CN113367883A - Cornea bandage mirror that in situ becomes glue individuation and joins in marriage suitable - Google Patents
Cornea bandage mirror that in situ becomes glue individuation and joins in marriage suitable Download PDFInfo
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- CN113367883A CN113367883A CN202110638599.1A CN202110638599A CN113367883A CN 113367883 A CN113367883 A CN 113367883A CN 202110638599 A CN202110638599 A CN 202110638599A CN 113367883 A CN113367883 A CN 113367883A
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- cornea
- photosensitive material
- situ
- bandage
- bandage lens
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- 210000004087 cornea Anatomy 0.000 title claims abstract description 24
- 238000011065 in-situ storage Methods 0.000 title claims abstract description 20
- 239000003292 glue Substances 0.000 title description 2
- 239000000463 material Substances 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 239000011248 coating agent Substances 0.000 claims abstract description 4
- 238000000576 coating method Methods 0.000 claims abstract description 4
- 230000001678 irradiating effect Effects 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 4
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 8
- 239000003999 initiator Substances 0.000 claims description 7
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical group N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 4
- XDLMVUHYZWKMMD-UHFFFAOYSA-N 3-trimethoxysilylpropyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)CCCOC(=O)C(C)=C XDLMVUHYZWKMMD-UHFFFAOYSA-N 0.000 claims description 4
- 208000028006 Corneal injury Diseases 0.000 claims description 4
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 238000011282 treatment Methods 0.000 abstract description 9
- 208000027418 Wounds and injury Diseases 0.000 abstract description 6
- 230000006378 damage Effects 0.000 abstract description 6
- 239000000017 hydrogel Substances 0.000 abstract description 6
- 208000014674 injury Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 239000000499 gel Substances 0.000 abstract description 3
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 3
- 230000001788 irregular Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 206010015958 Eye pain Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- ZHPNWZCWUUJAJC-UHFFFAOYSA-N fluorosilicon Chemical compound [Si]F ZHPNWZCWUUJAJC-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011337 individualized treatment Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0061—Devices for putting-in contact lenses
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
- C08F226/10—N-Vinyl-pyrrolidone
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention discloses an in-situ gelling individualized fitting corneal bandage lens, and relates to the technical field of ocular surface injury repair. The cornea bandage mirror is used for repairing the damaged part of the cornea of the eye, and is made of a photosensitive material; the specific application and operation method of the corneal bandage lens comprises the following steps: dripping liquid photosensitive material on the damaged part of the cornea of the eye by an injector, and uniformly coating the liquid photosensitive material on the surface of the damaged cornea while filling the damaged part by utilizing the liquidity and plasticity of the liquid; irradiating for 10s by using a light source with the wavelength of 395nm to generate sound polymerization reaction; after the liquid photosensitive material is quickly gelatinized in situ, a bandage lens covering the injured part and the surface of the cornea is formed. The invention can pass the photosensitive hydrogel material; the material can form gel in situ to achieve the purpose of individual matching, and the individual matching biological bandage lens based on the photosensitive material provides an individual treatment means for ocular surface injury diseases with huge treatment demands in clinic.
Description
Technical Field
The invention belongs to the technical field of ocular surface injury repair, and particularly relates to an in-situ gelling individualized fitting corneal bandage lens.
Background
The therapeutic corneal contact lens is also called corneal bandage lens, and is a soft corneal contact lens used for protecting the ocular surface and treating or assisting in treating ocular surface injury, and the action principle of the therapeutic corneal contact lens is that a barrier effect is formed between an eyelid and a cornea, epithelial repair is promoted, bare corneal nerves can be covered, and the symptoms of ocular pain caused by mechanical friction are relieved. The application of the corneal bandage lens in ophthalmology covers most diseases causing the pathological changes of ocular surface epithelium, and the corneal bandage lens is an important and very common treatment means recommended by the ophthalmology department of the Chinese medical society and the clinical consensus and guidance of ophthalmology.
At present, the most common materials used for preparing the corneal bandage lens are silicon and hydrogel polymers, which are organic high molecular materials, have hydrophilicity, have a two-phase material framework, namely have two channels of fluorine silicon and hydrogel, have better oxygen permeability and can meet the requirement of continuous wearing. However, silicon, hydrogel polymer bandage lenses still have certain disadvantages: 1) the finished lens has a single specification, and cannot be individually selected according to the size of the eye fissure of the patient and the width degree of the conjunctival sac; 2) the artificially synthesized high polymer material lacks biological characteristics and only has a simple physical barrier effect; 3) lack of drug-loading performance and can not have the effect of drug-mechanical combination. Therefore, the research and development of the novel bandage lens which can meet the requirement of individualized treatment in clinic and has biological effect has important clinical value.
Because the existing corneal bandage lens, namely the therapeutic corneal contact lens, is formed in vitro, the specification is single, and the individual adaptation can not be carried out, and the corneal bandage lens is embodied in the following aspects: (1) the treatment requirements of different palpebral fissure sizes and conjunctival sac sizes cannot be met; (2) can't satisfy irregular cornea injury, especially impaired base portion is uneven, can't carry out treatment (3) of filled formula and need patient compliance better at present, regular follow-up change, degradable biomaterial is planned to adopt in this patent.
Disclosure of Invention
The invention provides an in-situ gelling individualized fitting corneal bandage lens, which solves the problems.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the invention relates to a cornea bandage lens which is individually matched by in-situ gelling and is used for repairing damaged parts of cornea;
the cornea bandage mirror is made of a photosensitive material;
the specific application and operation method of the corneal bandage lens comprises the following steps:
s01: dripping liquid photosensitive material on the damaged part of the cornea of the eye by an injector, and uniformly coating the liquid photosensitive material on the surface of the damaged cornea while filling the damaged part by utilizing the liquidity and plasticity of the liquid;
s02: irradiating for 10s by using a light source with the wavelength of 395nm to generate sound polymerization reaction;
s03: after the liquid photosensitive material is quickly gelatinized in situ, a bandage lens covering the injured part and the surface of the cornea is formed.
Further, the formula of the photosensitive material is as follows:
gamma-methacryloxypropyltrimethoxysilane: 20-25 parts;
n-vinylpyrrolidone: 20-35 parts;
hydroxyethyl methacrylate: 0.2-1 part;
photo/thermal initiator: 0.5-2 parts;
solvent: 30-60 parts.
Further, the photoinitiator employs D1173.
Further, the thermal initiator is azobisisobutyronitrile.
Further, the solvent is one or more of methanol, ethanol, propanol, butanol or butanediol.
Compared with the prior art, the invention has the following beneficial effects:
the invention can pass through the photosensitive hydrogel material for irregular corneal injury, different individual palpebral fissure sizes and conjunctival sac sizes in clinic; the material can form gel in situ to achieve the purpose of individual matching, and the individual matching biological bandage lens based on the photosensitive material provides an individual treatment means for ocular surface injury diseases with huge treatment demands in clinic.
Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic diagram of an in-situ gelling individually adapted corneal bandage lens according to the present invention;
fig. 2 is a diagram of the formulation of the photosensitive material of the corneal bandage lens of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Specific example 1:
referring to fig. 1-2, an in situ gelling, individually adapted corneal bandage lens of the present invention is used for repairing damaged portions of the cornea of the eye;
the cornea bandage mirror is made of photosensitive material;
the specific application and operation method of the corneal bandage lens comprises the following steps:
s01: dripping liquid photosensitive material on the damaged part of the cornea of the eye by an injector, and uniformly coating the liquid photosensitive material on the surface of the damaged cornea while filling the damaged part by utilizing the liquidity and plasticity of the liquid;
s02: irradiating for 10s by using a light source with the wavelength of 395nm to generate sound polymerization reaction;
s03: after the liquid photosensitive material is quickly gelatinized in situ, a bandage lens covering the injured part and the surface of the cornea is formed.
The formula of the photosensitive material is as follows:
gamma-methacryloxypropyltrimethoxysilane: 25 parts of (1);
n-vinylpyrrolidone: 30 parts of (1);
hydroxyethyl methacrylate: 1 part;
photo/thermal initiator: 1 part;
solvent: and 43 parts.
Wherein, D1173 is adopted as the photoinitiator.
Wherein the solvent is methanol.
Specific example 2:
the difference between this embodiment and embodiment 1 is that:
the formula of the photosensitive material is as follows:
gamma-methacryloxypropyltrimethoxysilane: 25 parts of (1);
n-vinylpyrrolidone: 35 parts of (B);
hydroxyethyl methacrylate: 0.2 part;
photo/thermal initiator: 0.8 part;
solvent: 39 parts.
Wherein, the thermal initiator adopts azobisisobutyronitrile.
Wherein the solvent is ethanol.
Has the advantages that:
the invention can pass through the photosensitive hydrogel material for irregular corneal injury, different individual palpebral fissure sizes and conjunctival sac sizes in clinic; the material can form gel in situ to achieve the purpose of individual matching, and the individual matching biological bandage lens based on the photosensitive material provides an individual treatment means for ocular surface injury diseases with huge treatment demands in clinic.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (5)
1. The utility model provides an in situ gelatinization individuation is joined in marriage cornea bandage mirror that adapts, is used for the partial restoration of cornea injury of eye, its characterized in that:
the cornea bandage mirror is made of a photosensitive material;
the specific application and operation method of the corneal bandage lens comprises the following steps:
s01: dripping liquid photosensitive material on the damaged part of the cornea of the eye by an injector, and uniformly coating the liquid photosensitive material on the surface of the damaged cornea while filling the damaged part by utilizing the liquidity and plasticity of the liquid;
s02: irradiating for 10s by using a light source with the wavelength of 395nm to generate sound polymerization reaction;
s03: after the liquid photosensitive material is quickly gelatinized in situ, a bandage lens covering the injured part and the surface of the cornea is formed.
2. The in-situ gel forming individualized fitting corneal bandage lens of claim 1, wherein the photosensitive material is formulated as follows:
gamma-methacryloxypropyltrimethoxysilane: 20-25 parts;
n-vinylpyrrolidone: 20-35 parts;
hydroxyethyl methacrylate: 0.2-1 part;
photo/thermal initiator: 0.5-2 parts;
solvent: 30-60 parts.
3. The in-situ gel forming individualized fitting corneal bandage lens of claim 2, wherein D1173 is used as the photoinitiator.
4. The in-situ gel forming individualized fitting corneal bandage lens of claim 2, wherein said thermal initiator is azobisisobutyronitrile.
5. The in-situ gelling individualized fitting corneal bandage lens according to claim 1, wherein said solvent is one or more of methanol, ethanol, propanol, butanol, or butanediol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110638599.1A CN113367883A (en) | 2021-06-08 | 2021-06-08 | Cornea bandage mirror that in situ becomes glue individuation and joins in marriage suitable |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110638599.1A CN113367883A (en) | 2021-06-08 | 2021-06-08 | Cornea bandage mirror that in situ becomes glue individuation and joins in marriage suitable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113367883A true CN113367883A (en) | 2021-09-10 |
Family
ID=77572783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110638599.1A Pending CN113367883A (en) | 2021-06-08 | 2021-06-08 | Cornea bandage mirror that in situ becomes glue individuation and joins in marriage suitable |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113367883A (en) |
-
2021
- 2021-06-08 CN CN202110638599.1A patent/CN113367883A/en active Pending
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