CN113368362A - 用于谐振脑部γ节律震荡波的光声振动波装置及用途 - Google Patents

用于谐振脑部γ节律震荡波的光声振动波装置及用途 Download PDF

Info

Publication number
CN113368362A
CN113368362A CN202110421807.2A CN202110421807A CN113368362A CN 113368362 A CN113368362 A CN 113368362A CN 202110421807 A CN202110421807 A CN 202110421807A CN 113368362 A CN113368362 A CN 113368362A
Authority
CN
China
Prior art keywords
brain
photoacoustic
vibration wave
rhythm
resonating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110421807.2A
Other languages
English (en)
Inventor
刘书朋
曹茂红
姜剑国
赵宝库
姜胜华
刘新国
张恒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN202110421807.2A priority Critical patent/CN113368362A/zh
Publication of CN113368362A publication Critical patent/CN113368362A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0022—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the tactile sense, e.g. vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0027—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the hearing sense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A61M2021/0044—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus by the sight sense

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Rehabilitation Therapy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种用于谐振脑部γ节律震荡波的光声振动波装置及用途，产生谐振脑部γ节律震荡波的γ节律的光声震荡波。本发明的装置可以将γ节律的光声振动波相结合共同作用于脑部神经刺激，作为一种有效无创的AD物理治疗方法。

Description

用于谐振脑部γ节律震荡波的光声振动波装置及用途
技术领域
本发明涉及一种光声振动波装置及用途。
背景技术
据世界卫生组织预测，2050年全世界老年人口将达到20.2亿，阿尔茨海默病（Alzheimer’s disease, AD）又名老年性痴呆症，发病率与年龄相关，65岁以上人群发病率为5%，75岁以上的老人10%患有智能障碍，80岁以上发病率超过30%，成为失智老人的最主要原因，目前单单中国AD患者人数就超过1000万人。
脑电图有不同节律的脑电波组成，包括α波、β波、θ波和δ波，一些疾病会出现不同的脑电节律波的改变，节律的改变反映出脑部振荡波的改变。α节律声光刺激有利于昏迷患者的促醒治疗，另外对α节律降低或消失症的患者也有良好治疗作用，β节律脑部刺激有利于注意力缺陷障碍伴多动的治疗。γ节律和β节律和α节律控制光声节律，可根据脑部不同情况，使用不同节律调控刺激神经活动。目前已经有研究报道采用光或声来治疗疾病的，有一定的治疗效果。特别是对老年痴呆的患者的治疗，治疗效果不甚明显。
发明内容
本发明的目的在于提供一种能产生谐振脑部γ节律震荡波的γ节律光声震荡波的光声振动波装置及用途。
本发明的技术解决方案是：
一种用于谐振脑部γ节律震荡波的光声振动波装置，其特征是：产生谐振脑部γ节律震荡波的γ节律的光声震荡波。
一所述的用于谐振脑部γ节律震荡波的光声振动波装置在谐振脑部γ节律震荡波中的应用。
γ节律的光声振动波能够谐振脑部的γ节律振荡波，激活脑部神经活动的振荡，调节振荡，能够有效的激活脑部神经活动，降低脑部淀粉样沉淀蛋白和tau蛋白含量，恢复老年痴呆的认知能力，减轻AD疾病症状。
本发明的装置可以将γ节律的光声振动波相结合共同作用于脑部神经刺激，作为一种有效无创的AD物理治疗方法。
附图说明
下面结合附图和实施例对本发明作进一步说明。
图1是 声光振动波用于模型小鼠的治疗实验示意图。
图2 是小鼠迷宫实验运动轨迹用于小鼠记忆力的检测示意图。
具体实施方式
一种用于谐振脑部γ节律震荡波的光声振动波装置，其特征是：产生谐振脑部γ节律震荡波的γ节律的光声震荡波。
一所述的用于谐振脑部γ节律震荡波的光声振动波装置在谐振脑部γ节律震荡波中的应用。
γ节律的光声振动波能够谐振脑部的γ节律振荡波，激活脑部神经活动的振荡，调节振荡，能够有效的激活脑部神经活动，降低脑部淀粉样沉淀蛋白和tau蛋白含量，恢复老年痴呆的认知能力，减轻AD疾病症状。
例1：采用γ节律的光声振动波相结合的仪器，作用于5xFAD转基因AD小鼠，对小鼠进行20Hz、40Hz、80Hz光声振动信号的刺激，记录小鼠脑部视听及感觉区域的电生理信号，并对电生理信号进行时域和频域信号分析。治疗后对小鼠进行水迷宫记忆测试，小鼠脑组织免疫组化分析，Tau和Aβ分析，并对小鼠脑部核磁成像图像分析。
例2：
（1）γ节律的光声振动波仪为光声振动波治疗开放式闪光刺激+声音+振动治疗。治疗AD患者60名，分为治疗组和对照组。治疗组常规治疗+γ节律的光声振动波治疗，治疗每周5天，每次30min，连续24周，对照组常规治疗。所有参与者均接受神经心理学和神经功能评估，包括简易精神状态检查量表（MMSE）、AD评估量表认知子量表（ADAS cog12）、日常生活能力量表（ADCS-ADL）、老年抑郁症量表（GDS）、神经精神量表（NPI）、匹茨堡睡眠质量指数（PSQI）和基线12周和24周的ADAS cog12、ADCS-ADL和PSQI。所有参与者将在基线检查24周时进行功能磁共振成像（fMRI），扫描评估患者治疗前后脑容量的变化情况，并进行血液/尿液生物标志物检测。
经过上述测试和分析，治疗组AD患者在认知和分子病理特征等方面优于对照组AD患者，说明γ节律的光声振动波治疗（开放式闪光刺激+声音+振动治疗）为有效无创的治疗方法。
例3：
分组和例2雷同，γ节律光声振动波治疗为眼罩式闪光+声音+振动治疗，每周5天，每次30min，连续24周。
经过上述测试和分析，治疗组AD患者在认知和分子病理特征等方面优于对照组AD患者，说明γ节律的光声振动波治疗（眼罩式闪光+声音+振动治疗）为有效无创的治疗方法。
上面结合附图对本发明实施例进行了说明，但本发明不限于上述实施例，还可以根据本发明的发明创造的目的做出多种变化，凡依据本发明技术方案的精神实质和原理下做的改变、修饰、替代、组合、简化，均应为等效的置换方式，只要符合本发明的发明目的，只要不背离本发明的技术原理和发明构思，都属于本发明的保护范围。

Claims (2)

1.一种用于谐振脑部γ节律震荡波的光声振动波装置，其特征是：产生谐振脑部γ节律震荡波的γ节律的光声震荡波。
2.一种权利要求1所述的用于谐振脑部γ节律震荡波的光声振动波装置在谐振脑部γ节律震荡波中的应用。
CN202110421807.2A 2021-04-20 2021-04-20 用于谐振脑部γ节律震荡波的光声振动波装置及用途 Pending CN113368362A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110421807.2A CN113368362A (zh) 2021-04-20 2021-04-20 用于谐振脑部γ节律震荡波的光声振动波装置及用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110421807.2A CN113368362A (zh) 2021-04-20 2021-04-20 用于谐振脑部γ节律震荡波的光声振动波装置及用途

Publications (1)

Publication Number Publication Date
CN113368362A true CN113368362A (zh) 2021-09-10

Family

ID=77569802

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110421807.2A Pending CN113368362A (zh) 2021-04-20 2021-04-20 用于谐振脑部γ节律震荡波的光声振动波装置及用途

Country Status (1)

Country Link
CN (1) CN113368362A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115054831A (zh) * 2022-07-13 2022-09-16 安徽中实华粹医疗器械有限公司 采用光声磁振动波谐振活化脑部方法的装置

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106963371A (zh) * 2017-03-29 2017-07-21 天津大学 基于神经振荡活动检测大鼠学习记忆和认知功能的方法
CN108697889A (zh) * 2015-11-24 2018-10-23 麻省理工学院 用于预防、减轻和/或治疗痴呆的系统和方法
CN110548226A (zh) * 2019-07-31 2019-12-10 中国医学科学院生物医学工程研究所 一种根据节律耦合特征建立经颅磁刺激模式的方法
CN112515684A (zh) * 2020-11-30 2021-03-19 上海交通大学 一种个性化干预音乐推荐系统

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108697889A (zh) * 2015-11-24 2018-10-23 麻省理工学院 用于预防、减轻和/或治疗痴呆的系统和方法
CN106963371A (zh) * 2017-03-29 2017-07-21 天津大学 基于神经振荡活动检测大鼠学习记忆和认知功能的方法
CN110548226A (zh) * 2019-07-31 2019-12-10 中国医学科学院生物医学工程研究所 一种根据节律耦合特征建立经颅磁刺激模式的方法
CN112515684A (zh) * 2020-11-30 2021-03-19 上海交通大学 一种个性化干预音乐推荐系统

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115054831A (zh) * 2022-07-13 2022-09-16 安徽中实华粹医疗器械有限公司 采用光声磁振动波谐振活化脑部方法的装置

Similar Documents

Publication Publication Date Title
Motl et al. Physical activity and cognitive function in multiple sclerosis
Babiloni et al. Abnormalities of cortical neural synchronization mechanisms in subjects with mild cognitive impairment due to Alzheimer’s and Parkinson’s diseases: an EEG study
Mander et al. Inflammation, tau pathology, and synaptic integrity associated with sleep spindles and memory prior to β-amyloid positivity
Gorina-Careta et al. Neonatal frequency-following responses: a methodological framework for clinical applications
D. Chorna et al. Feasibility of event-related potential (ERP) biomarker use to study effects of mother’s voice exposure on speech sound differentiation of preterm infants
CN113368362A (zh) 用于谐振脑部γ节律震荡波的光声振动波装置及用途
Nava et al. The emergence of the multisensory brain: From the womb to the first steps
Gupta et al. Evaluating the effect of repetitive transcranial magnetic stimulation in cerebral palsy children by employing electroencephalogram signals
Abdullahi et al. Beta and gamma EEG oscillatory waves of the frontal cortex increase after wet cupping therapy in healthy humans
Tsai et al. Remission of depression is associated with asymmetric hemispheric variation in EEG complexity before antidepressant treatment
Di Lernia et al. Sonoception: Synthetic auditory stimulation of the insula alters proxies of interoceptive processing at behavioral and cortical levels.
Pritchard et al. EMG levels in the occipitofrontalis muscles under an experimental stress condition
Algin et al. EEG biomarker for alzheimer’s disease
Kahn et al. Gamma sensory stimulation and effects on the brain
Papagiannopoulou Auditory processing in ASD & sound-based interventions
Walter Electro-encephalography
RU2462182C2 (ru) Способ ранней диагностики хронических нарушений мозгового кровообращения, обусловленных артериальной гипотензией
Ma et al. Self‐Directed Neurofeedback Treatment for Subjective Tinnitus Patients Evaluated by Multimodal Functional Imaging
Ulyanov et al. EEG markers of attention sustainability detected in neuropsychological testing in different age groups
Zhong et al. Abnormal resting-state functional connectivity of hippocampal subregions in children with primary nocturnal enuresis
Voitiuk The importance of neuroimaging methods in the diagnosis of epilepsy in young men: literature review and own clinical case
Choi et al. The effects of horizontal eye movement on mental health indices and psychophysiological activities in healthy subjects
Chorna et al. Feasibility of ERP biomarker use to study effects of mother’s voice exposure on speech sound differentiation of preterm infants
Borich et al. Using actigraphy and transcranial magnetic stimulation to assess the relationship between sleep and visuomotor skill learning
Larie et al. Brain wave patterns in patients with chronic low back pain: a case-control study

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20210910

RJ01 Rejection of invention patent application after publication