CN113318294A - Implantable intrathecal drug infusion pump - Google Patents
Implantable intrathecal drug infusion pump Download PDFInfo
- Publication number
- CN113318294A CN113318294A CN202110539264.4A CN202110539264A CN113318294A CN 113318294 A CN113318294 A CN 113318294A CN 202110539264 A CN202110539264 A CN 202110539264A CN 113318294 A CN113318294 A CN 113318294A
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- China
- Prior art keywords
- pump
- infusion pump
- implantable
- drug
- shell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 80
- 229940079593 drug Drugs 0.000 title claims abstract description 34
- 238000001802 infusion Methods 0.000 title claims abstract description 23
- 238000007913 intrathecal administration Methods 0.000 title claims abstract description 23
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 25
- 238000002347 injection Methods 0.000 claims abstract description 21
- 239000007924 injection Substances 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims description 23
- 241000463219 Epitheca Species 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract description 4
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 abstract description 2
- 208000000094 Chronic Pain Diseases 0.000 abstract description 2
- 208000002193 Pain Diseases 0.000 abstract description 2
- 208000005392 Spasm Diseases 0.000 abstract description 2
- 229960000794 baclofen Drugs 0.000 abstract description 2
- 238000011866 long-term treatment Methods 0.000 abstract description 2
- 229960005181 morphine Drugs 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 3
- 230000008499 blood brain barrier function Effects 0.000 description 2
- 210000001218 blood-brain barrier Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 206010010071 Coma Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 210000001951 dura mater Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention relates to the technical field of infusion devices, in particular to an implantable intrathecal drug infusion pump. The implantable intrathecal drug infusion pump comprises an upper shell, a middle shell component and a lower shell, wherein the middle shell component comprises a drug injection port arranged at the center of the shell, a peristaltic pump, a motor driving mechanism, a circuit board and a battery are sequentially arranged in the shell and around the drug injection port, the motor driving mechanism comprises a driving gear connected with a motor, the driving gear is meshed with the peristaltic pump, a catheter component is connected on the peristaltic pump in a surrounding manner, and a drug storage chamber is arranged at the lower end of the drug injection port in the shell. The implantable intrathecal drug infusion pump can be used for intrathecal infusion of morphine, baclofen and other drugs, is used for long-term treatment of refractory chronic pain and refractory central spasm, and is beneficial to reducing the burden of patients and saving social resources.
Description
Technical Field
The invention relates to a drug infusion pump, in particular to an implantable intrathecal drug infusion pump.
Background
Patients take or inject analgesic drugs, spasmolytic drugs, central chemotherapy drugs and the like orally or statically for a long time, dosage needs to be increased, after the concentration of the periphery rises, the medicine can penetrate through a blood brain barrier to reach a target point, but meanwhile, the high-concentration drugs at the periphery can bring serious side effects: addiction, constipation, nausea, emesis, coma, lethargy, and impairment of liver and kidney functions; the intrathecal administration directly injects the medicine under the dura mater to reach the cerebrospinal fluid and the central nervous system and avoid the blood brain barrier, so the dosage is small and a plurality of side effects can be avoided; the device for intrathecal administration is also available in the market, but is in a semi-implanted type, a medicine box is arranged outside the body, the middle of the medicine box is connected through a puncture device, and the puncture port is arranged on the body surface, so that a patient can not leave a department for a long time, can not use the medicine box for a long time, is not beneficial to personal sanitation and hygiene, is easy to cause infection, even the infection can enter the center, causes serious consequences, can not perform nuclear magnetic resonance, and is not beneficial to the diagnosis and treatment of tumors.
Disclosure of Invention
The invention aims to solve the defects and provides an implantable intrathecal drug infusion pump.
In order to overcome the defects in the background art, the technical scheme adopted by the invention for solving the technical problems is as follows: the implantable intrathecal drug infusion pump comprises an upper shell, a middle shell component and a lower shell, wherein the middle shell component comprises a drug injection port arranged at the center of the shell, a peristaltic pump, a motor driving mechanism, a circuit board and a battery are sequentially arranged in the shell and around the drug injection port, the motor driving mechanism comprises a driving gear connected with a motor, the driving gear is meshed with the peristaltic pump, a catheter component is connected on the peristaltic pump in a surrounding manner, and a drug storage chamber is arranged at the lower end of the drug injection port in the shell.
According to another embodiment of the present invention, it is further included that the catheter assembly includes a pump tube, one end of the pump tube is connected to the drug storage chamber through a built-in inlet connection tube to form a pump tube liquid inlet, and the other end of the pump tube is connected to the liquid outlet through a built-in outlet connection tube.
According to another embodiment of the invention, the peristaltic pump further comprises a rotary table, a gear connected to the upper end of the rotary table, and roller frames engaged around the rotary table, wherein each roller frame is fixedly connected with a roller.
According to another embodiment of the invention, the pump tube is arranged around and clamped at the side of the roller.
According to another embodiment of the invention, the medicine storage chamber is composed of a medicine storage bin and a high-pressure gas chamber, and the medicine storage bin is arranged in the high-pressure gas chamber.
According to another embodiment of the invention, the medicine injection port is connected with the medicine storage bin through a connecting inclined hole.
According to another embodiment of the present invention, the shell further comprises a first-aid opening formed on the shell of the middle shell assembly.
According to another embodiment of the present invention, it further comprises that the upper and lower cases are detachably connected to the upper and lower ends of the middle case assembly, and the medicine injection port is connected to the middle case assembly.
The invention has the beneficial effects that: the implantable intrathecal drug infusion pump can be used for intrathecal infusion of morphine, baclofen and other drugs, is used for long-term treatment of refractory chronic pain and refractory central spasm, and is beneficial to reducing the burden of patients and saving social resources.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic structural view in a left side view;
FIG. 3 is a schematic view of the structure of FIG. 1 except for the upper case;
FIG. 4 is a schematic top view of the structure of FIG. 3;
FIG. 5 is a schematic view of the structure of FIG. 3 in the direction B-B;
FIG. 6 is a schematic view of the structure in the direction A-A in FIG. 4;
FIG. 7 is a schematic view of the structure of FIG. 4 in the direction C-C;
FIG. 8 is a schematic view of the structure of FIG. 4 in the direction D-D;
FIG. 9 is a schematic structural view showing an operating state of the peristaltic pump;
FIG. 10 is a schematic structural view of another operating state of the peristaltic pump;
wherein: 1. the device comprises an upper shell, 2, a middle shell component, 3, a lower shell, 4, a peristaltic pump, 5, a motor driving mechanism, 6, a catheter component, 7, a medicine storage bin, 8, a medicine injection port, 9, a battery, 10, a circuit board, 11, a motor, 12, a driving gear, 13, a medicine storage chamber, 14, a pump pipe, 15, an outlet connecting pipe, 16, a high-pressure gas chamber, 17, an inlet connecting pipe, 18, a liquid outlet, 19, a rotary table, 20, a roller frame, 21, a roller, 22, a gear, 23 and a first-aid port.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 8, which include an upper case 1, a middle case assembly 2, and a lower case 3, the middle case assembly 2 includes a medicine injection port 8 disposed at the center of the case, in the shell, peristaltic pump 4, motor driving mechanism 5, circuit board 10 and battery 9 are set in turn around medicine injection port 8, motor driving mechanism 5 includes driving gear 12 connected with motor 11 and motor 11, driving gear 12 is meshed with peristaltic pump 4, conduit assembly 6 is connected around peristaltic pump 4, one end of conduit assembly 6 is connected in the shell, medicine storage chamber 13 is set at the lower end of medicine injection port 8, one end of conduit assembly 6 is connected with medicine storage chamber 13, then peristaltic pump 4 is surrounded, the other end is connected to liquid outlet 18, the whole structure runs through motor 11, motor 11 drives driving gear 12, then peristaltic pump 4 is driven to rotate, the liquid medicine in the medicine storage bin is pushed forwards by the peristaltic pump 4 pressing the pump tube in the pipe assembly 6.
Preferably, as shown in fig. 7 and 8, the catheter assembly 6 comprises a pump tube 14, the pump tube 14 is an elastic pump tube, one end of the pump tube 14 is connected to the medicine storage chamber 13 through a built-in inlet connecting tube 17 to form a pump tube liquid inlet, and the other end of the pump tube 14 is connected to a liquid outlet 18 through a built-in outlet connecting tube 15, wherein the inlet connecting tube 17 and the outlet connecting tube 15 are inserted into and connected to two ends of the pump tube 14.
Preferably, as shown in fig. 5, the peristaltic pump 4 comprises a rotary table 19, a gear 22 connected to the upper end of the rotary table 19, and roller frames 20 engaged around the rotary table 19, wherein each roller frame 20 is fixedly connected with a roller 21, and the pump tube 14 is pressed against the side of the roller 21.
Preferably, the pump tube 14 surrounds and is clamped below the roller 21, and the roller 21 rotates to push the liquid medicine in the medicine storage bin forward.
Preferably, as shown in fig. 6, the medicine storage chamber 13 is composed of a medicine storage bin 7 and a high-pressure gas chamber 16, the medicine storage bin 7 is arranged in the high-pressure gas chamber 16, the medicine storage chamber 13 is a sealed structure, and the high-pressure gas in the high-pressure gas chamber 16 is used as a propelling power to propel the medicine liquid in the medicine storage bin 7 forwards.
Preferably, the medicine injection port 8 is connected with the medicine storage bin 7 through a connecting inclined hole.
Preferably, as shown in fig. 1, the housing of the mid-housing assembly 2 is also provided with an emergency port 23. The first-aid opening 23 is used for filling liquid medicine and drawing liquid from the first-aid opening, and the first-aid opening 23 can directly draw out the liquid medicine transferred by the peristaltic pump, so that the liquid medicine cannot flow out of the liquid outlet and cannot enter a human body.
Preferably, the upper case 1 and the lower case 3 are detachably coupled to the upper and lower ends of the middle case assembly 2, and the medicine injection port 8 is coupled to the upper case 1.
Examples
When in use, before the intrathecal drug infusion pump is implanted into the body, the injector is used for injecting the drug liquid into the drug injection port, after the intrathecal drug infusion pump is implanted into the body, the doctor judges the positions of the medicine injection port and the first-aid port through the template provided by the doctor to fill liquid medicine and draw liquid from the first-aid port, after the medicine is injected, as shown in fig. 1-10, the battery 9 supplies power to the motor 11, the motor 11 operates, the motor 11 drives the driving gear 12, the driving gear 12 drives the gear 22 at the upper end of the peristaltic pump 4 to rotate, the gear 22 drives the turntable 19 to rotate, the turntable 19 drives the roller frame 20 engaged around the turntable 19 to rotate, the roller frame 20 rotates to rotate the roller 21 fixedly connected to the roller frame 20, the liquid medicine in the pump tube 14 clamped at the lower end of the roller 21 is slowly squeezed out, as shown in fig. 9 and 10, namely, when the peristaltic pump 4 works, the high-pressure gas in the high-pressure gas chamber 16 of the medicine storage chamber 13 is used as propulsion power to propel the medicine liquid in the medicine storage bin 7 forwards.
When first aid is needed, the first aid opening can directly extract the liquid medicine transferred by the peristaltic pump, so that the liquid medicine cannot flow out of the liquid outlet and cannot enter the human body.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. The utility model provides an intrathecal drug infusion pump of implantable, includes epitheca (1), mesochite subassembly (2) and inferior valve (3), a serial communication port, mesochite subassembly (2) sets gradually peristaltic pump (4), motor drive mechanism (5), circuit board (10) and battery (9) including arranging injection mouth (8) at the casing center in, around injection mouth (8) in the casing, motor drive mechanism (5) include drive gear (12) that motor (11) and motor (11) are connected, drive gear (12) meshing peristaltic pump (4), encircle on peristaltic pump (4) and connect catheter subassembly (6), in the casing, the lower extreme of injection mouth (8) is equipped with storage medicine cavity (13).
2. The implantable intrathecal infusion pump as in claim 1, wherein the catheter assembly (6) comprises a pump tube (14), one end of the pump tube (14) being connected to the drug reservoir chamber (13) by a built-in inlet connection tube (17) forming a pump tube inlet, the other end of the pump tube (14) being connected to the liquid outlet (18) by a built-in outlet connection tube (15).
3. The implantable intrathecal infusion pump as in claim 1, wherein the peristaltic pump (4) comprises a rotating disc (19), a gear (22) connected to the upper end of the rotating disc (19), and roller stands (20) engaged around the rotating disc (19), each roller stand (20) being fixedly connected to a roller (21).
4. The implantable intrathecal infusion pump as in claim 1, 2 or 3, wherein the pump tube (14) is wrapped around, clipped to the side of the roller (21).
5. The implantable intrathecal infusion pump as in claim 1, wherein the drug reservoir chamber (13) is composed of a drug reservoir (7) and a high pressure gas chamber (16), the drug reservoir (7) being placed in the high pressure gas chamber (16).
6. The implantable intrathecal infusion pump as in claim 1 or 5, wherein the drug injection port (8) is connected to the drug reservoir (7) by means of a connecting angled hole.
7. The implantable intrathecal infusion pump as in claim 1, wherein the housing of the mid-housing assembly (2) is further provided with a first-aid port (23).
8. The implantable intrathecal infusion pump as in claim 1, wherein the upper and lower housings (1, 3) are detachably connected to the upper and lower ends of the middle housing assembly (2), and the injection port (8) is connected to the middle housing assembly (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110539264.4A CN113318294A (en) | 2021-05-18 | 2021-05-18 | Implantable intrathecal drug infusion pump |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110539264.4A CN113318294A (en) | 2021-05-18 | 2021-05-18 | Implantable intrathecal drug infusion pump |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113318294A true CN113318294A (en) | 2021-08-31 |
Family
ID=77415890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110539264.4A Pending CN113318294A (en) | 2021-05-18 | 2021-05-18 | Implantable intrathecal drug infusion pump |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113318294A (en) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5752930A (en) * | 1995-04-28 | 1998-05-19 | Medtronic, Inc. | Implantable techniques for infusing equal volumes of agents to spaced sites |
| US20020151846A1 (en) * | 2001-04-13 | 2002-10-17 | Christenson Steven R. | Implantable drug delivery device with peristaltic pump having retracting roller |
| US20020173755A1 (en) * | 2001-04-13 | 2002-11-21 | Christenson Steven R. | Implantable drug delivery device with peristaltic pump having a bobbin roller assembly |
| US6485464B1 (en) * | 2000-04-28 | 2002-11-26 | Medtronic, Inc. | Reduced height implantable drug infusion device |
| US20030199855A1 (en) * | 2002-04-22 | 2003-10-23 | Rogers Charles R. | Implantable infusion device with optimized peristaltic pump motor drive |
| US20070073250A1 (en) * | 2005-07-08 | 2007-03-29 | Schneiter James A | Implantable port |
| US20090264870A1 (en) * | 2008-04-18 | 2009-10-22 | Medtronic, Inc. | Implantable infusion device having filter |
| CN204745191U (en) * | 2015-06-25 | 2015-11-11 | 佛山可为医疗科技有限公司 | Accurate medicine infusion system |
| CN204910236U (en) * | 2015-08-28 | 2015-12-30 | 武汉大学 | Implanted abdominal cavity multitube chemotherapy device |
| CN209771078U (en) * | 2018-12-17 | 2019-12-13 | 深圳市擎源医疗器械有限公司 | drug delivery device |
| US20200016368A1 (en) * | 2018-07-13 | 2020-01-16 | Medtronic, Inc. | Curved catheter for increased intrathecal drug dispersion |
| CN211188555U (en) * | 2019-09-27 | 2020-08-07 | 武汉大学 | Subcutaneous implantation type abdominal cavity chemotherapy device |
| CN216091721U (en) * | 2021-05-18 | 2022-03-22 | 常州瑞神安医疗器械有限公司 | Implantable intrathecal drug infusion pump |
-
2021
- 2021-05-18 CN CN202110539264.4A patent/CN113318294A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5752930A (en) * | 1995-04-28 | 1998-05-19 | Medtronic, Inc. | Implantable techniques for infusing equal volumes of agents to spaced sites |
| US6485464B1 (en) * | 2000-04-28 | 2002-11-26 | Medtronic, Inc. | Reduced height implantable drug infusion device |
| US20020151846A1 (en) * | 2001-04-13 | 2002-10-17 | Christenson Steven R. | Implantable drug delivery device with peristaltic pump having retracting roller |
| US20020173755A1 (en) * | 2001-04-13 | 2002-11-21 | Christenson Steven R. | Implantable drug delivery device with peristaltic pump having a bobbin roller assembly |
| US20030199855A1 (en) * | 2002-04-22 | 2003-10-23 | Rogers Charles R. | Implantable infusion device with optimized peristaltic pump motor drive |
| US20070073250A1 (en) * | 2005-07-08 | 2007-03-29 | Schneiter James A | Implantable port |
| US20090264870A1 (en) * | 2008-04-18 | 2009-10-22 | Medtronic, Inc. | Implantable infusion device having filter |
| CN204745191U (en) * | 2015-06-25 | 2015-11-11 | 佛山可为医疗科技有限公司 | Accurate medicine infusion system |
| CN204910236U (en) * | 2015-08-28 | 2015-12-30 | 武汉大学 | Implanted abdominal cavity multitube chemotherapy device |
| US20200016368A1 (en) * | 2018-07-13 | 2020-01-16 | Medtronic, Inc. | Curved catheter for increased intrathecal drug dispersion |
| CN209771078U (en) * | 2018-12-17 | 2019-12-13 | 深圳市擎源医疗器械有限公司 | drug delivery device |
| CN211188555U (en) * | 2019-09-27 | 2020-08-07 | 武汉大学 | Subcutaneous implantation type abdominal cavity chemotherapy device |
| CN216091721U (en) * | 2021-05-18 | 2022-03-22 | 常州瑞神安医疗器械有限公司 | Implantable intrathecal drug infusion pump |
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| Title |
|---|
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