CN113520570B - Adjustable freezing probe for bronchoscope interventional cryotherapy of bronchial nodule - Google Patents
Adjustable freezing probe for bronchoscope interventional cryotherapy of bronchial nodule Download PDFInfo
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- CN113520570B CN113520570B CN202110769653.6A CN202110769653A CN113520570B CN 113520570 B CN113520570 B CN 113520570B CN 202110769653 A CN202110769653 A CN 202110769653A CN 113520570 B CN113520570 B CN 113520570B
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- freezing
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- guide rod
- bronchial
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B18/0218—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques with open-end cryogenic probe, e.g. for spraying fluid directly on tissue or via a tissue-contacting porous tip
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
Abstract
The invention discloses an adjustable freezing probe for bronchoscope interventional cryotherapy of bronchial nodule, which comprises a connector, a hose and an adjustable freezing probe body, wherein the adjustable freezing probe body is arranged at the front end of the hose and is communicated with the front port of a cold inlet pipe, and the adjustable freezing probe body is respectively connected with a power plug and a controller through a power line and a control line. The medical personnel can move the adjustable freezing probe down to the focus of the patient under the guidance of the bronchoscope and then control the adjustable freezing probe to be unfolded, and the structure can be used for freezing a larger focus part at one time, so that a repeated freezing mode is avoided, the labor intensity of the medical personnel is reduced, the freezing efficiency of the freezing probe is improved, and great convenience is brought to the freezing treatment work of the patient suffering from bronchial tuberculosis.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an adjustable cryoprobe for the interventional cryotherapy of bronchial nodule through a bronchoscope.
Background
Bronchial nodule refers to tuberculosis that occurs in the trachea, bronchial mucosa, and submucosa. The most common infection route of adult bronchial tuberculosis is that mycobacterium tuberculosis in lung foci is directly implanted into bronchial mucosa, and secondly, the lung foci can also invade the bronchial mucosa through tissues around the bronchi; mycobacterium tuberculosis also affects the bronchial submucosa first by blood dissemination and lymphatic drainage, and then involves the mucosal layer. Tuberculosis bronchitis is mostly caused by the invasion of bronchi by the adjacent mediastinal lymphoid tuberculosis in children.
Medical staff can correspondingly treat the patient with the bronchial tuberculosis by adopting a freezing treatment method. The principle of cryotherapy is the destruction of biological substances by frozen cytotoxic effects. Freezing can cause water in cells to crystallize into ice, the cells stop dividing and melting, blood flow stops, and microthrombosis are formed. Ischemic injury leads to cell necrosis in a few days after cryotherapy. When the specific operation is carried out, the medical staff can insert the bronchoscope from the oral cavity or the nasal cavity of the patient with bronchial tuberculosis, and therefore the bronchus can be comprehensively checked. If the lesion is identified after examination, the corresponding tissue can be harvested using a sterilized cryoprobe accessed through the bronchoscope working channel. During operation, the freezing probe can directly act on the inner part of a focus part, so that the freezing effect is achieved. At present, most of the freezing probes applied to the freezing treatment are point-cooling probes, namely, the area of each freezing is small, and if the focus part of a patient is found to be more and overlarge, a plurality of times of freezing modes are required to completely freeze the focus part. By adopting the freezing mode, the labor intensity of medical personnel is improved, the freezing efficiency of the freezing probe is poor, the interventional therapy time under a bronchoscope of a patient is prolonged, the tolerance degree of the patient to therapy is reduced, and great inconvenience is brought to the cryotherapy work of the patient.
Disclosure of Invention
The adjustable freezing probe for the bronchoscope interventional cryotherapy of the bronchotuberculosis is reasonable in design, simple in structure and convenient to operate, and medical workers can move the adjustable freezing probe downwards to the focus of a patient under the guidance of a bronchoscope and then control the adjustable freezing probe to be unfolded.
In order to solve the technical problems, the invention adopts the following technical scheme to realize:
an adjustable cryoprobe for the interventional cryotherapy of bronchogenic nodule through a bronchoscope is characterized in that the cryoprobe comprises
The rear end of the connector is provided with a regulating valve connected with an output port of the carbon dioxide refrigerating device, the front end of the connector is provided with a pipe inserting port, and two sides of the connector are respectively provided with a power supply wire hole and a control wire hole;
the flexible pipe is internally provided with a cold inlet pipe, a power line and a control line along the axial direction, the rear end of the flexible pipe is connected with the pipe inserting port, the rear port of the cold inlet pipe penetrates through the connector to be communicated with the regulating valve, the rear end of the power line penetrates out of a power line hole of the connector and is connected with a power plug, and the rear end of the control line penetrates out of a control line hole of the connector and is connected with the controller;
the adjustable freezing probe body is arranged at the front end of the hose and communicated with a front port of the cold inlet pipe, and the adjustable freezing probe body is connected with a power plug and a controller through a power line and a control line respectively.
In a preferred embodiment of the present invention, the adjustable cryoprobe body includes a guide rod, a fixing seat and a sliding seat capable of sliding along an axial direction of the guide rod, a rear end of the guide rod is disposed at a front end of the hose, the fixing seat is fixedly mounted at a rear end of the guide rod, a plurality of first freezing tube bodies are hinged to a front end surface of the fixing seat at intervals along a circumferential direction thereof, the sliding seat is slidably disposed at a front end of the guide rod, second freezing tube bodies corresponding to the plurality of first freezing tube bodies one to one are hinged to a rear end surface of the sliding seat at intervals along a circumferential direction thereof, a rear end of the second freezing tube body is hinged to a front end of the first freezing tube bodies, an electric cylinder for driving the sliding seat to slide along an axial direction of the guide rod is disposed at a front end of the guide rod, and the electric cylinder is respectively connected to a power line and a control line.
In a preferred embodiment of the present invention, a freezing cavity communicated with the front end of the cold inlet pipe is arranged inside the fixing seat, the rear end of the first freezing pipe body is communicated with the freezing cavity, and the front end of the first freezing pipe body is communicated with the rear end of the second freezing pipe body.
In a preferred embodiment of the invention, the guide rod has an outer diameter smaller than the outer diameter of the hose.
In a preferred embodiment of the present invention, the plurality of first and second freezing pipe bodies are attached to the outer circumferential surface of the guide bar before being spread, and the outer diameter of the whole assembly is the same as the outer diameter of the hose.
In a preferred embodiment of the present invention, the first freezing pipe body and the second freezing pipe body are supported at an angle of 0 to 45 °.
Compared with the prior art, the medical personnel can move the adjustable freezing probe down to the focus of the patient under the guidance of the bronchoscope and then control the adjustable freezing probe to be unfolded, and the structure can be used for freezing a larger focus part at one time, so that a repeated freezing mode is avoided, the labor intensity of the medical personnel is reduced, the freezing efficiency of the freezing probe is improved, and great convenience is brought to the freezing treatment work of the patient suffering from bronchial tuberculosis.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic diagram of the reset structure of the adjustable cryoprobe of the present invention.
Fig. 3 is a schematic structural view of the adjustable cryoprobe of the present invention after expansion.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further explained below by combining the specific drawings.
Referring to fig. 1-3, an adjustable cryoprobe for bronchoscopically accessing cryotherapy of bronchial nodules is shown, comprising a connector 100, a flexible tube 200, and an adjustable cryoprobe body 300.
The rear end of the connector 100 is provided with a regulating valve 400 connected with the output port of the carbon dioxide refrigerating device, the front end of the connector 100 is provided with a socket, and the two sides of the connector 100 are respectively provided with a power supply wire hole 120 and a control wire hole 110.
A cold inlet pipe, a power line 220 and a control line 210 are distributed in the hose 200 along the axial direction, the rear end of the hose 200 is connected with the cannula port, the rear port of the cold inlet pipe penetrates through the connector 100 to be communicated with the regulating valve 400, the rear end of the power line 220 penetrates out of the power line hole 120 of the connector 100 and is connected with a power plug 600, and the rear end of the control line 210 penetrates out of the control line hole 110 of the connector 100 and is connected with the controller 500.
The outer diameter of the adjustable freezing probe body 300 can be adjusted according to the inner diameter of the bronchus of the patient with bronchial tuberculosis, the adjustable freezing probe body 300 is arranged at the front end of the hose 200 and communicated with the front port of the cold inlet pipe, and the adjustable freezing probe body 300 is connected with the power plug 600 and the controller 500 through the power line 220 and the control line 210 respectively.
An opening control button 510 which can control the frozen tube body to be gradually opened under the action of continuous pressing of fingers of medical staff is arranged on one side of the controller 500, a closing control button 520 which can control the frozen tube body to be gradually closed under the action of handheld continuous pressing of the medical staff is arranged on the other side of the controller 500, and a reset button 530 which can control the quick resetting of the opened frozen tube body is arranged on the controller 500 and between the opening control button 510 and the closing control button 520.
The adjustable freezing probe body 300 comprises a guide rod 310, a fixed seat 320 and a sliding seat 330 capable of sliding along the axial direction of the guide rod 310, the rear end of the guide rod 310 is arranged at the front end of the hose 200, the fixed seat 320 is fixedly arranged at the rear end of the guide rod 310, a plurality of first freezing pipe bodies 321 are hinged on the front end surface of the fixed seat 320 at intervals along the circumferential direction, the sliding seat 330 is arranged at the front end of the guide rod 310 in a sliding manner, second freezing pipe bodies 331 which are in one-to-one correspondence with the plurality of first freezing pipe bodies 321 are hinged on the rear end surface of the sliding seat 330 at intervals along the circumferential direction, the rear end of the second freezing pipe bodies 331 is hinged on the front end of the first freezing pipe bodies 321, an electric cylinder 340 for driving the sliding seat 330 to slide along the axial direction of the guide rod 310 is arranged at the front end of the guide rod 310, and the electric cylinder 340 is respectively connected with a power line 220 and a control line 210.
The freezing cavity communicated with the front port of the cold inlet pipe is arranged in the fixing seat 320, the rear end of the first freezing pipe body 321 is communicated with the freezing cavity, the front end of the first freezing pipe body 321 is communicated with the rear end of the second freezing pipe body 331, and by adopting the structure, the carbon dioxide freezing medium can conveniently flow into the first freezing pipe body 321 and the second freezing pipe body 331 to perform freezing treatment on the focus of the bronchial tuberculosis patient.
The outer diameter of the guide rod 310 is smaller than that of the hose 200, the first freezing tube body 321 and the second freezing tube body 331 are attached to the outer peripheral surface of the guide rod 310 before being spread, and the outer diameter of the whole assembly is the same as that of the hose 200.
The supporting angle of the first freezing pipe body 321 and the second freezing pipe body 331 is 0-45 degrees, medical staff can properly adjust the bronchus inner diameter of a patient suffering from bronchial tuberculosis according to the structure, disposable freezing of a large focus position is guaranteed, and inconvenience brought to the medical staff and the patient due to multiple freezing modes is avoided.
The method comprises the following specific operation steps:
when a medical worker carries out cryotherapy on a patient with bronchial tuberculosis, the regulating valve 400 is connected with an output port of a carbon dioxide refrigerating device, the power plug 600 is inserted into the power supply device, the adjustable freezing probe body 300 is guided by a bronchoscope to move downwards to a focus of the patient, then the medical worker continuously presses the opening control button 510 with fingers, the sliding seat 330 slides slowly towards the rear end of the guide rod 310 along the axial direction of the guide rod under the action of the electric cylinder 340, so that the first freezing tube body 321 and the second freezing tube body 331 are gradually opened, the medical worker observes the opening control button through the bronchoscope, when the second freezing tube body 331 is opened to be just in contact with a bronchus of the focus of the patient, the fingers of the medical worker leave the opening control button 510 to stop the first freezing tube body 321 and the second freezing tube body 331 being opened, and then the carbon dioxide refrigerating device is started, the knob 420 on the adjusting valve 400 is rotated to make the freezing medium carbon dioxide enter the cold inlet pipe through the input port 410 on the adjusting valve 400, then enter the freezing cavity through the cold inlet pipe, and then enter the interiors of the first freezing pipe body 321 and the second freezing pipe body 331 through the freezing cavity, so that the second freezing pipe body 331 performs the freezing treatment on the focus of the patient in a low-temperature state.
After the cryotherapy of focus department to the patient is accomplished, medical personnel only need press gently and restore button 530, and the first freezing body 321 that is strutted and second freezing body 331 will be hugged closely on the outer peripheral face of guide arm 310 by quick recovering, adopt this kind of mode to further improve this adjustable cryoprobe's practicality.
In addition, if the medical staff finds that the outer diameter of the whole second freezing tube body 331 which is formed by the plurality of second freezing tube bodies 331 which are opened is larger than the inner diameter of the bronchus of the focus of the patient, the medical staff continuously presses the closing control button 520 with the fingers, the sliding base 330 slides to the front end of the guide rod 310 slowly along the axial direction of the guide rod under the action of the electric cylinder 340, so that the first freezing tube body 321 and the second freezing tube body 331 are gradually closed, the medical staff observes the first freezing tube body through the bronchoscope, and when the second freezing tube body 331 is closed to be just in contact with the bronchus of the focus of the patient, the fingers of the medical staff leave the closing control button 520, so that the first freezing tube body 321 and the second freezing tube body 331 are stopped to be closed.
In conclusion, the medical staff can perform one-time freezing on a larger focus part by adopting the structure, so that a multi-time freezing mode is avoided, the labor intensity of the medical staff is reduced, the freezing efficiency of the freezing probe is improved, and great convenience is brought to the freezing treatment work of the patient suffering from the bronchial tuberculosis.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (5)
1. An adjustable cryoprobe for bronchoscope interventional cryotherapy of bronchial nodule is characterized by comprising
The rear end of the connector is provided with a regulating valve connected with an output port of a carbon dioxide refrigerating device, the front end of the connector is provided with a pipe inserting port, and two sides of the connector are respectively provided with a power supply wire hole and a control wire hole;
the flexible pipe is internally provided with a cold inlet pipe, a power line and a control line along the axial direction, the rear end of the flexible pipe is connected with the pipe inserting port, the rear port of the cold inlet pipe penetrates through the connector to be communicated with the regulating valve, the rear end of the power line penetrates out of a power line hole of the connector and is connected with a power plug, and the rear end of the control line penetrates out of a control line hole of the connector and is connected with the controller;
the adjustable freezing probe body is arranged at the front end of the hose and communicated with the front port of the cold inlet pipe, and the adjustable freezing probe body is respectively connected with a power plug and a controller through a power line and a control line;
the adjustable freezing probe body comprises a guide rod, a fixing seat and a sliding seat capable of sliding along the axis direction of the guide rod, wherein the rear end of the guide rod is arranged at the front end of a hose, the fixing seat is fixedly arranged at the rear end of the guide rod, a plurality of first freezing pipe bodies are hinged to the front end face of the fixing seat along the circumferential direction at intervals, the sliding seat is arranged at the front end of the guide rod in a sliding mode, the rear end face of the sliding seat is hinged to second freezing pipe bodies corresponding to the first freezing pipe bodies one to one along the circumferential direction at intervals, the rear end of the second freezing pipe body is hinged to the front end of the first freezing pipe body, an electric cylinder used for driving the sliding seat to slide along the axial direction of the guide rod is arranged at the front end of the guide rod, and the electric cylinder is connected with a power line and a control line respectively.
2. The adjustable cryoprobe for bronchoscopically interventional cryotherapy of bronchial nodules of claim 1, wherein: the inside of the fixing seat is provided with a freezing cavity communicated with the front end opening of the cold inlet pipe, the rear end of the first freezing pipe body is communicated with the freezing cavity, and the front end of the first freezing pipe body is communicated with the rear end of the second freezing pipe body.
3. The adjustable cryoprobe for bronchoscopically interventional cryotherapy of bronchial nodules of claim 1, wherein: the outer diameter of the guide rod is smaller than that of the hose.
4. The adjustable cryoprobe for bronchoscopically interventional cryotherapy of bronchial nodules of claim 1, wherein: the first freezing pipe bodies and the second freezing pipe bodies are tightly attached to the outer peripheral surface of the guide rod before being unfolded, and the outer diameter of the whole assembly is the same as that of the hose.
5. The adjustable cryoprobe for bronchoscopically interventional cryotherapy of bronchial nodules of claim 1, wherein: the supporting angle of the first freezing pipe body and the second freezing pipe body is 0-45 degrees.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110769653.6A CN113520570B (en) | 2021-07-07 | 2021-07-07 | Adjustable freezing probe for bronchoscope interventional cryotherapy of bronchial nodule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110769653.6A CN113520570B (en) | 2021-07-07 | 2021-07-07 | Adjustable freezing probe for bronchoscope interventional cryotherapy of bronchial nodule |
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| Publication Number | Publication Date |
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| CN113520570A CN113520570A (en) | 2021-10-22 |
| CN113520570B true CN113520570B (en) | 2022-09-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110769653.6A Active CN113520570B (en) | 2021-07-07 | 2021-07-07 | Adjustable freezing probe for bronchoscope interventional cryotherapy of bronchial nodule |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114027964A (en) * | 2021-11-05 | 2022-02-11 | 首都医科大学附属北京天坛医院 | Flexible cryogenic spray tube for spray cryotherapy in airways and method of use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109480998A (en) * | 2018-11-09 | 2019-03-19 | 宁波胜杰康生物科技有限公司 | A kind of expansible cryoablation conduit |
| WO2019052342A1 (en) * | 2017-09-12 | 2019-03-21 | 康沣生物科技(上海)有限公司 | Cryoablation catheter and system |
| CN209770532U (en) * | 2019-03-01 | 2019-12-13 | 四川捷祥医疗器械有限公司 | Cryoprobe and cryosurgical device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3289992A1 (en) * | 2007-11-21 | 2018-03-07 | Adagio Medical, Inc. | Flexible multi-tubular cryoprobe |
| US20120109118A1 (en) * | 2010-10-29 | 2012-05-03 | Medtronic Ablation Frontiers Llc | Cryogenic-radiofrequency ablation system |
| US10441338B2 (en) * | 2014-01-14 | 2019-10-15 | Medtronic Cryocath Lp | Balloon catheter with fluid injection elements |
| CN210810927U (en) * | 2019-08-22 | 2020-06-23 | 胥晓倩 | Disposable expandable fiberoptic bronchoscope sleeve |
-
2021
- 2021-07-07 CN CN202110769653.6A patent/CN113520570B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019052342A1 (en) * | 2017-09-12 | 2019-03-21 | 康沣生物科技(上海)有限公司 | Cryoablation catheter and system |
| CN109480998A (en) * | 2018-11-09 | 2019-03-19 | 宁波胜杰康生物科技有限公司 | A kind of expansible cryoablation conduit |
| CN209770532U (en) * | 2019-03-01 | 2019-12-13 | 四川捷祥医疗器械有限公司 | Cryoprobe and cryosurgical device |
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