CN113512774A

CN113512774A - Near-field direct-writing micro-nano 3D electrostatic spinning device

Info

Publication number: CN113512774A
Application number: CN202110865515.8A
Authority: CN
Inventors: 刘祎; 牛群; 吴炎凡; 张京钟; 葛阳; 闫飞; 曹炜
Original assignee: Suzhou Institute of Biomedical Engineering and Technology of CAS
Current assignee: Suzhou Institute of Biomedical Engineering and Technology of CAS
Priority date: 2021-07-29
Filing date: 2021-07-29
Publication date: 2021-10-19

Abstract

The invention discloses a near-field direct-writing micro-nano 3D electrostatic spinning device, which comprises: the device comprises a shell, a support, a Z-axis moving mechanism arranged on the support, a printing needle arranged on the Z-axis moving mechanism, a precision sample feeding mechanism connected with the printing needle through a pipeline, a temperature and humidity regulating mechanism, an XY-axis moving mechanism and a receiver platform arranged on the XY-axis moving mechanism. The near-field direct-writing micro-nano 3D electrostatic spinning device has a temperature and humidity precise control function, the temperature and the humidity of a spinning working environment can be controlled, and the influence of the spinning temperature and humidity environment on the deposition condition of spinning jet flow and the microstructure of fibers is reduced; the precise sample injection mechanism can ensure the stable supply of the spinning solution and improve the stability of spinning; the injector clamp can be adapted to injectors with different capacities, and the requirements of different spinning scenes are met.

Description

Near-field direct-writing micro-nano 3D electrostatic spinning device

Technical Field

The invention relates to the field of electrostatic spinning equipment, in particular to a near-field direct-writing micro-nano 3D electrostatic spinning device.

Background

Most electrostatic spinning instruments on the market mainly comprise a machine shell, a feeding device, a high-voltage generator, a spinning collector (a roller, a flat plate and the like), a spinning needle head and the like, the working distance between the spinning needle head and the collector is large, spinning polymers are disturbed in the spinning process, jet flow is unstable, and disordered nano fibers are formed. Such disordered nanofiber structures limit their applications in some situations, such as tissue engineering applications, where cells react and behave differently to microscopic patterns and their mechanical properties.

In recent years, researchers develop a near-field spinning technology, namely, the working distance from a spinning needle to a receiving plate is shortened, the control of electrostatic force on nano fibers is enhanced, the trend of the nano fibers is precisely controlled through the relative displacement motion of the spinning needle and the receiving plate, and the trend and the microstructure of the spinning nano fibers can be precisely controlled through path planning, namely, the setting of parameters such as working voltage, working distance, motion speed and the like. However, in the actual spinning operation process, the deposition condition of the spinning liquid jet and the microstructure of the fiber are influenced by the temperature and the humidity of the working environment and the feeding condition, the existing near-field spinning equipment lacks a temperature and humidity precise control system, and a reasonable solution cannot be provided for environmental factors, so that the product quality is influenced.

Therefore, a more reliable solution is now needed.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a near-field direct-writing micro-nano 3D electrostatic spinning device aiming at the defects in the prior art.

In order to solve the technical problems, the invention adopts the technical scheme that: a near-field direct-writing micro-nano 3D electrostatic spinning device comprises: the device comprises a shell, a bracket, a Z-axis moving mechanism arranged on the bracket, a printing needle arranged on the Z-axis moving mechanism, a precision sample feeding mechanism connected with the printing needle through a pipeline, a temperature and humidity regulating mechanism, an XY-axis moving mechanism and a receiver platform arranged on the XY-axis moving mechanism;

the inside of the shell is divided into a printing working space and an equipment space by a vertically arranged mounting partition plate, the Z-axis moving mechanism, the printing needle head, the precision sampling mechanism, the XY-axis moving mechanism and the receiver platform are all arranged in the printing working space, and the temperature and humidity regulating mechanism is arranged in the equipment space;

the temperature and humidity regulating mechanism is used for regulating the temperature and humidity in the printing working space, the XY-axis moving mechanism is used for driving the receiver platform to move in the X direction and the Y direction, and the Z-axis moving mechanism drives the printing needle head to move in the Z direction; the precise sample injection mechanism is used for conveying the spinning solution into the printing needle head and then outputting the spinning solution to a receiver on the receiver platform.

Preferably, the temperature and humidity control mechanism comprises a temperature control component and a humidity control component;

the installation partition plate is provided with an upper flow plate, an air guide pipeline arranged below the laminar flow plate, a heating chamber communicated with the lower end of the air guide pipeline, a refrigerating chamber communicated with the lower end of the heating chamber, heat conduction pipelines arranged on two sides of the refrigerating chamber and a lower flow plate arranged below the refrigerating chamber;

and the upper flow plate and the lower flow plate are both provided with a plurality of micropores communicated with the printing working space and the equipment space.

Preferably, the temperature control assembly comprises a first induced draft fan arranged at the upper end of the air guide pipeline, a heating heat conducting plate arranged in the heating chamber, a heater arranged on the heating heat conducting plate, a semiconductor refrigerator arranged on the inner wall of the refrigerating chamber, a refrigerating heat conducting plate arranged on the semiconductor refrigerator, a radiating fan arranged at the inner end of the heat conducting pipeline and positioned at the side part of the outer wall of the refrigerating chamber, and a second induced draft fan arranged at the lower end of the refrigerating chamber;

the outer end of the heat conducting pipe is communicated with the environment outside the shell.

Preferably, the humidity control assembly comprises a humidifier arranged on the installation partition plate, a humidification pipeline communicated with the humidifier and the air guide pipeline, a condensed water collecting tank arranged below the refrigeration heat-conducting plate, and a condensed water drain pipe communicated with the condensed water collecting tank.

Preferably, the precision sampling device is in including setting up installation shell on the support, setting are in apron on the installation shell, set up along the X direction spout on the apron, can follow the advance a kind push rod, the setting that the X direction removed in the spout is in be used for the drive in the installation shell advance a kind actuating mechanism and the setting of advancing a kind push rod motion and be in syringe anchor clamps on the apron.

Preferably, a fixing groove group for fixing the injector is formed in the injector clamp along the X direction, and the fixing groove group comprises a plurality of fixing grooves which are sequentially formed from top to bottom and have sequentially reduced cross-sectional sizes.

Preferably, a clamping groove which is communicated with the fixing groove and used for clamping an outer injection barrel pushing handle of the injector is formed in the injector clamp along the Y direction.

Preferably, a plurality of spring plungers are provided on an inner wall of the fixing groove.

Preferably, advance kind actuating mechanism including set up motor in the installation shell, with lead screw, the slide rail that sets up along the X direction, slidable setting that motor drive connects are in slider on the slide rail and connection just with lead screw thread fit's screw-nut, advance kind the push rod and connect on the screw-nut.

Preferably, the near-field direct-writing micro-nano 3D electrostatic spinning device further comprises a high-voltage power supply arranged on the support, and a temperature sensor and a humidity sensor arranged in the printing working space.

The invention has the beneficial effects that:

1. the near-field direct-writing micro-nano 3D electrostatic spinning device has a temperature and humidity precise control function, the temperature and the humidity of a spinning working environment can be controlled, and the influence of the spinning temperature and humidity environment on the deposition condition of spinning jet flow and the microstructure of fibers is reduced;

2) the precise sample injection mechanism can ensure the stable supply of the spinning solution and improve the stability of spinning; the injector clamp can be adapted to injectors with different capacities, so that the requirements of different spinning scenes are met; the injector clamp is provided with the heater, so that the temperature control of the spinning solution in the injector can be realized, and the device has the functions of solution near-field spinning and melt spinning;

3) according to the invention, the receiver platform and the printing needle head can move relatively in three dimensions, and can be adjusted to a smaller working distance, so that the control force on spinning jet flow is increased, the jet flow walking direction can be precisely controlled, a specific nanofiber pattern is prepared, and the effect of 3D printing is achieved.

Drawings

FIG. 1 is a schematic diagram of an internal structure of a near-field direct-writing micro-nano 3D electrostatic spinning device;

FIG. 2 is a schematic structural diagram of the near-field direct-writing micro-nano 3D electrostatic spinning device after a shell is removed;

FIG. 3 is a schematic structural diagram of a part of components of the temperature and humidity control mechanism according to the present invention;

fig. 4 is a schematic structural diagram of another view angle of the near-field direct-writing micro-nano 3D electrostatic spinning device with the outer shell removed;

FIG. 5 is a schematic structural diagram of a precise sampling mechanism according to the present invention;

FIG. 6 is a schematic view of the syringe clamp of the present invention engaged with a syringe;

FIG. 7 is a schematic diagram of the syringe clamp of the present invention;

fig. 8 is a schematic structural diagram of the sample injection driving mechanism of the present invention.

Description of reference numerals:

1-a housing; 10, installing a partition plate; 11 — print workspace; 12 — equipment space; 13-cabinet door; 100-upper laminar flow plate; 101-an air guide pipeline; 102-a heating chamber; 103-a refrigeration chamber; 104-heat conducting pipeline; 105-a lower laminar flow plate; 106-micropores;

2, a bracket;

3-Z axis movement mechanism;

4-printing the needle head;

5, a precision sample feeding mechanism; 50-mounting a shell; 51-a cover plate; 52-a chute; 53-sample injection push rod; 54-sample feeding driving mechanism; 55-syringe clamp; 56-fixed groove group; 57-card slot; 58-spring plunger; 59-syringe; 540-motor; 541-a screw rod; 542-a slide rail; 543-a slide block; 544-feed screw nut; 560-fixed slots; 590-outer injection barrel; 591-outer injection barrel push handle; 592-a piston;

6, a temperature and humidity regulating mechanism; 60-temperature regulating and controlling components; 61-humidity regulation and control component; 600 — a first extraction fan; 601-heating the heat conducting plate; 602-a heater; 603, a refrigeration heat-conducting plate; 604-a radiator fan; 605 — a second induced draft fan; 610, a humidifier; 611, a humidifying pipeline; 612-a condensate collection tank; 613-a condensate drain pipe;

7-XY axis moving mechanism;

8-a receiver platform;

9-power supply.

Detailed Description

The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.

It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.

Example 1

As shown in fig. 1 to 4, the near-field direct-writing micro-nano 3D electrostatic spinning device of the embodiment includes: the device comprises a shell 1, a support 2, a Z-axis moving mechanism 3 arranged on the support 2, a printing needle 4 arranged on the Z-axis moving mechanism 3, a precision sample feeding mechanism 5 connected with the printing needle 4 through a pipeline, a temperature and humidity regulation mechanism 6, an XY-axis moving mechanism 7, a receiver platform 8 arranged on the XY-axis moving mechanism 7, a power supply 9 arranged on the support 2, and a temperature sensor and a humidity sensor (not shown in the figure) arranged in a printing working space 11;

the inside of the shell 1 is separated by a vertically arranged mounting partition plate 2 to form a printing working space 11 and an equipment space 12, the Z-axis moving mechanism 3, the printing needle head 4, the precision sampling mechanism 5, the XY-axis moving mechanism 7 and the receiver platform 8 are all arranged in the printing working space 11, and the temperature and humidity regulating mechanism 6 is arranged in the equipment space 12;

the temperature and humidity regulating mechanism 6 is used for regulating the temperature and humidity in the printing working space 11, the XY-axis moving mechanism 7 is used for driving the receiver platform 8 to move in the X and Y directions, and the Z-axis moving mechanism 3 is used for driving the printing needle head 4 to move in the Z direction; the precise sample injection mechanism 5 is used for conveying the spinning solution into the printing needle 4 and then outputting the spinning solution to a receiver on a receiver platform 8.

According to the invention, the temperature and the humidity in the printing working space 11 are kept in the set proper ranges through the regulation and control of the temperature and humidity regulation and control mechanism 6, so that the adverse effects of the temperature and the humidity of the unsuitable working environment on the condition of spinning liquid jet flow deposition and the fiber microstructure in the spinning operation process can be prevented. In this embodiment, the temperature and humidity control mechanism 6 includes a temperature control component 60 and a humidity control component 61;

the installation clapboard 2 is provided with an upper laminar flow plate 100, an air guide pipeline 101 arranged below the laminar flow plate, a heating chamber 102 communicated with the lower end of the air guide pipeline 101, a cooling chamber 103 communicated with the lower end of the heating chamber 102, heat conduction pipelines 104 arranged at two sides of the cooling chamber 103 and a lower flow plate 105 arranged below the cooling chamber 103;

the upper flow plate 100 and the lower flow plate 105 are both densely provided with a plurality of micropores 106 for communicating the printing work space 11 and the equipment space 12.

In the preferred embodiment, the power supply 9 is a high voltage power supply.

The temperature control assembly 60 comprises a first induced draft fan 600 arranged at the upper end of the air guide pipeline 101, a heating heat conducting plate 601 arranged in the heating chamber 102, a heater 602 arranged on the heating heat conducting plate 601, a semiconductor refrigerator (not shown in the figure) arranged on the inner wall of the cooling chamber 103, a cooling heat conducting plate 603 arranged on the semiconductor refrigerator, a radiating fan 604 arranged at the inner end of the heat conducting pipeline 104 and positioned at the side part of the outer wall in the cooling chamber 103, and a second induced draft fan 605 arranged at the lower end in the cooling chamber 103; the outer end of the heat conducting pipe 104 communicates with the environment outside the housing 1 (by making a hole in the housing 1 at a corresponding location). The second induced draft fan 605 is used for dissipating the heat of the hot end of the semiconductor refrigerator to the outside of the casing 1 through the heat conducting pipe 104, and the cold end of the semiconductor refrigerator is connected with the refrigeration heat conducting plate 603, so as to absorb the heat from the refrigeration chamber 103.

The heating heat-conducting plate 601 and the refrigeration heat-conducting plate 603 can improve the heat exchange efficiency, and the refrigeration heat-conducting plate 603 also has the function of realizing dehumidification through condensation.

The humidity control assembly 61 includes a humidifier 610 disposed on the mounting partition 2, a humidification pipe 611 for communicating the humidifier 610 with the air guide pipe 101, a condensed water collecting tank 612 disposed below the refrigeration heat conducting plate 603, and a condensed water drain pipe 613 communicated with the condensed water collecting tank 612.

The working conditions of the components in the temperature and humidity control mechanism 6 can be controlled by a control chip built in the shell 1 or conventional control devices such as an upper computer arranged outside. In one embodiment, a control chip (which may be a conventional product) is disposed in the housing 1, and the control chip is connected to both the temperature control component 60 and the humidity control component 61.

In one embodiment, the side of the heating and cooling chambers 103 contacting the inner wall of the housing 1 is open, which facilitates the installation and maintenance of the internal components of the heating and cooling chambers 103; after the temperature and humidity control mechanism 6 is disposed in the casing 1, the opened side of the heating chamber and the cooling chamber 103 is sealed by the back plate of the casing 1.

In one embodiment, the housing 1 has a plurality of air holes communicating with the side of the lower flow plate 105.

In one embodiment, a cabinet door 13 is provided on the housing 1.

In one embodiment, the heater 602 employed is a PTC heater 602.

In one embodiment, the temperature regulation process is:

and (3) heating process: when the temperature sensor detects that the temperature in the printing working space 11 is lower than the set range, the control chip controls the heater 602 to start heating, the heat generated by the heater 602 is transmitted into the air guide pipeline 101 through the heating heat conduction plate 601, the first exhaust fan 600 works to dispersedly blow the hot air in the air guide pipeline 101 into the printing working space 11 through the upper flow plate 100 until the temperature in the printing working space 11 reaches the set range;

and (3) cooling: when the temperature sensor detects that the temperature in the printing working space 11 is higher than the set range, the heater 602 is controlled to stop heating, the semiconductor refrigerator starts refrigeration, the second air draft fan 605 starts operation, hot air in the printing working space 11 is pumped out through the lower flow plate 105 and enters the refrigeration chamber 103 to be cooled, and cooled cold air returns to the printing working space 11 through the heating chamber, the air guide pipeline 101 and the upper flow plate 100 in sequence under the action of the first air draft fan 600, so that the internal temperature of the printing working space 11 is reduced to the set range, and temperature regulation and control are realized.

The humidity regulation and control process comprises the following steps:

and (3) humidifying: when the humidity sensor detects that the humidity in the printing working space 11 is lower than the set range, the control chip controls the humidifier 610 to start, and under the action of the first induced draft fan 600, the humid air is dispersedly blown into the printing working space 11 through the humidifying pipeline 611 via the upper flow plate 100, so that the humidity in the printing working space 11 is increased to the set range;

and (3) a dehumidification process: when the humidity sensor detects that the humidity in the printing working space 11 is higher than a set range, the control chip controls the humidifier 610 to stop working, the semiconductor refrigerator is started, the second air draft fan 605 is started to work, humid air in the printing working space 11 is pumped out through the lower flow plate 105 and enters the refrigerating chamber 103, the humid air is condensed on the refrigerating heat conduction plate 603 of the refrigerating chamber 103, condensed water drops into the condensed water collecting tank 612 below under the action of weight and is finally discharged through the condensed water drain pipe 613, the dehumidified air is returned into the printing working space 11 through the heating chamber, the air guide pipeline 101 and the upper flow plate 100 under the action of the first air draft fan 600, the humidity in the printing working space 11 is reduced to the set range, and therefore humidity regulation and control are achieved.

Wherein, the dehumidification process and the temperature rise process need to be carried out in a staggered way.

Example 2

As a further improvement on embodiment 1, referring to fig. 5 to 8, in this embodiment, the precision sample injection device includes a mounting shell 50 disposed on the support 2, a cover plate 51 disposed on the mounting shell 50, a slide slot 52 disposed on the cover plate 51 along the X direction, a sample injection push rod 53 movable in the slide slot 52 along the X direction, a sample injection driving mechanism 54 disposed in the mounting shell 50 for driving the sample injection push rod 53 to move, and an injector 59 clamp 55 disposed on the cover plate 51.

Wherein, the injector 59 fixture 55 is provided with a fixing groove 560 group 56 along the X direction for fixing the injector 59, and the fixing groove 560 group 56 comprises a plurality of fixing grooves 560 which are sequentially arranged from top to bottom and have sequentially reduced section sizes. In this embodiment, 2 fixing grooves 560 are included to be able to accommodate syringes 59 of different capacities.

The clamp 55 of the syringe 59 is provided with a clamping groove 57 along the Y direction, which is communicated with the fixing groove 560 and is used for clamping an outer injection barrel pushing handle 591 of the syringe 59.

In a preferred embodiment, spring plungers 58 are provided on the inner wall of the fixing groove 560. The syringe 59 can be stably seated in the seating groove 560 by pressing action of the spring plungers 58.

When in use, the injector 59 is clamped in the fixing groove 560, the outer injection barrel pushing handle 591 of the injector 59 is clamped in the clamping groove 57, so that the position of the outer injection barrel 590 of the injector 59 in the X direction is limited, the circumferential position of the outer injection barrel 590 is limited by the pressing action of the spring plungers 58, and the outer injection barrel 590 can be stably arranged in the fixing groove 560; the sample injection driving mechanism 54 drives the sample injection push rod 53 to move forward along the X direction, so as to push the piston 592 of the injector 59, convey the spinning solution in the injector 59 into the printing needle 4 through the pipeline, and output the spinning solution to the receiver on the receiver platform 8 in a jet flow shape through the printing needle 4, so as to perform 3D printing. In the printing process, the XY-axis moving mechanism 7 is used for driving the receiver platform 8 to move in the X direction and the Y direction according to a set path, and the Z-axis moving mechanism 3 drives the printing needle head 4 to move in the Z direction according to the set path, so that a specific product is printed.

In one embodiment, the injector 59 holder 55 is made of heat conductive metal, and the injector 59 holder 55 is further provided with a heater 602, so that the temperature control of the spinning solution in the injector 59 can be realized, and the device of the present invention has the function of melt spinning.

In one embodiment, the sample injection driving mechanism 54 includes a motor 540 disposed in the mounting housing 50, a lead screw 541 drivingly connected to the motor 540, a slide rail 542 disposed along the X direction, a slide block 543 slidably disposed on the slide rail 542, and a lead screw nut 544 connected to the slide block 543 and threadedly engaged with the lead screw 541, and the sample injection push rod 53 is connected to the lead screw nut 544. The motor 540 drives the lead screw 541 to rotate, so that the lead screw nut 544 moves linearly, and the sample injection push rod 53 moves linearly in the X direction.

It should be understood that, the Z-axis moving mechanism 3 and the XY-axis moving mechanism 7 may employ a conventional linear displacement driving mechanism, such as a lead screw 541 motor 540 driving mechanism (e.g., the sample feeding driving mechanism 54), a belt pulley driving mechanism, etc. The method only needs to realize the corresponding linear displacement function, can be selected from conventional products, is not particularly limited in the invention, and is not repeated for specific structures.

In one embodiment, Polycaprolactone (PCL) is used as a spinning solution, and the printing process of the near-field direct-writing micro-nano 3D electrostatic spinning device is as follows:

firstly, injecting an acetic acid solution of polycaprolactone into an injector 59, then, installing the injector 59 on a clamp 55 of the injector 59, connecting the injector 59 and a printing needle 4 through a pipeline, placing a printing receiving disc (such as a conductive monocrystalline silicon wafer with a smooth surface) on a receiver platform 8, closing a cabinet door 13 of a shell 1, starting the near-field direct-writing micro-nano 3D electrostatic spinning device to work, wherein in the working process, a precise sampling device realizes the sample delivery of a spinning solution, and a temperature and humidity regulating and controlling mechanism 6 regulates and controls the temperature and humidity in a printing working space 11 to be kept in a set proper range.

While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.

Claims

1. A near-field direct-writing micro-nano 3D electrostatic spinning device is characterized by comprising: the device comprises a shell, a bracket, a Z-axis moving mechanism arranged on the bracket, a printing needle arranged on the Z-axis moving mechanism, a precision sample feeding mechanism connected with the printing needle through a pipeline, a temperature and humidity regulating mechanism, an XY-axis moving mechanism and a receiver platform arranged on the XY-axis moving mechanism;

2. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 1, wherein the temperature and humidity regulating mechanism comprises a temperature regulating component and a humidity regulating component;

3. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 2, wherein the temperature regulation and control assembly comprises a first induced draft fan arranged at the upper end of the air guide pipeline, a heating heat conduction plate arranged in the heating chamber, a heater arranged on the heating heat conduction plate, a semiconductor refrigerator arranged on the inner wall of the refrigerating chamber, a refrigerating heat conduction plate arranged on the semiconductor refrigerator, a radiating fan arranged at the inner end of the heat conduction pipeline and positioned at the side part of the outer wall of the refrigerating chamber, and a second induced draft fan arranged at the lower end of the refrigerating chamber;

4. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 3, wherein the humidity regulation and control assembly comprises a humidifier arranged on the installation partition plate, a humidification pipeline communicated with the humidifier and the air guide pipeline, a condensate water collecting tank arranged below the refrigeration heat conducting plate, and a condensate water drain pipe communicated with the condensate water collecting tank.

5. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 1, wherein the precision sample injection device comprises a mounting shell arranged on the support, a cover plate arranged on the mounting shell, a chute arranged on the cover plate along an X direction, a sample injection push rod capable of moving in the chute along the X direction, a sample injection driving mechanism arranged in the mounting shell and used for driving the sample injection push rod to move, and an injector clamp arranged on the cover plate.

6. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 5, wherein a fixing groove group for fixing the injector is formed in the injector clamp along the X direction, and the fixing groove group comprises a plurality of fixing grooves which are sequentially formed from top to bottom and have sequentially reduced cross-sectional sizes.

7. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 6, wherein a clamping groove which is communicated with the fixing groove and used for clamping an outer injection barrel pushing handle of an injector is formed in the injector clamp along the Y direction.

8. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 6, wherein a plurality of spring plungers are arranged on the inner wall of the fixing groove.

9. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 6, wherein the sample injection driving mechanism comprises a motor arranged in the mounting shell, a lead screw connected with the motor in a driving manner, a slide rail arranged along the X direction, a slide block arranged on the slide rail in a sliding manner, and a lead screw nut connected to the slide block and in threaded fit with the lead screw, and the sample injection push rod is connected to the lead screw nut.

10. The near-field direct-writing micro-nano 3D electrostatic spinning device according to claim 1, further comprising a high-voltage power supply arranged on the support, and a temperature sensor and a humidity sensor arranged in the printing work space.