CN113528912B - In-vivo absorbable metal anastomosis nail and preparation method thereof - Google Patents
In-vivo absorbable metal anastomosis nail and preparation method thereof Download PDFInfo
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- 230000003872 anastomosis Effects 0.000 title claims abstract description 74
- 229910052751 metal Inorganic materials 0.000 title claims abstract description 66
- 239000002184 metal Substances 0.000 title claims abstract description 66
- 238000001727 in vivo Methods 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title description 8
- 238000007747 plating Methods 0.000 claims abstract description 105
- 239000002994 raw material Substances 0.000 claims abstract description 101
- 239000011777 magnesium Substances 0.000 claims abstract description 88
- 239000011701 zinc Substances 0.000 claims abstract description 84
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 41
- 229910052761 rare earth metal Inorganic materials 0.000 claims abstract description 39
- 150000002910 rare earth metals Chemical class 0.000 claims abstract description 39
- 229910000861 Mg alloy Inorganic materials 0.000 claims abstract description 25
- 229910052742 iron Inorganic materials 0.000 claims abstract description 23
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 23
- 229910001297 Zn alloy Inorganic materials 0.000 claims abstract description 21
- 230000007797 corrosion Effects 0.000 claims abstract description 21
- 238000005260 corrosion Methods 0.000 claims abstract description 21
- 229910052802 copper Inorganic materials 0.000 claims abstract description 18
- 229910045601 alloy Inorganic materials 0.000 claims description 96
- 239000000956 alloy Substances 0.000 claims description 96
- 238000002844 melting Methods 0.000 claims description 61
- 230000008018 melting Effects 0.000 claims description 61
- 238000010438 heat treatment Methods 0.000 claims description 55
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical group [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 54
- 238000003723 Smelting Methods 0.000 claims description 39
- 229910052725 zinc Inorganic materials 0.000 claims description 36
- 238000010791 quenching Methods 0.000 claims description 32
- 230000000171 quenching effect Effects 0.000 claims description 32
- 230000001681 protective effect Effects 0.000 claims description 31
- 238000004519 manufacturing process Methods 0.000 claims description 30
- 238000002156 mixing Methods 0.000 claims description 29
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- 239000010949 copper Substances 0.000 claims description 28
- 229910052786 argon Inorganic materials 0.000 claims description 27
- 239000011248 coating agent Substances 0.000 claims description 25
- 238000000576 coating method Methods 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 25
- 238000004321 preservation Methods 0.000 claims description 20
- 229910052749 magnesium Inorganic materials 0.000 claims description 18
- 238000000137 annealing Methods 0.000 claims description 16
- 238000005266 casting Methods 0.000 claims description 16
- 239000013078 crystal Substances 0.000 claims description 16
- 238000005098 hot rolling Methods 0.000 claims description 16
- 238000007670 refining Methods 0.000 claims description 16
- 238000005491 wire drawing Methods 0.000 claims description 16
- 239000011575 calcium Substances 0.000 claims description 13
- 238000007598 dipping method Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 4
- 230000015556 catabolic process Effects 0.000 abstract description 6
- 238000006731 degradation reaction Methods 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 description 14
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- 208000002847 Surgical Wound Diseases 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
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- 208000027418 Wounds and injury Diseases 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
- C22C23/04—Alloys based on magnesium with zinc or cadmium as the next major constituent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
-
- C—CHEMISTRY; METALLURGY
- C21—METALLURGY OF IRON
- C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
- C21D9/00—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor
- C21D9/0068—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor for particular articles not mentioned below
-
- C—CHEMISTRY; METALLURGY
- C21—METALLURGY OF IRON
- C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
- C21D9/00—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor
- C21D9/52—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor for wires; for strips ; for rods of unlimited length
- C21D9/525—Heat treatment, e.g. annealing, hardening, quenching or tempering, adapted for particular articles; Furnaces therefor for wires; for strips ; for rods of unlimited length for wire, for rods
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/02—Making non-ferrous alloys by melting
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
- C22C18/02—Alloys based on zinc with copper as the next major constituent
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/002—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working by rapid cooling or quenching; cooling agents used therefor
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C2/00—Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor
- C23C2/04—Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor characterised by the coating material
- C23C2/06—Zinc or cadmium or alloys based thereon
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- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C2/00—Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor
- C23C2/34—Hot-dipping or immersion processes for applying the coating material in the molten state without affecting the shape; Apparatus therefor characterised by the shape of the material to be treated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
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Abstract
The invention relates to the technical field related to medical equipment, in particular to an in-vivo absorbable metal anastomosis nail, which comprises a U-shaped body; the U-shaped body is provided with a through groove, and the inner wall of the U-shaped body is provided with a plurality of locking grooves; the surface of the U-shaped body is provided with a plating layer; the anastomosis nail is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: zn, Ca, Fe, Mn, rare earth and the balance of Mg; the plating coat is composed of the following raw materials in parts by weight: mg, Ca, Cu and the balance of Zn; the anastomosis nail prepared by the embodiment of the invention has the characteristics of higher corrosion resistance, better tensile strength, good improvement on degradation speed and the like under the combined action of the plating layer and the structural improvement of the U-shaped body, and the pain of a patient caused by a secondary operation is effectively avoided.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to an in-vivo absorbable metal anastomosis nail and a preparation method thereof.
Background
The anastomat is a device used in medicine to replace manual suturing, suturing is fast in operation, operation is simple and convenient, tissue exposure time can be shortened obviously, trauma and bleeding are reduced, surgical complications are reduced effectively, and the anastomat is similar to a stapler and is used for separating or anastomosing tissues. According to different application ranges, the surgical stapler can be mainly divided into a skin stapler, a circular stapler for digestive tracts (esophagus, stomach and intestine and the like), a rectal stapler, a circular hemorrhoid stapler, a circumcision stapler, a blood vessel stapler, a hernia stapler, a lung cutting stapler and the like.
Currently, the materials of the clinical anastomosis nail mainly comprise stainless steel, titanium and titanium alloy, and magnesium alloy.
The existing clinical stainless steel or titanium and titanium alloy anastomosis nail is not degradable, so the anastomosis nail can be permanently existed in a human body as a foreign matter, slowly releases scraps and even toxic and irritant ions, causes serious inflammatory reaction of surrounding tissues, and reduces the biocompatibility and safety of an apparatus; although the staples supported by magnesium and magnesium alloy can be degraded, the problems of over-high corrosion rate, insufficient mechanical strength and the like exist.
Disclosure of Invention
The invention aims to provide an in-vivo absorbable metal anastomosis nail and a preparation method thereof, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
an in vivo absorbable metal anastomosis nail comprises a U-shaped body; the U-shaped body is provided with a plurality of uniformly distributed through grooves, the inner wall of the U-shaped body is provided with a plurality of locking grooves, and the locking grooves and the through grooves are arranged in a staggered manner;
the surface of the U-shaped body is provided with a plating layer with corrosion resistance and excellent biocompatibility;
the anastomosis nail is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 1.8 to 5.2 percent of Zn, 0.18 to 0.65 percent of Ca, 0.25 to 0.42 percent of Fe, 2.7 to 3.6 percent of Mn, 0.05 to 0.15 percent of rare earth and the balance of Mg;
the plating layer is composed of the following raw materials in parts by weight: 0.001 to 0.19 percent of Mg, 0.0009 to 1.5 percent of Ca, 0.0085 to 2 percent of Cu, and the balance of Zn.
The application adopts a further technical scheme that: and chamfering the upper corners of the U-shaped body.
The application adopts a further technical scheme that: the anastomosis nail is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 2.1 to 4.9 percent of Zn, 0.21 to 0.58 percent of Ca, 0.26 to 0.41 percent of Fe, 2.8 to 3.4 percent of Mn, 0.06 to 0.14 percent of rare earth and the balance of Mg;
the plating layer is composed of the following raw materials in parts by weight: 0.005-0.18% of Mg, 0.002-1.3% of Ca, 0.05-1.8% of Cu and the balance of Zn.
The application adopts a further technical scheme that: the anastomosis nail is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 2.8 to 4.2 percent of Zn, 0.32 to 0.48 percent of Ca, 0.32 to 0.38 percent of Fe, 2.95 to 3.2 percent of Mn, 0.08 to 0.12 percent of rare earth and the balance of Mg;
the plating layer is composed of the following raw materials in parts by weight: 0.06 to 0.12 percent of Mg, 0.5 to 1.1 percent of Ca, 0.8 to 1.2 percent of Cu and the balance of Zn.
The application adopts a further technical scheme that: the anastomosis nail is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 3.5% of Zn, 0.415% of Ca, 0.35% of Fe, 3.15% of Mn, 0.1% of rare earth and the balance of Mg;
the plating layer is composed of the following raw materials in parts by weight: 0.0955% Mg, 0.75045% Ca, 1.0043% Cu, and the balance Zn.
The invention relates to a preparation method of an in-vivo absorbable metal anastomosis nail, which comprises the following steps:
(1) preparing a raw material for manufacturing a U-shaped body according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing a raw material for manufacturing a plating layer according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body into the melting furnace, stirring, mixing, and then casting to obtain cast alloy in a heat preservation way; meanwhile, in a smelting furnace under the action of another protective atmosphere, heating the smelting furnace to 862-875 ℃, adding Zn for melting treatment, cooling to 705-740 ℃, simultaneously adding the prepared raw materials for coating into the smelting furnace, stirring and mixing, and then reducing the temperature to 660-680 ℃ and preserving the heat for 20-30 minutes to obtain the coating liquid.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 360-380 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) carrying out annealing heat treatment on the wire at 300 ℃ for 10min, and processing to obtain a U-shaped body;
(6) and covering the plating coating liquid on the U-shaped body by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
The application adopts a further technical scheme that: the protective atmosphere is argon.
Compared with the prior art, the technical scheme provided by the embodiment of the invention has the following beneficial effects:
the in-vivo absorbable metal anastomosis nail prepared by the embodiment of the invention is provided with the plating layer, and under the combined action of the structural improvement of the U-shaped body, the prepared in-vivo absorbable metal anastomosis nail has the characteristics of higher corrosion resistance, better tensile strength, good improvement on degradation speed and the like, the comprehensive performance of the in-vivo absorbable metal anastomosis nail is obviously improved, the anastomosis nail can be continuously absorbed, the surgical incision disappears after healing, the corrosion resistance is far higher than that of magnesium alloy while the biocompatibility is good, the degradation speed is greatly reduced, a longer-time mechanical support can be provided, the problem of early failure of the anastomosis nail is avoided, and the pain of a patient caused by a secondary operation is effectively avoided.
The improved structure of the U-shaped body improves the anastomosis stability and simultaneously reduces the contact area of the anastomosis nail body, and the anastomosis effect is not influenced and simultaneously the wound can be more conveniently degraded after healing.
Drawings
FIG. 1 is a schematic view of a structure of an in vivo absorbable metal staple in accordance with an embodiment of the present invention;
the reference numerals in the schematic drawings illustrate:
1-U-shaped body, 2-through groove, 3-locking groove and 4-plating coating.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments of the present invention, belong to the protection scope of the present invention, and the present invention is further described with reference to the embodiments below.
Example 1
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 3.5% of Zn, 0.415% of Ca, 0.35% of Fe, 3.15% of Mn, 0.1% of rare earth and the balance of Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.0955% Mg, 0.75045% Ca, 1.0043% Cu, and the balance Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, the smelting furnace is heated to 862 ℃ and then added with Zn for melting treatment, the temperature is reduced to 740 ℃, and then the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 660 ℃ and heat preservation is carried out for 30 minutes to obtain the plating layer liquid.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 380 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 2
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 1.8% of Zn, 0.18% of Ca, 0.25% of Fe, 3.6% of Mn, 0.15% of rare earth and the balance of Mg;
the plating coat 4 is composed of the following raw materials in parts by weight: 0.001% of Mg, 0.0009% of Ca, 2% of Cu and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, heating the smelting furnace to 862-875 ℃, adding Zn for melting treatment, cooling to 705-740 ℃, simultaneously adding the prepared raw material of the coating 4 into the smelting furnace, stirring and mixing, and then reducing the temperature to 660-680 ℃ and preserving the heat for 20-30 minutes to obtain the coating liquid.
(3) Putting the cast alloy into a heat treatment furnace, carrying out heat treatment at 360-380 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 3
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 5.2% Zn, 0.65% Ca, 0.42% Fe, 2.7% Mn, 0.05% rare earth, and the balance Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.19% of Mg, 1.5% of Ca, 0.0085% of Cu and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, the smelting furnace is heated to 875 ℃ and then added with Zn for melting treatment, the temperature is reduced to 705 ℃, and then the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 680 ℃ and heat preservation is carried out for 20 minutes to obtain the plating layer liquid.
(3) Putting the cast alloy into a heat treatment furnace, carrying out heat treatment at 360 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 4
Referring to fig. 1, an in vivo absorbable metal anastomosis nail comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 1.8% of Zn, 0.5% of Ca, 0.3% of Fe, 3% of Mn, 0.12% of rare earth and the balance of Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.001% of Mg, 1.5% of Ca, 1% of Cu and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of argon gas in protective atmosphere, the smelting furnace is heated to 869 ℃, Zn is added for melting treatment, the temperature is reduced to 718 ℃, the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 670 ℃ and the temperature is kept for 25 minutes to obtain the plating layer liquid.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 370 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 5
Referring to fig. 1, an in vivo absorbable metal anastomosis nail comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 4% of Zn, 0.2% of Ca, 0.35% of Fe, 3.2% of Mn, 0.1% of rare earth and the balance of Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.15% of Mg, 1% of Ca, 0.5% of Cu and the balance of Zn.
In this embodiment, the preparation method of the in vivo absorbable metal anastomotic nail comprises the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of argon gas in protective atmosphere, the smelting furnace is heated to 870 ℃, then Zn is added for melting treatment, the temperature is reduced to 715 ℃, then the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 670 ℃ and the temperature is kept for 28 minutes to obtain the plating layer liquid.
(3) Putting the cast alloy into a heat treatment furnace, carrying out heat treatment at 375 ℃, carrying out equiangular hot rolling treatment on the cast alloy after heat treatment, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 6
Referring to fig. 1, an in vivo absorbable metal anastomosis nail comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 2% of Zn, 0.45% of Ca, 0.35% of Fe, 3.3% of Mn, 0.11% of rare earth and the balance of Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.05% of Mg, 0.005% of Ca, 0.05% of Cu and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of argon gas in protective atmosphere, the smelting furnace is heated to 865 ℃, then Zn is added for melting treatment, the temperature is reduced to 720 ℃, then the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 665 ℃, and the plating layer liquid is obtained after heat preservation for 28 minutes.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 372 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 7
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 4% of Zn, 0.65% of Ca, 0.25% of Fe, 3% of Mn, 0.15% of rare earth and the balance of Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.001% of Mg, 0.3% of Ca, 0.8% of Cu and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, the smelting furnace is heated to 875 ℃ and then added with Zn for melting treatment, the temperature is reduced to 730 ℃, and then the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 670 ℃ and the temperature is kept for 21 minutes to obtain the plating layer liquid.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 368 ℃, carrying out equiangular hot rolling treatment on the cast alloy subjected to heat treatment, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 8
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 2.1% of Zn, 0.21% of Ca, 0.41% of Fe, 3.4% of Mn, 0.14% of rare earth and the balance of Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.005% of Mg, 0.002% of Ca, 1.8% of Cu and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, heating the smelting furnace to 862-875 ℃, adding Zn for melting treatment, cooling to 705-740 ℃, simultaneously adding the prepared raw material of the coating 4 into the smelting furnace, stirring and mixing, and then reducing the temperature to 660-680 ℃ and preserving the heat for 20-30 minutes to obtain the coating liquid.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 360-380 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 9
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 2.8% of Zn, 0.32% of Ca, 0.38% of Fe, 3.2% of Mn, 0.12% of rare earth and the balance of Mg;
the plating coat 4 is composed of the following raw materials in parts by weight: 0.06% of Mg, 0.5% of Ca, 1.2% of Cu and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, the smelting furnace is heated to 875 ℃ and then added with Zn for melting treatment, the temperature is reduced to 705 ℃, and then the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 680 ℃ and heat preservation is carried out for 20 minutes to obtain the plating layer liquid.
(3) Putting the cast alloy into a heat treatment furnace, carrying out heat treatment at 360 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and a U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 10
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 4.2% of Zn, 0.48% of Ca, 0.32% of Fe, 2.95% of Mn, 0.08% of rare earth and the balance of Mg;
the plating layer 4 is composed of the following raw materials in parts by weight: 0.12% of Mg, 1.1% of Ca, 0.8% of Cu and the balance of Zn.
In this embodiment, the preparation method of the in vivo absorbable metal anastomotic nail comprises the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, the smelting furnace is heated to 870 ℃, then Zn is added for melting treatment, the temperature is reduced to 715 ℃, then the raw material of the prepared plating coating 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 670 ℃, and the temperature is kept for 28 minutes to obtain the plating coating liquid.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 375 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Example 11
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of through grooves 2 which are uniformly distributed are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the surface of the U-shaped body 1 is provided with a plating layer 4 with corrosion resistance and excellent biocompatibility;
the anastomosis nail is jointly made of a U-shaped body 1 made of magnesium alloy and a plating layer 4 made of zinc alloy; the U-shaped body 1 is composed of the following raw materials in parts by weight: 4.9% of Zn, 0.58% of Ca, 0.26% -Fe, 2.8% of Mn, 0.06% of rare earth and the balance of Mg;
the plating coat 4 comprises the following raw materials, by weight, 0.18% of Mg, 1.3% of Ca, 0.05% of Cu, and the balance of Zn.
In this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) firstly, preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing raw materials for manufacturing a plating layer 4 according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way; meanwhile, in another smelting furnace under the action of protective atmosphere argon, the smelting furnace is heated to 875 ℃ and then added with Zn for melting treatment, the temperature is reduced to 730 ℃, and then the raw material of the prepared plating layer 4 is added into the smelting furnace, and after stirring and mixing treatment, the temperature is reduced to 670 ℃ and the temperature is kept for 21 minutes to obtain the plating layer liquid.
(3) Placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 368 ℃, carrying out equiangular hot rolling treatment on the cast alloy subjected to heat treatment, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment;
(6) and covering the plating coating liquid on the U-shaped body 1 by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
Comparative example 1
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the U-shaped body 1 is composed of the following raw materials in parts by weight: 3.5% of Zn, 0.415% of Ca, 0.35% of Fe, 3.15% of Mn, 0.1% of rare earth and the balance of Mg;
in this embodiment, the preparation method of the in vivo absorbable metal anastomotic nail comprises the following steps:
(1) preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way;
(3) placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 380 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment; thus obtaining the absorbable metal anastomosis nail in vivo.
Comparative example 2
Referring to fig. 1, an absorbable metal staple in vivo comprises a U-shaped body 1; a plurality of uniformly distributed through grooves 2 are formed in the U-shaped body 1, a plurality of locking grooves 3 are formed in the inner wall of the U-shaped body 1, and the locking grooves 3 and the through grooves 2 are arranged in a staggered mode;
the U-shaped body 1 is composed of the following raw materials in parts by weight: 3.5% of Zn, 0.415% of Ca, 0.35% of Fe, 3.15% of Mn, 0.1% of rare earth and the balance of Mg;
in this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way;
(3) placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 370 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and the U-shaped body 1 is obtained after processing treatment; thus obtaining the absorbable metal anastomosis nail in vivo.
Comparative example 3
An in vivo absorbable metal anastomosis nail comprises a U-shaped body 1;
the U-shaped body 1 is composed of the following raw materials in parts by weight: 3.5% of Zn, 0.415% of Ca, 0.35Fe, 3.15% of Mn, 0.1% of rare earth and the balance of Mg;
in this embodiment, the method for preparing the in vivo absorbable metal anastomosis staple includes the following steps:
(1) preparing raw materials for manufacturing a U-shaped body 1 according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg;
(2) melting Mg in a melting furnace under the action of argon in a protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body 1 into the melting furnace, stirring and mixing, and then casting the mixture into an as-cast alloy in a heat preservation way;
(3) placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 380 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) annealing heat treatment is carried out on the wire at 300 ℃ for 10min, and a U-shaped body 1 is obtained after processing treatment; thus obtaining the absorbable metal anastomotic nail in vivo.
The in vivo absorbable metal staples manufactured in the above examples 1 to 11 and comparative examples 1 to 2 were subjected to the related performance tests under the same conditions. The obtained test data of the corrosion resistance, the mechanical strength and the 30-day degradation rate of the implanted staples are as follows:
among them, comparative example 1 is different from example 1 in that the plating layer 4 is not provided;
comparative example 2 differs from example 1 in that the plating layer 4 is not provided;
the comparative example 3 is different from the example 1 in the structural difference of the U-shaped body 1.
As can be seen from the test results in the table above, the in vivo absorbable metal anastomosis nail prepared according to the embodiments 1 to 11 of the present invention has better comprehensive properties than the comparative examples 1, 2 and 3, can be absorbed continuously, disappears after the healing of the surgical incision, has good biocompatibility, can effectively reduce corrosion efficiency and significantly improve tensile strength of the anastomosis nail, has corrosion resistance far higher than that of magnesium alloy, greatly reduces degradation speed, can provide mechanical support for a longer time, avoids the problem of premature failure of the anastomosis nail, and effectively avoids the pain of the patient caused by the secondary operation.
From the test results of the comparative examples 1-3 and the example 1, the invention can ensure that the prepared in vivo absorbable metal anastomosis nail has the characteristics of higher corrosion resistance, better tensile strength, good improvement of degradation speed and the like under the combined action of the plating layer 4 and the structural improvement of the U-shaped body 1, and the comprehensive performance of the in vivo absorbable metal anastomosis nail is obviously improved.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
1. An in vivo absorbable metal anastomosis nail comprises a U-shaped body; the U-shaped body is characterized in that a plurality of uniformly distributed through grooves are formed in the U-shaped body, a plurality of locking grooves are formed in the inner wall of the U-shaped body, and the locking grooves and the through grooves are arranged in a staggered mode;
the surface of the U-shaped body is provided with a plating layer with corrosion resistance and excellent biocompatibility;
the anastomosis nail is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 1.8 to 5.2 percent of Zn, 0.18 to 0.65 percent of Ca, 0.25 to 0.42 percent of Fe, 2.7 to 3.6 percent of Mn, 0.05 to 0.15 percent of rare earth and the balance of Mg;
the plating coating comprises the following raw materials in parts by weight: 0.001-0.19% of Mg, 0.0009-1.5% of Ca, 0.0085-2% of Cu and the balance of Zn.
2. The in vivo absorbable metal staple of claim 1, wherein the upper corners of said U-shaped body are chamfered.
3. The in vivo absorbable metal staple of claim 2, wherein said staple is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 2.1-4.9% of Zn, 0.21-0.58% of Ca, 0.26-0.41% of Fe, 2.8-3.4% of Mn, 0.06-0.14% of rare earth and the balance of Mg;
the plating layer is composed of the following raw materials in parts by weight: 0.005-0.18% of Mg, 0.002-1.3% of Ca, 0.05-1.8% of Cu and the balance of Zn.
4. The in vivo absorbable metal staple of claim 3, wherein said staple is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 2.8 to 4.2 percent of Zn, 0.32 to 0.48 percent of Ca, 0.32 to 0.38 percent of Fe, 2.95 to 3.2 percent of Mn, 0.08 to 0.12 percent of rare earth and the balance of Mg;
the plating layer is composed of the following raw materials in parts by weight: 0.06-0.12% of Mg, 0.5-1.1% of Ca, 0.8-1.2% of Cu and the balance of Zn.
5. The in vivo absorbable metal staple of claim 4, wherein said staple is made of a U-shaped body made of magnesium alloy and a plating layer made of zinc alloy; the U-shaped body is composed of the following raw materials in parts by weight: 3.5% of Zn, 0.415% of Ca, 0.35% of Fe, 3.15% of Mn, 0.1% of rare earth and the balance of Mg;
the plating layer is composed of the following raw materials in parts by weight: 0.0955% of Mg, 0.75045% of Ca, 1.0043% of Cu and the balance of Zn.
6. A method of making an in vivo absorbable metal staple as defined in any one of claims 1-5, comprising the steps of:
(1) preparing a raw material for manufacturing a U-shaped body according to the weight parts of Zn, Ca, Fe, Mn, rare earth and Mg, and preparing a raw material for manufacturing a plating layer according to the weight parts of Mg, Ca, Cu and Zn;
(2) melting Mg in a melting furnace under the action of protective atmosphere, sequentially adding the prepared raw materials of the U-shaped body into the melting furnace, stirring, mixing, and then casting to obtain cast alloy in a heat preservation manner; meanwhile, in a smelting furnace under the action of another protective atmosphere, heating the smelting furnace to 862-875 ℃ and then adding Zn for melting treatment, cooling to 705-740 ℃, simultaneously adding the prepared raw material for coating into the smelting furnace, stirring and mixing, and then reducing the temperature to 660-680 ℃ and preserving the heat for 20-30 minutes to obtain a coating solution;
(3) placing the cast alloy into a heat treatment furnace, carrying out heat treatment at 360-380 ℃, carrying out equiangular hot rolling treatment on the heat-treated cast alloy, and refining crystal grains of the cast alloy to obtain an alloy primary product;
(4) quenching the alloy primary product after solution treatment, and performing wire drawing forming after quenching treatment to obtain wires with different diameters;
(5) carrying out annealing heat treatment on the wire at 300 ℃ for 10min, and processing to obtain a U-shaped body;
(6) and covering the plating coating liquid on the U-shaped body by using a hot dipping method to obtain the metal anastomosis nail capable of being absorbed in the body.
7. The method for preparing an in vivo absorbable metal anastomosis staple according to claim 6, wherein said protective atmosphere is argon.
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| CN201617885U (en) * | 2009-11-13 | 2010-11-03 | 常州新区佳森医用支架器械有限公司 | Absorbable magnesium alloy staple used for anastomat |
| CN101766835A (en) * | 2010-02-01 | 2010-07-07 | 上海交通大学 | Metal anastomotic nail absorbable in vivo and preparation method thereof |
| CN205041835U (en) * | 2015-06-18 | 2016-02-24 | 赵宇 | Nail is sewed up to degradable for anastomat |
| CN105640601B (en) * | 2016-04-08 | 2017-08-15 | 苏州奥芮济医疗科技有限公司 | Metal anastomotic nail absorbable in vivo and preparation method thereof |
| CN115181879A (en) * | 2019-01-30 | 2022-10-14 | 四川镁合医疗器械有限责任公司 | Degradable magnesium alloy in-situ composite anastomosis nail and preparation method thereof |
| CN210811265U (en) * | 2019-08-30 | 2020-06-23 | 江苏金力弹簧科技有限公司 | Anastomosis nail for minimally invasive surgery |
| CN110694121A (en) * | 2019-10-22 | 2020-01-17 | 兰州理工大学 | In-vivo degradable magnesium alloy anastomosis nail and preparation method thereof |
| CN111759384A (en) * | 2020-07-22 | 2020-10-13 | 北京大学人民医院 | Gastrointestinal anastomosis nail with degradable drug film layer and preparation method thereof |
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