CN113274314A - Application of salt sensitive hydrogel as intelligent water control and replenishing material - Google Patents
Application of salt sensitive hydrogel as intelligent water control and replenishing material Download PDFInfo
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Abstract
The invention relates to the technical field of cosmetics, in particular to application of salt-sensitive hydrogel as an intelligent water-controlling and water-replenishing material. The invention provides the application of the intelligent water replenishing material which has different degrees of water release aiming at different skin surface salt contents by utilizing the salt sensitive hydrogel which comprises polyglutamic acid and has the property of water release when meeting salt and the property of water release when the swelling ratio or the water absorbability of the gel is obviously reduced under the action of the added salt, can effectively fill the blank of the market and has wide market application prospect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to application of salt sensitive hydrogel as an intelligent water control and replenishing material.
Background
The salt content of the skin surface of each person is different and the salt content of different areas of the same face of each person is also different under the influence of factors such as salt intake, sweat discharge, air floatation dust amount, cleaning degree and the like. For example, in inland regions, compared with coastal regions, the environment is dry, the salt content of human skin is relatively higher, particularly, people living in saline-alkali regions often wash faces with water with high salt content, the skin is easily damaged, the problems of dryness and peeling occur, and serious people can also suffer from skin diseases such as dermatitis and the like; people who work outdoors, such as traffic police and tour guides, have the problems of less moisture and higher salt content on the skin surface because of frequent exposure to the sun or wind; after a lot of exercises such as athletes, fitness trainers or fat reducers, the salt content on the surface of the skin is obviously increased compared with that before the exercises. The moisture requirements of the skin surface are different due to different salt contents, for example, the water replenishing amount required is large when the salt content is high, otherwise, high salt concentration can form high osmotic pressure and absorb moisture from the skin superficial layer, and the effects of replenishing water and protecting skin cannot be achieved.
At present, moisturizing products on the market have poor pertinence, relatively general efficacy and single action mechanism, and lack products for specifically moisturizing according to different salt contents on the surface of skin, so that the effect of 'symptomatic drug administration' cannot be realized. Therefore, the conditions that the public evaluation of the same product is commendable and devastable and the public evaluation of the same product is seriously differentiated often occur, which not only is not beneficial to the sale of the product, but also brings great difficulty for consumers to select proper products.
Disclosure of Invention
Aiming at the technical problem that a water replenishing product specially developed for skins with different salt contents is lacked at present, the invention provides application of a salt sensitive hydrogel as an intelligent water control and replenishing material. Under the action of external salt, the expansion ratio or water absorbability of the salt sensitive hydrogel containing polyglutamic acid and having the property of releasing water when meeting salt is obviously reduced, so that water is released. The invention provides the application of the intelligent water-replenishing hydrogel which can release water to different degrees according to different skin surface salt contents by utilizing the performance, and the specific application can be in a mask form; the salt sensitive hydrogel selected by the invention has good moisture retention and non-greasy property, and can effectively release water aiming at the salty skin, thereby achieving the purpose of intelligent water control. The invention can effectively fill the blank of the market and has wide market application prospect.
The application of the salt-sensitive hydrogel as an intelligent water-controlling and water-replenishing material applies the salt-sensitive hydrogel with the water-releasing performance when meeting salt to the surface of the skin, and the salt content on the surface of the skin is self-adapted to replenish a proper amount of water.
Further, the salt-sensitive hydrogel comprises one or more of polyglutamic acid hydrogel, hyaluronic acid hydrogel and xanthan gum hydrogel.
Further, the preparation method of the salt-sensitive hydrogel comprises the following steps:
(1) mixing a salt sensitive aqueous solution with the concentration of 0.1-0.2 g/mL with a cross-linking agent, and heating in a water bath to perform a cross-linking reaction to obtain a salt sensitive glue block;
(2) and adding the salt sensitive gel block into water, homogenizing and crushing to obtain a uniform fluid state, thereby obtaining the salt sensitive hydrogel.
The salt-limited sensitive hydrogel disclosed by the invention is used for preparing a salt-limited sensitive aqueous solution with the concentration of 0.1-0.2 g/mL, and the prepared product has good water replenishing and moisturizing effects and is not sticky, so that the phenomenon that the solution property is close to that of water and cannot achieve a good effect due to the fact that the salt-limited sensitive concentration is too low is avoided.
Furthermore, the concentration of the salt-sensitive substances (polyglutamic acid, hyaluronic acid and/or xanthan gum) in the salt-sensitive hydrogel is 0.001-0.02 g/mL.
Further, in the step (1), the cross-linking agent is 1, 4-butanediol diglycidyl ether, and the mass-to-volume ratio of the salt sensitivity to the cross-linking agent is 10-50 g: 1mL, stirring and mixing the salt sensitive aqueous solution and the cross-linking agent at 30 ℃ and 700-1100 r/min for 30min, heating in a water bath at 40-62 ℃ for 5h, and performing cross-linking to obtain the salt sensitive glue block.
Further, the salt-sensitive hydrogel is loaded on a carrier, the carrier is selected from non-woven fabrics, gauze, plant fiber facial mask paper, silk facial mask paper and/or other skin-acceptable facial mask carriers, and the loading method is to coat the salt-sensitive hydrogel on the surface of the carrier. The hydrogel is attached to the mask carrier, and the mask carrier has a good forming effect by virtue of the skeleton effect of the mask carrier, so that the facial coating time can be effectively shortened, and the use efficiency is improved.
Further, drying the carrier loaded with the salt-sensitive hydrogel to obtain a dry gel carrier loaded with the salt-sensitive hydrogel, wherein the drying condition is that the carrier is dried at 80-100 ℃ until the water content is less than 5%. The mask loaded with the salt sensitive hydrogel with different properties and loading capacity can be selected and produced according to the factors such as packaging or transportation conditions and the like, so that the mask is convenient for consumers to use. The dry carrier is beneficial to long-term storage and transportation and carrying, and has stronger capability of enduring the change of environmental temperature.
Furthermore, the carrier is loaded with at least one auxiliary material acceptable for human body, and the auxiliary material can be one or the combination of more of glycerol, collagen peptide and chromogen.
Furthermore, the mass of the salt-sensitive hydrogel loaded on one carrier is 0.075-0.3 g/cm2。
The beneficial effect of the invention is that,
the salt-sensitive hydrogel is used as an intelligent water-controlling and water-replenishing material by utilizing the characteristics of the salt-sensitive hydrogel, does not contain any preservative, and has safe components;
the salt-sensitive hydrogel is influenced by the salt content of the skin contact surface, can release water with different degrees, forms a local gel dryness and humidity self-adaptive environment, shows personalized and regional intelligent water replenishing effects, and improves the skin contact comfort level.
Drawings
In order to more clearly illustrate the embodiments or technical solutions in the prior art of the present invention, the drawings used in the description of the embodiments or prior art will be briefly described below, and it is obvious for those skilled in the art that other drawings can be obtained based on these drawings without creative efforts.
FIG. 1 is a graph showing a comparison of the adsorption amounts of the respective groups in test example 2;
FIG. 2 is a line graph showing salt concentration-water analysis yield in test example 3.
Detailed Description
In order to make those skilled in the art better understand the technical solution of the present invention, the technical solution in the embodiment of the present invention will be clearly and completely described below with reference to the drawings in the embodiment of the present invention, and it is obvious that the described embodiment is only a part of the embodiment of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
An intelligent water-controlling and water-replenishing facial mask comprises 430cm2The surface of the carrier is uniformly coated with 60g of polyglutamic acid hydrogel, so that the polyglutamic acid hydrogel is loaded on the carrier, and the polyglutamic acid hydrogel is prepared by adopting the following method:
(1) accurately weighing 100g of polyglutamic acid, adding the polyglutamic acid into 1L of water, uniformly stirring to obtain a polyglutamic acid aqueous solution with the concentration of 0.1g/mL, adding 5mL of 1, 4-butanediol diglycidyl ether into the polyglutamic acid aqueous solution, stirring and mixing for 30min at 30 ℃ and 1000r/min, heating in a water bath at 60 ℃ for 5h, and obtaining a polyglutamic acid gel block through crosslinking;
(2) adding the polyglutamic acid gel blocks into water according to a proportion, homogenizing and crushing to a uniform fluid state to obtain the polyglutamic acid hydrogel with the concentration of 0.003 g/mL.
When the intelligent water-controlling and water-replenishing mask is prepared, other human-body-acceptable auxiliary materials such as glycerol and the like can be loaded on the carrier.
Example 2
An intelligent facial mask for controlling water and supplementing water comprises 370cm2The carrier, the surface of which is loaded with polyglutamic acid hydrogel dry glue;
the polyglutamic acid hydrogel is prepared by the following method:
(1) accurately weighing 200g of polyglutamic acid, adding the polyglutamic acid into 1L of water, uniformly stirring to obtain a polyglutamic acid aqueous solution with the concentration of 0.2g/mL, adding 8mL of 1, 4-butanediol diglycidyl ether into the polyglutamic acid aqueous solution, stirring and mixing for 30min at 30 ℃ and 800r/min, heating in a water bath at 45 ℃ for 5h, and obtaining a polyglutamic acid gel block through crosslinking;
(2) adding the polyglutamic acid gel blocks into water according to a proportion, homogenizing and crushing to a uniform fluid state to obtain polyglutamic acid hydrogel with the concentration of 0.01 g/mL;
the carrier adopts the following method to load the polyglutamic acid hydrogel dry gel:
(3) 30g of polyglutamic acid hydrogel was uniformly coated on the surface of the support and dried at 90 ℃ until the water content was < 5%.
When the intelligent water-controlling and water-replenishing mask is prepared, other human-body-acceptable auxiliary materials such as glycerol and the like can be loaded on the carrier. The intelligent water-controlling and water-replenishing mask is soaked in 5-10 g of aqueous solution, and after swelling for 2-5 min, the cross-linked polyglutamic acid can reach a water absorption saturation state of 50-95% (optimally 75-85%), so that the mask can be used.
Example 3
An intelligent facial mask for controlling water and supplementing water comprises 450cm2The surface of the carrier is uniformly coated with 50g of hyaluronic acid hydrogel, so that the hyaluronic acid hydrogel is loaded on the carrierThe hyaluronic acid hydrogel is prepared by the following method:
(1) accurately weighing 90g of hyaluronic acid, adding the hyaluronic acid into 1L of water, uniformly stirring to obtain a hyaluronic acid aqueous solution with the concentration of 0.09g/mL, adding 5mL of 1, 4-butanediol diglycidyl ether into the hyaluronic acid aqueous solution, stirring and mixing for 30min at 30 ℃ and 900r/min, heating in a water bath at 55 ℃ for 5h, and obtaining a hyaluronic acid gel block through crosslinking;
(2) adding the hyaluronic acid gel blocks into water according to a proportion, homogenizing and crushing the mixture into a uniform fluid state to obtain the hyaluronic acid hydrogel with the concentration of 0.006 g/mL.
When the intelligent water-controlling and water-replenishing mask is prepared, other human-body-acceptable auxiliary materials such as collagen peptide and the like can be loaded on the carrier.
Example 4
An intelligent water-controlling and water-replenishing facial mask comprises 480cm2The carrier, the carrier surface coats with 40g xanthan gum aquogel evenly, makes xanthan gum aquogel load on the carrier, xanthan gum aquogel adopts the following method to make:
(1) accurately weighing 180g of xanthan gum, adding the xanthan gum into 1L of water, uniformly stirring to obtain a xanthan gum aqueous solution with the concentration of 0.18g/mL, adding 5mL of 1, 4-butanediol diglycidyl ether into the xanthan gum aqueous solution, stirring and mixing for 30min at 30 ℃ and 950r/min, heating in a water bath at 50 ℃ for 5h, and obtaining a xanthan gum block through crosslinking;
(2) adding xanthan gum blocks into water according to a certain proportion, homogenizing and crushing to obtain a uniform fluid state, and obtaining the xanthan gum hydrogel with the concentration of 0.003 g/mL.
When the intelligent water-controlling and water-replenishing mask is prepared, other human-body-acceptable auxiliary materials such as vitreous chromogen and the like can be loaded on the carrier.
Comparative example 1
Accurately weighing 0.4g of polyglutamic acid, adding the polyglutamic acid into 10mL of water, uniformly stirring to obtain a polyglutamic acid aqueous solution with the concentration of 0.04g/mL, sucking 40 mu L of 1, 4-butanediol diglycidyl ether by using a liquid transfer gun, adding the solution into the polyglutamic acid aqueous solution, stirring and mixing the solution at 30 ℃ and 1000r/min for 30min, heating the solution in a water bath at 60 ℃ for 5h, and obtaining a polyglutamic acid gel block through crosslinking;
adding the polyglutamic acid gel blocks into water according to a proportion, homogenizing and crushing to a uniform fluid state to obtain the polyglutamic acid hydrogel with the concentration of 0.01 g/mL.
Comparative example 2
Adding agar 0.01g/mL into purified water, heating to 60-80 deg.C, dissolving in water, and cooling to room temperature to obtain hydrogel. After homogenate and crushing, the hydrogel does not have the salt sensitivity characteristic of releasing water when meeting salt and does not have the intelligent water replenishing effect on the surface of skin. Likewise, collagen has similar properties and cannot be used as an intelligent water control and replenishing material.
Comparative example 3
2g of the acrylic copolymer (crosslinked) was accurately weighed, added to 10mL of water, and stirred well to obtain an acrylic copolymer product having a concentration of 0.2 g/mL. Although the acrylic copolymer belongs to salt-sensitive hydrogel with water release when meeting salt, the acrylic copolymer is synthesized by petrochemical raw materials and is a non-renewable resource; and the acrylic copolymer is difficult to naturally degrade and is not an environment-friendly green material.
Comparative example 4
An intelligent water-controlling and water-replenishing facial mask comprises 430cm2The carrier, the surface of carrier is evenly coated with 60g of hydroxyethyl cellulose hydrogel, the hydroxyethyl cellulose hydrogel is loaded on the carrier, the hydroxyethyl cellulose hydrogel is prepared by the following method:
(1) accurately weighing 100g of hydroxyethyl cellulose, adding the hydroxyethyl cellulose into 1L of water, uniformly stirring to obtain a 0.1g/mL hydroxyethyl cellulose aqueous solution, adding 5mL of 1, 4-butanediol diglycidyl ether into the hydroxyethyl cellulose aqueous solution, stirring and mixing for 30min at 30 ℃ and 1000r/min, heating in a 60 ℃ water bath for 5h, and performing crosslinking to obtain a hydroxyethyl cellulose gel block;
(2) and adding the hydroxyethyl cellulose gel blocks into water according to a proportion, homogenizing and crushing the mixture to a uniform fluid state to obtain the hydroxyethyl cellulose hydrogel with the concentration of 0.003 g/mL.
Although hydroxyethyl cellulose belongs to salt-sensitive hydrogel capable of releasing water when meeting salt, the hydroxyethyl cellulose is obtained by taking natural components such as cellulose and the like as raw materials and chemically treating the raw materials by organic reagents, acid, alkali and the like, and toxic and harmful gas, liquid and other wastes are generated in the preparation process, so that the environmental control pressure is increased.
Comparative example 5
1g of polyglutamic acid was accurately weighed, added to 10mL of water, and stirred uniformly to obtain a 0.1g/mL aqueous solution of polyglutamic acid.
Comparative example 6
2g of polyglutamic acid was accurately weighed, added to 10mL of water, and stirred uniformly to obtain a 0.2g/mL aqueous solution of polyglutamic acid.
Test example 1 moisture retention function test
The polyglutamic acid hydrogels of examples 1 and 2 and comparative examples 1 to 4 were tested for their moisturizing performance using water as a blank control by the following specific method:
cutting a non-woven fabric with the mass of 0.0825 (+ -0.0025) g, wherein the non-woven fabric just can cover a cover glass with the mass of about 4.6g at 7.5cm × 2.5cm, uniformly coating 1 (+ -0.025) g of polyglutamic acid hydrogel on the non-woven fabric, transferring the non-woven fabric and the cover glass to a constant temperature and humidity box with the temperature of 48 ℃ and the humidity of 36% RH, and respectively recording the total mass of the cover glass, the non-woven fabric on the cover glass and the total mass of the product when the cover glass and the non-woven fabric are at 0min, 10min, 20min, 30min, 40min and 50 min.
The moisturizing rates of the respective groups at different times were calculated according to the following formulas, and the results are shown in table 1.
Moisture retention rate mt/m0,
In the formula, mtThe total mass of the cover glass sheet in the constant temperature and humidity box and the non-woven fabrics and products on the cover glass sheet at the time t,
m0the total mass of the cover glass, non-woven fabrics and products on the cover glass before entering the constant temperature and humidity chamber.
TABLE 1 statistical table of moisture retention rates of different time groups
As can be seen from Table 1, the moisture retention of each group gradually decreases with time, and the moisture retention of examples 1 and 2 at each test time is higher than that of comparative example 1 and blank control group, the moisture retention of comparative example 1 is slightly higher than that of blank control group, and the difference between the two is not great, which indicates that the polyglutamic acid hydrogel prepared from the polyglutamic acid aqueous solution with the concentration of 0.1-0.2 g/mL has good moisture retention performance. Meanwhile, the moisture retention rates of the comparative examples 2 to 4 are higher than those of the comparative example 1 and the blank control group, which shows that the substances also have good moisture retention. The hydrogel of comparative example 3 was synthesized from petrochemical raw materials and is a non-renewable resource; and the acrylic copolymer is difficult to naturally degrade and is not an environment-friendly green material. The hydrogel of comparative example 4 is obtained by chemical treatment with organic reagents, acids, alkalis, etc., and the preparation process may generate toxic and harmful gases, liquids, etc., which increases environmental management pressure.
Test example 2 non-tackiness test
The non-stickiness test was performed on the polyglutamic acid hydrogels of examples 1 and 2 and comparative examples 5 and 6 by the following specific method:
1g of each group of samples are respectively smeared on a glass slide, shredded paper scraps are uniformly scattered on the glass slide, then the glass slide is placed in an oven with the temperature of 80 ℃, the glass slide is taken out after water is evaporated, the glass slide is erected, the shredded paper scraps which are not adsorbed fall off, and the total mass of the glass slide, the products and the adsorbed shredded paper scraps at the moment is recorded.
The adsorption amounts of the respective groups were calculated according to the following formula, and the lower the adsorption amount, the better the non-stickiness effect. The results are shown in FIG. 1.
The adsorption capacity is m' -m,
wherein m' is the total mass of the dried glass slide, the product and the adsorbed shredded paper scrap;
and m is the total mass of the glass slide and the product before drying.
As shown in FIG. 1, the polyglutamic acid hydrogels of examples 1 and 2 are non-sticky, while the non-crosslinked polyglutamic acids of comparative examples 5 and 6 are sticky.
Test example 3 Water replenishing function test
The salt-sensitive hydrogels of examples 1-4 and comparative examples 1 and 2 were tested for water-replenishing function, and the specific method was:
cutting a non-woven fabric with the mass of 0.0825 (+ -0.0025) g, wherein the non-woven fabric just can cover a glass slide with the mass of about 4.6g and 7.5cm by 2.5cm, and uniformly coating 1 (+ -0.025) g of the polyglutamic acid hydrogel in the example 1 on the non-woven fabric (three hydrogel glass slides are prepared);
cutting a non-woven fabric with the mass of 0.0825 (+ -0.0025) g, wherein the non-woven fabric can just cover a glass slide with the mass of about 4.6g and 7.5cm by 2.5cm, and uniformly coating 1 (+ -0.025) g of NaCl aqueous solution with the concentration of 0%, 0.9% and 1.8%;
three hydrogel slides of example 1 were vertically combined with 0, 0.9, and 1.8% NaCl aqueous solution (water) coverslips, respectively, and the water separation was recorded to draw a salt concentration-water separation amount line graph.
The hydrogels of examples 2-4 and comparative examples 1, 2 were treated in the same manner.
As shown in FIG. 2, when the concentration of the NaCl aqueous solution is 0, no liquid flows out from each group, when the concentration of the NaCl aqueous solution is 0.9%, more water is separated out in examples 1-4 than in comparative examples 1 and 2, when the concentration of the NaCl aqueous solution is 1.8%, the difference between the water separation output of examples 1-4 and the water separation output of comparative examples 1 and 2 is more remarkable, and particularly, the water separation output of example 2 reaches more than 0.1g, which shows that the polyglutamic acid hydrogel in the intelligent water control mask can separate out water when meeting salt content, can release different water amounts according to the difference of salt content, and releases large water amount when the salt content is high, so that the intelligent water control mask is very suitable for people with high skin surface salt content.
Although the present invention has been described in detail by referring to the drawings in connection with the preferred embodiments, the present invention is not limited thereto. Various equivalent modifications or substitutions can be made on the embodiments of the present invention by those skilled in the art without departing from the spirit and scope of the present invention, and these modifications or substitutions are within the scope of the present invention/any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention.
Claims (10)
1. The application of the salt-sensitive hydrogel as an intelligent water-controlling and water-replenishing material is characterized in that the salt-sensitive hydrogel with the salt-releasing performance is applied to the surface of the skin, and the salt content on the surface of the skin is self-adapted to replenish a proper amount of water.
2. The use of claim 1, wherein the salt-sensitive hydrogel comprises one or a combination of polyglutamic acid hydrogel, hyaluronic acid hydrogel and xanthan gum hydrogel.
3. The use of claim 2, wherein the salt-sensitive hydrogel is prepared by a method comprising:
(1) mixing a salt sensitive aqueous solution with the concentration of 0.1-0.2 g/mL with a cross-linking agent, and heating in a water bath to perform a cross-linking reaction to obtain a salt sensitive glue block;
(2) and adding the salt sensitive gel block into water, homogenizing and crushing to obtain a uniform fluid state, thereby obtaining the salt sensitive hydrogel.
4. The use of claim 3, wherein the salt-sensitive hydrogel has a salt-sensitive concentration of 0.001 to 0.02 g/mL.
5. The use according to claim 3, wherein in step (1), the crosslinking agent is 1, 4-butanediol diglycidyl ether, and the mass-to-volume ratio of the salt-sensitive substance to the crosslinking agent is 10 to 50 g: 1mL, stirring and mixing the salt sensitive aqueous solution and the cross-linking agent at 30 ℃ and 700-1100 r/min for 30min, heating in a water bath at 40-62 ℃ for 5h, and performing cross-linking to obtain the salt sensitive glue block.
6. The use of claim 1, wherein the salt-sensitive hydrogel is supported on a carrier.
7. The use according to claim 6, wherein the carrier loaded with the salt-sensitive hydrogel is dried to obtain a carrier loaded with a dry gel of the salt-sensitive hydrogel.
8. The use of claim 7, wherein the carrier further comprises at least one human acceptable excipient.
9. The use of claim 8, wherein the excipient is one or more of glycerol, collagen peptide, and chromophoric factor.
10. The use according to claim 7, wherein the salt-sensitive hydrogel is supported on a carrier having a mass of 0.075 to 0.3g/cm2。
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CN202110495611.8A CN113274314B (en) | 2021-05-07 | 2021-05-07 | Application of salt-sensitive hydrogel as intelligent water control and water supplement material |
PCT/CN2021/000151 WO2022232958A1 (en) | 2021-05-07 | 2021-07-13 | Use of salt-sensitive hydrogel as intelligent water-control and water-replenishing material |
GB2307847.0A GB2616151A (en) | 2021-05-07 | 2021-07-13 | Use of salt-sensitive hydrogel as intelligent water-control and water-replenishing material |
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CN101914225A (en) * | 2010-08-05 | 2010-12-15 | 江南大学 | Method for preparing hyaluronic acid gel by using macromolecule photocrosslinking agent |
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CN111481497A (en) * | 2019-01-28 | 2020-08-04 | 北京万生人和科技有限公司 | Hydrogel |
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CN1803124A (en) * | 2005-01-12 | 2006-07-19 | 东海生物科技股份有限公司 | Gama-poly glutamic acid, gama-poly glutamic acid salt and use of hydrogel thereof |
CN101914225A (en) * | 2010-08-05 | 2010-12-15 | 江南大学 | Method for preparing hyaluronic acid gel by using macromolecule photocrosslinking agent |
CN104721873A (en) * | 2015-03-12 | 2015-06-24 | 北京蒙博润生物科技有限公司 | Preparation of flaky cross-linked sodium hyaluronate hydrogel |
CN105342882A (en) * | 2015-10-27 | 2016-02-24 | 山东省药学科学院 | Multi-efficiency compound moisturizing essence and application method thereof |
CN105255173A (en) * | 2015-11-10 | 2016-01-20 | 山东省药学科学院 | Preparation method of crosslinked polyglutamic acid hydrogel |
CN111481497A (en) * | 2019-01-28 | 2020-08-04 | 北京万生人和科技有限公司 | Hydrogel |
CN109908015A (en) * | 2019-03-26 | 2019-06-21 | 山东省药学科学院 | A kind of antiallergic repairs moisture-keeping composition and its preparation method and application |
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