CN113264880A

CN113264880A - Preparation method of 4-halogenated isoquinoline compound

Info

Publication number: CN113264880A
Application number: CN202110571238.XA
Authority: CN
Inventors: 张谦; 季慧慧; 邓诗军; 李栋
Original assignee: Hubei University of Technology
Current assignee: Hubei University of Technology
Priority date: 2021-05-25
Filing date: 2021-05-25
Publication date: 2021-08-17
Anticipated expiration: 2041-05-25
Also published as: CN113264880B

Abstract

The invention relates to a preparation method of a 4-halogenated isoquinoline compound, which is characterized in that Ag is added into a reactor₂O catalyst, reactant I, reactant II and K₂S₂O₈Placing a reactor in an oil bath kettle at the temperature of 60-100 ℃ for heating reaction for 4-12 hours, pouring the reaction liquid into a separating funnel, adding distilled water, extracting with ethyl acetate, combining the obtained organic phases, performing rotary drying by a rotary evaporator, and separating and purifying the crude product by column chromatography to obtain a 4-halogenated isoquinoline compound; wherein the first reactant is isoquinoline; and the reactant II is KX, and X is halogen. The invention takes isoquinoline group as a positioning group, and carries out halogenation reaction on the 4 th position of isoquinoline to synthesize the 4-halogenated isoquinoline compound. The method has the advantages of mild reaction conditions, high yield and environmental friendliness. Through detection, the synthesized 4-halogenated isoquinoline compound has better biological activity and can be applied to the fields of medicine synthesis, pesticide synthesis, paint dye synthesis and the like.

Description

Preparation method of 4-halogenated isoquinoline compound

Technical Field

The invention relates to a preparation method of an aromatic quinoline compound catalyzed and synthesized by transition metal, in particular to a preparation method of a 4-halogenated isoquinoline compound.

Background

The aromatic quinoline compounds are important chemical intermediates and products, and the compounds are widely applied to the fields of medicines, pesticides, coatings, dyes and the like. For example: isoquinoline can be used for manufacturing pesticides, antimalarial drugs, rubber vulcanization accelerators and chemical reagents for measuring rare metals. The methylquinoline can be used for manufacturing color film sensitizing agents and dyes, and can also be used as solvents, impregnants, corrosion inhibitors, quinine drugs, pesticides and the like. The common application of the aromatic quinoline compounds arouses great interest of researchers, and the research in the field is one of the current research hotspots.

Disclosure of Invention

The invention aims to provide a preparation method of a 4-halogenated isoquinoline compound, which has the advantages of simple process, mild reaction and environmental friendliness, aiming at the current situation.

The scheme adopted by the invention for solving the technical problems is as follows:

a process for the preparation of a 4-haloisoquinoline compound comprising the steps of: adding Ag into the reactor₂O catalyst, reactant I, reactant II and K₂S₂O₈Placing a reactor in an oil bath kettle at the temperature of 60-100 ℃ for heating reaction for 4-12 hours, pouring the reaction liquid into a separating funnel, adding distilled water, extracting with ethyl acetate, combining the obtained organic phases, performing rotary drying by a rotary evaporator, and separating and purifying the crude product by column chromatography to obtain a 4-halogenated isoquinoline compound; wherein the content of the first and second substances,

the first reactant is isoquinoline;

and the reactant II is KX, and X is halogen.

Preferably, the KX is potassium chloride or potassium bromide.

Preferably, Ag is in the reactor₂The proportion of the O catalyst, the reactant I, the reactant II, the oxidant and the acetonitrile solution is 0.04 mmol: 0.2 mmol: 1 mmol: 0.6 mmol: 2 mL.

Preferably, the spherical container at the bottom end of the reactor is immersed in the silicone oil to a depth that the height of the silicone oil is higher than that of the reaction liquid in the spherical container of the micro reaction tube.

Preferably, the content of acetonitrile in the acetonitrile solution is more than or equal to 99.9 percent.

Preferably, the purity of the first reactant is more than or equal to 99.0 percent, and Ag is₂The purity of O is more than or equal to 99.0 percent, the purity of the reactant II is more than or equal to 98 percent, and the purity of potassium persulfate is more than or equal toThe degree is more than or equal to 99.5 percent.

Preferably, the magnetic stirrer rotates at a speed of 100 to 650 revolutions per second.

The invention also aims to provide a 4-halogenated isoquinoline compound which is prepared by the method.

The invention also aims to provide application of the 4-halogenated isoquinoline compound in the fields of medicine synthesis, pesticide synthesis and paint dye synthesis.

The invention takes isoquinoline group as a positioning group, and carries out halogenation reaction on the 4 th position of isoquinoline to synthesize the 4-halogenated isoquinoline compound. The method has the advantages of mild reaction conditions, high yield and environmental friendliness. Through detection, the synthesized 4-halogenated isoquinoline compound has better biological activity and can be applied to the fields of medicine synthesis, pesticide synthesis, paint dye synthesis and the like.

Detailed Description

The following examples are provided to further illustrate the present invention for better understanding, but the present invention is not limited to the following examples.

The general reaction formula for the following examples is:

the acetonitrile solution used in the examples had a main component acetonitrile content of 99.9%, a purity of isoquinoline of 99.0%, a purity of silver oxide of 99.0%, a purity of potassium bromide or chloride of 98%, and a purity of potassium persulfate of 99.5%.

Example 1 preparation of 4-Chloroisoquinoline

0.04mmol of Ag is added into a reactor₂O catalyst, 0.2mmol of isoquinoline, 1mmol of potassium chloride, 0.6mmol of K₂S₂O₈2mL acetonitrile solution and magneton. Placing the reactor in an oil bath kettle at 100 deg.C for heatingThe reaction time is 12 hours. The spherical container at the bottom end of the reactor is immersed in the silicone oil, and the immersion depth is that the height of the silicone oil is higher than that of the reaction liquid in the spherical container of the micro reaction tube. The rotation speed of the magnetic stirrer was adjusted to 650 rpm, and after completion of the reaction, the reaction mixture was poured into a separatory funnel, 15mL of distilled water was added, and extraction was performed 3 times with 10mL of ethyl acetate. The organic phases are combined and dried by a rotary evaporator, and the crude product is separated and purified by column chromatography to obtain the 4-chloro isoquinoline compound with the yield of 48 percent.

By hydrogen nuclear magnetic resonance¹H NMR(400MHz,CDCl₃):δ7.60-7.64(m,1H),7.74-7.76(m,1H),7.94(d,J＝8.20Hz,1H),8.13(dd,J＝8.88Hz,J＝0.80Hz,1H),8.51(s,1H),9.08(s,1H)；¹³C NMR(100MHz,CDCl₃):δ122.3,126.7,127.2,127.4,128.4,130.4,132.5,140.8,150.1。

EXAMPLE 2 preparation of 4-Bromoisoquinoline

0.04mmol of Ag was added to the reactor₂O catalyst, 0.2mmol of isoquinoline, 1mmol of potassium bromide, 0.6mmol of K₂S₂O₈Oxidant, 2mL acetonitrile solution and magneton one. The reactor was placed in a 100 ℃ oil bath and heated for 12 hours. The spherical container at the bottom end of the reactor is immersed in the silicone oil, and the immersion depth is that the height of the silicone oil is higher than that of the reaction liquid in the spherical container of the micro reaction tube. The rotation speed of the magnetic stirrer was adjusted to 650 rpm, and after completion of the reaction, the reaction mixture was poured into a separatory funnel, 15mL of distilled water was added, and extraction was performed 3 times with 10mL of ethyl acetate. The organic phases are combined and dried by a rotary evaporator, and the crude product is separated and purified by column chromatography to obtain the 4-bromoisoquinoline compound with the yield of 58%.

While the foregoing is directed to the preferred embodiment of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow.

Claims

1. A method for preparing a 4-halogenated isoquinoline compound, which is characterized by comprising the following steps: adding Ag into the reactor₂O catalyst, reactant I, reactant II and K₂S₂O₈Placing a reactor in an oil bath kettle at the temperature of 60-100 ℃ for heating reaction for 4-12 hours, pouring the reaction liquid into a separating funnel, adding distilled water, extracting with ethyl acetate, combining the obtained organic phases, performing rotary drying by a rotary evaporator, and separating and purifying the crude product by column chromatography to obtain a 4-halogenated isoquinoline compound; wherein the content of the first and second substances,

the first reactant is isoquinoline;

and the reactant II is KX, and X is halogen.

2. The method for producing a 4-haloisoquinoline compound according to claim 1, wherein KX is potassium chloride or potassium bromide.

3. The method of claim 1, wherein the Ag is in the reactor₂The proportion of the O catalyst, the reactant I, the reactant II, the oxidant and the acetonitrile solution is 0.04 mmol: 0.2 mmol: 1 mmol: 0.6 mmol: 2 mL.

4. The method for producing a 4-haloisoquinoline compound according to claim 1, wherein the spherical vessel at the bottom end of the reactor is immersed in the silicone oil to a depth that the height of the silicone oil is higher than the height of the reaction liquid in the spherical vessel of the microreaction tube.

5. The method for producing a 4-haloisoquinoline compound according to claim 1, wherein the acetonitrile content in the acetonitrile solution is not less than 99.9%.

6. The method of claim 1, wherein the first reactant has a purity of 99.0% or more and Ag₂The purity of O is more than or equal to 99.0 percent, the purity of the reactant II is more than or equal to 98 percent, and the purity of the potassium persulfate is more than or equal to 99.5 percent.

7. The process for preparing a 4-haloisoquinoline compound according to claim 1, wherein: the magnetic stirrer rotates at a speed of 100 to 650 revolutions per second.

8. A4-halogenated isoquinoline compound characterized by being prepared by the method of any one of claims 1 to 6.

9. Use of the 4-haloisoquinoline compounds according to claim 8 in the fields of pharmaceutical synthesis, pesticide synthesis and coating dye synthesis.