CN113425405A - Microwave ablation simulation temperature field correction method based on side-opening temperature measurement - Google Patents
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00714—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
Abstract
The invention discloses a microwave ablation simulation temperature field correction method based on side-by-side temperature measurement, which takes in-vitro pork liver as an example and comprises the following steps: constructing a liver microwave ablation simulation model according to the size of the pork liver; setting ablation dosage, namely ablation power, ablation time and probe positions (the insertion depth of a temperature measuring needle and the ablation needle, the side-opening distance between the temperature measuring needle and the ablation needle and the like), completing simulated ablation according to the preset ablation dosage, and obtaining temperature change data of a temperature measuring point with the preset side-opening distance; designing in-vitro pig liver microwave ablation, inserting an ablation needle and a temperature measuring needle into a pig liver side by side according to preset distance positions, starting actual ablation, and obtaining actual temperature data of the same site; comparing the actual temperature data with the simulation temperature data, establishing a relation model, and correcting the simulation temperature; and (5) verifying the model. The method provides a correction scheme for the precise microwave ablation process, and has important reference value for preoperative simulation and simulation treatment of microwave ablation.
Description
Technical Field
The invention relates to the technical field of microwave ablation preoperative simulation, in particular to a microwave ablation simulation temperature field correction method based on side-by-side temperature measurement.
Background
The microwave thermal ablation therapy is considered to be a novel and effective method for treating malignant tumors after operations, chemotherapy, radiotherapy, immunotherapy and the like due to the advantages of obvious curative effect, minimal invasion, small toxic and side effects, few complications and the like, plays a great role in clinical tumor treatment, and is widely applied to more than 10 solid tumors such as liver cancer, lung cancer, kidney cancer, thyroid cancer and the like. However, there are still many scientific and technical problems to be solved in the microwave tumor thermal ablation, and one of the most important problems is preoperative temperature field simulation of the microwave ablation treatment effect.
The simulation result of the tissue microwave ablation temperature field is obtained under relatively ideal conditions. Ex vivo porcine liver has been considered as a "gold standard" sample for microwave ablation. There was also some discrepancy with the ex vivo porcine liver experimental results and simulations because of the difficulty in accurately mimicking the effects of tissue and blood perfusion. It is necessary to correct the simulated temperature field according to the actual temperature field.
At present, no microwave ablation simulation temperature field correction model based on side-opening temperature measurement exists.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a microwave ablation simulation temperature field correction method based on side-by-side temperature measurement, and an effective microwave ablation simulation temperature field correction model based on side-by-side temperature measurement is established by the method.
In order to achieve the purpose, the invention adopts the technical scheme that:
a microwave ablation simulation temperature field correction method based on bypass temperature measurement realizes correction of a microwave ablation simulation temperature field under the same condition according to the obtained actual temperature of a tissue in a microwave ablation process, and comprises the following steps:
s1, constructing a tissue microwave ablation simulation model according to the size of the tissue;
s2, setting ablation dosage, namely ablation power, ablation time and probe position, completing simulated ablation, and obtaining temperature change data of the preset bypass distance temperature measurement site;
s3, designing in vitro tissue microwave ablation, inserting an ablation needle and a temperature measuring needle into in vitro tissue side by side according to a preset distance position, starting actual microwave ablation, and obtaining actual temperature data of the same site;
s4, comparing multiple groups of actual temperature data of different sites under different ablation doses with simulation temperature data, establishing a relation model, and correcting the simulation temperature;
the specific steps of S4 include:
s401: outputting the simulated temperature value as S (t), wherein the experimentally measured temperature value is E (t), and t is the time point of data acquisition;
s402: curve fitting is carried out by taking S (t) as the horizontal axis x of the coordinate, and taking E (t) as the vertical axis y of the coordinate;
s403: obtaining:
y＝1.0284*x+2.43
i.e. the corrected temperature S1(t) is:
S1(t)＝1.0284*S(t)+2.43；
and S5, verifying the model.
Further, the temperature change simulation model in the microwave ablation simulation model in step S1 is implemented by using Comsol Multiphysics multi-physical field coupling software, which includes geometric design of the ablation needle and the tissue, setting of boundary conditions, setting of tissue dielectric property parameters, and setting of thermophysical property parameters.
Further, the ablation dosage in the step S2 is a combination of microwave ablation power and ablation duration; the probe position includes the depth of the microwave ablation needle inserted into the tissue and the coordinates of the thermometry site.
Further, the actual microwave ablation of the isolated tissue in the step S3 is realized by a microwave ablation and temperature acquisition system.
Further, the microwave ablation and temperature acquisition system comprises: the microwave ablation device comprises a microwave source 1, a microwave ablation needle 2, a temperature measuring needle 3, a temperature data collecting plate 5 and a PC6, wherein the microwave source 1 and the microwave ablation needle 2 are connected with each other, the temperature measuring needle 3, the temperature data collecting plate 5 and the PC6 are sequentially connected, and the microwave temperature measuring needle 2 and the temperature measuring needle 3 are inserted into an isolated tissue 4.
Preferably, the microwave source 1 is a 2450MHz microwave source, and the microwave ablation needle 2 is a Y-2450-B1 microwave ablation needle. The diameter of the temperature measuring needle 3 is 1.2mm, and the length is 180 mm; the microwave ablation needle 2 is a KY-2450-B1 microwave ablation needle, the diameter of the microwave ablation needle is 1.9mm, and the length of the microwave ablation needle is 150 mm.
Further, the microwave ablation needle 2 and the temperature measuring needle 3 are arranged in parallel in the in vitro tissue 4.
Further, the insertion depth of the microwave ablation needle 2 in actual microwave ablation and the position of the temperature measuring needle 3 are kept consistent with the simulation settings, wherein: the microwave ablation needle 2 and the temperature measuring needle 3 are inserted in the same plane; and performing microwave ablation according to the same power time to obtain temperature data of the whole ablation process.
Further, in step S4, the actual temperature data is compared with the simulated temperature data, and a relationship model between the two sets of data is established based on the actual temperature, so as to correct the simulated temperature.
Further, in the step S5, the model verification is to perform the in vitro tissue microwave ablation simulation and the actual ablation again under a certain same condition according to the established correction model, compare the simulation temperature data with the actual temperature data, and determine the model error.
Furthermore, in a plurality of groups of simulation ablation and actual ablation data acquisition experiments, the ablation power is selected from 50W, 60W and 70W, and the ablation time is respectively 3min, 5min, 7min and 10 min.
Furthermore, the temperature measuring needle and the microwave ablation needle are inserted into the tissue on the same plane, the microwave energy radiation point of the microwave ablation needle is 1cm away from the needle point, so that the microwave ablation needle is inserted into the tissue by 8cm, the temperature measuring needle is inserted into the tissue by 7cm, and the distance between the two needles is selected from 0.3cm, 0.5cm, 1.0cm and 1.5 cm; the ablation power, time and distance are matched arbitrarily.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention establishes a microwave ablation simulation temperature field correction model based on side-by-side temperature measurement effectively, and ensures that the microwave ablation simulation temperature field is more fit with the actual ablation temperature field.
2. The method has important significance for the visual simulation of the treatment effect before the microwave ablation operation, and can provide important reference for a doctor to determine a treatment plan.
Drawings
FIG. 1 is a schematic diagram of a microwave ablation and temperature acquisition system of the present invention;
FIG. 2 is a simulated temperature variation curve of different sites under 50W-5min ablation dosage in example 2 of the present invention;
FIG. 3 is the actual temperature variation curve of different sites under 50W-5min ablation dosage in example 2 of the present invention;
FIG. 4 is a modified model curve in example 2 of the present invention;
FIG. 5 is a comparison of the temperature field ablation zone after modification with the actual ablation zone in example 2 of the present invention; wherein (a) is the corrected simulated temperature field; (b) is the actual ablation zone.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
A microwave ablation simulation temperature field correction method based on bypass temperature measurement realizes correction of a microwave ablation simulation temperature field under the same condition according to the obtained actual temperature of a tissue in a microwave ablation process, and comprises the following steps:
s1, constructing a tissue microwave ablation simulation model according to the size of the tissue;
the temperature change simulation model in the microwave ablation simulation model in the step S1 is implemented by using Comsol Multiphysics multi-physical field coupling software, and includes geometric structure design of an ablation needle and a tissue, boundary condition setting, tissue dielectric property parameters and thermophysical property parameter setting;
s2, setting ablation dosage, namely ablation power, ablation time and probe position, completing simulated ablation, and obtaining temperature change data of the preset bypass distance temperature measurement site;
the ablation dosage in the step S2 is a combination of microwave ablation power and ablation duration; the probe position comprises the depth of the microwave ablation needle inserted into the tissue and the coordinates of the temperature measurement site;
s3, designing in vitro tissue microwave ablation, inserting an ablation needle and a temperature measuring needle into in vitro tissue side by side according to a preset distance position, starting actual microwave ablation, and obtaining actual temperature data of the same site;
the actual microwave ablation of the isolated tissue in the step S3 is realized through a microwave ablation and temperature acquisition system;
in particular, the microwave ablation and temperature acquisition system comprises: the microwave ablation device comprises a microwave source 1, a microwave ablation needle 2, a temperature measuring needle 3, a temperature data collecting plate 5 and a PC6, wherein the microwave source 1 and the microwave ablation needle 2 are connected with each other, the temperature measuring needle 3, the temperature data collecting plate 5 and the PC6 are sequentially connected, and the microwave temperature measuring needle 2 and the temperature measuring needle 3 are inserted into an isolated tissue 4.
Preferably, the microwave source 1 is a 2450MHz microwave source, and the microwave ablation needle 2 is a Y-2450-B1 microwave ablation needle. The diameter of the temperature measuring needle 3 is 1.2mm, and the length is 180 mm; the microwave ablation needle 2 is a KY-2450-B1 microwave ablation needle, the diameter of the microwave ablation needle is 1.9mm, and the length of the microwave ablation needle is 150 mm.
Preferably, the microwave ablation needle 2 and the temperature measuring needle 3 are arranged in parallel in the isolated tissue 4.
Specifically, the insertion depth of the microwave ablation needle 2 in the actual microwave ablation, the position of the thermometer needle 3 and the simulation settings are all kept consistent, wherein: the microwave ablation needle 2 and the temperature measuring needle 3 are inserted in the same plane; carrying out microwave ablation according to the same power time to obtain temperature data of the whole ablation process;
s4, comparing multiple groups of actual temperature data of different sites under different ablation doses with simulation temperature data, establishing a relation model, and correcting the simulation temperature;
in step S4, the actual temperature data is compared with the simulated temperature data, and a relationship model between the two sets of data is established with the actual temperature as a standard, so as to correct the simulated temperature.
The specific steps of step S4 include:
s401: outputting the simulated temperature value as S (t), wherein the experimentally measured temperature value is E (t), and t is the time point of data acquisition;
s402: curve fitting is carried out by taking S (t) as the horizontal axis x of the coordinate, and taking E (t) as the vertical axis y of the coordinate;
s403: obtaining:
y＝1.0284*x+2.43
i.e. the corrected temperature S1(t) is:
S1(t)＝1.0284*S(t)+2.43；
and S5, verifying the model.
Specifically, in step S5, the model verification is to perform the in vitro tissue microwave ablation simulation and the actual ablation again under a certain same condition according to the established correction model, compare the simulation temperature data and the actual temperature data, and determine the model error.
Furthermore, in a plurality of groups of simulation ablation and actual ablation data acquisition experiments, the ablation power is selected from 50W, 60W and 70W, and the ablation time is respectively 3min, 5min, 7min and 10 min.
Furthermore, the temperature measuring needle and the microwave ablation needle are inserted into the tissue on the same plane, the microwave energy radiation point of the microwave ablation needle is 1cm away from the needle point, so that the microwave ablation needle is inserted into the tissue by 8cm, the temperature measuring needle is inserted into the tissue by 7cm, and the distance between the two needles is selected from 0.3cm, 0.5cm, 1.0cm and 1.5 cm; the ablation power, time and distance are matched arbitrarily.
Example 2
A microwave ablation simulation temperature field correction method based on side-by-side temperature measurement takes pork liver as an example and comprises the following steps:
s1, constructing a liver microwave ablation simulation model according to the size of the pork liver;
s2, setting ablation dosage, namely ablation power, ablation time and probe position, completing simulated ablation, and obtaining temperature change data of the preset bypass distance temperature measurement site;
s3, designing in-vitro pig liver microwave ablation, inserting an ablation needle and a temperature measuring needle into a pig liver side by side according to a preset distance position, starting actual ablation, and obtaining actual temperature data of the same site;
s4, comparing multiple groups of actual temperature data of different sites under different ablation doses with simulation temperature data, establishing a relation model, and correcting the simulation temperature;
and S5, verifying the model.
As shown in fig. 1, the microwave ablation and temperature acquisition system comprises: the microwave ablation device comprises a microwave source 1, a microwave ablation needle 2, a temperature measuring needle 3, a temperature data acquisition board 5 and a PC6, wherein the microwave source 1 and the microwave ablation needle 2 are connected with each other, the temperature measuring needle 3, the temperature data acquisition board 5 and the PC6 are sequentially connected, and the microwave temperature measuring needle 2 and the temperature measuring needle 3 are inserted into an isolated tissue 4; the diameter of the temperature measuring needle 3 is 1.2mm, and the length is 180 mm; the microwave ablation needle 2 is a KY-2450-B1 microwave ablation needle, the diameter of the microwave ablation needle is 1.9mm, and the length of the microwave ablation needle is 150 mm; the microwave source 1 is a 2450MHz microwave source.
Before the experiment, the microwave ablation needle 2 is inserted into the liver by 8cm to ensure that the whole ablation area is in the liver parenchyma; inserting the temperature measuring needle 3 into the needle body for 7cm and placing the temperature measuring needle 3 and the microwave ablation needle 2 in parallel; in multiple data acquisition experiments, the ablation power was selected from 50W, 60W and 70W, and the ablation time was 3min, 5min, 7min and 10min, respectively. The distance between the two needles is selected from 0.3cm, 0.5cm, 1.0cm and 1.5 cm; the ablation power, time and distance are matched arbitrarily.
Fig. 2 is a simulated temperature variation curve of different sites under an ablation dosage of 50W-5min in the microwave ablation simulated temperature field correction method based on side-by-side temperature measurement provided by this embodiment.
Fig. 3 is an actual temperature change curve of different sites under an ablation dosage of 50W-5min in the microwave ablation simulation temperature field correction method based on side-by-side thermometry according to the embodiment of the present invention.
Fig. 4 is a corrected model curve of a microwave ablation simulation temperature field correction method based on side-by-side thermometry according to an embodiment of the present invention.
S401: outputting the simulated temperature value as S (t), wherein the experimentally measured temperature value is E (t), and t is the time point of data acquisition;
s402: curve fitting is carried out by taking S (t) as the horizontal axis (x) of the coordinate and E (t) as the vertical axis (y) of the coordinate;
s403: obtaining:
y＝1.0284*x+2.43
i.e. the corrected temperature S1t is:
S1(t)＝1.0284*S(t)+2.43
as shown in table 1, the relative error of the correction model constructed by the method for correcting the temperature field in microwave ablation simulation based on side-by-side temperature measurement is shown.
And performing isolated pig liver microwave ablation simulation and actual ablation under a certain same condition again according to the established correction model, comparing the simulation temperature data with the actual temperature data, and determining the model error.
TABLE 1 relative error between simulated temperature data and actual temperature data before and after correction
Fig. 5 is a comparison between the corrected temperature field ablation region and the actual ablation region of the microwave ablation simulation temperature field correction method based on side-by-side thermometry provided in this embodiment. Plot a is the simulated temperature field after correction and plot b is the actual ablation zone, with 55 ℃ as the critical temperature for cell death, also used as the threshold temperature for the simulated active zone.
As shown in table 2, the size error of the simulated ablation region and the actual ablation region before and after correction is compared, and as can be seen from table 2, the correction effect of the correction model is better, and the error between simulation and actual is greatly reduced, so that the simulation result is more fit with the actual ablation result.
TABLE 2 ablation zone size error
| Error of relative error | Short diameter | Major diameter | Short diameter: short diameter |
| Before correction | 6.9％ | 2.4％ | 8.5％ |
| After correction | 0.7％ | 2.3％ | 1.7％ |
The invention discloses a microwave ablation simulation temperature field correction method based on side-by-side temperature measurement, which takes in-vitro pork liver as an example and comprises the following steps: constructing a liver microwave ablation simulation model according to the size of the pork liver; setting ablation dosage, namely ablation power, ablation time and probe positions (the insertion depth of a temperature measuring needle and the ablation needle, the side-opening distance between the temperature measuring needle and the ablation needle and the like), completing simulated ablation according to the preset ablation dosage, and obtaining temperature change data of a temperature measuring point with the preset side-opening distance; designing in-vitro pig liver microwave ablation, inserting an ablation needle and a temperature measuring needle into a pig liver side by side according to preset distance positions, starting actual ablation, and obtaining actual temperature data of the same site; comparing the actual temperature data with the simulation temperature data, establishing a relation model, and correcting the simulation temperature; and (5) verifying the model. The method provides a correction scheme for the precise microwave ablation process, and has important reference value for preoperative simulation and simulation treatment of microwave ablation.
The above description is only of the preferred embodiments of the present invention, and it should be noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the invention and these are intended to be within the scope of the invention.
Claims (10)
1. A microwave ablation simulation temperature field correction method based on side-opening temperature measurement is characterized by comprising the following steps: the method realizes the correction of the microwave ablation simulation temperature field under the same condition according to the obtained actual temperature of the tissue in the microwave ablation process, and comprises the following steps:
s1, constructing a tissue microwave ablation simulation model according to the size of the tissue;
s2, setting ablation dosage, namely ablation power, ablation time and probe position, completing simulated ablation, and obtaining temperature change data of the preset bypass distance temperature measurement site;
s3, designing in vitro tissue microwave ablation, inserting an ablation needle and a temperature measuring needle into in vitro tissue side by side according to a preset distance position, starting actual microwave ablation, and obtaining actual temperature data of the same site;
s4, comparing multiple groups of actual temperature data of different sites under different ablation doses with simulation temperature data, establishing a relation model, and correcting the simulation temperature;
the specific steps of S4 include:
s401: outputting the simulated temperature value as S (t), wherein the experimentally measured temperature value is E (t), and t is the time point of data acquisition;
s402: curve fitting is carried out by taking S (t) as the horizontal axis x of the coordinate, and taking E (t) as the vertical axis y of the coordinate;
s403: obtaining:
y＝1.0284*x+2.43
i.e. the corrected temperature S1(t) is:
S1(t)＝1.0284*S(t)+2.43；
and S5, verifying the model.
2. The method for correcting the temperature field for microwave ablation simulation based on bypass temperature measurement as claimed in claim 1, wherein the temperature variation simulation model in the microwave ablation simulation model in step S1 is implemented by using Comsol Multiphysics multi-physical field coupling software, which includes geometric design, boundary condition setting, tissue dielectric property parameter and thermophysical property parameter setting of a microwave ablation needle and a tissue.
3. The microwave ablation simulation temperature field correction method based on side-by-side temperature measurement as claimed in claim 2, characterized in that: the ablation dosage in the step S2 is a combination of microwave ablation power and ablation duration; the probe position includes the depth of the microwave ablation needle inserted into the tissue and the coordinates of the thermometry site.
4. The microwave ablation simulation temperature field correction method based on bypass temperature measurement as claimed in claim 3, wherein the actual microwave ablation of the isolated tissue in step S3 is realized by a microwave ablation and temperature acquisition system.
5. The method for correcting the temperature field of microwave ablation simulation based on side-by-side temperature measurement as claimed in claim 4, wherein the microwave ablation and temperature acquisition system comprises: the microwave ablation device comprises a microwave source (1), a microwave ablation needle (2), a temperature measuring needle (3), a temperature data acquisition board (5) and a PC (6), wherein the microwave source (1) and the microwave ablation needle (2) are connected with each other, the temperature measuring needle (3), the temperature data acquisition board (5) and the PC (6) are sequentially connected, and the microwave temperature measuring needle (2) and the temperature measuring needle (3) are inserted into an isolated tissue (4).
6. The microwave ablation simulation temperature field correction method based on bypass temperature measurement as claimed in claim 5, characterized in that the microwave source (1) is a 2450MHZ microwave source, and the microwave ablation needle (2) is a Y-2450-B1 microwave ablation needle.
7. The microwave ablation simulation temperature field correction method based on side-by-side temperature measurement according to claim 5, characterized in that the microwave ablation needle (2) and the temperature measurement needle (3) are arranged in parallel in the isolated tissue (4).
8. The method for correcting the microwave ablation simulation temperature field based on the side branch temperature measurement according to the claim 5, wherein the insertion depth of the microwave ablation needle (2) in the actual microwave ablation and the position of the temperature measurement needle (3) are all consistent with the simulation settings, and wherein: the microwave ablation needle (2) and the temperature measuring needle (3) are inserted in the same plane; and performing microwave ablation according to the same power time to obtain temperature data of the whole ablation process.
9. The method for correcting the temperature field of microwave ablation simulation based on bypass temperature measurement as claimed in claim 1, wherein in step S4, the actual temperature data is compared with the simulation temperature data, and a relationship model between the two sets of data is established based on the actual temperature, so as to correct the simulation temperature.
10. The method for correcting the temperature field of microwave ablation simulation based on bypass temperature measurement as claimed in claim 1, wherein in step S5, the model verification comprises performing isolated tissue microwave ablation simulation and actual ablation again under the same condition according to the established correction model, comparing the simulation temperature data with the actual temperature data, and determining the model error.
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| CN110974412A (en) * | 2019-12-17 | 2020-04-10 | 南京航空航天大学 | Temperature-based real-time evaluation method and device for Young modulus of microwave ablation tissue |
| CN111488714A (en) * | 2020-04-10 | 2020-08-04 | 桂林电子科技大学 | Method for accurately calculating wind speed of hot air reflow soldering nozzle |
| CN111700678A (en) * | 2020-06-23 | 2020-09-25 | 南京诺源医疗器械有限公司 | Control method of microwave ablation treatment dosage for liver tumor |
| CN112668220A (en) * | 2020-12-23 | 2021-04-16 | 天津大学 | Method for measuring three-dimensional thermal deformation of aerospace device structure based on finite element analysis |
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| CN116983075A (en) * | 2023-09-28 | 2023-11-03 | 海杰亚（北京）医疗器械有限公司 | Temperature monitoring compensation algorithm and system for ablation needle |
| CN116983075B (en) * | 2023-09-28 | 2023-12-22 | 海杰亚（北京）医疗器械有限公司 | Temperature monitoring compensation algorithm and system for ablation needle |
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