CN113351271A - Control method and controller of PCR analyzer - Google Patents
Control method and controller of PCR analyzer Download PDFInfo
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- CN113351271A CN113351271A CN202110511532.1A CN202110511532A CN113351271A CN 113351271 A CN113351271 A CN 113351271A CN 202110511532 A CN202110511532 A CN 202110511532A CN 113351271 A CN113351271 A CN 113351271A
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- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
Abstract
The invention relates to a control method of a PCR analyzer, which comprises the following steps: acquiring project information of a current PCR analysis project; acquiring state information of each reagent slot of the PCR analyzer, and distributing an idle reagent slot for a current PCR analysis project according to the state information; sending uncovering instruction information for opening the allocated reagent slot; judging whether a user puts a reagent cup into the allocated reagent slot position, if so, sending cover closing instruction information for closing the allocated reagent slot position; extracting amplification program parameters according to the project information, setting an amplification program, and operating the amplification program to perform PCR amplification; and extracting amplification result analysis parameters according to the project information, setting a result analysis program, and operating the result analysis program to perform PCR result analysis. The invention can realize intelligent propulsion of PCR analysis process, automatically realize distribution of reagent slots, amplification program setting and amplification result analysis, avoid complicated manual setting operation and error and omission and improve analysis efficiency.
Description
Technical Field
The invention relates to the technical field of biomedical treatment, in particular to a control method of a PCR analyzer, a controller, a computer storage medium and the PCR analyzer.
Background
PCR, polymerase chain reaction, is a molecular biology technique for amplifying specific DNA fragments, and can be regarded as special DNA replication in vitro, and the biggest characteristic of PCR is that a trace amount of DNA can be greatly increased. In the PCR, DNA is denatured at a high temperature of 95 ℃ in vitro to become a single strand, a primer and the single strand are combined according to the principle of base complementary pairing at a low temperature (usually about 60 ℃), the temperature is adjusted to the most suitable reaction temperature (about 72 ℃) for DNA polymerase, and the DNA polymerase synthesizes a complementary strand along the direction from phosphate to pentose. The PCR instrument manufactured based on polymerase is actually a temperature control device, and can be well controlled among denaturation temperature, renaturation temperature and extension temperature.
At present, the PCR analyzer still needs to be operated in a manual mode, information input, confirmation, control and the like are needed to be carried out on analysis items manually, and the mode is easy to make mistakes and low in efficiency.
Disclosure of Invention
In view of the above, it is necessary to provide a control method and a controller for a PCR analyzer, so as to solve the problems of the PCR analysis process that the manual operation is relied on, the error is easy to occur, and the efficiency is low.
The invention provides a control method of a PCR analyzer, which comprises the following steps:
acquiring project information of a current PCR analysis project;
acquiring state information of each reagent slot of the PCR analyzer, and distributing an idle reagent slot for a current PCR analysis project according to the state information;
sending uncovering instruction information for opening the allocated reagent slot;
judging whether a user puts a reagent cup into the allocated reagent slot position, if so, sending cover closing instruction information for closing the allocated reagent slot position;
extracting amplification program parameters according to the project information, setting an amplification program, and operating the amplification program to perform PCR amplification;
and extracting amplification result analysis parameters according to the project information, setting a result analysis program, and operating the result analysis program to perform PCR result analysis.
Further, acquiring item information of the current PCR analysis item specifically includes:
acquiring sample information, detection reagent information, amplification program parameter information, amplification result analysis parameter information and patient information of a current PCR analysis project to obtain project information;
and numbering the current PCR analysis item, and associating the sample information, the detection reagent information, the amplification program parameter information, the amplification result analysis parameter information and the patient information with the numbering information of the current PCR analysis item.
Further, after allocating a free reagent slot for the current PCR analysis item according to the status information, the method further includes:
the status of the dispensed reagent slot is modified to in use.
Further, extracting amplification program parameters and setting an amplification program according to the project information, and extracting amplification result analysis parameters and setting a result analysis program according to the project information specifically include:
the item information comprises detection reagent information, amplification program parameter information and amplification result analysis parameter information of the current PCR analysis item;
and setting an amplification program and a result analysis program according to the detection reagent information, the amplification program parameter information and the amplification result analysis parameter information.
Further, the method also comprises the following steps: and displaying the running state of the PCR analyzer in real time, and outputting prompt information of the next operation.
The invention also provides a controller of the PCR analyzer, which comprises a processor and a memory, wherein the memory is stored with a computer program, and the computer program is executed by the processor to realize the control method of the PCR analyzer.
The present invention also provides a computer storage medium, wherein the computer storage medium stores a computer program that, when executed by a processor, implements a method of controlling the PCR analyzer.
The invention also provides a PCR analyzer, which comprises a controller of the PCR analyzer, a code scanner, a slot bottom plate, an amplification detection device and a switch cover control device;
the code scanner is electrically connected with the controller and is used for collecting the item information of the current PCR analysis item;
the amplification detection device is detachably inserted into the reagent slot position of the slot bottom plate;
the slot bottom plate comprises a plurality of reagent slot positions, and each reagent slot position is electrically connected with the controller and used for sending the state information of the reagent slot position to the controller;
the cover opening and closing control device is electrically connected with the controller and receives the cover opening instruction information and the cover closing instruction information;
the cover opening and closing control device is respectively connected with the upper covers of the reagent slots and is used for controlling the upper covers of the distributed reagent slots to be opened according to the cover opening instruction information and controlling the upper covers of the reagent slots which are already put into the reagent cups to be closed according to the cover closing instruction information.
Further, the controller further comprises a touch screen, and the touch screen is electrically connected with the processor and used for performing human-computer interaction operation.
Further, the system also comprises a printing device and a peripheral communication device;
the printing device is electrically connected with the controller and is used for printing a PCR analysis result;
the peripheral communication device is electrically connected to the controller and is configured to provide an interface for interacting with peripheral devices.
Has the advantages that: according to the method, the project information of the PCR analysis project is obtained, so that the problems of high error probability and low efficiency in manual entry are solved; distributing idle reagent slots to current PCR analysis items according to the use states of the current reagent slots of the PCR analyzer, automatically popping up the upper cover by the distributed reagent slots according to the cover opening instruction information, and waiting for a user to put in a reagent cup; judging whether a user puts in a reagent cup or not, and sending cover closing instruction information to automatically close the upper cover of the reagent slot position after the user puts in the reagent cup; and automatically setting an amplification program and an amplification result analysis program according to the item information acquired by scanning the code, performing PCR amplification based on the set amplification program, and performing PCR result analysis based on the set result analysis program. The invention can realize the automatic information input, the automatic matching of the reagent slot position, the automatic opening and closing of the reagent slot position, the automatic setting of the amplification program and the automatic analysis of the amplification result during the PCR analysis, thereby realizing the automatic propulsion of the whole PCR analysis process, avoiding the excessive dependence of the operation process of the PCR analyzer on people, reducing the error rate and improving the analysis efficiency.
Drawings
FIG. 1 is a flowchart of a method of controlling a PCR analyzer according to a first embodiment of the present invention;
FIG. 2 is a schematic circuit diagram of a PCR analyzer according to a first embodiment of the present invention.
Detailed Description
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate preferred embodiments of the invention and together with the description, serve to explain the principles of the invention and not to limit the scope of the invention.
Example 1
As shown in fig. 1, embodiment 1 of the present invention provides a method for controlling a PCR analyzer, including the steps of:
s1, acquiring item information of the current PCR analysis item;
s2, acquiring state information of each reagent slot of the PCR analyzer, and distributing an idle reagent slot for the current PCR analysis project according to the state information;
s3, sending uncovering instruction information for opening the allocated reagent slot;
s4, judging whether the user puts the reagent cup in the allocated reagent slot position, if so, sending cover closing instruction information for closing the allocated reagent slot position;
s5, extracting amplification program parameters according to the project information, setting an amplification program, and operating the amplification program to perform PCR amplification;
and S6, extracting amplification result analysis parameters according to the project information, setting a result analysis program, and operating the result analysis program to analyze the PCR result.
According to the method, the project information of the PCR analysis project is firstly acquired, and the acquisition of the project information can be realized in a code scanning mode, so that the problems of high error probability and low efficiency in manual entry are solved; distributing idle reagent slots to current PCR analysis items according to the use states of the current reagent slots of the PCR analyzer, automatically popping up the upper cover by the distributed reagent slots according to the cover opening instruction information, and waiting for a user to put in a reagent cup; judging whether a user puts in the reagent cup, wherein the judgment of whether the reagent cup is put in or not can be realized by adopting a hardware detection mode, for example, the judgment can be realized by a mode that light intensity thresholds of special wavelength light are different under the condition that the reagent cup is present or absent, and the judgment of whether the reagent cup is put in or not can also be realized by man-machine interaction, namely, confirmation information is output, and an instruction for confirming that the reagent cup is put in is waited to be input by the user; after a user puts the reagent cup into the reagent cup, sending cover closing instruction information to automatically close the reagent slot position upper cover; and automatically setting an amplification program and an amplification result analysis program according to the item information acquired by scanning the code, performing PCR amplification based on the set amplification program, and performing PCR result analysis based on the set result analysis program.
The embodiment can realize automatic information input, automatic reagent slot position matching, automatic reagent slot position opening and closing, and automatic setting of an amplification program and a result analysis program during PCR analysis, thereby realizing automatic propulsion of the whole PCR analysis process, avoiding excessive dependence of the operation process of the PCR analyzer on people, reducing the error rate and improving the analysis efficiency.
Preferably, the acquiring of the item information of the current PCR analysis item specifically includes:
acquiring sample information, detection reagent information, amplification program parameter information, amplification result analysis parameter information and patient information of a current PCR analysis project to obtain project information;
and numbering the current PCR analysis item, and associating the sample information, the detection reagent information, the amplification program parameter information, the amplification result analysis parameter information and the patient information with the numbering information of the current PCR analysis item.
In this embodiment, the item information includes sample information, detection reagent information, amplification program parameter information, amplification result analysis parameter information, and patient information, and after the item information is obtained, all item information of the same item is associated for subsequent reference, query, and the like, for example, a user may query reagent information and patient information of a corresponding PCR analysis item according to the sample information.
Preferably, after allocating a free reagent slot for the current PCR analysis item according to the status information, the method further includes:
the status of the dispensed reagent slot is modified to in use.
The state detection of the reagent slot position can be realized by a hardware detection mode, and then the state acquisition, the state updating and the like are carried out, but the hardware detection usually needs time, if the state of a certain reagent slot position is not timely modified to be used after the reagent slot position is allocated, and other items need to be allocated to the reagent slot position at the moment, the phenomenon of repeated allocation can occur, so that the state of the corresponding reagent slot position is immediately modified after the reagent slot position is allocated in the embodiment. After the state of the allocated reagent slot position is modified, the detection state obtained by detecting the allocated reagent slot position can be obtained, whether the detection state is consistent with the current state or not is judged, if not, the reagent slot position is not utilized in time after allocation, and therefore prompt information is output, and a user is prompted to check and process the reagent slot position.
Preferably, the extracting amplification program parameters and setting an amplification program according to the item information, and the extracting amplification result analysis parameters and setting a result analysis program according to the item information specifically include:
the item information comprises detection reagent information, amplification program parameter information and amplification result analysis parameter information of the current PCR analysis item;
and setting an amplification program and a result analysis program according to the detection reagent information, the amplification program parameter information and the amplification result analysis parameter information.
At present, when a PCR analyzer carries out analysis, amplification programs are manually set, and errors are easily caused by the manual setting mode. Therefore, in the embodiment, the amplification program parameters and the amplification result analysis parameters are synchronously acquired while the detection reagent information is acquired, and the defect of manual setting is overcome.
Preferably, the method further comprises the following steps: and displaying the running state of the PCR analyzer in real time, and outputting prompt information of the next operation.
Because the operation of the PCR analyzer is easy to make mistakes during the manual operation process and the efficiency is low, the current operation state is displayed in real time during each operation step, so that the user can clearly know which step is currently performed, and meanwhile, prompt information of the operation of the next step is output to prompt the user what needs to be done next. The embodiment fixes the running process of the PCR analyzer, thereby greatly improving the accuracy and efficiency of the operation.
The method comprises the following steps of displaying the running state of the PCR analyzer in real time, and outputting prompt information of the next operation, and specifically comprises the following steps: when acquiring the project information recorded into the current PCR analysis project, displaying the project information; after the reagent slot positions are distributed for the current PCR analysis project, outputting the information of the distributed reagent slot positions, such as the serial numbers of the reagent slot positions, the position diagrams and the like, and prompting a user to put in a reagent cup; after a user puts in the reagent cup, displaying the closing state of the reagent slot position, and prompting the user to automatically set an amplification program in the next step; after the automatic setting of the amplification program is finished, the set amplification program and corresponding item information are displayed, and a user can manually correct the automatically set amplification program according to a display result, and if the automatic setting is wrong, the user manually adjusts the automatically set amplification program; and after the PCR analysis is finished based on the selected amplification program, displaying the analysis result, prompting the user to finish the analysis, inquiring whether the user needs to print the analysis result, and executing a printing command if the user selects to need.
It should be understood that the foregoing is illustrative only and is not to be construed as limiting the invention.
Example 2
As shown in fig. 2, embodiment 2 of the present invention provides a controller 1 of a PCR analyzer, which includes a processor 11 and a memory 12, where the memory 12 stores a computer program, and when the computer program is executed by the processor 11, the controller implements the control method of the PCR analyzer provided in embodiment 1.
The controller 1 of the PCR analyzer provided in the embodiment of the present invention is configured to implement a control method of the PCR analyzer, and therefore, the controller 1 of the PCR analyzer also has the technical effect of the control method of the PCR analyzer, which is not described herein again.
Example 3
Embodiment 3 of the present invention provides a computer storage medium having stored thereon a computer program that, when executed by a processor, implements the control method of the PCR analyzer provided in embodiment 1.
The computer storage medium provided by the embodiment of the invention is used for realizing the control method of the PCR analyzer, so that the technical effect of the control method of the PCR analyzer is achieved, and the computer storage medium also has the technical effect, and is not described herein again.
Example 4
As shown in fig. 2, embodiment 4 of the present invention provides a PCR analyzer, including a controller 1 of the PCR analyzer, further including a code scanner 2, a slot substrate 3, an amplification detection device 4, and a switch cover control device 5;
the code scanner 2 is electrically connected with the controller 1 and is used for collecting item information of a current PCR analysis item;
the amplification detection device 4 is detachably inserted into the reagent slot position 31 of the slot bottom plate 3;
the slot bottom plate 3 comprises a plurality of reagent slot positions 31, and each reagent slot position 31 is electrically connected with the controller 1 and used for sending status information of the reagent slot position to the controller 1;
the cover opening and closing control device 5 is electrically connected with the controller 1 and receives the cover opening instruction information and the cover closing instruction information;
the cover opening and closing control device 5 is respectively connected with the upper cover of each reagent slot 31 and is used for controlling the opening of the upper cover of the allocated reagent slot 31 according to the cover opening instruction information and controlling the closing of the upper cover of the reagent slot 31 which is already put into the reagent cup according to the cover closing instruction information.
The PCR analyzer of the present embodiment includes a barcode scanner 2, a slot substrate 3, an amplification detection device 4, and an open/close cover control device 5.
The code scanner 2 executes automatic code scanning operation, scans the code of the bar code information of the sample, the detection reagent and the patient, and automatically inputs the sample information, the detection reagent information and the patient information.
The amplification detection device 4 is used for realizing PCR detection analysis, and an interface is realized by adopting the prior art. The amplification detection device 4 in this embodiment includes a plurality of optical detection channels, a temperature sensor, a thermal cycling control system, and a reagent tank containing a reagent cup. The amplification detection device 4 has an external bus interface and can operate independently.
The slot bottom plate 3 is used for inserting the amplification detection device 4, the slot bottom plate 3 is provided with a plurality of slots, namely reagent slots 31, and eight reagent slots 31 are provided in the embodiment.
The number of the amplification detection devices 4 is configured according to the actual scene requirements, and the maximum number of the amplification detection devices 4 can be configured to be the same as the number of the reagent slots 3, in this embodiment, the maximum number of eight amplification detection devices 4 are configured, and the amplification detection devices 4 are connected through a communication bus and are controlled by the controller 1 in a unified manner.
The lid opening and closing control device 5 includes a lid opening and closing control circuit for transmitting the lid opening instruction information and the lid closing instruction information to the actuator, and an actuator for opening and closing the upper lid of the reagent slot 31. Specifically, the actuating mechanism is realized by adopting the prior art, and the opening and closing of the upper cover can be realized, for example, the actuating mechanism can be realized by adopting a motor, an electric push rod and the like.
The specific operation flow of the PCR analyzer provided in this embodiment is as follows: the code scanner 2 scans and records sample information, detection reagent information, amplification program parameter information, amplification result analysis parameter information and patient information, transmits item information obtained by scanning codes to the controller 1, and the controller 1 associates the sample, the detection reagent, the amplification program parameter information, the amplification result analysis parameter information and the patient according to the item information; the controller 1 allocates the idle reagent slot positions 31 according to the using states of the reagent slot positions 31 of the current PCR analyzer, the allocated reagent slot positions 31 automatically bounce the upper cover according to a switch instruction sent by the controller, wait for a user to put in a reagent cup, simultaneously pop up prompt information on a main control screen to prompt the user to put in the reagent cup, and after the user puts in the reagent cup, the main control screen guides the user to perform the next operation and automatically close the upper cover of the reagent slot positions 31; the controller 1 automatically sets an amplification program and an amplification result analysis program according to the detection reagent information obtained by scanning the code, and the amplification detection device 4 completes PCR amplification and analysis based on the set amplification program and result analysis program.
The PCR analyzer provided by the embodiment can realize automatic code scanning and information acquisition, automatic reagent slot position allocation, automatic cover opening and closing control, and automatic setting of an amplification program and a result analysis program.
Preferably, as shown in fig. 2, the controller 1 further includes a touch screen 13, and the touch screen 13 is electrically connected to the processor 11 and is configured to perform a human-computer interaction operation.
In this embodiment, the controller 1 is provided with a touch screen 13, and the controller 1 controls the whole analysis process and provides a human-computer interaction interface through the touch screen 13. After each reagent slot 31 is amplified, the master control screen displays the PCR analysis result of the corresponding reagent slot 31.
Preferably, as shown in fig. 2, the system further comprises a printing device 6 and a peripheral communication device 7;
the printing device 6 is electrically connected with the controller 1 and is used for printing PCR analysis results;
the peripheral communication means 7 are electrically connected to the controller 1 and are used to provide an interface for interaction with peripheral devices.
Specifically, in the embodiment, the printing device 6 is a thermal printer, and after the PCR analysis result is output to the touch screen 13 for display, and after the user confirms that the PCR analysis result is correct and selects the print result option, the printing device 6 prints the current PCR analysis result for the user to refer to.
The peripheral communication device 7 in this embodiment includes a wired network interface, a wireless network interface, a USB interface, and the like, and provides an interface for interaction between the PCR analyzer and the peripheral device.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention.
Claims (10)
1. A control method of a PCR analyzer is characterized by comprising the following steps:
acquiring project information of a current PCR analysis project;
acquiring state information of each reagent slot of the PCR analyzer, and distributing an idle reagent slot for a current PCR analysis project according to the state information;
sending uncovering instruction information for opening the allocated reagent slot;
judging whether a user puts a reagent cup into the allocated reagent slot position, if so, sending cover closing instruction information for closing the allocated reagent slot position;
extracting amplification program parameters according to the project information, setting an amplification program, and operating the amplification program to perform PCR amplification;
and extracting amplification result analysis parameters according to the project information, setting a result analysis program, and operating the result analysis program to perform PCR result analysis.
2. The method for controlling a PCR analyzer according to claim 1, wherein the acquiring of the item information of the current PCR analysis item specifically includes:
acquiring sample information, detection reagent information, amplification program parameter information, amplification result analysis parameter information and patient information of a current PCR analysis project to obtain project information;
and numbering the current PCR analysis item, and associating the sample information, the detection reagent information, the amplification program parameter information, the amplification result analysis parameter information and the patient information with the numbering information of the current PCR analysis item.
3. The method of controlling a PCR analyzer according to claim 1, further comprising, after allocating a free reagent slot to a current PCR analysis item according to the status information:
the status of the dispensed reagent slot is modified to in use.
4. The method for controlling a PCR analyzer according to claim 1, wherein the extracting amplification program parameters and setting an amplification program according to the item information, and the extracting amplification result analysis parameters and setting a result analysis program according to the item information specifically include:
the item information comprises detection reagent information, amplification program parameter information and amplification result analysis parameter information of the current PCR analysis item;
and setting an amplification program and a result analysis program according to the detection reagent information, the amplification program parameter information and the amplification result analysis parameter information.
5. The method for controlling a PCR analyzer according to claim 1, further comprising: and displaying the running state of the PCR analyzer in real time, and outputting prompt information of the next operation.
6. A controller for a PCR analyzer, comprising a processor and a memory, the memory having a computer program stored thereon, the computer program, when executed by the processor, implementing a method of controlling a PCR analyzer according to any one of claims 1-5.
7. A computer storage medium characterized in that the computer program realizes the control method of the PCR analyzer according to any one of claims 1 to 5 when executed by a processor.
8. A PCR analyzer comprising the controller of the PCR analyzer of claim 6, further comprising a code scanner, a slot floor, an amplification detection means, and an open/close cover control means;
the code scanner is electrically connected with the controller and is used for collecting the item information of the current PCR analysis item;
the amplification detection device is detachably inserted into the reagent slot position of the slot bottom plate;
the slot bottom plate comprises a plurality of reagent slot positions, and each reagent slot position is electrically connected with the controller and used for sending the state information of the reagent slot position to the controller;
the cover opening and closing control device is electrically connected with the controller and receives the cover opening instruction information and the cover closing instruction information;
the cover opening and closing control device is respectively connected with the upper covers of the reagent slots and is used for controlling the upper covers of the distributed reagent slots to be opened according to the cover opening instruction information and controlling the upper covers of the reagent slots which are already put into the reagent cups to be closed according to the cover closing instruction information.
9. The PCR analyzer as claimed in claim 8, wherein the controller further comprises a touch screen electrically connected to the processor for performing human-computer interaction.
10. The PCR analyzer of claim 8, further comprising a printing device and a peripheral communication device;
the printing device is electrically connected with the controller and is used for printing a PCR analysis result;
the peripheral communication device is electrically connected to the controller and is configured to provide an interface for interacting with peripheral devices.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2432901A (en) * | 1999-12-13 | 2001-06-18 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | High-throughput tissue microarray technology and applications |
| CN112394185A (en) * | 2019-08-19 | 2021-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Reference substance position distribution method and sample analysis system |
| CN112501000A (en) * | 2020-11-17 | 2021-03-16 | 温州市中心医院 | Portable nucleic acid detection case |
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2021
- 2021-05-11 CN CN202110511532.1A patent/CN113351271B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2432901A (en) * | 1999-12-13 | 2001-06-18 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | High-throughput tissue microarray technology and applications |
| CN112394185A (en) * | 2019-08-19 | 2021-02-23 | 深圳迈瑞生物医疗电子股份有限公司 | Reference substance position distribution method and sample analysis system |
| CN112501000A (en) * | 2020-11-17 | 2021-03-16 | 温州市中心医院 | Portable nucleic acid detection case |
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