CN113522121A - Constant temperature oscillator for research, development and preparation of antibacterial peptide - Google Patents
Constant temperature oscillator for research, development and preparation of antibacterial peptide Download PDFInfo
- Publication number
- CN113522121A CN113522121A CN202110860492.1A CN202110860492A CN113522121A CN 113522121 A CN113522121 A CN 113522121A CN 202110860492 A CN202110860492 A CN 202110860492A CN 113522121 A CN113522121 A CN 113522121A
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- Prior art keywords
- box
- cavity
- heat preservation
- constant temperature
- movable
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000003910 polypeptide antibiotic agent Substances 0.000 title abstract description 31
- 238000004321 preservation Methods 0.000 claims description 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 230000000844 anti-bacterial effect Effects 0.000 claims description 11
- 230000003115 biocidal effect Effects 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 238000003825 pressing Methods 0.000 claims description 6
- 229920001971 elastomer Polymers 0.000 claims description 3
- 229920001821 foam rubber Polymers 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000004080 punching Methods 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 230000010355 oscillation Effects 0.000 abstract description 28
- 230000000694 effects Effects 0.000 abstract description 14
- 102000044503 Antimicrobial Peptides Human genes 0.000 description 3
- 108700042778 Antimicrobial Peptides Proteins 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229940124350 antibacterial drug Drugs 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000002277 temperature effect Effects 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
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- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a constant temperature oscillator for research, development and preparation of antibacterial peptide, which comprises an oscillator, an oscillation box arranged at the top of the oscillator and a box cover hinged at the top of the oscillation box, wherein a movable box with an upward opening is arranged in the oscillation box; according to the invention, the movable box is movably arranged in the oscillating box, so that the movable box can be conveniently moved and impacted in the oscillating box in a transverse manner through the moving wheel when the oscillating box oscillates, the oscillating effect on the antibacterial peptide test tube is further improved, the antibacterial peptide test tube in the movable box can be conveniently kept at a constant temperature while oscillating through the mounting plate and the bottom plate in the movable box, the oscillating effect on the antibacterial peptide test tube is conveniently improved, and the oscillating efficiency on the antibacterial peptide in the test tube is improved.
Description
Technical Field
The invention relates to the technical field of antibacterial peptides, in particular to a constant-temperature oscillator for research, development and preparation of antibacterial peptides.
Background
The antibacterial peptide has obvious advantages in the research of novel antibacterial drugs due to the broad-spectrum efficient antibacterial activity and the unique antibacterial mechanism, the effect of the antibacterial peptide in infection defense is as important as an antibody, an immune cell and a phagocyte, and compared with other current novel safe antibacterial drugs, the genetically engineered antibacterial peptide has the advantages of broad spectrum, efficient antibacterial property, no drug resistance, good heat stability, good water solubility, no toxicity, no residue and the like;
at present, when the antibacterial peptide is prepared and researched, the antibacterial peptide in a test tube needs to be oscillated and shaken up by an oscillator so as to accelerate the reaction rate of the antibacterial peptide; however, in the existing oscillator, when the number of the existing oscillators is large, the test tube filled with the antimicrobial peptide is placed on the test tube rack and then oscillated, but at a low temperature, the environmental temperature is low, so that the fungus activity in the test tube is easily reduced, and the oscillating effect of the oscillator on the antimicrobial peptide in the test tube is reduced; therefore, the above problems need to be dealt with.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides a constant temperature oscillator for developing and preparing antibacterial peptide.
In order to achieve the purpose, the invention adopts the following technical scheme: the constant-temperature oscillator for research, development and preparation of the antibacterial peptide comprises an oscillator, an oscillation box arranged at the top of the oscillator and a box cover hinged to the top of the oscillation box, wherein a movable box with an upward opening is arranged in the oscillation box, an installation plate is horizontally arranged in the upper part of the movable box, a bottom plate is arranged on the inner bottom surface of the movable box, a heat preservation cavity is arranged in the installation plate, and a constant-temperature cavity is arranged in the bottom plate;
a shunting cavity is formed in the inner wall of the box body on one side of the movable box, a converging cavity is formed in the inner wall of the box body on the other side of the movable box, an air inlet pipe is arranged on one side of the oscillating box, and an air conveying hose communicated with the shunting cavity is arranged on one side of the movable box; the other side of the oscillating box is provided with an air outlet pipe, the other side of the movable box is provided with an exhaust hose communicated with the confluence cavity, the air inlet pipe is communicated with the air delivery hose, and the air outlet pipe is communicated with the exhaust hose;
the heat preservation cavity and the constant temperature cavity are communicated with the flow distribution cavity and the flow converging cavity.
Preferably, a plurality of openings which are sealed with the heat preservation cavity are vertically and uniformly formed in the top surface of the mounting plate, each heat preservation seat is arranged on the bottom surface of the mounting plate at the bottom of each opening, an air inlet cavity is formed in each heat preservation seat, and the air inlet cavity is communicated with the heat preservation cavity.
Preferably, the heat preservation seat is in a conical round pipe shape, the heat preservation seat is communicated with the placement opening, an inserting ring pipe is sleeved on the outer side of the top face of the heat preservation seat, and the inserting ring pipe is inserted into the heat preservation cavity in a sealing mode.
Preferably, the placing opening and the heat preservation seat are vertically inserted with an anti-sliding sleeve.
Preferably, the four corners of the bottom surface of the movable box and the front and rear ends of the lower parts of the two side surfaces are respectively provided with a movable wheel, and the front and rear ends of the two sides of the bottom surface in the oscillating box are respectively transversely matched with the movable wheels to be provided with a strip-shaped movable groove.
Preferably, the bottom plate bottom surface cooperation is placed a mouthful punching press and is had a plurality of curved constant head tanks, the pad is equipped with the one deck foam-rubber cushion in the constant head tank, just the bottom plate is the rubber material.
Preferably, the top surface has seted up the spout in the case lid, the level is equipped with the sliding plate in the spout, the level is equipped with the clamp plate below the sliding plate, all be equipped with the spring telescopic link between sliding plate bottom surface four corners and the clamp plate top surface.
Compared with the prior art, the invention has the beneficial effects that: according to the invention, the movable box is movably arranged in the oscillating box, so that the movable box can be conveniently moved and impacted in the oscillating box in a transverse manner through the moving wheel when the oscillating box oscillates, the oscillating effect on the antibacterial peptide test tube is further improved, the antibacterial peptide test tube in the movable box can be conveniently kept at constant temperature while oscillating through the mounting plate and the bottom plate in the movable box, the oscillating effect on the antibacterial peptide test tube is conveniently improved, and the oscillating efficiency on the antibacterial peptide in the test tube is improved.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without limiting the invention. In the drawings:
FIG. 1 is a schematic front view of the present invention;
FIG. 2 is a schematic cross-sectional close-up structure of the oscillating box of the present invention;
FIG. 3 is a schematic view of the open cross-section structure of the vibration box of the present invention;
FIG. 4 is a schematic cross-sectional view of the movable box and the mounting plate of the present invention;
FIG. 5 is a sectional view of the insulation base and mounting plate of the present invention.
Number in the figure: 1. an oscillator; 2. an oscillation box; 3. a box cover; 4. a movable box; 5. mounting a plate; 6. a base plate; 7. an air inlet pipe; 8. an air outlet pipe; 9. a heat preservation seat; 10. a heat preservation cavity; 11. a constant temperature cavity; 12. anti-sliding sleeves; 13. inserting a ring pipe; 14. a moving wheel; 15. a sliding plate; 16. and (7) pressing a plate.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example (b): referring to fig. 1-5, the constant temperature oscillator for research, development and preparation of antimicrobial peptides comprises an oscillator 1, an oscillation box 2 mounted on the top of the oscillator 1, and a box cover 3 hinged to the top of the oscillation box 2, wherein the oscillator 1 is of the type HX-ZD-200A-04, a movable box 4 with an upward opening is arranged in the oscillation box 2, a mounting plate 5 is horizontally arranged in the upper part of the movable box 4, a bottom plate 6 is arranged on the inner bottom surface of the movable box 4, a heat preservation cavity 10 is arranged in the mounting plate 5, and a constant temperature cavity 11 is arranged in the bottom plate 6; set up the movable box 4 in vibration case 2 through the activity, be convenient for make movable box 4 carry out the sideslip striking through removing wheel 14 in vibration case 2 when vibration case 2 vibrates, further improve the oscillation effect to the antibiotic peptide test tube, mounting panel 5 and bottom plate 6 through the movable box 4, be convenient for make the antibiotic peptide test tube of movable box 4 inside carry out the constant temperature in the oscillation, be convenient for improve the oscillation effect to the antibiotic peptide test tube, the oscillation efficiency to the antibiotic peptide of test tube inside has been improved.
In the invention, a shunting cavity is formed in the inner wall of the box body at one side of the movable box 4, a converging cavity is formed in the inner wall of the box body at the other side of the movable box 4, an air inlet pipe 7 is arranged at one side of the oscillating box 2, and an air conveying hose communicated with the shunting cavity is arranged at one side of the movable box 4; an air outlet pipe 8 is arranged on the other side of the oscillating box 2, an exhaust hose communicated with the confluence cavity is arranged on the other side of the movable box 4, the air inlet pipe 7 is communicated with the air delivery hose, and the air outlet pipe 8 is communicated with the exhaust hose; the heat preservation cavity 10 and the constant temperature cavity 11 are communicated with the flow dividing cavity and the flow converging cavity; facilitating the circulation of the gas.
In the invention, a plurality of placing openings which are sealed with the heat preservation cavities 10 are uniformly and vertically formed in the top surface of the mounting plate 5, the bottom surface of the mounting plate 5 at the bottom of each placing opening is provided with a heat preservation seat 9, an air inlet cavity is formed in each heat preservation seat 9, and the air inlet cavity is communicated with the heat preservation cavities 10; the heat preservation seat 9 is convenient to heat up, and the constant temperature effect on the antibacterial peptide test tube is improved.
In the invention, the heat preservation seat 9 is in a conical round pipe shape, the heat preservation seat 9 is communicated with the placing opening, the outer side of the top surface of the heat preservation seat 9 is sleeved with the inserting ring pipe 13, and the inserting ring pipe 13 is hermetically inserted into the heat preservation cavity 10; an anti-sliding sleeve 12 is vertically inserted into the placing opening and the heat preservation seat 9; through 12 anti-collision protection of being convenient for carry out the anti-collision protection to the antibiotic peptide test tube when the oscillation, prevent that the antibiotic peptide test tube from taking place the breakage.
In the invention, the four corners of the bottom surface of the movable box 4 and the front and rear ends of the lower parts of the two side surfaces are respectively provided with a movable wheel 14, and the front and rear ends of the two sides of the bottom surface in the oscillating box 2 are respectively transversely matched with the movable wheels 14 to be provided with a strip-shaped movable groove; the movable box 4 is convenient to move and impact in the oscillation box 2, and the oscillation effect on the antibacterial peptide test tube is further improved.
In the invention, a plurality of arc-shaped positioning grooves are punched on the bottom surface of the bottom plate 6 in a matching and placing opening, a layer of spongy cushion is padded in each positioning groove, and the bottom plate 6 is made of rubber; the protection performance of the antibacterial peptide test tube on the bottom of the test tube during oscillation is improved conveniently.
In the invention, a sliding groove is formed in the inner top surface of the box cover 3, a sliding plate 15 is horizontally arranged in the sliding groove, a pressing plate 16 is horizontally arranged below the sliding plate 15, and spring telescopic rods are arranged between four corners of the bottom surface of the sliding plate 15 and the top surface of the pressing plate 16; through the cooperation of sliding plate 15 and clamp plate 16 and spring telescopic link, be convenient for after case lid 3 is closed, compress tightly the operation to the end cap of antibiotic peptide test tube, prevent to take place because of the phenomenon that the oscillation leads to the end cap pine of antibiotic peptide test tube to take off.
The working principle is as follows: in this embodiment, the present invention also provides a method for using the constant temperature oscillator for developing and preparing the antibacterial peptide, which includes the following steps:
firstly, electrically connecting an oscillator 1 with external control equipment through a wire, communicating the outer end of an air outlet pipe 8 of an air inlet pipe 7 with external heating equipment, then opening a box cover 3, then inserting a plurality of antibacterial peptide test tubes with oscillation into a placing port one by one, and enabling the bottom ends of the antibacterial peptide test tubes to abut against positioning grooves of a bottom plate 6;
secondly, closing the box cover 3, and enabling the pressing plate 16 to be tightly pressed on the plug of the antibacterial peptide test tube under the elastic force of the telescopic rod of the spring, so that the phenomenon that the plug of the antibacterial peptide test tube is loosened due to oscillation is prevented; then, the oscillator 1 is started to enable the oscillation box 2 to oscillate, the movable box 4 is enabled to transversely move and impact in the oscillation box 2 through the moving wheel 14 through the oscillation of the oscillation box 2, and the movement of the movable box 4 is not influenced while the gas flows through the arranged gas conveying hose and the arranged exhaust hose, so that the oscillation effect on the antibacterial peptide test tube is further improved;
thirdly, constant-temperature gas is conveyed into the gas inlet pipe 7 through external heating equipment, the gas enters the shunt cavity through the gas conveying hose, the gas in the shunt cavity respectively enters the heat preservation cavity 10 and the constant-temperature cavity 11, and further the mounting plate 5 and the bottom plate 6 are synchronously heated, so that the temperature between the mounting plate 5 and the bottom plate 6 is conveniently raised in the air, and the movable box 4 has a constant-temperature oscillation effect;
step four, after the constant-temperature gas is in the heat-preserving chamber 10, the constant-temperature gas enters the air inlet chamber of the heat-preserving seat 9, so that the heat-preserving seat 9 is heated, and the constant-temperature effect on the antibacterial peptide test tube is improved;
and step five, after the gas enters the heat preservation cavity 10 and the constant temperature cavity 11, the gas simultaneously enters the confluence cavity and is discharged into external heating equipment through an air outlet pipe 8 connected with an exhaust hose, so that the gas is circulated, and the constant temperature effect inside the oscillation box 2 is improved.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (7)
1. Be used for antibiotic peptide to research and develop preparation and use constant temperature oscillator, including oscillator (1), install vibration box (2) at oscillator (1) top and articulate case lid (3) at vibration box (2) top, its characterized in that: a movable box (4) with an upward opening is arranged in the oscillating box (2), a mounting plate (5) is horizontally arranged in the upper part of the movable box (4), a bottom plate (6) is arranged on the inner bottom surface of the movable box (4), a heat preservation cavity (10) is arranged in the mounting plate (5), and a constant temperature cavity (11) is arranged in the bottom plate (6);
a shunting cavity is formed in the inner wall of the box body on one side of the movable box (4), a converging cavity is formed in the inner wall of the box body on the other side of the movable box (4), an air inlet pipe (7) is arranged on one side of the oscillating box (2), and an air conveying hose communicated with the shunting cavity is arranged on one side of the movable box (4); an air outlet pipe (8) is arranged on the other side of the oscillating box (2), an exhaust hose communicated with the confluence cavity is arranged on the other side of the movable box (4), the air inlet pipe (7) is communicated with the air delivery hose, and the air outlet pipe (8) is communicated with the exhaust hose;
the heat preservation cavity (10) and the constant temperature cavity (11) are communicated with the diversion cavity and the confluence cavity.
2. The constant temperature oscillator for development and preparation of antibacterial peptides according to claim 1, wherein: the vertical mouth of placing of a plurality of and heat preservation chamber (10) confined, every have evenly been seted up to mounting panel (5) top surface place a mounting panel (5) bottom surface of portion all is equipped with heat preservation seat (9), set up the chamber of admitting air in heat preservation seat (9), the chamber of admitting air sets up with heat preservation chamber (10) intercommunication.
3. The constant temperature oscillator for development and preparation of antibacterial peptides according to claim 2, wherein: the heat preservation seat (9) is in a conical round pipe shape, the heat preservation seat (9) is communicated with the placement opening, an inserting ring pipe (13) is sleeved on the outer side of the top surface of the heat preservation seat (9), and the inserting ring pipe (13) is inserted into the heat preservation cavity (10) in a sealing mode.
4. The constant temperature oscillator for development and preparation of antibacterial peptides according to claim 3, wherein: an anti-sliding sleeve (12) is vertically inserted in the placing opening and the heat preservation seat (9).
5. The constant temperature oscillator for development and preparation of antibacterial peptides according to claim 1, wherein: the movable box is characterized in that movable wheels (14) are arranged at four corners of the bottom surface of the movable box (4) and at the front end and the rear end of the lower portion of the two side surfaces of the movable box, and the front end and the rear end of the two sides of the bottom surface in the oscillating box (2) are transversely matched with the movable wheels (14) to form a strip-shaped movable groove.
6. The constant temperature oscillator for development and preparation of antibacterial peptides according to claim 1, wherein: the bottom plate (6) bottom surface cooperation is placed a mouthful punching press and is had a plurality of curved constant head tanks, the pad is equipped with the one deck foam-rubber cushion in the constant head tank, just bottom plate (6) are the rubber material.
7. The constant temperature oscillator for development and preparation of antibacterial peptides according to claim 1, wherein: the box cover is characterized in that a sliding groove is formed in the inner top surface of the box cover (3), a sliding plate (15) is horizontally arranged in the sliding groove, a pressing plate (16) is horizontally arranged below the sliding plate (15), and spring telescopic rods are arranged between four corners of the bottom surface of the sliding plate (15) and the top surface of the pressing plate (16).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110860492.1A CN113522121A (en) | 2021-07-29 | 2021-07-29 | Constant temperature oscillator for research, development and preparation of antibacterial peptide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110860492.1A CN113522121A (en) | 2021-07-29 | 2021-07-29 | Constant temperature oscillator for research, development and preparation of antibacterial peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113522121A true CN113522121A (en) | 2021-10-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110860492.1A Pending CN113522121A (en) | 2021-07-29 | 2021-07-29 | Constant temperature oscillator for research, development and preparation of antibacterial peptide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113522121A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4907893A (en) * | 1988-10-31 | 1990-03-13 | Graciela Niemeck | Thermo-roto mixer apparatus |
| CN108554475A (en) * | 2018-04-17 | 2018-09-21 | 佛山市健群生物科技有限公司 | A kind of anticollision medical tubes rack |
| CN208544652U (en) * | 2018-07-06 | 2019-02-26 | 义乌市中心医院 | A kind of mannitol insulating box |
| CN208975676U (en) * | 2018-08-30 | 2019-06-14 | 福晨(天津)化学试剂有限公司 | A kind of chemical reagent closed constant temperature oscillator |
| CN211227152U (en) * | 2019-09-29 | 2020-08-11 | 南京启真基因工程有限公司 | Diabetes susceptibility gene screening kit |
| CN211996655U (en) * | 2020-02-06 | 2020-11-24 | 嘉兴弘正检测有限公司 | Sewage preservation sample reserving device for environmental protection detection |
| CN212268337U (en) * | 2020-03-19 | 2021-01-01 | 王健 | Sample storage device for river sewage detection |
| CN212663637U (en) * | 2020-07-10 | 2021-03-09 | 王婷婷 | Clinical laboratory uses combination formula sampling device |
| CN213800835U (en) * | 2020-11-02 | 2021-07-27 | 苏州科曼纺织科技有限公司 | Chemical reagent auxiliary agent is deposited with placing case |
-
2021
- 2021-07-29 CN CN202110860492.1A patent/CN113522121A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4907893A (en) * | 1988-10-31 | 1990-03-13 | Graciela Niemeck | Thermo-roto mixer apparatus |
| CN108554475A (en) * | 2018-04-17 | 2018-09-21 | 佛山市健群生物科技有限公司 | A kind of anticollision medical tubes rack |
| CN208544652U (en) * | 2018-07-06 | 2019-02-26 | 义乌市中心医院 | A kind of mannitol insulating box |
| CN208975676U (en) * | 2018-08-30 | 2019-06-14 | 福晨(天津)化学试剂有限公司 | A kind of chemical reagent closed constant temperature oscillator |
| CN211227152U (en) * | 2019-09-29 | 2020-08-11 | 南京启真基因工程有限公司 | Diabetes susceptibility gene screening kit |
| CN211996655U (en) * | 2020-02-06 | 2020-11-24 | 嘉兴弘正检测有限公司 | Sewage preservation sample reserving device for environmental protection detection |
| CN212268337U (en) * | 2020-03-19 | 2021-01-01 | 王健 | Sample storage device for river sewage detection |
| CN212663637U (en) * | 2020-07-10 | 2021-03-09 | 王婷婷 | Clinical laboratory uses combination formula sampling device |
| CN213800835U (en) * | 2020-11-02 | 2021-07-27 | 苏州科曼纺织科技有限公司 | Chemical reagent auxiliary agent is deposited with placing case |
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Application publication date: 20211022 |