carbon material as well as preparation method and application thereof |
| CN107235472A (en) * | 2017-05-24 | 2017-10-10 | 华中科技大学 | Porous vertical graphene nano wall array of N doping and preparation method and application |
| CN110186986A (en) * | 2019-06-21 | 2019-08-30 | 福建工程学院 | Electrochemical glucose sensor and its detection method without enzyme |
| CN111269615A (en) * | 2020-03-20 | 2020-06-12 | 辽宁大学 | Antioxidant particle-free copper conductive ink and preparation method thereof |
| CN112521802A (en) * | 2020-11-26 | 2021-03-19 | 东北大学 | Particle-free nickel-based conductive ink and preparation method thereof |
-
2021
- 2021-07-05 CN CN202110758334.5A patent/CN113545778A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105462365A (en) * | 2014-09-11 | 2016-04-06 | 中国科学院苏州纳米技术与纳米仿生研究所 | Electric conduction nanometer copper ink preparation method |
| CN106450590A (en) * | 2016-11-04 | 2017-02-22 | 中南大学 | Copper/nitrogen double-doped porous fibrous carbon material as well as preparation method and application thereof |
| CN107235472A (en) * | 2017-05-24 | 2017-10-10 | 华中科技大学 | Porous vertical graphene nano wall array of N doping and preparation method and application |
| CN110186986A (en) * | 2019-06-21 | 2019-08-30 | 福建工程学院 | Electrochemical glucose sensor and its detection method without enzyme |
| CN111269615A (en) * | 2020-03-20 | 2020-06-12 | 辽宁大学 | Antioxidant particle-free copper conductive ink and preparation method thereof |
| CN112521802A (en) * | 2020-11-26 | 2021-03-19 | 东北大学 | Particle-free nickel-based conductive ink and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9708640B2 (en) | Electrospun nanofibrous membranes and disposable glucose biosensor | |
| CN107049299A (en) | A kind of anti-interference cardiac electricity detecting system, detection method, Special flexible Graphene electrodes and preparation method thereof and purposes | |
| CN105286856B (en) | Inhibit motion artifacts graphene flexibility electrocardiograph dry electrode | |
| JP6953431B2 (en) | Multiple transdermal extraction and detection devices for non-invasive monitoring of substances and usage | |
| WO2014025430A2 (en) | Wearable electrochemical sensors | |
| Das et al. | Chemically reduced graphene oxide-based dry electrodes as touch sensor for electrocardiograph measurement | |
| CN102824168B (en) | Flexible physiological dry electrode and preparation method thereof | |
| Sharifuzzaman et al. | MXene/fluoropolymer‐derived laser‐carbonaceous all‐fibrous nanohybrid patch for soft wearable bioelectronics | |
| CN110974251A (en) | Micro-needle pressing type electrochemical sensor based on mobile phone platform | |
| CN107328830B (en) | A kind of biosensor | |
| CN113545778A (en) | Porous blood sugar electrode material and preparation method thereof | |
| CN114367672B (en) | Silver-gold core-shell nanowire, enzyme-free glucose sensor electrode, preparation and detection | |
| Zhao et al. | Wearable electrochemical sensors for the detection of organic metabolites and drugs in sweat | |
| CN106108890A (en) | A kind of medical dry electrode with high conduction performance and manufacture method thereof | |
| CN110186976A (en) | The working electrode and preparation method thereof of glucose monitoring probe | |
| KR102346539B1 (en) | Non-invasive wearable glucose sensor, glucose concentration measuring device comprising the same, manufacturing method of the glucose sensor, and glucose concentration measuring method using the glucose sensor | |
| KR20190102503A (en) | A high sensitive sensor for analyzing glucose comprising multichannel carbon nantofiber and a method for preparing the same | |
| Jiang et al. | Sponge-inspired MXene@ CeO2 detector for ultra-sensitive detection of glucose | |
| Jinchuang et al. | Design and implementation of multi-parameter portable biological information measurement system | |
| CN113397551A (en) | Flexible leather electrode material based on liquid metal and preparation method thereof | |
| CN208709880U (en) | A kind of bioelectrical signals flexibility dry-type electrode | |
| Song et al. | Performance of a flexible electrode based on natural leather | |
| CN111426733B (en) | Electrode material for ascorbic acid sensor, biosensor, preparation method and application of biosensor | |
| CN111157592A (en) | Electrostatic spinning glucose detection membrane and preparation method thereof | |
| CN115067958A (en) | Flexible graphene electrode for electrocardio sensor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |