CN113372245A - Synthesis method of N-benzoyl-O, O-p-toluenesulfonyl-diethanolamine - Google Patents
Synthesis method of N-benzoyl-O, O-p-toluenesulfonyl-diethanolamine Download PDFInfo
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- CN113372245A CN113372245A CN202110672313.1A CN202110672313A CN113372245A CN 113372245 A CN113372245 A CN 113372245A CN 202110672313 A CN202110672313 A CN 202110672313A CN 113372245 A CN113372245 A CN 113372245A
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- CN
- China
- Prior art keywords
- diethanolamine
- benzoyl
- toluenesulfonyl
- reaction
- chloride
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
Abstract
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Claims (5)
Priority Applications (1)
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CN202110672313.1A CN113372245B (en) | 2021-06-17 | 2021-06-17 | Synthetic method of N-benzoyl-O, O-p-toluenesulfonyl-diethanolamine |
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CN202110672313.1A CN113372245B (en) | 2021-06-17 | 2021-06-17 | Synthetic method of N-benzoyl-O, O-p-toluenesulfonyl-diethanolamine |
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CN113372245A true CN113372245A (en) | 2021-09-10 |
CN113372245B CN113372245B (en) | 2023-01-13 |
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CN202110672313.1A Active CN113372245B (en) | 2021-06-17 | 2021-06-17 | Synthetic method of N-benzoyl-O, O-p-toluenesulfonyl-diethanolamine |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2830035A (en) * | 1954-07-22 | 1958-04-08 | Ciba Ltd | Heat-hardenable aminoplast resin molding compositions, their manufacture and molded articles therefrom |
EP0550006A2 (en) * | 1991-12-31 | 1993-07-07 | LIFEGROUP S.p.A. | Use of N-acyl derivatives of aminoalcohols for the manufacture of a medicament for the treatment of pathologies involving mast cells |
CN101605767A (en) * | 2006-12-14 | 2009-12-16 | 詹森药业有限公司 | The method for preparing piperazinyl phenyl carboxamides derivatives and Diazesuberane yl-benzamide derivatives |
CN106380427A (en) * | 2016-08-30 | 2017-02-08 | 京博农化科技股份有限公司 | Synthesis method of N-cyclopropyl-[[(2-methoxybenzoyl)amino]sulfonyl]benzamide |
CN106470981A (en) * | 2014-06-23 | 2017-03-01 | 北京新天宇科技开发有限公司 | The new derivatives of 2 [3 cyano group 4 isobutoxy phenyl] 4 methylthiazol 5 formic acid, its preparation method and application |
US20170247403A1 (en) * | 2012-03-06 | 2017-08-31 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd. | Tetracyclic anthraquinone derivatives |
CN107428780A (en) * | 2015-01-14 | 2017-12-01 | 百时美施贵宝公司 | Benzodiazepine * dimers, its conjugate and preparation and application |
-
2021
- 2021-06-17 CN CN202110672313.1A patent/CN113372245B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2830035A (en) * | 1954-07-22 | 1958-04-08 | Ciba Ltd | Heat-hardenable aminoplast resin molding compositions, their manufacture and molded articles therefrom |
EP0550006A2 (en) * | 1991-12-31 | 1993-07-07 | LIFEGROUP S.p.A. | Use of N-acyl derivatives of aminoalcohols for the manufacture of a medicament for the treatment of pathologies involving mast cells |
CN101605767A (en) * | 2006-12-14 | 2009-12-16 | 詹森药业有限公司 | The method for preparing piperazinyl phenyl carboxamides derivatives and Diazesuberane yl-benzamide derivatives |
US20170247403A1 (en) * | 2012-03-06 | 2017-08-31 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd. | Tetracyclic anthraquinone derivatives |
CN106470981A (en) * | 2014-06-23 | 2017-03-01 | 北京新天宇科技开发有限公司 | The new derivatives of 2 [3 cyano group 4 isobutoxy phenyl] 4 methylthiazol 5 formic acid, its preparation method and application |
CN107428780A (en) * | 2015-01-14 | 2017-12-01 | 百时美施贵宝公司 | Benzodiazepine * dimers, its conjugate and preparation and application |
CN106380427A (en) * | 2016-08-30 | 2017-02-08 | 京博农化科技股份有限公司 | Synthesis method of N-cyclopropyl-[[(2-methoxybenzoyl)amino]sulfonyl]benzamide |
Non-Patent Citations (2)
Title |
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CHOWDARI NAIDU S.ET AL: "Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates", 《JOURNAL OF MEDICINAL CHEMISTRY》 * |
YAR MUHAMMAD ET AL: "Synthesis, biological evaluation and study of the effect of various N-substituents on the thermal stabilities of some new diethanolamine derivatives", 《ASIAN JOURNAL OF CHEMISTRY》 * |
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CN113372245B (en) | 2023-01-13 |
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Inventor after: Zou Congwei Inventor after: Zhang Yan Inventor after: Li Fu Inventor after: Liu Guoxiang Inventor after: Liu Yufei Inventor after: Zhang Rongcui Inventor before: Zhang Yan Inventor before: Zou Congwei Inventor before: Li Fu Inventor before: Liu Guoxiang Inventor before: Liu Yufei Inventor before: Zhang Rongcui |
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