CN113440641A - Coconut fat solvent for resisting human papilloma virus and preparation method and application thereof - Google Patents
Coconut fat solvent for resisting human papilloma virus and preparation method and application thereof Download PDFInfo
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- CN113440641A CN113440641A CN202110812253.9A CN202110812253A CN113440641A CN 113440641 A CN113440641 A CN 113440641A CN 202110812253 A CN202110812253 A CN 202110812253A CN 113440641 A CN113440641 A CN 113440641A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/184—Carboxylic acids; Anhydrides, halides or salts thereof
- D06M13/188—Monocarboxylic acids; Anhydrides, halides or salts thereof
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/224—Esters of carboxylic acids; Esters of carbonic acid
- D06M13/2243—Mono-, di-, or triglycerides
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/02—Natural fibres, other than mineral fibres
- D06M2101/04—Vegetal fibres
- D06M2101/06—Vegetal fibres cellulosic
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Abstract
The invention provides a coconut fat solvent for resisting human papilloma virus, a preparation method and application thereof, wherein the weight ratio of the coconut fat solvent to the human papilloma virus is 1: 0.6: 0.3: 0.1 of cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid are mixed, stirred for 45min at the speed of 220r/min and uniformly stirred to obtain the coconut fat solvent resisting the human papilloma virus; and coating the coconut fat solvent for resisting the human papilloma virus on the organic fiber for forming, and then obtaining the coconut fat fiber for resisting the human papilloma virus after traction and rolling. The anti-HPV virus coconut fat solvent has the function of resisting HPV virus with the activity rate of 99.02 percent and is safe to food.
Description
Technical Field
The invention relates to a coconut fat solvent for resisting human papilloma virus, a preparation method and application thereof, which are applied to the technical field of medical health and can prevent pointed condyloma or cervical cancer caused by infection of Human Papilloma Virus (HPV). The coconut fat solvent for resisting human papilloma virus is used for preparing coconut fat fibers for resisting human papilloma virus, which are prepared by taking non-woven fabric as a carrier and adding a proper amount of coconut fat solvent for resisting human papilloma virus, and the coconut fat fibers for resisting human papilloma virus can be used for preparing sanitary napkins (core materials), sanitary pads (core materials), tampons (core materials), sanitary (urine) pants (core materials), sanitary cloth sheets and sanitary wet tissues with the function of resisting HPV virus; or a disposable sanitary product which directly acts the coconut fat solvent for resisting the human papilloma virus on human skin or mucous membrane. The anti-human papilloma virus coconut fat solvent is abbreviated as follows: the coconut fat solvent resisting HPV virus, the coconut fat fiber resisting HPV virus in the invention is abbreviated as: coconut fiber resisting HPV virus.
Background
The human is the only host of Human Papilloma Virus (HPV), the infection source is patients and virus carriers, the HPV virus has strict host specificity and tissue tropism and can only infect human skin and mucous membrane cells, the HPV virus is transmitted by directly contacting infected persons or contacting polluted articles, genital tract infection is mainly transmitted by sexual contact, the HPV virus is related to a large number of people, 80% of sexually-living women and 50% of men can be infected with the HPV virus in life, the disease generated after the human is infected with the HPV virus is condyloma acuminatum, cervical carcinoma is mainly caused by HPV virus infection, namely the necessary condition for generating the cervical carcinoma is HPV virus infection. Like influenza virus or new coronavirus, none of the drugs has been able to completely eliminate HPV viruses so far.
Disclosure of Invention
The invention aims to solve the technical problem that the anti-HPV virus coconut fat solvent (and a preparation method and application thereof) has the function of resisting HPV virus and is safe to food grade, and aims to overcome the technical defect that the existing disposable sanitary products (non-woven fabric fibers) such as sanitary napkins, sanitary pads, tampons, sanitary (urine) pants, sanitary cloth sheets, sanitary wet tissues and the like and the disposable sanitary coating products (pastes, liquids and agents) for human skin or mucous membranes have no anti-HPV virus function.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention aims to provide a coconut fat solvent for resisting human papilloma virus, which is obtained by mixing and stirring cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid, wherein the weight ratio of the cold-pressed coconut crude oil to the lauric acid to the caprylic/capric glyceride to the caproic acid is 1: 0.6: 0.3: 0.1.
in the technical scheme, the lauric acid in the cold-pressed coconut crude oilC1247-49% of octanoic acidC88-9% of capric acidC10The content is 6-8%.
In the technical scheme, the iodine value/(g/100 g) of the lauric acid is less than or equal to 3.0.
In the technical scheme, the peroxidation value (mmol/kg) of the caprylic/capric glyceride is less than or equal to 1.0, and the saponification value (calculated by KOH)/(mg/g) is 325-360.
In the technical scheme, the content omega/%, of the caproic acid is more than or equal to 98.0.
The invention also provides a preparation method of the anti-human papilloma virus coconut solvent, which comprises the following steps:
mixing the components in a weight ratio of 1: 0.6: 0.3: 0.1 of cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid are mixed, stirred for 45min at the speed of 220r/min and uniformly stirred to obtain the coconut fat solvent resisting the human papilloma virus.
The invention also aims to provide the application of the coconut fat solvent for resisting the human papilloma virus in preparing a disposable sanitary coating product directly acting on human skin or mucous membrane.
In the above technical solution, the disposable hygienic coating article refers to a disposable coating agent, a coating paste or a coating liquid.
The fourth purpose of the invention is to provide the application of the anti-human papilloma virus biological coconut fat solvent in the preparation of anti-human papilloma virus coconut fat fibers.
The fifth purpose of the invention is to provide a coconut fat fiber for resisting human papilloma virus,the coconut fat solvent for resisting human papilloma virus is coated on organic fiber for forming, and then the coconut fat solvent is obtained after traction and rolling, the thickness is 1.2-1.6 mm, and the specification is 42g/m2。
The invention also aims to provide a preparation method of the coconut fat fiber for resisting human papilloma virus, which comprises the following steps:
(1) mixing the components in a weight ratio of 1: 0.6: 0.3: 0.1 of cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid are mixed, stirred for 45min at the speed of 220r/min and uniformly stirred to obtain the coconut fat solvent resisting the human papilloma virus.
(2) And (2) coating the coconut fat solvent for resisting the human papilloma virus obtained in the step (1) on organic fibers by a casting machine for forming, and then drawing and rolling to obtain the coconut fat fiber for resisting the human papilloma virus.
In the above technical scheme, in the step (2), the coconut fat solvent coating amount of the coconut fat fiber resisting human papilloma virus is 10g/m2。
In the above technical scheme, in the step (2), the organic fiber is viscose fiber or spunlace nonwoven fabric, the thickness is 1-1.3 mm, and the specification is 32g/m2。
In the above technical scheme, in the step (2), the coconut fat fiber resisting human papilloma virus has a thickness of 1.2-1.6 mm and a specification of 42g/m2。
The seventh purpose of the invention is to provide an application of the coconut fat fiber for resisting human papilloma virus in preparing disposable sanitary products such as sanitary towels, sanitary pads, tampons, sanitary diapers, sanitary pants, sanitary cloth sheets, sanitary wet tissues and the like.
The Human Papilloma Virus (HPV) genome is double-stranded circular DNA, has no envelope and capsid protein, is stable in a pH value range of 5-9, can be inactivated below the pH value of 5, invades cells through damaged skin or mucous membrane, only stays in the skin and the mucous membrane, has high affinity with the skin and the mucous membrane, and is easy to form persistent infection. Based on the above, the anti-HPV coconut fat solvent and anti-HPV coconut fat fiber of the invention have the following anti-HPV principles:
lauric acid having a pH value of 4-4.5 in cold-pressed coconut crude oil in an anti-HPV virus coconut butter solventC12Octanoic acid, octanoic acidC8Capric acidC10Can resist HPV virus activity.
The pH value of lauric acid (separated from coconut crude oil) in the coconut butter solvent resisting HPV virus is 4.5, and the lauric acid can dissolve HPV virus capsid protein to lose adsorption capacity.
The pH value of caprylic capric acid glyceride (prepared by separating caprylic capric acid from coconut crude oil and then reacting with glycerol) in the HPV virus resistant coconut fat solvent is 4.3, and the caprylic capric acid glyceride can prevent HPV virus from entering cells through cell membranes.
Fourthly, caproic acid (obtained by fractionating coconut crude oil) in coconut fat solvent resisting HPV virus has a pH value of 4, and can interfere HPV virus to prevent assembly maturation and collapse HPV virus nucleic acid.
The pH value range of the normal skin of the people is between 4 and 6, the pH value plays an important role in maintaining the acid barrier of the skin to resist the invasion of bacteria and viruses, the HPV virus-resistant coconut fat solvent with the pH value not more than 4.5 acts on the surface of the skin to form an acidic protective barrier, the pH value of the skin is regulated to be in an acidic state below 5, the pH value of the skin habitat is balanced, and the HPV virus is prevented from breaking through the skin or mucous membrane barrier to cause infection.
Compared with the prior disposable sanitary article technology, the invention has the following beneficial effects
The anti-HPV coconut fat solvent (fiber) can dissolve HPV capsid protein to lose adsorption force, can prevent HPV from penetrating cell membranes to enter cells, can interfere HPV to prevent assembling maturation and collapse HPV nucleic acid, can form an acidic protective barrier when acting on the surface of skin, can adjust the pH value of the skin to be in an acidic state below 5, balances the pH value of the skin habitat, and prevents HPV from breaking through the skin or mucous membrane barrier to cause infection. The anti-HPV virus coconut fat solvent and the coconut fat fiber of the invention achieve unexpected technical effects, solve the technical problems which people are eagerly to solve but are still unsolved in the field of medical health and health, have no obvious and novel technical scheme which is not easy to think of and is practical for the technical personnel in the field, and have prominent substantive characteristics and remarkable progress.
Detailed Description
The following detailed description of the embodiments of the present invention is provided, but the present invention is not limited to the following descriptions:
the invention will now be illustrated with reference to specific examples:
example 1:
a coconut fat solvent for resisting human papilloma virus is prepared by the following steps:
mixing the components in a weight ratio of 1: 0.6: 0.3: 0.1 of cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid are mixed, stirred for 45min at the speed of 220r/min and uniformly stirred to obtain the coconut fat solvent resisting the human papilloma virus; lauric acid in the cold-pressed coconut crude oilC1247-49% of octanoic acidC88-9% of capric acidC10The content is 6-8%; the iodine value/(g/100 g) of the lauric acid is less than or equal to 3.0; the peroxidation value (mmol/kg) of the caprylic-capric glyceride is less than or equal to 1.0, the saponification value (calculated by KOH)/(mg/g) is 325-360, and the content omega/%, of caproic acid is more than or equal to 98.0.
Example 2:
coconut fat fiber for resisting human papilloma virus is prepared by the following method:
coating the anti-human papilloma virus coconut fat solvent obtained in the example 1 on organic fibers by a casting machine for molding, and then obtaining the anti-human papilloma virus coconut fat fibers after traction and rolling; the thickness of the coconut fat fiber for resisting human papilloma virus is 1.2-1.6 mm, and the specification is 42g/m2. The coating amount of the coconut fat solvent for resisting the human papilloma virus is 10g/m2(ii) a The organic fiber is a spunlace nonwoven fabric with the thickness of 1-1.3 mm and the specification of 32g/m2. The coconut fat fiber against human papilloma virus obtained in this example was of the type: V-C81012(0535), at the time of submissionThe sample name was named "coconut oil solvent (fiber) for disposable sanitary article".
Detection reporting
The coconut fat fiber (type: V-C81012(0535), sample name at the time of inspection is named as "coconut fat solvent (fiber) of disposable sanitary product") of anti-human papilloma virus obtained in example 2 of the invention is sent to Shanghai micro-spectrographic chemical engineering service Limited company for inspection, and the inspection items are as follows: the activity of the HPV6 of the anti-human papilloma virus is detected by the following method: ISO18184:2019, detection instrument is: the biological safety cabinet has the detection results shown in table 1:
table 1 shows the coconut butter solvent (fiber) type of the disposable hygienic article: anti-HPV 6 viral Activity of V-C81012(0535)
Remarking: the laboratory temperature was 35.6 ℃ and 56% RH.
As shown in Table 1, the third party testing organization verified that the anti-HPV coconut fat solvent and the anti-HPV coconut fat fiber provided by the invention have the function of resisting HPV virus.
The above examples are only for illustrating the technical concept and features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims (10)
1. The coconut fat solvent for resisting human papilloma virus is characterized by being obtained by mixing and stirring cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid, wherein the weight ratio of the cold-pressed coconut crude oil to the lauric acid to the caprylic/capric glyceride to the caproic acid is 1: 0.6: 0.3: 0.1.
2. the coconut solvent against human papilloma virus according to claim 1, wherein lauric acid in cold-pressed coconut crude oilC1247-49% of octanoic acidC88-9% of decanoic acidC10The content is 6-8%; the iodine value/(g/100 g) of the lauric acid is less than or equal to 3.0; the peroxide value (mmol/kg) of the caprylic/capric glyceride is less than or equal to 1.0, and the saponification value (calculated by KOH)/(mg/g) is 325-360; the content of caproic acid
3. The process of claim 1 for preparing a coconut solvent against human papilloma virus, comprising the steps of: mixing the components in a weight ratio of 1: 0.6: 0.3: 0.1 of cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid are mixed, stirred for 45min at the speed of 220r/min and uniformly stirred to obtain the coconut fat solvent resisting the human papilloma virus.
4. Use of the coconut fat solvent against human papillomavirus according to claim 1 for the preparation of a disposable hygienic coating means for direct application to human skin or mucous membranes, characterized in that said disposable hygienic coating means is a disposable coating agent, a coating paste or a coating liquid.
5. Use of the coconut solvent against human papillomavirus of claim 1 for the preparation of coconut coir against human papillomavirus.
6. A coconut fat fiber resisting human papilloma virus, which is characterized in that the coconut fat fiber resisting human papilloma virus is obtained by coating the coconut fat solvent resisting human papilloma virus of claim 1 on organic fiber for molding, drawing and rolling, and the coconut fat fiber is 1.2-1.6 mm in thickness and 42g/m in specification2。
7. The method of claim 6, comprising the steps of:
(1) mixing the components in a weight ratio of 1: 0.6: 0.3: 0.1 of cold-pressed coconut crude oil, lauric acid, caprylic/capric glyceride and caproic acid are mixed, stirred for 45min at the speed of 220r/min and uniformly stirred to obtain the coconut fat solvent resisting the human papilloma virus.
(2) And (2) coating the coconut fat solvent for resisting the human papilloma virus obtained in the step (1) on organic fibers by a casting machine for forming, and then drawing and rolling to obtain the coconut fat fiber for resisting the human papilloma virus.
8. The process according to claim 7, wherein in the step (2), the coconut fat fiber against human papillomavirus has a coconut fat solvent-coated amount of 10g/m2。
9. The method according to claim 7, wherein in the step (2), the organic fiber is viscose fiber or spunlace nonwoven fabric, the thickness is 1-1.3 mm, and the specification is 32g/m2。
10. The use of coconut palm fiber against Human Papilloma Virus (HPV) as claimed in claim 6 for the preparation of disposable sanitary products such as sanitary napkins, panty liners, tampons, panty diapers, panty sheets, wet wipes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110812253.9A CN113440641A (en) | 2021-07-19 | 2021-07-19 | Coconut fat solvent for resisting human papilloma virus and preparation method and application thereof |
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| CN202110812253.9A CN113440641A (en) | 2021-07-19 | 2021-07-19 | Coconut fat solvent for resisting human papilloma virus and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114042116A (en) * | 2021-11-12 | 2022-02-15 | 北京健翔嘉业日用品有限责任公司 | Natural coconut fat solvent for resisting human immunodeficiency virus, preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114042116A (en) * | 2021-11-12 | 2022-02-15 | 北京健翔嘉业日用品有限责任公司 | Natural coconut fat solvent for resisting human immunodeficiency virus, preparation method and application |
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