CN113267630A - 基于RGMa片段的诊断测定 - Google Patents

基于RGMa片段的诊断测定 Download PDF

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Publication number
CN113267630A
CN113267630A CN202110521844.0A CN202110521844A CN113267630A CN 113267630 A CN113267630 A CN 113267630A CN 202110521844 A CN202110521844 A CN 202110521844A CN 113267630 A CN113267630 A CN 113267630A
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rgma
rgma fragment
level
subject
fragment
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Chinese (zh)
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S.巴霍恩
B.K.米勒
M.施米德特
A.斯特里宾格
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AbbVie Deutschland GmbH and Co KG
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AbbVie Deutschland GmbH and Co KG
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    • GPHYSICS
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/285Demyelinating diseases; Multipel sclerosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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CN202110521844.0A 2014-09-10 2015-09-09 基于RGMa片段的诊断测定 Pending CN113267630A (zh)

Applications Claiming Priority (3)

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US201462048745P 2014-09-10 2014-09-10
US62/048745 2014-09-10
CN201580048412.5A CN107076757A (zh) 2014-09-10 2015-09-09 基于RGMa片段的诊断测定

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CN202110521844.0A Pending CN113267630A (zh) 2014-09-10 2015-09-09 基于RGMa片段的诊断测定

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US (3) US20160069907A1 (cg-RX-API-DMAC7.html)
EP (1) EP3191847A1 (cg-RX-API-DMAC7.html)
JP (1) JP6879905B2 (cg-RX-API-DMAC7.html)
CN (2) CN107076757A (cg-RX-API-DMAC7.html)
AU (2) AU2015314240A1 (cg-RX-API-DMAC7.html)
BR (1) BR112017004883A2 (cg-RX-API-DMAC7.html)
CA (1) CA2956814A1 (cg-RX-API-DMAC7.html)
MX (2) MX385216B (cg-RX-API-DMAC7.html)
TW (2) TW202119030A (cg-RX-API-DMAC7.html)
WO (1) WO2016038084A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007067416A2 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2510001B1 (en) * 2009-12-08 2015-12-02 AbbVie Deutschland GmbH & Co KG Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration
PE20211376A1 (es) 2018-07-19 2021-07-27 Univ School St Marianna Medicine Agente terapeutico o profilactico para la mielopatia asociada al htlv-1 (ham), y metodo de tratamiento del ham
EP4091632A4 (en) * 2020-01-15 2024-07-10 Osaka University AGENTS FOR THE PREVENTION OR TREATMENT OF DIABETIC AUTONOMOUS NEUROPATHY
CN112402554B (zh) * 2020-10-26 2022-03-01 中国中医科学院广安门医院 一种治疗脑白质病的中药组合物及其应用
US12306192B2 (en) 2021-02-08 2025-05-20 Cedars-Sinai Medical Center Method of detecting cognitive impairment
EP4374300A4 (en) * 2021-07-23 2025-06-11 Cedars-Sinai Medical Center Methods and systems for the early detection of ocular and/or neurological conditions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1316055A (zh) * 1998-07-03 2001-10-03 基因创新有限公司 神经变性的鉴别诊断
WO2011071059A1 (ja) * 2009-12-09 2011-06-16 国立大学法人大阪大学 T細胞活性化阻害剤、これを含有する医薬組成物およびt細胞活性化阻害物質のスクリーニング方法
CN102656190A (zh) * 2009-12-08 2012-09-05 雅培股份有限两合公司 用于在视网膜神经纤维层变性治疗中使用的针对rgm a蛋白质的单克隆抗体
CA2839777A1 (en) * 2011-06-22 2012-12-27 Universite Laval Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease
CN103298834A (zh) * 2010-08-03 2013-09-11 Abbvie公司 双重可变结构域免疫球蛋白及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4986370B2 (ja) * 2000-12-22 2012-07-25 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ Rgmおよびそのモジュレーターの用途
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
WO2012047706A2 (en) * 2010-10-06 2012-04-12 Massachusetts Eye & Ear Infirmary Methods for promotiing reinnervation of auditory hair cells
EP3369746A1 (en) * 2012-01-27 2018-09-05 AbbVie Deutschland GmbH & Co KG Composition and method for diagnosis and treatment of diseases associated with neurite degeneration

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1316055A (zh) * 1998-07-03 2001-10-03 基因创新有限公司 神经变性的鉴别诊断
CN102656190A (zh) * 2009-12-08 2012-09-05 雅培股份有限两合公司 用于在视网膜神经纤维层变性治疗中使用的针对rgm a蛋白质的单克隆抗体
WO2011071059A1 (ja) * 2009-12-09 2011-06-16 国立大学法人大阪大学 T細胞活性化阻害剤、これを含有する医薬組成物およびt細胞活性化阻害物質のスクリーニング方法
CN102811739A (zh) * 2009-12-09 2012-12-05 田边三菱制药株式会社 T细胞活化抑制剂、含有其的药物组合物以及抑制t细胞活化的物质的筛选方法
CN103298834A (zh) * 2010-08-03 2013-09-11 Abbvie公司 双重可变结构域免疫球蛋白及其用途
CA2839777A1 (en) * 2011-06-22 2012-12-27 Universite Laval Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease

Non-Patent Citations (3)

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Title
NARDOS G: "SKI-1 and Furin Generate Multiple RGMa Fragments that Regulate Axonal Growth", DEVELOPMENTAL CELL, vol. 22, no. 2, pages 391 - 402, XP028891647, DOI: 10.1016/j.devcel.2011.11.022 *
徐雁;: "多发性硬化的生物学标记物", 中国神经免疫学和神经病学杂志, no. 02, pages 88 - 92 *
杨丽立;王维治;: "神经变性疾病脑脊液生物学标志物研究进展", 中国现代神经疾病杂志, no. 02, pages 76 - 79 *

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BR112017004883A2 (pt) 2017-12-05
AU2015314240A1 (en) 2017-02-09
MX385216B (es) 2025-03-14
US20200241012A1 (en) 2020-07-30
TW202119030A (zh) 2021-05-16
WO2016038084A1 (en) 2016-03-17
TW201617612A (zh) 2016-05-16
CN107076757A (zh) 2017-08-18
JP2017526930A (ja) 2017-09-14
US20160069907A1 (en) 2016-03-10
US20220018855A1 (en) 2022-01-20
EP3191847A1 (en) 2017-07-19
CA2956814A1 (en) 2016-03-17
JP6879905B2 (ja) 2021-06-02
AU2022200160A1 (en) 2022-02-10
MX2021009528A (es) 2021-09-08
MX2017003063A (es) 2017-06-14

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Application publication date: 20210817