CN113331335A - Prebiotic composition, solid beverage and preparation method of solid beverage - Google Patents

Prebiotic composition, solid beverage and preparation method of solid beverage Download PDF

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Publication number
CN113331335A
CN113331335A CN202110593024.2A CN202110593024A CN113331335A CN 113331335 A CN113331335 A CN 113331335A CN 202110593024 A CN202110593024 A CN 202110593024A CN 113331335 A CN113331335 A CN 113331335A
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China
Prior art keywords
parts
oligosaccharide
solid beverage
prebiotic composition
prebiotic
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Pending
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CN202110593024.2A
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Chinese (zh)
Inventor
熊欣
王颖
游海军
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Hubei Mingde Medical Technology Co ltd
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Hubei Mingde Medical Technology Co ltd
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Priority to CN202110593024.2A priority Critical patent/CN113331335A/en
Publication of CN113331335A publication Critical patent/CN113331335A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a prebiotic composition, a solid beverage and a preparation method thereof, wherein the prebiotic composition comprises the following raw materials in parts by weight: 50-70 parts of fructo-oligosaccharide, 10-30 parts of isomaltooligosaccharide, 5-15 parts of inulin, 5-10 parts of galacto-oligosaccharide, 2-6 parts of stachyose, 2-6 parts of xylo-oligosaccharide, 1-3 parts of oat beta-glucan and 1-3 parts of chitosan oligosaccharide. According to the invention, multiple prebiotics are compounded, and the ratio of prebiotics inulin to isomaltooligosaccharide and the ratio of oat beta-glucan to chitosan oligosaccharide in the components are adjusted, so that the components have synergistic effect, the intestinal flora is effectively balanced, a large amount of intestinal beneficial bacteria are proliferated, the intestinal function is adjusted, and further the constipation is obviously improved. Erythritol with good palatability can be added into the prebiotic composition to prepare solid beverage, which is especially suitable for people with fast pace of life, insufficient intake of dietary fiber, irregular life and rest, unbalanced intestinal flora and lack of exercise.

Description

Prebiotic composition, solid beverage and preparation method of solid beverage
Technical Field
The invention relates to the technical field of health-care food, and in particular relates to a prebiotic composition, a solid beverage and a preparation method thereof.
Background
In recent years, with the improvement of living standard of people, the intake of high protein, high calorie food and fine food is greatly increased, the intake of dietary fiber is obviously reduced, and various 'rich diseases', such as obesity, hyperglycemia, hyperlipidemia, hypertension, constipation and the like, are further caused. Constipation is a common disease, seriously affects the life quality of people, is easy to suffer from constipation in different age groups, and is a high-incidence group of constipation particularly for the old. Because the traditional medicine can not fundamentally treat chronic diseases such as intestinal dysfunction, abnormal glycolipid metabolism and the like, only symptoms can be controlled. For the source intestinal flora imbalance, a medicine or health-care food which can adjust the intestinal flora, fundamentally treat chronic diseases, relieve the pain of patients, reduce side effects and benefit the patients with the intestinal flora imbalance is urgently needed.
Prebiotics are substances that promote the growth and reproduction of probiotics. It is a non-digestible food ingredient that improves human health by selectively activating the growth and activity of one or more microorganisms in the human intestinal tract. Prebiotics have multiple effects: for example, prebiotics can increase the volume of the intestine and shorten the retention time of digesta in the intestine by producing intestinal gas through the fermentation of the intestinal flora, thereby promoting defecation; prebiotics lower intestinal pH by changing from protein fermentation (ammonia production, high pH) to more carbohydrate fermentation (acid production); the prebiotics can also provide energy for the intestinal probiotics, proliferate the probiotics, inhibit the growth of harmful bacteria, improve the microenvironment of the intestinal tract and regulate the balance of the intestinal bacteria.
Disclosure of Invention
The invention aims to provide a prebiotic composition, a solid beverage and a preparation method thereof, and the prebiotic composition and the solid beverage can be used for uniformly proliferating beneficial bacteria in intestinal tracts, improving intestinal flora, promoting bowel clearing and relaxing, improving constipation and maintaining intestinal health by compounding a plurality of prebiotics and exerting a synergistic effect among the components.
In order to achieve the purpose, the invention adopts the technical scheme that:
the invention provides a prebiotic composition, which comprises the following raw materials in parts by weight: 50-70 parts of fructo-oligosaccharide, 10-30 parts of isomaltooligosaccharide, 5-15 parts of inulin, 5-10 parts of galacto-oligosaccharide, 2-6 parts of stachyose, 2-6 parts of xylo-oligosaccharide, 1-3 parts of oat beta-glucan and 1-3 parts of chitosan oligosaccharide.
Preferably, in the prebiotic composition, the weight ratio of inulin to isomaltooligosaccharide is 1:1 to 3.
Preferably, in the prebiotic composition, the weight ratio of inulin to isomaltooligosaccharide is 1: 2.
preferably, in the prebiotic composition, the weight ratio of oat beta-glucan to chitosan oligosaccharide is 1: 1.
Preferably, the prebiotic composition comprises the following raw materials in parts by weight: 60 parts of fructo-oligosaccharide, 20 parts of isomaltooligosaccharide, 10 parts of inulin, 8 parts of galacto-oligosaccharide, 5 parts of stachyose, 4 parts of xylo-oligosaccharide, 2 parts of oat beta-glucan and 2 parts of chitosan oligosaccharide.
The invention also provides application of the prebiotic composition in preparation of medicines, functional foods and health-care foods with the functions of clearing bowels and relaxing bowels.
The invention also provides a prebiotic solid beverage for clearing bowels and relaxing bowels, which comprises the prebiotic composition.
Preferably, the solid beverage further comprises: sugar and/or sugar alcohol.
Preferably, the solid beverage further comprises: 1-3 parts of erythritol by weight.
The invention also provides a preparation method of the prebiotics solid beverage for clearing bowels and relaxing bowels, which comprises the following steps:
s1, weighing the raw material components in parts by weight;
s2, fully mixing the weighed raw materials;
and S3, quantitatively packaging the uniformly mixed materials to obtain the prebiotics solid beverage.
Compared with the prior art, the invention has the beneficial effects that: according to the invention, multiple prebiotics are compounded, and the ratio of prebiotics inulin to isomaltooligosaccharide and the ratio of oat beta-glucan to chitosan oligosaccharide in the components are adjusted, so that the components have synergistic effect, the intestinal flora is effectively balanced, a large amount of intestinal beneficial bacteria are proliferated, the intestinal function is adjusted, and further the constipation is obviously improved. Erythritol with good palatability can be added into the prebiotic composition to prepare prebiotic solid beverage, which is especially suitable for people with fast pace of life, insufficient intake of dietary fiber, irregular work and rest of life, unbalanced intestinal flora and lack of exercise.
Drawings
Fig. 1 is a graph of the effect of prebiotic solid beverages of examples 1-6 of the present invention on the defecation time of a subject;
fig. 2 is a graph of the effect of prebiotic solid beverages of examples 1-6 of the present invention on the frequency of defecation in a subject;
fig. 3 is a graph of the effect of prebiotic solid beverages of examples 1-6 of this invention on a subject's difficult to defecate condition;
fig. 4 is a graph showing the effect of prebiotic solid beverages of examples 1-6 of the present invention on the proliferation of fecal bifidobacteria in a subject.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides a prebiotics solid beverage for clearing bowels and relaxing bowels, which comprises the following raw materials in parts by weight: 60 parts of fructo-oligosaccharide, 20 parts of isomaltooligosaccharide, 10 parts of inulin, 8 parts of galacto-oligosaccharide, 5 parts of stachyose, 4 parts of xylo-oligosaccharide, 2 parts of oat beta-glucan, 2 parts of chitosan oligosaccharide and 2 parts of erythritol.
The preparation method of the prebiotics solid beverage comprises the following steps:
s1, weighing the raw material components according to the parts by weight;
s2, fully mixing the weighed raw materials;
and S3, quantitatively packaging the uniformly mixed materials, wherein each bag contains 10g of the uniformly mixed materials, so as to obtain the prebiotics solid beverage.
Example 2
The present embodiment is different from embodiment 1 in that: the prebiotics solid beverage comprises the following raw materials in parts by weight: 52 parts of fructo-oligosaccharide, 12 parts of isomaltooligosaccharide, 5 parts of inulin, 5 parts of galacto-oligosaccharide, 2 parts of stachyose, 2 parts of xylo-oligosaccharide, 1 part of oat beta-glucan, 1 part of chitosan oligosaccharide and 1 part of erythritol.
Example 3
The present embodiment is different from embodiment 1 in that: the prebiotics solid beverage comprises the following raw materials in parts by weight: 68 parts of fructo-oligosaccharide, 30 parts of isomaltooligosaccharide, 13 parts of inulin, 10 parts of galacto-oligosaccharide, 6 parts of stachyose, 6 parts of xylo-oligosaccharide, 3 parts of oat beta-glucan, 3 parts of chitosan oligosaccharide and 3 parts of erythritol.
Example 4
The present embodiment is different from embodiment 1 in that: the prebiotics solid beverage comprises 30 parts of isomaltooligosaccharide and 10 parts of inulin, and the rest components are the same as in example 1.
Example 5
The present embodiment is different from embodiment 1 in that: the prebiotics solid beverage comprises 20 parts of isomaltooligosaccharide and 20 parts of inulin, and the rest components are the same as example 1.
Example 6
The present embodiment is different from embodiment 1 in that: in the prebiotics solid beverage, 3 parts of oat beta-glucan and 1 part of chitosan oligosaccharide are contained, and the rest components are the same as those in the embodiment 1.
Evaluation protocol
Subject: 120 sub-healthy people with constipation problem.
The experimental method comprises the following steps: subjects were randomly divided into A, B, C, D, E, F six experimental groups of 20 people each. A, B, C, D, E, F six groups of the prebiotic solid beverage prepared in examples 1-6 are respectively provided for administration for 2 weeks, and are taken 2 times a day, and one bag of prebiotic solid beverage is taken once.
And (4) judging the efficacy: registering defecation time, defecation frequency, defecation difficulty and the like before and after the subject uses the prebiotics solid beverage; and (4) comparing and analyzing the improvement condition, and randomly selecting people for each example to perform a probiotic proliferation influence test. The results of the measurement were as follows:
the defecation time before and after the subjects use the prebiotic solid beverage is shown in figure 1, and the results show that the prebiotic solid beverage prepared by the invention in the examples 1-6 can obviously improve the defecation time of sub-healthy people, wherein the defecation time of the A group and the C group is relatively more than 10min, and the A group is the most after the prebiotic solid beverage in the examples 1 and 3 is used. When the ratio of isomaltose hypgather to inulin in the composition was changed as shown in examples 4 and 5, the number of people who had stood for more than 25min was still relatively large, i.e., the improvement effect on the stooling time was somewhat reduced, as compared to example 1.
The frequency of defecation before and after the subjects use the prebiotic solid beverage is shown in figure 2, and the results show that the prebiotic solid beverage prepared by the invention in the examples 1-6 can increase the frequency of defecation of sub-healthy people, wherein the frequency of defecation of the A group and the C group, namely the prebiotic solid beverage prepared by the examples 1 and 3, is relatively more than that of the A group with 1-2 days per time, and the A group is the most. When the ratio of isomaltooligosaccharide to inulin in the composition was changed compared to that in example 1, the number of people with defecation frequency of 4-5 days/time was relatively large, that is, the effect of improving defecation frequency of the prebiotic solid beverage shown in example 4-5 was relatively reduced.
The statistical result of whether the subjects have difficulty in defecation before and after using the prebiotics solid beverage is shown in fig. 3, and the results show that the prebiotics solid beverages prepared in the examples 1-6 of the invention can improve the situation of difficulty in defecation of the sub-health people, wherein the A group has the advantages that the subjects have easy defecation and the number of people without difficulty in defecation is obviously increased after using the prebiotics solid beverage shown in the example 1. When the content of the components is changed, particularly the proportion of the isomaltooligosaccharide and the inulin is changed, the number of people who often have difficult defecation is relatively large, namely the effect of improving the difficult defecation of the sub-health people by the prebiotics solid beverage shown in the example 4-5 is reduced to different degrees.
The statistical results of the detected amount of bifidobacteria in feces before and after the subjects use the prebiotic solid beverage are shown in fig. 4, and the results show that the prebiotic solid beverages prepared in examples 1-6 of the present invention can significantly promote the proliferation of intestinal probiotics, wherein the proliferation effect of group a is the best. When the content of the components is changed, particularly the proportion of the isomaltooligosaccharide and the inulin is changed, the proliferation amount of the intestinal probiotics is reduced, namely the proliferation effect of the prebiotics solid beverage shown in the example 4-5 on the intestinal probiotics is reduced to different degrees.
The prebiotics solid beverage has the advantages of having obvious effects of clearing intestines and relaxing bowels, increasing the intake of people with insufficient dietary fiber intake, conditioning the balance of intestinal flora and improving the intestinal function. And the change of the proportion of the raw materials in the components has certain influence on the defecation promoting and probiotic proliferation effects, when the raw material components are the formula shown in example 1, the formula can promote the proliferation of the intestinal probiotics to the maximum extent, and has the most obvious improvement effect on the defecation time, the defecation frequency and the defecation difficulty degree of a subject.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention.

Claims (10)

1. The prebiotic composition is characterized by comprising the following raw materials in parts by weight: 50-70 parts of fructo-oligosaccharide, 10-30 parts of isomaltooligosaccharide, 5-15 parts of inulin, 5-10 parts of galacto-oligosaccharide, 2-6 parts of stachyose, 2-6 parts of xylo-oligosaccharide, 1-3 parts of oat beta-glucan and 1-3 parts of chitosan oligosaccharide.
2. Prebiotic composition according to claim 1, characterized in that the weight ratio of inulin and isomaltooligosaccharide in the prebiotic composition is 1:1 to 3.
3. Prebiotic composition according to claim 2, wherein the weight ratio of inulin to isomaltooligosaccharide in the prebiotic composition is 1: 2.
4. the prebiotic composition of claim 1, wherein the weight ratio of oat beta-glucan to chitosan oligosaccharide in the prebiotic composition is from 1: 1.
5. the prebiotic composition of claim 1, comprising the following raw materials in parts by weight: 60 parts of fructo-oligosaccharide, 20 parts of isomaltooligosaccharide, 10 parts of inulin, 8 parts of galacto-oligosaccharide, 5 parts of stachyose, 4 parts of xylo-oligosaccharide, 2 parts of oat beta-glucan and 2 parts of chitosan oligosaccharide.
6. Use of prebiotic composition according to any of claims 1-5 in the manufacture of a medicament, functional food, health food having bowel clearing and laxative properties.
7. A prebiotic solid beverage for clearing the bowels and relaxing the bowels, which is characterized in that the prebiotic composition of any one of claims 1 to 5 is included in the solid beverage.
8. The prebiotic solid beverage for relaxing bowels according to claim 7, further comprising: sugar and/or sugar alcohol.
9. The prebiotic solid beverage for bowel cleansing and relaxing according to claim 8, further comprising: 1-3 parts of erythritol by weight.
10. The method for preparing prebiotic solid beverage for bowel cleansing and laxation according to any one of claims 7 to 9, wherein the method comprises:
s1, weighing the raw material components in parts by weight;
s2, fully mixing the weighed raw materials;
and S3, quantitatively packaging the uniformly mixed materials to obtain the prebiotics solid beverage.
CN202110593024.2A 2021-05-28 2021-05-28 Prebiotic composition, solid beverage and preparation method of solid beverage Pending CN113331335A (en)

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CN113841775A (en) * 2021-09-06 2021-12-28 无棣珍康生物科技有限公司 Beneficial food capable of removing malignant free radicals
CN114586982A (en) * 2022-03-01 2022-06-07 武汉英纽林生物科技有限公司 Nutritional formula product for improving constipation during pregnancy
CN114651982A (en) * 2022-03-22 2022-06-24 北大荒完达山乳业股份有限公司 Composition capable of delaying postprandial blood sugar, preparation method and application thereof
CN115152918A (en) * 2022-07-04 2022-10-11 广东唯盈达健康科技有限公司 Formula and production process of multi-element probiotic solid beverage
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CN116019226A (en) * 2022-12-14 2023-04-28 青岛琛蓝生物营养技术有限公司 Chitosan oligosaccharide prebiotic composition for relaxing bowel and enhancing immunity and application thereof
CN116869169A (en) * 2023-09-07 2023-10-13 四川合泰新光生物科技有限公司 Composition with function of relaxing bowels and preparation method and application thereof

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CN116019226A (en) * 2022-12-14 2023-04-28 青岛琛蓝生物营养技术有限公司 Chitosan oligosaccharide prebiotic composition for relaxing bowel and enhancing immunity and application thereof
CN116869169A (en) * 2023-09-07 2023-10-13 四川合泰新光生物科技有限公司 Composition with function of relaxing bowels and preparation method and application thereof
CN116869169B (en) * 2023-09-07 2023-11-28 四川合泰新光生物科技有限公司 Composition with function of relaxing bowels and preparation method and application thereof

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Application publication date: 20210903