CN113397580A - AVM model construction method based on hemodynamics analysis - Google Patents
AVM model construction method based on hemodynamics analysis Download PDFInfo
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- CN113397580A CN113397580A CN202110853909.1A CN202110853909A CN113397580A CN 113397580 A CN113397580 A CN 113397580A CN 202110853909 A CN202110853909 A CN 202110853909A CN 113397580 A CN113397580 A CN 113397580A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/032—Transmission computed tomography [CT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0263—Measuring blood flow using NMR
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/501—Clinical applications involving diagnosis of head, e.g. neuroimaging, craniography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/504—Clinical applications involving diagnosis of blood vessels, e.g. by angiography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
Abstract
The invention provides an AVM model construction method based on hemodynamic analysis, which comprises the steps of reconstructing CT, nuclear magnetism and DSA original data, performing hemodynamic analysis on the DSA data, defining hemodynamic characteristics of different positions of malformed blood supply artery, malformed corpuscle, drainage vein and the like, giving different colors, fusing the different colors to a three-dimensional reconstructed arteriovenous malformation model in a multi-mode manner, and printing on a computer to obtain an arteriovenous malformation model capable of visually reflecting the hemodynamic characteristics. The AVM model construction method based on the hemodynamic analysis, provided by the invention, obtains the arteriovenous malformation image data of a clinical patient by virtue of the iconography examination, performs the hemodynamic analysis by utilizing the color blood flow coding perfusion technology, distinguishes and expresses the blood flow characteristics by visual gradient colors, performs three-dimensional reconstruction and 3D prints out an arteriovenous malformation model, and can be used for preoperative simulation and rehearsal, reduce the surgical risk and enhance the confidence of doctors.
Description
Technical Field
The invention relates to a model construction method, in particular to an AVM model construction method based on hemodynamics analysis.
Background
Arteriovenous malformations (AVMs) are abnormal connections between cerebral arteries and veins, and there is no capillary connection between the cerebral arteries and the cerebral veins, resulting in malformed masses in which the arteries are shunted directly to the veins. Bleeding from arteriovenous malformations is the leading cause of death, and is the most complex of cerebrovascular diseases, with not only multiple blood supplies and drains, but also complex hemodynamic changes.
The cerebral arteriovenous malformation has different sizes, positions, forms, blood supply arteries and drainage veins, and completely identical arteriovenous malformations do not exist, so the treatment difficulty is high, and the treatment of the cerebral arteriovenous malformations comprises the following steps: surgical resection, interventional embolization, and radiation therapy or combination therapy. The cerebral arteriovenous malformation operation is the most difficult operation in the angiopathy operation, is much more difficult than the aneurysm operation, and requires years of operation training and experience of an operating doctor.
The prerequisite condition of the operation of arteriovenous malformation is that the size, characteristics, position and relation of arteriovenous malformation and peripheral tissues, position and relation of blood supply artery and drainage vein, and hemodynamics characteristics of arteriovenous malformation are also very important in malformation operation. According to the traditional method, a doctor needs to construct a three-dimensional arteriovenous malformation model in the brain and sea according to a two-dimensional clinical image picture, the method has limitations, and the hemodynamic characteristics of arteriovenous malformation are difficult to conceive, so that high requirements are provided for the professional knowledge and clinical experience of the doctor.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provides an AVM model construction method based on hemodynamic analysis, and solves the problem that the existing three-dimensional arteriovenous malformation model is difficult to construct.
In order to solve the technical problems, the invention provides the following technical scheme:
an AVM model construction method based on hemodynamics analysis comprises the following steps:
a. performing skull CT thin-layer scanning, skull nuclear magnetic scanning and whole brain angiography examination on a patient to respectively obtain corresponding original DICOM data;
b. b, performing post-processing on the original DICOM data obtained in the step a by using Mimics software to obtain a three-dimensional image of arteriovenous malformation;
c. b, performing hemodynamic analysis on the data obtained by the whole cerebral angiography examination in the step a by using a color blood flow coding perfusion technology to obtain blood flow data;
d. according to the blood flow data obtained in the step c, giving a gradient color to the three-dimensional image obtained in the step b;
e. and D, printing the three-dimensional image obtained in the step D on a computer by using a 3D printing machine to obtain an AVM model.
Further, the blood flow data in step c includes the average blood flow passing time of the key positions of normal artery, blood supply artery, different parts of malformed ball and drainage vein.
Furthermore, the average blood flow passing time reflects the flow velocity of the blood flow, the color is given to the three-dimensional image according to the flow velocity of the blood flow, the red represents the blood vessel with high flow velocity, the blue represents the blood vessel with low flow velocity, and the color shows gradient change between the highest value and the lowest value of the flow velocity.
Further, the model of the 3D printer is Objet Connex 350.
Furthermore, the material of the model is photosensitive resin.
The invention relates to an AVM model construction method based on hemodynamic analysis, which obtains arteriovenous malformation image data of clinical patients by means of imaging examination, performs hemodynamic analysis by utilizing a color blood flow coding perfusion technology, distinguishes and expresses the characteristics of blood flow by visual gradient color, performs three-dimensional reconstruction, prints an arteriovenous malformation model by a 3D printer, can be used for preoperative simulation and exercise, reduces surgical risks and enhances the confidence of doctors.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic view of a 3D printed model of a right temporal venule malformation from multiple perspectives in the present case;
fig. 2 is a schematic diagram comparing right temporal lobe arteriovenous malformation radiography, 3D printing model and intraoperative condition in the case of the present invention.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
An AVM model construction method based on hemodynamics analysis comprises the following steps:
a. performing skull CT thin-layer scanning, skull nuclear magnetic scanning and whole brain angiography examination on a patient to respectively obtain corresponding original DICOM data;
b. b, performing post-processing on the original DICOM data obtained in the step a by using Mimics software to obtain a three-dimensional image of arteriovenous malformation;
c. b, performing hemodynamic analysis on the data obtained by the whole cerebral angiography examination in the step a by using a color blood flow coding perfusion technology to obtain blood flow data;
d. according to the blood flow data obtained in the step c, giving a gradient color to the three-dimensional image obtained in the step b;
e. and D, printing the three-dimensional image obtained in the step D on a computer by using a 3D printing machine to obtain an AVM model.
The blood flow data in the step c comprise the average passing time of blood flow at multiple key positions of normal arteries, blood supply arteries, different parts of malformed masses and drainage veins.
The blood flow average passing time reflects the flow velocity of the blood flow, the color is given to the three-dimensional image according to the flow velocity of the blood flow, the red represents the blood vessel with high flow velocity, the blue represents the blood vessel with low flow velocity, and the color of the flow velocity between the highest value and the lowest value presents gradient change.
The model of the 3D printer is Objet Connex 350.
The material of the model is photosensitive resin.
Case (2):
a24-year-old male patient is admitted to the hospital after finding intracranial space occupation for 2 weeks, mainly due to repeated headache for 5 years. The nuclear magnetic resonance examination of the head shows that: the right temporal lobe occupies space, and the blood vessel runs empty, and arteriovenous malformation is considered. The malformed masses were found to be supplied by the right middle cerebral artery and finally drawn into the superior sagittal sinus by the large drainage vein, as detected by Digital Subtraction Angiography (DSA): reconstructing arteriovenous malformation according to DSA and original standard DICOM data of magnetic resonance venous imaging (MRV), and performing hemodynamic analysis on data obtained by whole brain angiography examination by using a color blood flow coding perfusion technology to obtain blood flow data; the obtained three-dimensional image is given gradient colors, and the printing of a colorful and multi-texture integral model is respectively carried out, the 3D printing model is shown in figure 1, and the neurosurgery and the interventionalist carry out preoperative discussion and the formulation of an operation plan. Finally, the patient is subjected to craniotomy arteriovenous malformation resection operation. Fig. 2 is a schematic diagram comparing right temporal lobe arteriovenous malformation radiography, 3D printing model and intraoperative situation, wherein: a: a digital subtraction angiography side bitmap, wherein a displayed blood supply artery is a right middle cerebral artery; b: the 3D model is enlarged to display the blood supply artery; c: blood supply arteries are seen inside the malformed masses in the operation; d: a digital subtraction angiography lateral bitmap, wherein thick black blood vessels are drainage veins; e: the 3D model enlargements show the drainage veins; f: the intraoperative images show gross drainage veins.
The invention relates to an AVM model construction method based on hemodynamic analysis, which obtains arteriovenous malformation image data of clinical patients by means of imaging examination, performs hemodynamic analysis by utilizing a color blood flow coding perfusion technology, distinguishes and expresses the characteristics of blood flow by visual gradient color, performs three-dimensional reconstruction, prints an arteriovenous malformation model by a 3D printer, can be used for preoperative simulation and exercise, reduces surgical risks and enhances the confidence of doctors.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. An AVM model construction method based on hemodynamics analysis is characterized by comprising the following steps:
a. performing skull CT thin-layer scanning, skull nuclear magnetic scanning and whole brain angiography examination on a patient to respectively obtain corresponding original DICOM data;
b. b, performing post-processing on the original DICOM data obtained in the step a by using Mimics software to obtain a three-dimensional image of arteriovenous malformation;
c. b, performing hemodynamic analysis on the data obtained by the whole cerebral angiography examination in the step a by using a color blood flow coding perfusion technology to obtain blood flow data;
d. according to the blood flow data obtained in the step c, giving a gradient color to the three-dimensional image obtained in the step b;
e. and D, printing the three-dimensional image obtained in the step D on a computer by using a 3D printing machine to obtain an AVM model.
2. The method for constructing an AVM model based on hemodynamic analysis of claim 1, wherein: the blood flow data in the step c comprise the average passing time of blood flow at multiple key positions of normal arteries, blood supply arteries, different parts of malformed masses and drainage veins.
3. The method for constructing an AVM model based on hemodynamic analysis of claim 2, wherein: the blood flow average passing time reflects the flow velocity of the blood flow, the color is given to the three-dimensional image according to the flow velocity of the blood flow, the red represents the blood vessel with high flow velocity, the blue represents the blood vessel with low flow velocity, and the color of the flow velocity between the highest value and the lowest value presents gradient change.
4. The method for constructing an AVM model based on hemodynamic analysis of claim 1, wherein: the model of the 3D printer is Objet Connex 350.
5. The method for constructing an AVM model based on hemodynamic analysis of claim 1, wherein: the material of the model is photosensitive resin.
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Citations (6)
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| US20160314601A1 (en) * | 2015-04-21 | 2016-10-27 | Heartflow, Inc. | Systems and methods for risk assessment and treatment planning of arterio-venous malformation |
| CN107049484A (en) * | 2017-01-21 | 2017-08-18 | 绍兴市人民医院 | Intracranial aneurysm 3D model Method of printings based on DSA data |
| US20180174490A1 (en) * | 2016-12-15 | 2018-06-21 | The Brigham And Women's Hospital, Inc. | Methods and systems for generating fluid simulation models |
| CN108523997A (en) * | 2018-04-28 | 2018-09-14 | 上海交通大学医学院附属仁济医院 | Cortex structure, the cerebrovascular and intracerebral lesion 3D printing model and preparation method thereof |
| US20200316868A1 (en) * | 2019-04-04 | 2020-10-08 | The Regents Of The University Of Colorado, A Body Corporate | Ultra-high resolution 3d printed anatomical and structural models |
| US20210219849A1 (en) * | 2020-01-17 | 2021-07-22 | Canon Medical Systems Corporation | Apparatus and method of determining dynamic vascular parameters of blood flow |
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2021
- 2021-07-27 CN CN202110853909.1A patent/CN113397580A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160314601A1 (en) * | 2015-04-21 | 2016-10-27 | Heartflow, Inc. | Systems and methods for risk assessment and treatment planning of arterio-venous malformation |
| US20180174490A1 (en) * | 2016-12-15 | 2018-06-21 | The Brigham And Women's Hospital, Inc. | Methods and systems for generating fluid simulation models |
| CN107049484A (en) * | 2017-01-21 | 2017-08-18 | 绍兴市人民医院 | Intracranial aneurysm 3D model Method of printings based on DSA data |
| CN108523997A (en) * | 2018-04-28 | 2018-09-14 | 上海交通大学医学院附属仁济医院 | Cortex structure, the cerebrovascular and intracerebral lesion 3D printing model and preparation method thereof |
| US20200316868A1 (en) * | 2019-04-04 | 2020-10-08 | The Regents Of The University Of Colorado, A Body Corporate | Ultra-high resolution 3d printed anatomical and structural models |
| US20210219849A1 (en) * | 2020-01-17 | 2021-07-22 | Canon Medical Systems Corporation | Apparatus and method of determining dynamic vascular parameters of blood flow |
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