CN113244201A - Partially neutralized polyacrylic acid hydrogel patch with high carboxyl content - Google Patents
Partially neutralized polyacrylic acid hydrogel patch with high carboxyl content Download PDFInfo
- Publication number
- CN113244201A CN113244201A CN202110568722.7A CN202110568722A CN113244201A CN 113244201 A CN113244201 A CN 113244201A CN 202110568722 A CN202110568722 A CN 202110568722A CN 113244201 A CN113244201 A CN 113244201A
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- CN
- China
- Prior art keywords
- partially neutralized
- neutralized polyacrylic
- hydrogel patch
- polyacrylic acid
- product
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a partially neutralized polyacrylic acid hydrogel patch with high carboxyl content, which is prepared by mixing carboxyl and sodium carboxylate in a ratio of 70: 30 the partially neutralized polyacrylic acid formed by the preparation is used as an adhesive to prepare a hydrogel patch. According to the invention, unsaturated ethylenic bonds on acrylic acid are broken under the induction of a photoinitiator in UV light, a free radical reaction is generated, a sodium polyacrylate high molecular product is generated, and simultaneously, the proportion of partially neutralized polypropylene is changed to obtain a carboxyl group and sodium carboxylate of 70: 30, the hydrogel patch is prepared from the polyacrylic acid material, so that the proportion of carboxyl in the product is greatly increased, the product adhesiveness can be improved, the product crosslinking strength can also be improved, the use value of the product at present is broken through, a larger market is expanded for improving the viscosity of the external patch, and the requirement of improving the viscosity of the product in the market is met.
Description
Technical Field
The invention belongs to the technical field of hydrogel materials, and particularly relates to a partially neutralized polyacrylic acid hydrogel patch with high carboxyl content.
Background
The partially neutralized polyacrylic acid product is the first hydrogel adhesive for external use invented by the company Showa Denko K.K., and mainly uses the aqueous matrix of hydrogel as carrier, so that it is good in safety and affinity for human body, and its drug-loading capacity is large.
It can be seen that the larger the proportion of carboxyl groups in the product, the better the viscosity of the product, and the carboxyl groups are needed for the crosslinking reaction, if the carboxyl groups are excessively consumed for crosslinking, the fewer the carboxyl groups used for forming hydrogen bonds with the skin, and if all the carboxyl groups are crosslinked, the product has no viscosity and is not suitable for being used as an external patch, but if the crosslinking is too little, the patch is too soft, the strength of the colloid is greatly reduced, and therefore, the ratio of carboxyl groups (COOH) to sodium carboxylates (COONa) is increased in consideration of the viscosity of the product and the strength of the patch. Currently, the highest proportion of internationally produced partially neutralized polyacrylic acid is COOH: COONa ═ 65: 35, this is NP800 product from showa electrician in japan, and AH106X product from east asia in japan, which is also 65: 35. since sodium carboxylate can only provide water solubility of the product and does not play any role in crosslinking and adhesion to the skin, increasing the ratio of carboxyl groups is the most central technology. NP700 product COOH from japan showa electrician: COONa ═ 50: 50, AH105X product synthesized in east Asia of Japan is also the same ratio, and AP-40F produced by Sumitomo chemical company of Japan, PN55 produced by Norex of England and the like are also the highest ratio of carboxyl groups produced by them is 65%, and thus the viscosity of the product cannot be maximized.
Disclosure of Invention
The object of the present invention is to remedy the drawbacks of the prior art by providing a partially neutralized polyacrylic hydrogel patch with a high carboxyl group content.
In order to achieve the above object, the present invention provides the following technical solutions:
a partially neutralized polyacrylic acid hydrogel patch with high carboxyl content, using a carboxyl group (COOH) and a sodium carboxylate group (COONa) of 70: 30 the partially neutralized polyacrylic acid formed by the preparation is used as an adhesive to prepare a hydrogel patch.
Further, the carboxyl group and the sodium carboxylate are 70: 30, and the technological process comprises the steps of proportioning, light polymerization, granulation, drying, coarse crushing, drying again, fine powdering and sieving.
Further, the ingredients and the light polymerization specifically comprise the following steps:
(1) dissolving poly-pure acrylic acid in purified water, cooling to room temperature, slowly scooping 16% caustic soda solution with a scoop to form a mixed mother liquor, and cooling for later use;
(2) dissolving urea and sodium formate in purified water to obtain a mixed solution A;
(3) dissolving azo photoinitiator V50 in purified water to obtain a mixed solution B;
(4) and adding the mixed solution A and the mixed solution B into the mixed mother solution, irradiating for 10 minutes by using UV light, and finishing the photocuring reaction to obtain a solid colloid.
The partially neutralized polyacrylic acid hydrogel patch with high carboxyl content is prepared by the following specific steps:
(1) weighing and preparing raw materials of each part according to the following proportion:
a first part: 25% of glycerin
Partially neutralized polyacrylic acid 5%
0.15 percent of dihydroxyaluminium aminoacetate
EDTA disodium salt 0.10%
A second part: purified water is supplemented to 100%
Tartaric acid 0.20%
Brilliant blue 850.001%
The third part is 0.3 percent of alcohol
0.3 percent of functional components
0.2 percent of preservative
(2) Mixing the three parts, stirring to obtain hydrogel colloid, coating with the colloid, and aging to obtain hydrogel patch.
Further, the functional components are traditional Chinese medicine extracts or facial mask essence.
The invention has the advantages that:
the invention utilizes unsaturated ethylenic bond on acrylic acid to be broken under the induction of photoinitiator in UV light, and free radical reaction is generated, so as to generate sodium polyacrylate high molecular product, and simultaneously, the ratio of partial neutralization polypropylene is changed, so that Carboxyl (COOH) and sodium carboxylate (COONa) are 70: 30, the hydrogel patch is prepared from the polyacrylic acid material, so that the proportion of carboxyl in the product is greatly increased, the product adhesiveness can be improved, the product crosslinking strength can also be improved, the use value of the product at present is broken through, a larger market is expanded for improving the viscosity of the external patch, and the requirement of improving the viscosity of the product in the market is met.
Detailed Description
The technical scheme of the invention is further explained by combining the specific examples as follows:
example 1
A partially neutralized polyacrylic acid hydrogel patch with high carboxyl content, using a carboxyl group (COOH) and sodium carboxylate (COONa) of 70: 30 the partially neutralized polyacrylic acid formed by the preparation is used as an adhesive to prepare a hydrogel patch.
The partially neutralized polyacrylic acid process flow comprises the steps of proportioning, photopolymerizing, granulating, drying, coarse crushing, drying again, fine powdering and sieving, wherein the steps of proportioning and photopolymerizing are as follows:
(1) dissolving 2000g of poly-pure acrylic acid in 3175g of pure water, cooling to room temperature, then slowly scooping 1390g of 16% caustic soda solution with a scoop to form a mixed mother solution, and cooling for later use;
(2) 60g of urea and 3.0g of sodium formate are dissolved in 400g of purified water to obtain a mixed solution A;
(3) dissolving 2.2g of azo photoinitiator V50 in 100g of purified water to obtain a mixed solution B;
(4) and adding the mixed solution A and the mixed solution B into the mixed mother solution, wherein the total amount is about 7.13 kg, 800 g of the mixed solution is taken in each plate, irradiating the mixed solution by using UV light for 10 minutes, and finishing the photocuring reaction to obtain a solid colloid.
The obtained partially neutralized polyacrylic acid with high carboxyl content is used for preparing the antipyretic patch, and the preparation method comprises the following steps:
(1) weighing and preparing raw materials of each part according to the following proportion:
a first part: 25% of glycerin
Partially neutralized polyacrylic acid 5%
0.15 percent of dihydroxyaluminium aminoacetate
EDTA disodium salt 0.10%
A second part: purified water is supplemented to 100%
Tartaric acid 0.20%
Brilliant blue 850.001%
The third part is 0.3 percent of alcohol
0.15 percent of borneol
Mint 0.15%
0.2 percent of preservative
(2) Mixing the three parts, stirring to obtain hydrogel colloid, coating with the colloid, and aging to obtain the final product.
The same formulation was used, selecting a commercially available 65: 35 partially neutralized polyacrylic acid, and further selected 70: 30 parts of the neutralized polyacrylic acid, under the same production conditions, the resulting finished product was measured for tackiness by the rolling ball method (GB 4851-1998), and it was experimentally determined that the tack holding property of the high proportion of carboxyl groups produced by the present invention was improved by 30% as compared with the tack holding property of the ordinary proportion of patches.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. A partially neutralized polyacrylic acid hydrogel patch with a high carboxyl group content, characterized in that the ratio of carboxyl groups (COOH) to sodium carboxylate groups (COONa) is 70: 30 the partially neutralized polyacrylic acid formed by the preparation is used as an adhesive to prepare a hydrogel patch.
2. The high carboxyl content partially neutralized polyacrylic hydrogel patch according to claim 1, wherein the carboxyl groups are 70: 30, and the technological process comprises the steps of proportioning, light polymerization, granulation, drying, coarse crushing, drying again, fine powdering and sieving.
3. The high carboxyl content partially neutralized polyacrylic hydrogel patch according to claim 2, wherein the compounding and photopolymerizing steps are as follows:
(1) dissolving poly-pure acrylic acid in purified water, cooling to room temperature, slowly scooping 16% caustic soda solution with a scoop to form a mixed mother liquor, and cooling for later use;
(2) dissolving urea and sodium formate in purified water to obtain a mixed solution A;
(3) dissolving azo photoinitiator V50 in purified water to obtain a mixed solution B;
(4) and adding the mixed solution A and the mixed solution B into the mixed mother solution, irradiating for 10 minutes by using UV light, and finishing the photocuring reaction to obtain a solid colloid.
4. The partially neutralized polyacrylic hydrogel patch with high carboxyl content according to claim 1, prepared by the following method:
(1) weighing and preparing raw materials of each part according to the following proportion:
a first part: 25% of glycerin
Partially neutralized polyacrylic acid 5%
0.15 percent of dihydroxyaluminium aminoacetate
EDTA disodium salt 0.10%
A second part: purified water is supplemented to 100%
Tartaric acid 0.20%
Brilliant blue 850.001%
The third part is 0.3 percent of alcohol
0.3 percent of functional components
0.2 percent of preservative
(2) Mixing the three parts, stirring to obtain hydrogel colloid, coating with the colloid, and aging to obtain hydrogel patch.
5. The high carboxyl content partially neutralized polyacrylic acid hydrogel patch according to claim 4, wherein the functional ingredient is a herbal extract or a mask essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110568722.7A CN113244201A (en) | 2021-05-25 | 2021-05-25 | Partially neutralized polyacrylic acid hydrogel patch with high carboxyl content |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110568722.7A CN113244201A (en) | 2021-05-25 | 2021-05-25 | Partially neutralized polyacrylic acid hydrogel patch with high carboxyl content |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113244201A true CN113244201A (en) | 2021-08-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110568722.7A Pending CN113244201A (en) | 2021-05-25 | 2021-05-25 | Partially neutralized polyacrylic acid hydrogel patch with high carboxyl content |
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| CN (1) | CN113244201A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114306286A (en) * | 2021-10-30 | 2022-04-12 | 钱峙涛 | Hydrogel patch and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001240683A (en) * | 2000-02-25 | 2001-09-04 | Beiersdorf Ag | Pressure sensitive adhesive composition based on acrylate having uv crosslinked structure |
| CN1758902A (en) * | 2003-03-07 | 2006-04-12 | 东亚合成株式会社 | Cataplasm base and cataplasm using the same |
| JP2008088290A (en) * | 2006-10-02 | 2008-04-17 | Toagosei Co Ltd | Poly(meth)acrylic acid partially neutralized product and method for producing the same |
| CN101926833A (en) * | 2010-08-06 | 2010-12-29 | 云南白药集团无锡药业有限公司 | Hydrogel patch and preparation method thereof |
| CN102614517A (en) * | 2012-04-16 | 2012-08-01 | 武汉纺织大学 | Preparation method of hydrogel patch matrix |
| CN103387627A (en) * | 2013-07-11 | 2013-11-13 | 淮北汇强高分子材料有限公司 | Partly-neutralized polyacrylic acid used for preparing hydrogel and preparation method thereof |
| CN111615381A (en) * | 2018-01-18 | 2020-09-01 | 大化制药株式会社 | Pharmaceutical composition for transdermal administration in the form of a hydrogel patch |
-
2021
- 2021-05-25 CN CN202110568722.7A patent/CN113244201A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001240683A (en) * | 2000-02-25 | 2001-09-04 | Beiersdorf Ag | Pressure sensitive adhesive composition based on acrylate having uv crosslinked structure |
| CN1758902A (en) * | 2003-03-07 | 2006-04-12 | 东亚合成株式会社 | Cataplasm base and cataplasm using the same |
| JP2008088290A (en) * | 2006-10-02 | 2008-04-17 | Toagosei Co Ltd | Poly(meth)acrylic acid partially neutralized product and method for producing the same |
| CN101926833A (en) * | 2010-08-06 | 2010-12-29 | 云南白药集团无锡药业有限公司 | Hydrogel patch and preparation method thereof |
| CN102614517A (en) * | 2012-04-16 | 2012-08-01 | 武汉纺织大学 | Preparation method of hydrogel patch matrix |
| CN103387627A (en) * | 2013-07-11 | 2013-11-13 | 淮北汇强高分子材料有限公司 | Partly-neutralized polyacrylic acid used for preparing hydrogel and preparation method thereof |
| CN111615381A (en) * | 2018-01-18 | 2020-09-01 | 大化制药株式会社 | Pharmaceutical composition for transdermal administration in the form of a hydrogel patch |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114306286A (en) * | 2021-10-30 | 2022-04-12 | 钱峙涛 | Hydrogel patch and preparation method thereof |
| CN114306286B (en) * | 2021-10-30 | 2023-08-18 | 钱峙涛 | Hydrogel patch and preparation method thereof |
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Application publication date: 20210813 |