CN113288127A - Hearing detection device and detection method based on time-frequency modulation perception threshold - Google Patents

Hearing detection device and detection method based on time-frequency modulation perception threshold Download PDF

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CN113288127A
CN113288127A CN202110388122.2A CN202110388122A CN113288127A CN 113288127 A CN113288127 A CN 113288127A CN 202110388122 A CN202110388122 A CN 202110388122A CN 113288127 A CN113288127 A CN 113288127A
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time
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frequency modulation
modulation
electroencephalogram signal
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CN113288127B (en
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冀飞
陈继跃
郑奕
刘晶
李楠
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6th Medical Center of PLA General Hospital
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Abstract

The invention belongs to the technical field of auditory test and detection, and particularly relates to a hearing detection device based on auditory cortex time-frequency modulation evoked potential, which comprises: the tester terminal is used for sending a sound source emission instruction to the sound source output device; the sound source output device is used for transmitting a stimulating sound signal with time-frequency modulation to the testee according to the sound source transmitting instruction; the guide electrode is used for recording electroencephalogram signals after evoked auditory cortex potential and auditory neuron response processing are carried out on the stimulation sound signals with time frequency modulation; the reference electrode is used for recording electroencephalogram signals recorded by the guide electrode and providing reference electroencephalogram signals; and the data processing terminal is used for processing the received electroencephalogram signal and the reference electroencephalogram signal, then carrying out speech sound time domain and frequency domain modulation processing on the received electroencephalogram signal and the reference electroencephalogram signal, separating to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, drawing a test waveform curve, and detecting the hearing condition of the testee according to the test waveform curve.

Description

Hearing detection device and detection method based on time-frequency modulation perception threshold
Technical Field
The invention belongs to the technical field of auditory test and detection, and particularly relates to a hearing detection device and a hearing detection method based on a time-frequency modulation detection threshold.
Background
Currently, there are many methods for treating ear disease patients, but a comprehensive hearing test is performed before diagnosis is confirmed. Pure tone audiometry is the most popular and effective examination method in the otology field, and is at the most important position in clinical application. It is an examination technique that learns the state of the auditory system function by observing, recording and analyzing the subject's response to controlled acoustic stimuli. Doctors can diagnose the deafness property, the hearing impairment degree, the residual hearing quality and the like through detection, more importantly, the single-ear hearing loss condition can be obtained, parameter basis is provided for wearing the hearing aid, and different types of hearing aid products are correctly selected according to actual conditions.
Most of existing hospitals carry out hearing detection on detected persons manually, in the process, the detected persons are often required to be explained with detection rules firstly, and then the detection sound size is required to be adjusted correspondingly according to the actual detection conditions of the detected persons. Although such a detection process is simple, a long-time work causes boring of detection personnel, and repeated detection often takes much effort and time of the detection personnel, so that the work efficiency of the detection personnel is greatly reduced.
Disclosure of Invention
In order to solve the above-mentioned defects existing in the prior art, the invention provides a hearing detection device based on auditory cortex time-frequency modulation evoked potential, the device includes: the device comprises a tester terminal, a sound source output device, a plurality of reference electrodes, a grounding electrode, a guide electrode and a data processing terminal;
the tester terminal is used for sending a sound source emission instruction to the sound source output device;
the sound source output device is arranged in the ear of the subject and used for transmitting a stimulating sound signal with time-frequency modulation to the subject according to the sound source transmitting instruction;
the guide electrode is arranged at the top of the skull of a subject and used for recording electroencephalogram signals after evoked auditory cortex potential and auditory neuron response processing are carried out on stimulation sound signals with time-frequency modulation, and the electroencephalogram signals are input to the data processing terminal;
the ground electrode is placed on the lower forehead of the subject and is used as a ground electrode for generating a ground signal;
the reference electrode is arranged at the ear lobe or mastoid of the subject and is used for recording the electroencephalogram signal recorded by the guide electrode and providing a reference electroencephalogram signal, and the reference electroencephalogram signal is input to the data processing terminal;
the data processing terminal is used for processing the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performing speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signal, separating to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, drawing a test waveform curve by taking the time modulation rate as an abscissa and the frequency modulation density as an ordinate, and detecting the hearing condition of a subject according to the test waveform curve.
As an improvement of the above technical solution, the stimulating acoustic signal with time-frequency modulation is:
S(x,t)=A×[2π×(ωt+Ωx)+Φ]
wherein, S (x, t) is a stimulating sound signal with time-frequency modulation transmitted at time t, i.e. a function of time (t) and logarithmic frequency (x), and x is log2(f/f 1); f is the audio frequency of the stimulating acoustic signal with time-frequency modulation, and f1 is the minimum frequency; a is the frequency modulation amplitude of the traveling wave, which is determined by simultaneously and properly adjusting the modulation depth of all carrier waves; when the value of a is set between 0 and 1, the frequency modulation of its corresponding flat traveling envelope is 0 to 100%; omega is the frequency density per octave period (cycle/octave, c/o), phi is the carrier randomized frequency modulation initial phase in radians, ranging from 0 to 2 pi; ω is the temporal modulation rate, expressed in the number of scans per second (Hz), i.e., Hz/s.
As an improvement of the above technical solution, the data processing terminal includes: the device comprises a signal processing module and a curve generating module;
the signal processing module is used for processing the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal; wherein the processed EEG signal is the EEG signal minus a reference EEG signal;
and the curve generation module is used for carrying out speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signals, separating to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, drawing a test waveform curve by taking the time modulation rate as a horizontal coordinate and the frequency modulation density as a vertical coordinate, and detecting the hearing condition of the testee according to the test waveform curve.
As an improvement of the above technical solution, the hearing condition of the subject includes: auditory cortex time-frequency modulation evoked potential threshold, latency and vibration, and whether the time modulation rate and the frequency modulation density of the test waveform curve are abnormal or not respectively.
As one improvement of the above technical solution, the stimulation interval time is 500 ms.
As an improvement of the above technical solution, the sound source output device is an earphone.
The invention also provides a hearing detection method based on the time-frequency modulation detection threshold, which comprises the following steps:
the tester terminal sends a sound source emission instruction to the sound source output device;
the sound source output device transmits a stimulating sound signal with time-frequency modulation to a testee according to a sound source transmitting instruction;
the guide electrode records an electroencephalogram signal which carries out evoked auditory cortex potential and auditory neuron response processing on a stimulating sound signal with time frequency modulation, and the electroencephalogram signal is input to the data processing terminal;
the reference electrode setting record provides a reference electroencephalogram signal for the electroencephalogram signal recorded by the guide electrode, and the reference electroencephalogram signal is input to the data processing terminal;
the data processing terminal processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performs speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signal, separates to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, draws a test waveform curve by taking the time modulation rate as an abscissa and the frequency modulation density as an ordinate, and detects the hearing condition of a subject according to the test waveform curve.
As one improvement of the above technical solution, the data processing terminal processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performs speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signal, separates to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, draws a test waveform curve with the time modulation rate as abscissa and the frequency modulation density as ordinate, and detects the hearing condition of the subject according to the test waveform curve; the specific process comprises the following steps:
the signal processing module processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal; wherein the processed EEG signal is the EEG signal minus a reference EEG signal;
the curve generation module carries out speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signals, a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density are obtained through separation, a test waveform curve is drawn by taking the time modulation rate as a horizontal coordinate and the frequency modulation density as a vertical coordinate, and the hearing condition of a subject is detected according to the test waveform curve.
Compared with the prior art, the invention has the beneficial effects that:
the device can visually detect whether abnormal signals exist in the time-frequency modulation stimulating sound signals or not, greatly improves the working efficiency, does not need manual interference detection results, can accurately obtain subjective detection results, and avoids the problem of low accuracy caused by manual objective detection results; the whole detection process does not need manual operation, and the detection efficiency is greatly improved.
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FIG. 1 is a schematic diagram of a hearing test device based on a time-frequency modulation detection threshold according to the present invention;
FIG. 2 is a flow chart of a hearing test method based on a time-frequency modulation detection threshold of the present invention.
Detailed Description
The invention will now be further described with reference to the accompanying drawings.
As shown in fig. 1, the present invention provides a hearing test apparatus based on a time-frequency modulation detection threshold, which comprises: the device comprises a tester terminal, a sound source output device, a plurality of reference electrodes, a grounding electrode, a guide electrode and a data processing terminal;
the tester terminal is used for sending a sound source emission instruction to the sound source output device;
the sound source output device is arranged in the ear of the subject and used for continuously transmitting a time-frequency modulation stimulation sound signal with stimulation intervals to the subject according to a sound source transmitting instruction; wherein the time of the stimulation interval is 500 ms;
wherein, the stimulating sound signal with time-frequency modulation is:
S(x,t)=A×[2π×(ωt+Ωx)+Φ]
wherein S (x, t) is a stimulating sound signal with time-frequency modulation, namely a function of time (t) and logarithmic frequency (x), x is log2(f/f 1; f is the audio frequency of the stimulating sound signal with time-frequency modulation, f1 is the minimum frequency, A is the traveling wave frequency modulation amplitude determined by simultaneously and properly adjusting the modulation depth of all the traveling wave sounds, when the value of A is set to be between 0 and 1, the frequency modulation of the corresponding flat traveling wave envelope is between 0 and 100 percent, omega is the frequency density of a unit per octave period (cycle/octave, c/o), phi is the initial phase of carrier randomization expressed in radians, and ranges from 0 to 2 pi, omega is the time modulation rate and is expressed in the scanning times per second (Hz), namely Hz/S.
Preferably, the sound source output device is an earphone.
The guide electrode is arranged at the top of the skull of a subject and used for recording electroencephalogram signals after evoked auditory cortex potential and auditory neuron response processing are carried out on stimulation sound signals with time-frequency modulation, and the electroencephalogram signals are input to the data processing terminal;
the ground electrode is placed on the lower forehead of the subject and is used as a ground electrode for generating a ground signal;
the reference electrode is arranged at the ear lobe or mastoid of the subject and is used for recording the electroencephalogram signal recorded by the guide electrode and providing a reference electroencephalogram signal, and the reference electroencephalogram signal is input to the data processing terminal;
the data processing terminal is used for processing the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performing speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signal, separating to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, drawing a test waveform curve by taking the time modulation rate as an abscissa and the frequency modulation density as an ordinate, and detecting the hearing condition of a subject according to the test waveform curve.
Specifically, the data processing terminal includes: the device comprises a signal processing module and a curve generating module;
the signal processing module is used for processing the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal; wherein the processed EEG signal is the EEG signal minus a reference EEG signal;
and the curve generation module is used for carrying out speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signals, separating to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, drawing a test waveform curve by taking the time modulation rate as a horizontal coordinate and the frequency modulation density as a vertical coordinate, and detecting the hearing condition of the testee according to the test waveform curve.
Wherein the hearing condition of the subject comprises: auditory cortex time-frequency modulation evoked potential threshold, latency and vibration, and whether the time modulation rate and the frequency modulation density of the test waveform curve are abnormal or not respectively.
As shown in fig. 2, the present invention further provides a hearing test method based on a time-frequency modulation detection threshold, which includes:
the tester terminal sends a sound source emission instruction to the sound source output device;
the sound source output device transmits a stimulating sound signal with time-frequency modulation to a testee according to a sound source transmitting instruction;
the guide electrode records an electroencephalogram signal which carries out evoked auditory cortex potential and auditory neuron response processing on a stimulating sound signal with time frequency modulation, and the electroencephalogram signal is input to the data processing terminal;
the reference electrode setting record provides a reference electroencephalogram signal for the electroencephalogram signal recorded by the guide electrode, and the reference electroencephalogram signal is input to the data processing terminal;
the data processing terminal processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performs speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signal, separates to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, draws a test waveform curve by taking the time modulation rate as an abscissa and the frequency modulation density as an ordinate, and detects the hearing condition of a subject according to the test waveform curve.
Specifically, the signal processing module processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal; wherein the processed EEG signal is the EEG signal minus a reference EEG signal;
the curve generation module carries out speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signals, a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density are obtained through separation, a test waveform curve is drawn by taking the time modulation rate as a horizontal coordinate and the frequency modulation density as a vertical coordinate, and the hearing condition of a subject is detected according to the test waveform curve.
The hearing condition of the subject comprises: auditory cortex time-frequency modulation evoked potential threshold, latency and vibration, and whether the time modulation rate and the frequency modulation density of the test waveform curve are abnormal or not respectively.
Specifically, the speech sound time domain and frequency domain modulation (time frequency modulation for short) technology is a technology that a speech input signal presents an output signal of a profile with a specific frequency domain modulation density and time domain modulation rate after passing through a peripheral auditory filter library system established by Matlab, that is, the output signal presents the time frequency modulation component of the speech signal in a time rate and a frequency density within a certain range. And uploading the audio signal of the speech sound time-frequency modulation to a customized sound source module of a scientific research module of the auditory evoked potential instrument, outputting the audio signal through an insert earphone, and performing weighting calibration through a sound level meter. Auditory cortex time-frequency modulation evoked potential means inducing auditory cortex long latent period potential by time-frequency modulation sound, and recording auditory cortex time-frequency modulation evoked potential threshold, latency and amplitude.
In the present embodiment, a red recording electrode and a blue recording electrode are placed on the right and left mastoids or earlobes, respectively, of the subject as reference electrodes; placing a white recording electrode on the skull top of a subject to serve as a recording electrode; a black recording electrode was placed on the lower forehead of the subject as grade. The detection process of the auditory cortex time-frequency modulation evoked potential threshold value is as follows:
detecting auditory cortex time-frequency modulation evoked potential threshold, starting at 60dB nHL, recording P1, N1 and P2 waves, repeating each waveform for three times, determining that the stimulation intensity of the emitted stimulation sound signals with time-frequency modulation is gradually increased by 10dB or decreased by 10dB, then increasing by 5dB again until the last group of waveforms disappear, repeating and superposing for three times, wherein the waveforms are not repetitive, namely the stimulation intensity corresponding to the stimulation sound signals with time-frequency modulation of the last group is the potential threshold, taking the potential threshold as the auditory field of the subject, and detecting the hearing state of the subject according to the auditory field;
if the hearing range is greater than or equal to a preset hearing range threshold value, the hearing state of the subject is good;
if the hearing range is less than the preset threshold value, the hearing state of the subject is poor.
The detection process of the latency period comprises the following steps:
according to the obtained test curve, acquiring the transverse length of each period of the waveform as an actual measurement latency, comparing the actual measurement latency with a preset latency threshold, and detecting the hearing state of the subject; wherein, the positive waveform and the negative waveform of the waveform curve are taken as a period;
if the measured latency is greater than or equal to a preset latency threshold, the hearing state of the subject is poor;
and if the observed latency is less than the preset latency threshold, the hearing state of the subject is good.
The detection process of the amplitude is as follows:
according to the obtained test curve, acquiring the longitudinal length of each period of the waveform as an actually measured amplitude, comparing the actually measured amplitude with a preset amplitude threshold value, and detecting the hearing state of the subject; wherein, the longitudinal length of the positive waveform or the negative waveform of the waveform curve is the longitudinal length of one period;
if the measured amplitude is greater than or equal to the preset amplitude threshold value, the hearing state of the subject is good;
if the measured amplitude is less than a predetermined amplitude threshold, the hearing status of the subject is poor.
The detection process for detecting whether the time modulation rate and the frequency modulation density of the test waveform curve are abnormal respectively comprises the following steps:
starting from 60dB nHL, recording P1, N1 and P2 waves, repeating each waveform for three times, determining that the stimulation intensity of the transmitted stimulation sound signals with time-frequency modulation is increased by 10dB or decreased by 10dB, then increasing by 5dB until the last group of waveforms disappear, repeating and superposing for three times, and the waveforms are not repetitive.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and are not limited. Although the present invention has been described in detail with reference to the embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (8)

1. A hearing detection device based on auditory cortex time-frequency modulation evoked potential is characterized in that the device comprises: the device comprises a tester terminal, a sound source output device, a plurality of reference electrodes, a grounding electrode, a guide electrode and a data processing terminal;
the tester terminal is used for sending a sound source emission instruction to the sound source output device;
the sound source output device is arranged in the ear of the subject and used for transmitting a stimulating sound signal with time-frequency modulation to the subject according to the sound source transmitting instruction;
the guide electrode is arranged at the top of the skull of a subject and used for recording electroencephalogram signals after evoked auditory cortex potential and auditory neuron response processing are carried out on stimulation sound signals with time-frequency modulation, and the electroencephalogram signals are input to the data processing terminal;
the ground electrode is placed on the lower forehead of the subject and is used as a ground electrode for generating a ground signal;
the reference electrode is arranged at the ear lobe or mastoid of the subject and is used for recording the electroencephalogram signal recorded by the guide electrode and providing a reference electroencephalogram signal, and the reference electroencephalogram signal is input to the data processing terminal;
the data processing terminal is used for processing the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performing speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signal, separating to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, drawing a test waveform curve by taking the time modulation rate as an abscissa and the frequency modulation density as an ordinate, and detecting the hearing condition of a subject according to the test waveform curve.
2. The hearing test apparatus according to claim 1, wherein the stimulus sound signal with time-frequency modulation is:
S(x,t)=A×[2π×(ωt+Ωx)+Φ]
s (x, t) is a stimulating sound signal with time-frequency modulation transmitted at the moment t; x is log2(f/f 1); f is the audio frequency of the stimulating acoustic signal with time-frequency modulation, and f1 is the minimum frequency; a is the frequency modulation amplitude of the traveling wave, which is determined by simultaneously and properly adjusting the modulation depth of all carrier waves; when the value of a is set between 0 and 1, the frequency modulation of its corresponding flat traveling envelope is 0 to 100%; omega is the frequency density per octave period in units, phi is the carrier randomized frequency modulation initial phase expressed in radians, ranging from 0 to 2 pi; ω is the temporal modulation rate.
3. The hearing test device according to claim 1, wherein the data processing terminal comprises: the device comprises a signal processing module and a curve generating module;
the signal processing module is used for processing the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal; wherein the processed EEG signal is the EEG signal minus a reference EEG signal;
and the curve generation module is used for carrying out speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signals, separating to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, drawing a test waveform curve by taking the time modulation rate as a horizontal coordinate and the frequency modulation density as a vertical coordinate, and detecting the hearing condition of the testee according to the test waveform curve.
4. The hearing test device according to claim 3, wherein the hearing profile of the subject comprises: auditory cortex time-frequency modulation evoked potential threshold, latency and vibration, and whether the time modulation rate and the frequency modulation density of the test waveform curve are abnormal or not respectively.
5. The hearing test device according to claim 1, wherein the stimulation interval is 500 ms.
6. The hearing test device according to claim 1, wherein the sound source output device is an earphone.
7. A hearing test method based on a time-frequency modulation detection threshold, which is implemented based on the hearing test device based on the time-frequency modulation detection threshold as claimed in any one of the claims 1 to 6, wherein the method comprises:
the tester terminal sends a sound source emission instruction to the sound source output device;
the sound source output device transmits a stimulating sound signal with time-frequency modulation to a testee according to a sound source transmitting instruction;
the guide electrode records an electroencephalogram signal which carries out evoked auditory cortex potential and auditory neuron response processing on a stimulating sound signal with time frequency modulation, and the electroencephalogram signal is input to the data processing terminal;
the reference electrode setting record provides a reference electroencephalogram signal for the electroencephalogram signal recorded by the guide electrode, and the reference electroencephalogram signal is input to the data processing terminal;
the data processing terminal processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performs speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signal, separates to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, draws a test waveform curve by taking the time modulation rate as an abscissa and the frequency modulation density as an ordinate, and detects the hearing condition of a subject according to the test waveform curve.
8. The hearing test method based on the time-frequency modulation detection threshold as claimed in claim 17, wherein the data processing terminal processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal, performs speech sound time-domain and frequency-domain modulation processing on the processed electroencephalogram signal, separates to obtain a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density, draws a test waveform curve with the time modulation rate as abscissa and the frequency modulation density as ordinate, and detects the hearing condition of the subject according to the test waveform curve; the specific process comprises the following steps:
the signal processing module processes the received electroencephalogram signal and the reference electroencephalogram signal to obtain a processed electroencephalogram signal; wherein the processed EEG signal is the EEG signal minus a reference EEG signal;
the curve generation module carries out speech sound time domain and frequency domain modulation processing on the processed electroencephalogram signals, a plurality of groups of processing signals consisting of time modulation rate and frequency modulation density are obtained through separation, a test waveform curve is drawn by taking the time modulation rate as a horizontal coordinate and the frequency modulation density as a vertical coordinate, and the hearing condition of a subject is detected according to the test waveform curve.
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NAI DING ET AL: "Neural coding of continuous speech in auditory cortex during monaural and dichotic listening", 《J NEUROPHYSIOL》 *
陈继跃 等: "言语声时域和频域调制察觉阈的测试及其临床应用", 《听力学及言语疾病杂志》 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024067034A1 (en) * 2022-09-27 2024-04-04 华为技术有限公司 Hearing detection method, apparatus and system
CN118230745A (en) * 2024-05-23 2024-06-21 玖益(深圳)医疗科技有限公司 Continuous modulation sound signal generation method, tinnitus matching method, and storage medium

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