CN113351017B - Extraction device for gaseous iodine in loop for producing iodine-125 - Google Patents
Extraction device for gaseous iodine in loop for producing iodine-125 Download PDFInfo
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- CN113351017B CN113351017B CN202110697116.5A CN202110697116A CN113351017B CN 113351017 B CN113351017 B CN 113351017B CN 202110697116 A CN202110697116 A CN 202110697116A CN 113351017 B CN113351017 B CN 113351017B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D59/00—Separation of different isotopes of the same chemical element
- B01D59/22—Separation by extracting
- B01D59/26—Separation by extracting by sorption, i.e. absorption, adsorption, persorption
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B7/00—Halogens; Halogen acids
- C01B7/13—Iodine; Hydrogen iodide
- C01B7/14—Iodine
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- Chemical Kinetics & Catalysis (AREA)
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Abstract
The invention belongs to the field of radioisotope preparation, and relates to a device for extracting gaseous iodine in a loop for producing iodine-125, which comprises a turntable, an extraction mechanism and a fixed seat, wherein the extraction mechanism is arranged in the turntable, one end of each of two symmetrically arranged air nozzles is fixedly connected with the turntable and is butted and communicated with a first gas channel in the extraction mechanism, the other end of each of the two symmetrically arranged air nozzles is inserted into the fixed seat and is respectively butted and communicated with two second gas channels in the fixed seat, the two second gas channels, the two air nozzles and the first gas channel form a closed circulating gas loop for gas to enter and exit, and an iodine separation material is arranged in the first gas channel. The extraction mechanism can be plugged on the loop device as an independent structure. The extraction mechanism can prevent iodine-125 generated in the loop from participating in the irradiation of the circulation loop. Only the extraction mechanism needs to be leached during recovery, so that the processes of xenon-125 gas transfer, liquid nitrogen freezing, target cylinder cutting and the like are reduced, the operation flow is simplified, the repeated use is realized, and the cost is reduced.
Description
Technical Field
The invention belongs to the technical field of radioisotope preparation, relates to a device for extracting gaseous iodine in a loop for producing iodine-125, and is particularly suitable for extracting and separating the iodine-125 during the irradiation production of the iodine-125 by a continuous circulation loop method.
Background
Iodine-125 is an important medical radionuclide (T)1/259.407d), because of its advantages of longer half-life, moderate energy and small radiation damage to human tissues, it has been widely used in biomedicine, radioimmunoassay, in vitro diagnosis and close-range implantation for treating tumors. However, at present, domestic iodine-125 raw materials completely depend on import for a long time. Therefore, the research and development of the novel iodine-125 production process are developed, the foreign monopoly is broken through, the core key technology is mastered, the localization of the iodine-125 raw material is realized, and the method has great scientific and practical significance for promoting the development of the nuclear medicine whole industrial chain.
By utilizing the advantages of reactors and matched resources, a large amount of experimental verification is completed in our hospital, and a technical method and a device for producing iodine-125 by a continuous cyclic irradiation method are provided, and a patent is granted (CN 1068954068). In order to reduce the content of iodine-126 impurities, improve the quality of iodine-125 and improve the utilization rate of xenon-124 gas, the method creatively designs an iodine-125 extraction device in a loop device, the design and the use of the device not only can realize the preparation of high-quality iodine-125, but also reduces the processes of xenon-125 gas transfer, xenon-125 decay, liquid nitrogen freezing, target cylinder cutting, alkali liquor leaching, extraction and the like required by the traditional method, greatly simplifies the process flow and reduces the cost. However, the loop production apparatus in this method is a gas loop, and iodine-125 is volatilizedHas strong radioactivity, and the extraction device has certain radioactivity after absorbing iodine-125, thereby considering the safety in the production process (the gas leakage rate is less than or equal to 1 multiplied by 10)-7Pa·m3S) and high efficiency practicality (efficient recovery of iodine, simplified operation, reduced exposure to personnel dose), it is desirable to design an extraction device that can be easily inserted and extracted from the circuit, has a low leakage rate, and is self-shielding. Based on the above, the invention designs a device for extracting gaseous iodine, which is particularly suitable for extracting iodine-125 in a loop for producing iodine-125 by a continuous circulation irradiation method.
Disclosure of Invention
The invention aims to provide a device for extracting gaseous iodine in a loop for producing iodine-125, which aims to solve the potential safety hazard caused by volatilization of the gaseous iodine-125 in the existing loop device for producing the iodine-125, efficiently recover, simplify the extraction operation process of the iodine-125, reduce the irradiation dose of personnel, meet the requirement of high air tightness and save the cost.
The invention is realized by the following technical scheme: including the carousel, draw mechanism, fixing base, draw the mechanism to install in the carousel, the one end fixed connection of two air faucets that the symmetry set up the carousel and with draw first gas passage butt joint, intercommunication in the mechanism, each the other end of air cock inserts the fixing base and respectively with two second gas passage butt joints, intercommunication in the fixing base, two second gas passage and two air faucets, first gas passage form the gaseous business turn over of confession, inclosed circulating gas return circuit, set up iodine separating material in the first gas passage.
Preferably, the extraction mechanism includes two connectors and a column core, each of the connectors is connected to two ends of the column core in a butt joint manner, one of the connectors is provided with an air inlet duct, the other of the connectors is provided with an air outlet duct, one end of the air inlet duct and one end of the air outlet duct are respectively connected to two ends of the inner hole of the column core in a butt joint manner, the other ends of the air inlet duct and the air outlet duct are respectively connected to each of the air nozzles in a butt joint manner, and the air inlet duct, the inner hole of the column core and the air outlet duct form the first gas channel.
Preferably, the extraction mechanism further comprises a first threaded sleeve, a second threaded sleeve, two pressing sleeves and two first filter screens, the first threaded sleeve is fixed in the air inlet end of the column core, the second threaded sleeve is fixed in the air outlet end of the column core, the first filter screens are respectively clamped inside the first threaded sleeve and the second threaded sleeve, the pressing sleeves are respectively sleeved inside the first threaded sleeve and the second threaded sleeve, and the first filters are located between the pressing sleeves and the corresponding first threaded sleeve and the corresponding second threaded sleeve.
Preferably, the extraction mechanism further comprises a gasket and a second filter screen, the second filter screen is located inside the first threaded sleeve, and the gasket is located between the second filter screen and the corresponding first filter screen.
Preferably, a clamping plate and an extending plate are further respectively arranged at one end, close to the rotary table, of the fixed seat, the rotary table is arranged between the clamping plate and the extending plate, a locking plate is arranged at one end, far away from the fixed seat, of the extending plate, the locking plate is rotatable, a hook groove is formed in one end, far away from the fixed seat, of the clamping plate, and one end, far away from the extending plate, of the locking plate is rotatable to the hook groove.
Preferably, the extension plate and the locking plate are connected by a positioning bolt.
Preferably, each air faucet is in threaded connection with the rotating disc.
Preferably, a sealing ring is sleeved outside each connector and each air faucet.
Preferably, the outer diameter of the column core is 4-10mm, the wall thickness is less than or equal to 2mm, the column height is less than or equal to 3cm, and the mesh number of the first filter screen and the second filter screen is greater than or equal to 300 meshes.
Preferably, the sum of the thicknesses of the fixed seat and the rotary disc is greater than or equal to 20 mm.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) through setting up and drawing mechanism, fixing base, carousel, will draw the mechanism to install in the carousel, air cock and carousel fixed connection, with fixing base swing joint, and set up gas passage respectively in drawing mechanism, fixing base to set up iodine separating material in gas passage, form inclosed circulationAnd the gas loop, the extraction device and other equipment form an integral loop system together after being connected with the loop device. The extraction mechanism and the turntable are independent structures and can be plugged in and pulled out from the loop device. The extraction mechanism prevents the iodine-125 generated in the loop from participating in the further conversion of the circulation loop into iodine-126 impurities through irradiation, reduces the content of the iodine-126 impurities to the maximum extent, improves the quality of the iodine-125, and simultaneously improves the repeated utilization rate of the xenon-124 gas. In the process of recovering the iodine-125, the iodine can be recovered by simply leaching the extraction mechanism125I]Dissolving sodium into solution. Compared with the extraction method of iodine in the traditional method, the extraction device of the invention reduces the complicated processes of xenon-125 gas transfer, liquid nitrogen freezing, target cylinder cutting and the like, is simple and practical, greatly simplifies the operation flow, reduces the cost, and can be reused.
(2) And a sealed circulating gas loop is formed by the joint, the column core, the gas inlet pore channel and the gas outlet pore channel and the second gas channel.
(3) By arranging the first threaded sleeve, the second threaded sleeve, the pressing sleeve, the first filter screen, the gasket and the second filter screen, the sealing performance of a circulating gas loop is ensured to be good, and the requirement that the leakage rate is less than or equal to 1 multiplied by 10 is met-7Pa·m3Requirement of/s. Meanwhile, gas entering and exiting is filtered, and the blockage of a gas circuit is avoided.
(4) Cardboard, extension board, jam plate, positioning bolt's setting plays limiting displacement to the carousel, prevents that the carousel from removing by oneself, ensures the inseparable combination of carousel and fixing base, provides overall device's stability, reliability.
Drawings
The accompanying drawings, which are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principles of the invention. In the drawings:
FIG. 1 is a cross-sectional view of the present invention;
FIG. 2 is an enlarged view of a portion of the structure at A in FIG. 1;
FIG. 3 is a schematic structural diagram of an extraction base according to the present invention;
in the figure: 1 carousel, 2 fixing bases, 3 air cocks, 401 inlet channel, 402 outlet channel, 5 second gas channels, 6 joints, 7 post cores, 8 first swivel nuts, 9 second swivel nuts, 10 pressure cover, 11 first filter screen, 12 packing rings, 13 second filter screens, 14 cardboard, 15 extension boards, 16 jam plates, 17 hook grooves, 18 positioning bolt, 19 sealing washers.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.
Example 1
The utility model provides an extraction element for producing gaseous state iodine in return circuit of iodine-125, includes carousel 1, draws mechanism, fixing base 2, draw the mechanism to install in carousel 1, draw and be equipped with the first gas passage who supplies the gas circulation in the mechanism, be equipped with two second gas passage 5 that supply the gas circulation in the fixing base 2, one of them second gas passage 5 is the passageway that the gas got into, another second gas passage 5 is the passageway that the gas flows out, be provided with two air cocks 3 between carousel 1 and fixing base 2 symmetrically, each air cock 3 all is equipped with the gas passage with outside intercommunication, the one end of each air cock 3 inserts carousel 1 and with threaded connection, and with draw the first gas passage butt joint in the mechanism, the intercommunication, the other end of each air cock 3 movably inserts fixing base 2, and respectively with two second gas passage 5 butt joints in the fixing base 2, The intercommunication, a gas cock 3 corresponds a second gas passage 5 that 2 gas supplies of fixing base got into, and another gas cock 3 corresponds another second gas passage 5 that 2 gas supplies of fixing base gas outflow, two second gas passage 5 and two gas cocks 3, first gas passage form the gaseous business turn over of confession, inclosed circulating gas return circuit.
The fixed base 2 is connected with an external loop device for producing iodine-125, and forms an integral loop system together with other equipment, one end of the air faucet 3 is fixedly connected with the rotary table 1, and the other end of the air faucet is non-fixedly connected with the fixed base 2, so that the rotary table 1 and the two air faucets 3 can be pulled out of the fixed base 2 together, and the two air faucets 3 can be inserted into the fixed base 2 during installation.
Example 2:
this example is a modification made on the basis of example 1.
On the basis of embodiment 1, the extraction mechanism comprises two joints 6 and a column core 7, wherein the column core 7 is a hollow tubular structure, and an iodine-125 adsorbing material is filled in the column core 7. Each of the joints 6 is butted at two ends of the column core 7, one of the joints 6 is provided with an air inlet channel 401 communicated with the outside, the other of the joints 6 is provided with an air outlet channel 402 communicated with the outside, the air inlet channel 401 and the air outlet channel 402 are both L-shaped channels, one ends of the air inlet channel 401 and the air outlet channel 402 are respectively butted at two ends of the inner hole of the column core 7, the other ends of the air inlet channel 401 and the air outlet channel 402 are respectively butted with the gas channel of each air nozzle 3 correspondingly, and the air inlet channel 401, the inner hole of the column core 7 and the air outlet channel 402 jointly form the first gas channel for gas to enter and exit.
The rotary table 1 is cylindrical, a through inner hole is formed in the rotary table 1, the structure of the inner hole is matched with the peripheral structures of the two joints 6 and the column core 7, the column core 7 and the two joints 6 can be arranged in the rotary table 1, threads can be formed on the inner hole wall, threads are formed on the outer peripheral surfaces of the two joints 6 and the column core 7, and the joints 6 and the column core 7 are connected with the rotary table 1 through the threads.
In order to strengthen the airtightness between the column core 7 and the joint 6 and to filter the gas between the gas nozzle 3 and the joint 6, the extraction mechanism is further provided with a first thread insert 8, a second thread insert 9, two pressure sleeves 10 and two first filter screens 11, the first thread insert 8 is fixed in the gas inlet end of the column core 7, the second thread insert 9 is fixed in the gas outlet end of the column core 7, and the first thread insert 8, the second thread insert 9 and the column core 7 can be connected by adopting threaded connection. Each first filter screen 11 is fixedly clamped inside the first threaded sleeve 8 and the second threaded sleeve 9 respectively, each pressing sleeve 10 is sleeved inside the first threaded sleeve 8 and the second threaded sleeve 9 respectively and is in threaded connection with the first threaded sleeve 8 and the second threaded sleeve 9, and each first filter is located between the pressing sleeve 10 and the corresponding first threaded sleeve 8 and the corresponding second threaded sleeve 9.
Because the gaseous impurity that gets into from external loop gear, in order to strengthen the filter effect of post core 7 inlet end, avoid impurity to get into and cause the jam to whole gas passage in the post core 7 to strengthen the leakproofness, it still is equipped with packing ring 12, second filter screen 13 to draw the mechanism, second filter screen 13 fixed card is in first swivel nut 8, packing ring 12 is located second filter screen 13 with first filter screen 11.
Example 3:
this embodiment is an improvement over embodiment 1 and embodiment 2.
A clamping plate 14 and an extending plate 15 are respectively arranged at one end of the fixed seat 2 close to the rotary table 1, the extending plate can be integrally formed with the fixed seat 2, the rotary table 1 can be placed between the clamping plate 14 and the extending plate 15, a locking plate 16 is arranged at one end of the extending plate 15 far away from the fixed seat 2, the locking plate 16 is connected with the extending plate 15 through a positioning bolt 18, the locking plate 16 can rotate relative to the extending plate 15, a through hook groove 17 is arranged at one end of the clamping plate 14 far away from the fixed seat 2, one end of the locking plate 16 far away from the extending plate 15 can rotate into the hook groove 17 and can be detachably fixed with the hook groove 17, for example, a pin can be used for fixing the locking plate 16 with the hook groove 17, the locking plate 16, the positioning bolt 18 and the hook groove 17 are matched, and can apply extrusion force towards the fixed seat 2 to the rotary table 1, so that the rotary table 1 and the fixed seat 2 are combined more tightly, meanwhile, the rotary table 1 is convenient to pull out from the fixed seat 2. The fixed seat 2, the clamping plate 14, the extension plate 15, the locking plate 16 and the positioning bolt 18 jointly form an extraction base.
In the invention, a sealing ring 19 can be sleeved outside each connector 6 and each air tap 3, and the sealing ring 19 can be made of polyimide or perfluorinated rubber; the fixed seat 2, the rotary table 1, the column core 7, the filter screen, the thread sleeve, the pressing sleeve 10 and the gasket are all made of stainless steel 301 or 304; the outer diameter of the column core 7 is 4-10mm, the wall thickness is less than or equal to 2mm, the column height is less than or equal to 3cm, and the mesh number of the filter screen is more than or equal to 300 meshes; the sum of the thicknesses of the fixed seat 2 and the rotary table 1 is more than or equal to 20mm, namely the thickness of the self-shielding is more than or equal to 20 mm. The total weight of the whole set of extraction device does not exceed 2kg, and the leakage rate is less than or equal to 1 multiplied by 10-7Pa·m3/s。
When the iodine extraction and separation device is used, according to the structure shown in the attached drawing 1, the column core 7 is inserted into the rotary table 1 and filled with iodine extraction and separation materials, the pressing sleeve 10, the filter screen, the gasket, the threaded sleeve and the joint 6 are sequentially assembled, each air nozzle 3 is connected with the rotary table 1 and then connected with the fixed seat 2, the assembled rotary table 1 is installed on an extraction base, and the rotary table 1 is hermetically installed on the fixed seat 2 through the rubber ring. The locking plate 16 is then rotated into the hook slot 17, locking the turntable 1. The fixed seat 2 is fixed with an external loop device, the extraction device, the loop device and other equipment which are installed form a closed circulation loop, and gaseous iodine realizes continuous circulation in the loop under the drive of the pump. In the circulation process, when the mixed gas passes through the extraction device, the iodine-125 is selectively extracted, and other gases continue to circulate into the irradiation device for irradiation decay, so that the circulation is repeated, and the efficient selective recovery of the iodine-125 is realized. After a period of extraction is finished, the locking plate 16 is rotated to release the limit of the turntable 1, the turntable 1 is taken down by the manipulator, and the sodium iodide solution can be obtained by simply leaching the turntable 1.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. An apparatus for extracting gaseous iodine from a loop for the production of iodine-125, comprising: the iodine extraction device comprises a rotary table (1), an extraction mechanism and a fixed seat (2), wherein the extraction mechanism is installed in the rotary table (1), one ends of two symmetrically arranged air nozzles (3) are fixedly connected with the rotary table (1) and are in butt joint and communication with a first gas channel in the extraction mechanism, the other end of each air nozzle (3) is movably inserted into the fixed seat (2) and is in butt joint and communication with two second gas channels (5) in the fixed seat (2) respectively, the two second gas channels (5), the two air nozzles (3) and the first gas channel form a closed circulating gas loop for gas to enter and exit, and an iodine separation material is arranged in the first gas channel;
the fixed seat (2) is connected with an external loop for producing iodine-125, the two air nozzles (3) are inserted into the fixed seat (2) during installation, and the turntable (1) and the two air nozzles (3) can be pulled out of the fixed seat (2) together.
2. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 1, wherein: draw mechanism includes two joints (6), post core (7), each joint (6) butt joint is in the both ends of post core (7), one set up inlet channel (401) in joint (6), another set up outlet channel (402) in joint (6), inlet channel (401), outlet channel's (402) one end butt joint respectively two ends of post core (7) hole, inlet channel (401), the other end of outlet channel (402) correspond respectively and butt joint respectively air cock (3), inlet channel (401), post core (7) hole, outlet channel (402) are constituteed first gas passage.
3. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 2, wherein: the extraction mechanism further comprises a first threaded sleeve (8), a second threaded sleeve (9), two pressing sleeves (10) and two first filter screens (11), the first threaded sleeve (8) is fixed in the air inlet end of the column core (7), the second threaded sleeve (9) is fixed in the air outlet end of the column core (7), the first filter screens (11) are respectively clamped inside the first threaded sleeve (8) and the second threaded sleeve (9), the pressing sleeves (10) are respectively sleeved inside the first threaded sleeve (8) and the second threaded sleeve (9), and the first filter screens are located between the pressing sleeves (10) and the corresponding first threaded sleeve (8) and the corresponding second threaded sleeve (9).
4. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 3, wherein: the extraction mechanism further comprises a gasket (12) and a second filter screen (13), the second filter screen (13) is located inside the first threaded sleeve (8), and the gasket (12) is located between the second filter screen (13) and the corresponding first filter screen (11).
5. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 1, wherein: fixing base (2) are close to the one end of carousel (1) still is equipped with cardboard (14), extension board (15) respectively, carousel (1) is arranged in between cardboard (14), extension board (15), the one end that extension board (15) kept away from fixing base (2) is equipped with jam plate (16), jam plate (16) are rotatable, cardboard (14) are kept away from hook groove (17) have been seted up to the one end of fixing base (2), jam plate (16) are kept away from the one end of extension board (15) is rotatable extremely in hook groove (17).
6. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 5, wherein: the extension plate (15) and the lock plate (16) are connected by a positioning bolt (18).
7. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 1, wherein: each air tap (3) is in threaded connection with the turntable (1).
8. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 2, wherein: and sealing rings (19) are sleeved outside the joints (6) and the air nozzles (3).
9. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 4, wherein: the outer diameter of the column core (7) is 4-10mm, the wall thickness is less than or equal to 2mm, the column height is less than or equal to 3cm, and the filter screen mesh number of the first filter screen (11) and the second filter screen (13) is more than or equal to 300 meshes.
10. An extraction device of gaseous iodine in a circuit for the production of iodine-125 according to claim 1, wherein: the sum of the thicknesses of the fixed seat (2) and the rotary table (1) is more than or equal to 20 mm.
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| WO2023098981A1 (en) * | 2021-11-30 | 2023-06-08 | Framatome Gmbh | Device for subjecting probes to irradiation in the core of a heavy water reactor, diverter, installation for producing activated probes in the core of a heavy water reactor and heavy water reactor |
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