CN113317996A - Tooth whitening product based on pyroelectric effect and preparation method thereof - Google Patents
Tooth whitening product based on pyroelectric effect and preparation method thereof Download PDFInfo
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- CN113317996A CN113317996A CN202110555940.7A CN202110555940A CN113317996A CN 113317996 A CN113317996 A CN 113317996A CN 202110555940 A CN202110555940 A CN 202110555940A CN 113317996 A CN113317996 A CN 113317996A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/242—Exothermic; Self-heating; Heating sensation
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Abstract
The invention discloses a tooth whitening product based on a pyroelectric effect and a preparation method thereof, wherein the preparation method of the tooth whitening product comprises the following steps: mixing the pyroelectric material with the gel to prepare the pyroelectric gel, coating the pyroelectric gel on the surface of the tooth covering object, and finally pasting the backing layer on the pyroelectric gel to obtain the tooth whitening product based on the pyroelectric effect. The tooth whitening product prepared by the invention can realize tooth whitening by utilizing the temperature change of the oral cavity caused by diet, respiration, conversation, movement and other factors in daily life, and has simple method and low cost.
Description
Technical Field
The invention relates to the field of tooth whitening products, in particular to a tooth whitening product based on a pyroelectric effect and a preparation method thereof.
Background
Oral health is more and more paid attention by the public, and as some daily activities (such as smoking, tea drinking and the like), eating habits (such as berries, beverages, red wine, seasonings and the like) and poor oral hygiene conditions and the like of people easily cause tooth discoloration, in recent years, the tooth whitening industry is rapidly developed, and related tooth whitening technical researches are widely concerned.
There are a number of methods of tooth whitening currently on the market. One common method of tooth whitening is the use of whitening toothpaste to treat discoloration and staining of the tooth surface. Whitening toothpastes generally contain more abrasives and cleaning agents to remove harder stains than standard toothpastes. However, abrasives have limited effectiveness in tooth whitening and can cause damage to the enamel layer on the tooth surface, which can increase the chance of the tooth becoming discolored again.
Another method of whitening is to use chemical whitening actives, which are applied to the teeth for a period of time and the active acts on the teeth to ultimately achieve the whitening goal. A common whitening agent has a peroxide as a main component, and when a high concentration of hydrogen peroxide is used, the observed whitening effect is stronger, that is, as the concentration of hydrogen peroxide increases, the degree of penetration into teeth due to a concentration difference increases, and the amount of hydrogen peroxide causing a reaction increases, thereby improving the decomposition performance of pigments, that is, the tooth whitening effect.
However, the main whitening component of any whitening agent, such as 30% hydrogen peroxide, carbamide peroxide and the like, or cold light source whitening is hydrogen peroxide. Hydrogen peroxide has strong oxidizing property at high concentration, can damage skin and mucosa of people, can permeate into the structural depth of enamel, and can cause irreversible damage to the enamel and dentin, even damage to dental pulp, and cause untoward effects such as pulpitis and the like. Such methods can bleach the teeth in a short period of time, increasing tooth gloss, but over time, the teeth become more discolored and even more colored (dead pulp) due to the damaged enamel layer on the tooth surface. Moreover, the equipment for bleaching teeth is expensive, and a patient needs to pay higher cost for bleaching teeth each time; the operation process is complex, and special working conditions and strict working environment are required.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a tooth whitening product based on a pyroelectric effect and a preparation method thereof. The invention contacts the pyroelectric gel with teeth, realizes tooth whitening by utilizing the temperature change of the oral cavity caused by diet, respiration, conversation, movement and other factors in daily life, and has simple method and low cost.
The technical scheme of the invention is as follows:
the preparation method of the tooth whitening product based on the pyroelectric effect comprises the following steps: mixing the pyroelectric material with the gel to prepare the pyroelectric gel, coating the pyroelectric gel on the surface of the tooth covering object, and finally pasting the backing layer on the pyroelectric gel to obtain the tooth whitening product based on the pyroelectric effect.
The pyroelectric material is potassium sodium niobate or LiNbO3、LiTaO3、BaTiO3、BiFeO3One or more of CdS, lead magnesium niobate-lead titanate, barium strontium niobate and barium strontium titanate.
The particle size of the pyroelectric material is 50 nm-10 mu m.
The gel is a medical gel.
The mixing is that the pyroelectric material and the gel are mixed according to the mass ratio of 1: (10-1000) mixing and stirring uniformly.
The tooth covering is one or more of a tooth socket, a tooth paste, a tooth support and a tooth paste.
The back lining layer is one or more of an EVA film, a PVA film, a PLA film and a zein film.
The thickness of the coating is 1 mu m-1 mm.
A tooth whitening product prepared by a preparation method of the tooth whitening product based on the pyroelectric effect.
A tooth whitening method, comprising: and (3) stripping a back lining layer of the prepared tooth whitening product, contacting one surface of the tooth covering object with the pyroelectric gel with teeth, and taking down the tooth covering object after 0.5-8 h to realize the tooth whitening effect.
The beneficial technical effects of the invention are as follows:
(1) the pyroelectric gel is attached to teeth, and the pyroelectric property of the pyroelectric material is activated by utilizing the temperature change of the oral cavity caused by diet, respiration, conversation, movement and other factors in daily life, so that a large amount of active free radicals are generated, stains on the surfaces of the teeth are degraded, and the whitening of the teeth is realized.
(2) The tooth whitening product prepared by the invention can be contacted with teeth after coating the pyroelectric gel in the tooth coating, realizes tooth whitening by utilizing the temperature change of the oral cavity, is convenient to use, is safe and nontoxic due to the pyroelectric material, and cannot cause damage to teeth, skin, nerves, mucous membranes and the like.
(3) The pyroelectric gel used in the invention can be recycled, has a long period of validity, and can realize efficient tooth whitening.
Drawings
Fig. 1 is a schematic view of the composition and principle of the tooth whitening product according to the present invention.
FIG. 2 is a schematic diagram of the catalytic effect of the pyroelectric material used in the present invention.
Fig. 3 is an observation of the effect of the tooth whitening product prepared in example 2 of the present invention in tooth whitening.
FIG. 4 is a graph showing the results of experiments on the degradation of indigo carmine by the pyroelectric material used in example 2 of the present invention under the cold and heat cycles.
FIG. 5 is a graph showing the results of tests for determining the influence of the temperature change range and the number of cold and hot cycles on the active radicals of the pyroelectric material used in example 2 of the present invention.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings and examples.
Fig. 1 is a schematic view of the composition and principle of the tooth whitening product according to the present invention. As shown in fig. 1, when the gel containing the pyroelectric material is contacted with teeth, the pyroelectric material in the gel generates active free radicals under the change of the oral cavity temperature, and after the active free radicals meet stains on the surfaces of the teeth, the active free radicals attack conjugated double bonds in the stains, so that the stains are degraded, and the whitening effect is achieved.
FIG. 2 is a schematic diagram of the catalytic effect of the pyroelectric material used in the present invention. As shown in fig. 2, the surface of the pyroelectric material has different charges due to its own polarity. When the temperature of the pyroelectric material is raised, the heterogeneous charges on the surface of the pyroelectric material are released, and if the pyroelectric material is in an aqueous solution, the released heterogeneous charges are combined with molecules in water to form active free radicals (OH and O)2-, the active free radicals can degrade stains on the tooth surface. When the temperature stops changing, the surface of the pyroelectric material forms a new static balance. When the pyroelectric material is cooled, the pyroelectric material absorbs the heterogeneous charges from the water solution, then the charges remained in the water continue to react with the molecules in the water to form active free radicals (OH and O)2-). Therefore, catalytic degradation can be performed using the pyroelectric material as long as a continuous temperature change can be applied to the pyroelectric material.
Example 1
A tooth whitening product based on the pyroelectric effect is prepared by the following steps:
barium titanate (BaTiO) with a particle size of 50-200 nm3) And medical gel in a mass ratio of 1: 10, stirring at the speed of 200r/min for 5 hours to prepare barium titanate gel; coating the barium titanate gel on the surface of the tooth socket, wherein the coating thickness is 50 mu m, and finally pasting a back lining layer (EVA film) on the barium titanate gel to obtain the tooth whitening product based on the pyroelectric effect.
The application method of the tooth whitening product prepared in the embodiment 1 of the invention comprises the following steps: after the EVA film of the tooth whitening product prepared in the embodiment 1 of the invention is peeled, the side of the tooth socket with the barium titanate gel is contacted with teeth, and the tooth whitening function is realized after 0.5 h.
Example 2
A tooth whitening product based on the pyroelectric effect is prepared by the following steps:
mixing lead magnesium niobate-lead titanate (PMN-PT) with the particle size of 50-200 nm and medical gel in a mass ratio of 1: 300, stirring the mixture for 3.5 hours at the speed of 180r/min to prepare lead magnesium niobate-lead titanate gel; coating the lead magnesium niobate-lead titanate gel on the surface of the gutta-percha with the coating thickness of 400 mu m, and finally pasting a backing layer (PVA film) on the lead magnesium niobate-lead titanate gel to obtain the tooth whitening product based on the pyroelectric effect.
The application method of the tooth whitening product prepared in embodiment 2 of the invention comprises the following steps: after the PVA film of the tooth whitening product prepared in the embodiment 2 of the invention is peeled, one side of the gutta percha with the lead magnesium niobate-lead titanate gel is contacted with the tooth, and the gutta percha is taken down after 4 hours, so that the tooth whitening function is realized.
Example 3
A tooth whitening product based on the pyroelectric effect is prepared by the following steps:
mixing potassium sodium niobate with a particle size of 0.6-0.7 mu m and medical gel in a mass ratio of 1: 700, stirring the mixture for 2.5 hours at the speed of 150r/min to prepare potassium-sodium niobate gel; and coating the potassium-sodium niobate gel on the surface of the tooth paste to a thickness of 1 mu m, and finally pasting a backing layer (PLA film) on the potassium-sodium niobate gel to obtain the tooth whitening product based on the pyroelectric effect.
The application method of the tooth whitening product prepared in embodiment 3 of the invention comprises the following steps: after the PLA film of the tooth whitening product prepared in the embodiment 3 of the invention is peeled off, the surface of the tooth adhered with the potassium-sodium niobate gel is contacted with the tooth, and the tooth whitening product is taken down after 6 hours to realize the tooth whitening function.
Example 4
A method for preparing a tooth whitening product based on the pyroelectric effect, the method comprising the steps of:
mixing barium strontium niobate (SBN) with the particle size of 0.9-1.0 mu m and medical gel in a mass ratio of 1: 1000, stirring for 2 hours at the speed of 120r/min to prepare barium strontium niobate (SBN) gel; coating Strontium Barium Niobate (SBN) gel on the surface of the denture base with the coating thickness of 1mm, and finally pasting a backing layer (zein film) on the strontium barium niobate gel to obtain the tooth whitening product based on the pyroelectric effect.
The application method of the tooth whitening product prepared in the embodiment 4 of the invention comprises the following steps: after the zein film of the tooth whitening product prepared in the embodiment 4 of the invention is peeled, the surface of the denture with the strontium barium niobate gel is contacted with teeth, and the denture is taken down after 8 hours, so that the tooth whitening function is realized.
Test example:
soaking teeth in mixed solution of black tea, red wine, fruit-flavored beverage and blueberry juice for half a month to discolor teeth. Cleaning with toothbrush, and reserving the teeth without obvious whitening. After the PVA film of the tooth whitening product prepared in example 2 was peeled off, one side of the tooth socket having the lead magnesium niobate-lead titanate gel was brought into contact with teeth, the teeth using the tooth whitening product and the teeth not using the tooth whitening product (comparative example) were placed in beakers containing deionized water solutions, respectively, the beakers were placed in a transmission device of a thermal cycler, and the transmission rod driven the beakers to reciprocate in a high temperature bath and a low temperature bath. And immersing the beaker in the low-temperature tank for a certain time, when the temperature of the solution in the beaker reaches 36 ℃, rotating the transmission rod to lift the beaker out of the low-temperature tank, rotating the beaker for 180 degrees to enter the high-temperature tank, staying for a certain time until the temperature of the solution in the beaker reaches 61 ℃, lifting the beaker out of the high-temperature tank for one cycle, then moving the beaker into the low-temperature tank, and repeating the process to realize the reciprocating motion of the beaker between the high-temperature tank and the low-temperature tank. The temperature in the two tanks can be set through an operation panel on the cold-heat circulator. In the test example, teeth are whitened by heating and cooling in a temperature change range of 36-61 ℃ by using a cold-heat circulator on the basis of 36 ℃ which is close to the daily temperature of the oral cavity of a human body. Fig. 3 is a graph showing the experimental results of the test example, and it can be seen that the teeth using the tooth whitening product prepared in example 2 of the present application gradually lose their surface colors after repeated cooling and heating cycles at 36 to 61 ℃, and become completely white when the number of cooling and heating cycles reaches 2000 times. However, the teeth without the tooth whitening product have almost unchanged color after 2000 cycles of cooling and heating, and the whitening effect is negligible.
FIG. 4 is a graph showing the results of the experiment of the decomposition of indigo carmine by the pyroelectric material lead magnesium niobate-lead titanate used in example 2 of the present invention under the cooling and heating cycle. As shown in the figure, on the basis of 36 ℃ which is close to the daily temperature of the oral cavity of a human body, as shown in the figure (a), the indigo carmine can be basically and completely degraded after 13 cold and hot cycles within the temperature range of 26-36 ℃, namely delta T is-10 ℃; as shown in fig. b, indigo carmine can be completely degraded only after 16 cycles of cooling and heating at a temperature range of 31-36 ℃, i.e., Δ T-5 ℃. The two groups of comparative experiments show that when the delta T is less than 0, the temperature change amplitude is large, and the degradation speed is high. Similarly, when Δ T > 0, as shown in fig. (c) - (f), the temperature variation is large, the degradation rate is fast, and when Δ T ═ 20 ℃, the degradation rate is fastest, and only 2 cycles are needed, so that the indigo carmine is almost completely degraded. Comparing the two conditions of delta T less than 0 and delta T more than 0, the degradation effect is better when the delta T is more than 0.
The effective substances for degrading the stains are active substances (hydroxyl radicals and superoxide radicals), so in order to detect active substances actually generated in the whitening process, an Electron Paramagnetic Resonance (EPR) technology is used for detecting the active radicals generated in the pyroelectric catalysis process. FIG. 5 is a graph showing the results of tests for determining the influence of the temperature change range and the number of cold and hot cycles on the active radicals of the pyroelectric material used in example 2 of the present invention. In the figure, (a) and (c) are respectively detection graphs of hydroxyl radicals generated by PMN-PT under different temperature amplitudes and different cycle numbers. (b) And (d) generating a detection graph of superoxide radicals by PMN-PT under different temperature amplitudes and different cycle numbers. It can be seen that the larger the amplitude of the temperature change, the larger the number of cycles, and the more reactive radicals are detected.
In addition, the pyroelectric material can be recycled when the temperature is lower than the Curie point, and has a long effective period. The normal oral temperature is far lower than the Curie point of the pyroelectric material, so that the tooth whitening product based on the pyroelectric effect can realize the long-term and efficient tooth whitening function and can be repeatedly utilized.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (10)
1. A preparation method of a tooth whitening product based on a pyroelectric effect is characterized by comprising the following steps: mixing the pyroelectric material with the gel to prepare the pyroelectric gel, coating the pyroelectric gel on the surface of the tooth covering object, and finally pasting the backing layer on the pyroelectric gel to obtain the tooth whitening product based on the pyroelectric effect.
2. The method according to claim 1, wherein the pyroelectric material is potassium sodium niobate or LiNbO3、LiTaO3、BaTiO3、BiFeO3One or more of CdS, lead magnesium niobate-lead titanate, barium strontium niobate and barium strontium titanate.
3. The method according to claim 1, wherein the particle size of the pyroelectric material is 50nm to 10 μm.
4. The method of claim 1, wherein the gel is a medical gel.
5. The preparation method according to claim 1, wherein the mixing is performed by mixing the pyroelectric material with the gel in a mass ratio of 1: (10-1000) and uniformly stirring.
6. The method of claim 1, wherein the dental coating is one or more of a mouthpiece, a tooth gel, a dental tray, and a dental tape.
7. The method of claim 1, wherein the backing layer is one or more of an EVA film, a PVA film, a PLA film, and a zein film.
8. Tooth whitening product according to claim 1, characterized in that the coating has a thickness of 1 μm to 1 mm.
9. A tooth whitening product prepared by the preparation method of any one of claims 1 to 8.
10. A tooth whitening method, characterized in that it comprises: after the back lining layer of the tooth whitening product of claim 9 is peeled off, the side of the tooth covering with the pyroelectric gel is contacted with the surface of the tooth, and the tooth whitening product is taken down after 0.5-8 h.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115636666A (en) * | 2022-12-23 | 2023-01-24 | 北京大学口腔医学院 | Temperature change antibacterial composition, preparation method and application |
| CN116270727A (en) * | 2022-12-23 | 2023-06-23 | 北京大学口腔医学院 | Oral antibacterial composition, preparation method and application |
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| CN110464674A (en) * | 2019-08-19 | 2019-11-19 | 南京理工大学 | Tooth whitening products containing piezoelectric material |
| CN112641635A (en) * | 2020-12-11 | 2021-04-13 | 西安邮电大学 | Dental whitening and degerming coating material and preparation method and application thereof |
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2021
- 2021-05-21 CN CN202110555940.7A patent/CN113317996A/en active Pending
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| CN110464674A (en) * | 2019-08-19 | 2019-11-19 | 南京理工大学 | Tooth whitening products containing piezoelectric material |
| CN112641635A (en) * | 2020-12-11 | 2021-04-13 | 西安邮电大学 | Dental whitening and degerming coating material and preparation method and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115636666A (en) * | 2022-12-23 | 2023-01-24 | 北京大学口腔医学院 | Temperature change antibacterial composition, preparation method and application |
| CN116270727A (en) * | 2022-12-23 | 2023-06-23 | 北京大学口腔医学院 | Oral antibacterial composition, preparation method and application |
| CN116270727B (en) * | 2022-12-23 | 2023-11-14 | 北京大学口腔医学院 | Oral antibacterial composition, preparation method and application |
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