CN113456323B - Blood flow guiding device with coating - Google Patents

Blood flow guiding device with coating Download PDF

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Publication number
CN113456323B
CN113456323B CN202110838958.8A CN202110838958A CN113456323B CN 113456323 B CN113456323 B CN 113456323B CN 202110838958 A CN202110838958 A CN 202110838958A CN 113456323 B CN113456323 B CN 113456323B
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China
Prior art keywords
bracket body
bracket
blood flow
guiding device
coating
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Active
Application number
CN202110838958.8A
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Chinese (zh)
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CN113456323A (en
Inventor
何艳艳
贺迎坤
李天晓
段林
卢韬源
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Individual
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Priority to CN202110838958.8A priority Critical patent/CN113456323B/en
Publication of CN113456323A publication Critical patent/CN113456323A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
    • A61F2250/0007Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting length
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to a blood flow guiding device with a coating, the adjustable vascular coating stent comprises: the bracket body can be attached with polypeptide for inhibiting hemangioma growth in the blood vessel of the patient; the inner nest is embedded in the bracket body, and limiting rings are arranged at two ends of the inner nest, so that the inner nest and the bracket body keep a stable connection relationship; the adjusting component is arranged between the bracket body and the limiting ring so as to adjust the relative position between the inner nest and the bracket body; the connecting mechanism is arranged at two ends of the bracket body and is used for enabling the two bracket bodies to be connected into a whole, so that the number of the coating brackets can be increased according to the required length in actual use, the speed of releasing the medicine of the coating brackets can be controlled according to the required dosage, the design is novel, and the practicability is strong.

Description

Blood flow guiding device with coating
Technical Field
The invention relates to the medical field, in particular to a blood flow guiding device with a coating.
Background
Hemangiomas are congenital benign tumors or vascular malformations in the skin and soft tissue that are formed by the proliferation of angioblasts during the embryo, most commonly at birth or shortly after birth. Residual embryonic angioblasts, active endothelial-like germs invade adjacent tissues to form endothelial spline cords, which are connected with the left blood vessels after the tube formation to form hemangiomas, and the intratumoral blood vessels are self-organized and are not connected with surrounding blood vessels. Hemangiomas can occur throughout the body, with hemangiomas that occur in the oromaxillofacial region accounting for 60% of the total body, followed by the trunk and extremities. Most of these occur in facial skin, subcutaneous tissue and oral mucosa, tissues such as tongue, lip, and bottom of mouth, and a few occur in jawbone or deep tissues. .
Today, the medical community has invented a "coating stent", which is placed in a blood vessel so that the hemangioma does not have blood flowing through for a long time, and the hemangioma dies naturally on the basis that no blood provides nutrients for the hemangioma, thereby achieving the therapeutic effect.
When the coating bracket is used, the length of the coating bracket is set according to actual needs, so that when the length is insufficient or the length is too long, the rest of the corner material is required to be cut, and the rest of the corner material cannot be used, so that a certain degree of waste is caused.
Disclosure of Invention
The present invention is directed to a blood flow guiding device with a coating to solve the above-mentioned problems.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a coated blood flow guiding device, the adjustable vascular coating stent comprising:
the bracket body can be attached with polypeptide for inhibiting hemangioma growth in the blood vessel of the patient;
the inner nest is embedded in the bracket body, and limiting rings are arranged at two ends of the inner nest, so that the inner nest and the bracket body keep a stable connection relationship;
the adjusting component is arranged between the bracket body and the limiting ring so as to adjust the relative position between the inner nest and the bracket body;
the connecting mechanisms are arranged at two ends of the bracket body and are used for enabling the two bracket bodies to be connected into a whole.
As a further scheme of the invention: the support is characterized in that a concave table is arranged at one end of the support body, a boss is arranged at the other end of the support body, the concave table is matched with the limiting ring at one side, the boss is matched with the limiting ring at the other side, and the concave table and the boss can be mutually embedded through the connecting mechanism.
As still further aspects of the invention: the support body is provided with a plurality of through holes in the circumference, and the through holes are matched with through grooves in the inner nest, wherein the through holes are arranged at equal intervals in the circumference.
As still further aspects of the invention: the adjusting component comprises a rotating shaft rotatably arranged on the concave table, a gear fixedly arranged at one end of the rotating shaft close to the inner side of the concave table, and circular rack plates circumferentially equidistantly arranged on one of the limiting rings;
the other end of the rotating shaft is provided with a bulge.
As still further aspects of the invention: the connecting mechanism comprises a circular groove formed in one end, close to the concave table, of the bracket body, an elastic component movably arranged in the circular groove and a limiting component connected with the elastic component.
As still further aspects of the invention: the elastic component comprises a movable ring movably arranged in the circular groove, a telescopic rod which is circumferentially and equidistantly arranged on the movable ring and penetrates through the bracket body, and a pressure spring which is sleeved on the telescopic rod, and two ends of the pressure spring are respectively abutted against the movable ring and the bracket body;
and one end of the telescopic rod, which is far away from the movable ring, is fixedly connected with the limiting assembly.
As still further aspects of the invention: the limiting component comprises a connecting block fixedly installed at one end of the telescopic rod, which is far away from the movable ring, a pulley rotatably installed on the connecting block, and a locking track arranged on the boss and adapted to the pulley.
As still further aspects of the invention: the through groove is in a strip shape, and the length of the through groove is the same as the length of the through holes distributed on the bracket body.
As still further aspects of the invention: the polypeptide coating is applied to the stent body by plasma technology.
As still further aspects of the invention: the polypeptide is P8RI.
Compared with the prior art, the invention has the beneficial effects that:
the bracket bodies can be mutually connected by arranging the connecting mechanism, so that the length of the bracket body can be increased according to actual needs, and the practicability is high;
the relative positions of the inner nest and the coating bracket are adjusted through the adjusting component, so that the opening between the through hole and the through groove is adjustable, and the release amount of the medicine is adjustable.
Drawings
Fig. 1 is a schematic structural view of a stent body in one embodiment of an adjustable vascular coating stent.
Fig. 2 is a schematic illustration of the nested configuration of one embodiment of an adjustable vascular coating stent.
Fig. 3 is a schematic perspective view of an embodiment of an adjustable vascular coating stent.
Fig. 4 is a schematic rear perspective view of an embodiment of an adjustable vascular coating stent.
Fig. 5 is a schematic plan view of an embodiment of an adjustable vascular coating stent.
Fig. 6 is a cross-sectional view of fig. 5.
Fig. 7 is an enlarged schematic view at a in fig. 5.
In the figure: 1-bracket body, 2-through hole, 3-annular groove, 4-movable ring, 5-concave table, 6-boss, 7-locking track, 8-inner nest, 9-limit ring, 10-through groove, 11-circular rack board, 12-micro gear, 13-telescopic rod, 14-pressure spring, 15-connecting block, 16-pulley.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In addition, an element in the present disclosure may be referred to as being "fixed" or "disposed" on another element or being directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only and are not meant to be the only embodiment.
Referring to fig. 1 to 7, in an embodiment of the present invention, a blood flow guiding device with a coating, the adjustable vascular coating stent includes:
a stent body 1, wherein a polypeptide can be attached to the stent body 1 and used for inhibiting hemangioma growth in a blood vessel of a patient;
the inner nest 8 is embedded in the bracket body 1, limiting rings 9 are arranged at two ends of the inner nest 8, and the limiting rings 9 enable the inner nest 8 to keep a stable connection relation with the bracket body 1;
the adjusting component is arranged between the bracket body 1 and the limiting ring 9 to adjust the relative position between the inner nest 8 and the bracket body 1;
the connecting mechanisms are arranged at two ends of the bracket body 1 and are used for enabling the two bracket bodies 1 to be connected into a whole.
In the embodiment of the invention, when in use, the stent body 1 is firstly subjected to drug treatment to enable the surface of the stent body to be attached with drugs, the number of the stent bodies 1 is increased by selecting the required length according to actual conditions, the stent bodies 1 are connected through the connecting mechanism, the relative position between the inner nest 8 and the stent body 1 is regulated through the regulating mechanism, and the release amount of the drugs in blood vessels is controlled;
the above-mentioned drug treatment is: the polypeptide coating is coated on the stent body 1 by a plasma technology, so that the purposes of targeting and reducing inflammatory reaction of a lesion part and promoting rapid endothelium are achieved, and the polypeptide in the embodiment is P8RI.
It should be noted that the stent body 1 and the inner nest 8 are made of soft materials and have a certain supporting property after being made into a ring shape so as to adapt to the intravascular environment.
As an embodiment of the present invention, one end of the bracket body 1 is provided with a concave table 5, and the other end is provided with a convex table 6, wherein the concave table 5 is adapted to the limit ring 9 on one side, the convex table 6 is adapted to the limit ring 9 on the other side, and the concave table 5 and the convex table 6 can be mutually embedded through the connection mechanism.
In the embodiment of the invention, one end of the bracket body 1 is provided with the concave table 5, the other end is provided with the boss 6, so that the limiting rings 9 arranged on two sides of the inner nest 8 just can fix the inner nest 8 in the bracket body 1, and the concave table 5 and the boss 6 can be mutually embedded, so that the integrity is better when two coating brackets are spliced.
As an embodiment of the present invention, the bracket body 1 is circumferentially provided with a plurality of through holes 2, and the through holes 2 are matched with through grooves 10 circumferentially equidistantly arranged on the inner nest 8.
In the embodiment of the invention, the relative position between the inner nest 8 and the bracket body 1 is regulated by the regulating component, so that the opening formed between the through hole 2 and the through groove 10 is adjustable, and the opening size between the through hole 2 and the through groove 10 can be regulated according to actual conditions, thereby achieving the purpose of adjustable drug release.
It is also worth noting that the hole diameter of the through hole 2 is very small, and the number of the through holes on the stent body 1 is very large, when blood flows through the stent body 1, the blood cannot enter the hemangioma, and the hemangioma cannot be naturally dead due to the nutrition of the growth of the hemangioma after long-time no blood flows, so that the purpose of healing is achieved.
As an embodiment of the invention, the adjusting assembly comprises a rotating shaft rotatably mounted on the concave table 5, a gear 12 fixedly mounted on one end of the rotating shaft near the inner side of the concave table 5, and circular rack plates 11 circumferentially equidistantly arranged on one of the limiting rings 9;
the other end of the rotating shaft is provided with a bulge.
In the embodiment of the invention, when the opening size between the through hole 2 and the through groove 10 needs to be adjusted, the foreign object acts on the bulge to enable the rotating shaft to rotate and drive the gear 12 to rotate, the gear 12 is meshed with the circular rack plate 11 to drive the circular rack plate 11 to rotate, so that the inner nest 8 is driven to rotate relative to the bracket body 1, the relative position between the inner nest 8 and the bracket body is changed, the opening between the corresponding through hole 2 and the through groove 10 is changed, and the release amount of the medicine is controlled;
the opening size between the through hole 2 and the through groove 10 needs to be adjusted before the stent body 1 is placed in the blood vessel of the patient.
As an embodiment of the invention, the connecting mechanism comprises a circular groove 3 formed at one end of the bracket body 1 close to the concave table 5, an elastic component movably arranged in the circular groove 3, and a limiting component connected with the elastic component.
In the embodiment of the present invention, when the length of the stent body 1 needs to be increased in the actual use process, the plurality of stent bodies 1 can be connected by the connection mechanism, so as to obtain the stent body 1 with the required length.
As an embodiment of the invention, the elastic component comprises a movable ring 4 movably arranged in the circular groove 3, a telescopic rod 13 which is circumferentially and equidistantly arranged on the movable ring 4 and penetrates through the bracket body 1, and a pressure spring 14 which is sleeved on the telescopic rod 13 and two ends of which are respectively abutted against the movable ring 4 and the bracket body 1;
one end of the telescopic rod 13, which is far away from the moving ring 4, is fixedly connected with the limiting component.
In the embodiment of the invention, when the two bracket bodies 1 are used, the telescopic rod 13 is stretched outwards under the action of the limiting component by mutually rotating the two bracket bodies 1, the pressure spring 14 is further compressed at the moment, when the two bracket bodies rotate to a certain angle, the limiting component is clamped, the pressure spring 14 releases elastic potential energy at the moment, so that the two bracket bodies 1 are mutually connected, and meanwhile, under the action of the pressure spring 14, the connection is flexible, so that the bracket bodies 1 connected together have certain bending capacity, and the device can be better adapted to the vascular environment of a patient.
As an embodiment of the present invention, the limiting assembly includes a connecting block 15 fixedly installed at one end of the telescopic rod 13 far from the moving ring 4, a pulley 16 rotatably installed on the connecting block 15, and a locking track 7 disposed on the boss 6 and adapted to the pulley 16.
In the embodiment of the invention, when the two bracket bodies 1 are installed, after the pulley 16 is arranged at the inlet of the upper locking track 7, the two bracket bodies 1 are rotated in opposite directions, under the action of the locking track 7, the pulley 16 drives the telescopic rod 13 to move outwards, the compression spring 14 is compressed until the pulley 16 enters the other end of the locking track 7 and is clamped, at the moment, the compression spring 14 releases elastic potential energy, and the pulley 16 is limited in the locking track 7, so that the two bracket bodies 1 are kept in a connected state.
As an embodiment of the present invention, the through groove 10 is long and has the same length as the through holes 2 distributed on the bracket body 1.
In the embodiment of the invention, the lengths of the through grooves 10 are the same as the lengths of the through holes 2 distributed on the bracket body 1, so that when the inner nest 8 rotates, the through grooves 10 can synchronously open the through holes 2, and the consistency is maintained.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.

Claims (5)

1. A coated blood flow guiding device, the blood flow guiding device comprising:
the bracket comprises a bracket body (1), wherein a polypeptide coating is attached to the bracket body (1);
the inner nest (8) is embedded in the bracket body (1), limiting rings (9) are arranged at two ends of the inner nest (8), and the limiting rings (9) enable the inner nest (8) to keep a stable connection relation with the bracket body (1);
the adjusting component is arranged between the bracket body (1) and the limiting ring (9) to adjust the relative position between the inner nest (8) and the bracket body (1);
the connecting mechanism is arranged at two ends of the bracket body (1) and used for enabling the two bracket bodies (1) to be connected into a whole, one end of the bracket body (1) is provided with a concave table (5), the other end of the bracket body is provided with a boss (6), the concave table (5) is matched with one limiting ring (9) on one side, the boss (6) is matched with the limiting ring (9) on the other side, the concave table (5) and the boss (6) can be mutually embedded through the connecting mechanism, and the adjusting assembly comprises a rotating shaft rotatably arranged on the concave table (5), a gear (12) fixedly arranged at one end, close to the inner side of the concave table (5), of the rotating shaft and circular toothed plates (11) circumferentially equidistantly arranged on one of the limiting rings (9);
the other end of axis of rotation is provided with the arch, coupling mechanism is including seting up support body (1) is close to circular recess (3), the activity setting of concave station (5) one end are in elastic component in circular recess (3), with the spacing subassembly that elastic component is connected, elastic component is including the activity setting in movable ring (4) in circular recess (3), be circumference equidistance and install on movable ring (4) and run through telescopic link (13), the cover of support body (1) is established on telescopic link (13) and both ends respectively with movable ring (4) with pressure spring (14) of support body (1) butt, wherein, telescopic link (13) keep away from one end of movable ring (4) with spacing subassembly fixed connection, spacing subassembly is including fixed mounting telescopic link (13) keep away from connecting block (15) of movable ring (4) one end, rotate install pulley (16) on connecting block (15), set up on boss (6) and with locking of pulley (16) adaptation (7).
2. A blood flow guiding device with coating according to claim 1, characterized in that the stent body (1) is circumferentially provided with a plurality of through holes (2), the through holes (2) being adapted to through slots (10) circumferentially equally arranged on the inner nest (8).
3. A coated blood flow guiding device according to claim 2, characterized in that the through-slot (10) is elongated and has the same length as the through-holes (2) are distributed over the stent body (1).
4. A coated blood flow guiding device according to claim 1, wherein: the polypeptide coating is applied to the stent body by plasma technology.
5. A coated blood flow guiding device according to claim 4, wherein: the polypeptide is P8RI.
CN202110838958.8A 2021-07-23 2021-07-23 Blood flow guiding device with coating Active CN113456323B (en)

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CN113456323B true CN113456323B (en) 2023-07-25

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114983627A (en) * 2022-06-20 2022-09-02 柏为(武汉)医疗科技股份有限公司 Nasal cavity nesting support

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WO2000042946A1 (en) * 1999-01-22 2000-07-27 Al Saadon Khalid Expandable intravascular tubular stents
CN107647938A (en) * 2017-10-23 2018-02-02 郑州云启工业设备技术有限公司 A kind of combined type renal artery stent
CN208926716U (en) * 2018-04-10 2019-06-04 业聚医疗器械(深圳)有限公司 A kind of degradable blood vessel bracket with drug composite coating
CN210019816U (en) * 2019-04-03 2020-02-07 中国医学科学院阜外医院 Blood vessel support
CN110934621A (en) * 2019-12-10 2020-03-31 贺迎坤 Degradable blood flow guiding device
CN210447291U (en) * 2019-06-06 2020-05-05 镁荷津生物科技(上海)有限公司 Collapse-preventing degradable intravascular stent
CN111481326A (en) * 2019-01-27 2020-08-04 郑州大学第一附属医院 Intravascular adjustable interventional stent and use method thereof
CN111529152A (en) * 2020-05-15 2020-08-14 上海君联医疗设备有限公司 Blood vessel support
CN212261622U (en) * 2020-03-20 2021-01-01 南京普微森医疗科技有限公司 Combined type neurovascular stent convenient to adjust

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042946A1 (en) * 1999-01-22 2000-07-27 Al Saadon Khalid Expandable intravascular tubular stents
CN107647938A (en) * 2017-10-23 2018-02-02 郑州云启工业设备技术有限公司 A kind of combined type renal artery stent
CN208926716U (en) * 2018-04-10 2019-06-04 业聚医疗器械(深圳)有限公司 A kind of degradable blood vessel bracket with drug composite coating
CN111481326A (en) * 2019-01-27 2020-08-04 郑州大学第一附属医院 Intravascular adjustable interventional stent and use method thereof
CN210019816U (en) * 2019-04-03 2020-02-07 中国医学科学院阜外医院 Blood vessel support
CN210447291U (en) * 2019-06-06 2020-05-05 镁荷津生物科技(上海)有限公司 Collapse-preventing degradable intravascular stent
CN110934621A (en) * 2019-12-10 2020-03-31 贺迎坤 Degradable blood flow guiding device
CN212261622U (en) * 2020-03-20 2021-01-01 南京普微森医疗科技有限公司 Combined type neurovascular stent convenient to adjust
CN111529152A (en) * 2020-05-15 2020-08-14 上海君联医疗设备有限公司 Blood vessel support

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