CN113244016A - Stitching-free three-dimensional textile-based conductive myocardial patch and preparation method thereof - Google Patents
Stitching-free three-dimensional textile-based conductive myocardial patch and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a stitch-free three-dimensional textile-based conductive cardiac muscle patch and a preparation method thereof, wherein a plurality of barb short threads are vertically arranged on one side of the textile-based conductive cardiac muscle patch, and one end of each barb short thread is in contact with the surface of the textile-based conductive cardiac muscle patch; fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process; the axial perpendicular to weaving base conductive cardiac muscle patch's of the three-dimensional weaving base conductive cardiac muscle patch barb stub that makes plane, a plurality of barb stub evenly distributed is in weaving base conductive cardiac muscle patch with one side, and the barb stub is the stub that has the barb, and the barb is located on global of stub, and evenly arranges along the single direction. Compared with the traditional myocardial patch, the myocardial patch avoids the suture process in the implantation process of the myocardial patch, can realize myocardial repair through thoracoscopic surgery, reduces the operation difficulty and time, reduces postoperative complications, and has excellent clinical application prospect and market prospect.
Description
Technical Field
The invention belongs to the technical field of biological materials, and particularly relates to a suture-free three-dimensional textile-based conductive myocardial patch and a preparation method thereof.
Background
Myocardial Infarction (MI) and its complication are one of the main diseases causing death worldwide, the number of people dying from myocardial infarction in China is over 100 ten thousand each year, and the morbidity rises year by year. Although the widespread use of interventional therapy techniques and novel thrombolytic reinfusion therapies has resulted in significant reductions in acute phase mortality in patients with MI compared to the previous, the mortality rate of late-recovery complications of MI remains high. The main reason is that the myocardial tissue in the heart infarction area is gradually replaced by fibrotic scar tissue after necrosis, and the contractility and the electrical conductivity of the fibrotic scar tissue are far weaker than those of normal myocardial tissue, so that the whole heart has weakened blood ejection capability and disordered electrical conductivity, and the normal beating function is lost. Therefore, effective functional repair and reconstruction of damaged myocardial tissue is critical.
Electrical conductivity is an important factor in maintaining cardiac function. The introduction of the conductive material into the myocardial patch helps to restore electrical signal conduction to the myocardial infarcted area and suppress further increase in scar tissue. In addition, the natural myocardial tissue has obvious mechanical anisotropy, and the textile-based myocardial patch can realize an anisotropic structure through yarn arrangement. The most common method for fixing the conventional myocardial patch at the position of the myocardial infarction is a suture method, and the problems of complex operation process, large wound, easy generation of postoperative complications, long recovery time and the like exist.
Therefore, the development of a preparation method of the suture-free conductive myocardial patch with the anisotropic structure and a product thereof have very important significance.
Disclosure of Invention
The invention aims to solve the problem that a myocardial patch in the prior art needs complex suture, and provides a suture-free three-dimensional textile-based conductive myocardial patch with a barb structure and a preparation method thereof. According to the invention, the barb short thread is introduced in the z-axis direction (namely the direction perpendicular to the plane of the textile-based conductive myocardial patch) of the textile-based conductive myocardial patch, the myocardial patch with the barb structure is sent to a myocardial infarction part through a thoracoscopic operation, the barb short thread is inserted into the infarction part, and the suture-free effect of the patch is realized under the action of the barb structure.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a stitch-free three-dimensional textile-based conductive cardiac muscle patch comprises a textile-based conductive cardiac muscle patch and a plurality of barb short threads fixed with the textile-based conductive cardiac muscle patch;
the plurality of barb short lines are uniformly distributed (for example, stress concentration is generated due to nonuniform distribution, and tissues are seriously torn) on the same side of the textile-based conductive cardiac muscle patch;
the barb stub is the stub that has the barb, and the barb is located the global of stub, and all barbs are all towards textile base conductive cardiac muscle patch to guarantee that the barb can pierce the tissue smoothly, nevertheless hardly extract the tissue after piercing, unanimous with barb stylolite principle. The axial of stub is perpendicular (if not perpendicular, can cause the barb stub to pierce myocardium tissue difficulty, and the concrete expression is that required pressure of piercing is big, and serious can lead to the barb stub to buckle and can't pierce) in the plane of the electrically conductive myocardium patch of textile base (the electrically conductive myocardium patch of textile base is fabric construction, can regard as two-dimensional plane, the plane of the electrically conductive myocardium patch of textile base means two-dimensional plane).
The suture-free three-dimensional textile-based conductive myocardial patch can be delivered to a myocardial infarction part through thoracoscopic surgery, the barb short line is inserted into the infarction part, and the suture-free effect of the patch is realized through the barb structure. The invention provides a barb short line design in the z-axis direction, and avoids the suture problem in the implantation process of the myocardial patch. The prior art has focused primarily on how to design a myocardial patch that is consistent with the mechanical and electrical properties of natural myocardial tissue, and some studies focused on patch implantation means have also focused on imparting adhesion capability to the myocardial patch to the tissue, with no technical or research focus on such methods of mechanical fixation.
As a preferred technical scheme:
the non-sewing three-dimensional textile-based conductive myocardial patch has the advantages that the cross section of the barb is more than one of a circle, a triangle, a square, a wedge, an ellipse, an octagon, a rectangle and a flat shape.
According to the stitch-free three-dimensional textile-based conductive myocardial patch, the distance between adjacent barbs on the barb short lines is 0.1-0.5 mm, the included angle between each barb and the short line (trunk axis) is more than 0 and less than or equal to 80 degrees, and preferably 60 degrees; the number of rows of barbs is 1-4.
According to the stitch-free three-dimensional textile-based conductive myocardial patch, one end of the short line is in a bevel needle point shape (obtained by adopting a mechanical cutting or laser cutting process or directly obtained by pouring or 3D printing, and the bevel needle point shape is convenient for puncturing myocardial tissues), the other end of the short line is a plane, and one end where the plane is located is fixed with the textile-based conductive myocardial patch; the axial included angle between the inclined plane in the inclined plane needle point shape and the short line is 10-70 degrees, and preferably 30 degrees.
According to the stitch-free three-dimensional textile-based conductive myocardial patch, the warp density of the textile-based conductive myocardial patch is integral multiple of the warp density of the barb short lines, the weft density of the textile-based conductive myocardial patch is integral multiple of the weft density of the barb short lines, the warp density of the barb short lines is 10-500/cm (preferably 150-200/cm), and the weft density is 10-500/cm (preferably 150-200/cm); the warp density and the weft density respectively refer to the density along the warp direction and the weft direction; density refers to the number per unit length; the warp density and the weft density are independent, preferably the warp density and the weft density are equal, and the density of the barb short lines is in a multiple relation with the warp density and the weft density of the textile-based myocardial patch; the multiple relation means that the short threads are adhered to the warp and weft threads and are uniformly distributed. Taking the warp direction short threads as an example, the warp direction short threads are most closely divided into one weft yarn and one short thread, or every other two weft yarns and one short thread, and the like, and the two are in a multiple relation; the diameter of the short wire is related to the diameter of the fiber for the myocardial patch and is 0.5-1 time of the diameter of the fiber in the textile-based conductive myocardial patch; the length of the short line is 1-5 mm, preferably 2-3 mm; the short line is made of more than one of polylactic acid, polycaprolactone and polypropylene, preferably polycaprolactone or polypropylene. The pressure of the inclined plane needle point at the head end of the short line is high, the longest short line is only 5mm, the short line is not easy to bend (the moment is short), and the biological material with high rigidity is selected, so that the barb short line can be ensured to be inserted into tissues.
According to the sewing-free three-dimensional textile-based conductive cardiac muscle patch, the yarn raw material of the textile-based conductive cardiac muscle patch is conductive fiber, and the weave structure is plain weave, twill weave or satin weave.
The stitching-free three-dimensional textile-based conductive myocardial patch has the conductive fiber with the diameter of 20-100 mu m and the conductivity of 10-5～101S/m; the textile-based conductive myocardial patch is a woven fabric, the density of warp yarns is 100-500 yarns/cm, and the density of weft yarns is 100-500 yarns/cm.
The invention also provides a method for preparing the stitch-free three-dimensional textile-based conductive cardiac muscle patch, which comprises the steps of vertically placing a plurality of barb short lines on one side of the textile-based conductive cardiac muscle patch, wherein one ends of the barb short lines are in contact with the surface of the textile-based conductive cardiac muscle patch; and fixing the barbed short thread on one side of the textile-based conductive myocardial patch by adopting a hot melting process (specifically, melting a high polymer by ultrasonic wave or resistance heating in a hot melting machine, cooling, adhering the two materials together, and adopting the same principle as that of welding metal).
As a preferred technical scheme:
the preparation method of the barb short line comprises the following steps: the barbed suture is cut into short threads of desired length, which are then beveled at one end by a mechanical cutting or laser cutting process.
The method is characterized in that the preparation method of the barb short line comprises the following steps: the preparation method is characterized by preparing in a pouring or 3D printing mode.
The head end of the short wire adopted by the invention is in the shape of an inclined plane needle point, the axial included angle between the inclined plane of the inclined plane needle point and the short wire, the length of the short wire and the rigidity of the short wire can influence the difficulty degree during the penetration, the smaller the axial included angle between the inclined plane of the inclined plane needle point and the short wire is, the easier the penetration is, the smaller the length of the short wire is, the easier the penetration is, but the too short time can influence the fixity, the rigidity of the short wire is influenced by the raw materials, and the more the rigidity is, the easier the penetration is;
in addition, stub density is big, and fixed effect is better, but too closely can produce the resistance to the beating of heart, and barb density undersize can't realize exempting from to sew up, and too big injury to the tissue is big, exempts from to sew up the effect and also can worsen, has the interrelation between stub length and the barb density, and barb density and stub length have decided the barb number on a stub, can be through adjustment barb density and barb length to reach best fixed effect.
According to the texture structure of the textile-based conductive myocardial patch, particularly the structural design of the longitude and the weft, the barbed short threads are fixed on the warp and the weft, and a good fixing effect can be achieved on the premise of keeping uniform distribution.
Has the advantages that:
(1) the prepared myocardial patch has short lines with barb structures in the Z-axis direction, can be implanted into infarcted myocardium part through thoracoscopic operation, does not need to suture, fix and the like, and reduces operation difficulty and postoperative complications;
(2) the invention only adds the barbs vertical to the plane of the patch on the basis of the existing myocardial patch, avoids the complex step of sewing, can be suitable for any textile-based myocardial patch material, and the introduction of the Z-axis direction barb short line can not influence the inherent performance and structure of the myocardial patch.
Drawings
Fig. 1 is a schematic view of a structure and an application of a suture-free three-dimensional textile-based conductive myocardial patch.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
Example 1
A preparation method of a stitch-free three-dimensional textile-based conductive myocardial patch comprises the following specific steps:
(1) preparing barb short lines;
(1.1) writing a barb short line printing program;
wherein the length of the short line is 2mm, the diameter is 10 μm, one end of the short line is in the shape of an inclined needle point, and the other end is a plane; the axial included angle between the inclined plane in the inclined plane needle point shape and the short line is 60 degrees; the cross section of the barb is round; the barbs are positioned on the peripheral surface of the short line; the distance between adjacent barbs on the barb short line is 0.1mm, and the included angle between the barbs and the short line (trunk axis) is 60 degrees; all barbs face one end where the plane of the short line is located; the barbs are distributed in a row along the axial direction of the short line, the number of the rows of the barbs is 1, and included angles between two adjacent rows of the barbs are equal;
(1.2) carrying out 3D printing by using polylactic acid as a raw material;
(2) a textile-based conductive myocardial patch;
preparing a textile-based conductive myocardial patch by using conductive fibers (graphene modified fibers) as warp and weft yarns through a weaving process; wherein the conductive fiber has a diameter of 20 μm and a conductivity of 10-4S/m; the warp density is 100 pieces/cm, and the weft density is 100 pieces/cm; the weave structure is a plain weave;
(3) preparing a suture-free three-dimensional textile-based conductive myocardial patch;
(3.1) vertically placing a plurality of barb short threads on one side (corresponding to the warp and weft yarns) of the textile-based conductive myocardial patch, wherein one end of the plane of the barb short threads is in contact with the surface of the textile-based conductive myocardial patch; wherein the warp density of the barb short lines is 10 pieces/cm, and the weft density of the barb short lines is 50 pieces/cm;
(3.2) fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process, wherein the direction of the barb short line is the z-axis direction of the textile-based conductive cardiac muscle patch (namely the direction of the barb short line vertical to the plane of the textile-based conductive cardiac muscle patch); all barbs are directed towards the textile-based conductive myocardial patch.
The prepared stitching-free three-dimensional textile-based conductive cardiac muscle patch comprises a textile-based conductive cardiac muscle patch and barb short threads fixed with the textile-based conductive cardiac muscle patch.
Example 2
A preparation method of a stitch-free three-dimensional textile-based conductive myocardial patch comprises the following specific steps:
(1) preparing barb short lines;
(1.1) taking the existing commercial polycaprolactone barbed suture as a raw material; wherein the diameter of the barbed suture is 26 μm; the cross section of the barb is triangular; the barbs are positioned on the peripheral surface of the barbed suture line (trunk axis) and are uniformly distributed along a single direction; the distance between adjacent barbs of the barb suture line (trunk axis) is 0.2mm, and the included angle between the barbs and the barb suture line (trunk axis) is 60 degrees;
(1.2) cutting the barbed suture into short threads with the length of 3 mm; two ends of the short line are planes; the barbs are distributed in a row along the axial direction of the short line, the number of the rows of the barbs is 2, and included angles between two adjacent rows of the barbs are equal;
(1.3) cutting one end of the short line into a bevel needle point shape by mechanical cutting, wherein the axial included angle between the bevel of the bevel needle point shape and the barb short line is 60 degrees; and all barbs face to one end where the plane of the short line is located;
(2) a textile-based conductive myocardial patch;
preparing a textile-based conductive myocardial patch by using conductive fibers (carbon nanotube fibers) as warp and weft yarns through a weaving process; wherein the conductive fiber has a diameter of 30 μm and a conductivity of 101S/m; the warp density is 150 pieces/cm, and the weft density is 200 pieces/cm; the weave structure is twill;
(3) preparing a suture-free three-dimensional textile-based conductive myocardial patch;
(3.1) vertically placing a plurality of barb short threads on one side (corresponding to the warp and weft yarns) of the textile-based conductive myocardial patch, wherein one end of the plane of the barb short threads is in contact with the surface of the textile-based conductive myocardial patch; wherein the warp density of the barb short lines is 100 pieces/cm, and the weft density of the barb short lines is 200 pieces/cm;
(3.2) fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process, wherein the direction of the barb short line is the z-axis direction of the textile-based conductive cardiac muscle patch (namely the direction of the barb short line vertical to the plane of the textile-based conductive cardiac muscle patch); all barbs are directed towards the textile-based conductive myocardial patch.
The prepared stitching-free three-dimensional textile-based conductive cardiac muscle patch comprises a textile-based conductive cardiac muscle patch and barb short threads fixed with the textile-based conductive cardiac muscle patch.
Example 3
A preparation method of a stitch-free three-dimensional textile-based conductive myocardial patch comprises the following specific steps:
(1) preparing barb short lines;
and pouring the molten polypropylene solution into the barb short line die, and solidifying and molding. Wherein the short line has a length of 3mm and a diameter of 35 μm; one end of the short line is in a bevel needle point shape, and the other end is a plane; the axial included angle between the inclined plane in the inclined plane needle point shape and the short line is 10 degrees; the cross section of the barb is square; the barbs are positioned on the peripheral surface of the short line; the distance between adjacent barbs on the barb short line is 0.3mm, and the included angle between the barbs and the short line (trunk axis) is 10 degrees; all barbs face one end where the plane of the short line is located; the barbs are distributed in a row along the axial direction of the short line, the number of the rows of the barbs is 3, and included angles between two adjacent rows of the barbs are equal;
(2) a textile-based conductive myocardial patch;
preparing a textile-based conductive myocardial patch by using conductive fibers (silver fibers) as warp and weft yarns through a weaving process; wherein the conductive fiber has a diameter of 40 μm and a conductivity of 10-1S/m; the warp density is 300 pieces/cm, and the weft density is 300 pieces/cm; the weave structure is satin;
(3) preparing a suture-free three-dimensional textile-based conductive myocardial patch;
(3.1) vertically placing a plurality of barb short threads on one side (corresponding to the warp and weft yarns) of the textile-based conductive myocardial patch, wherein one end of the plane of the barb short threads is in contact with the surface of the textile-based conductive myocardial patch; wherein the warp density of the barb short lines is 150 pieces/cm, and the weft density of the barb short lines is 100 pieces/cm;
(3.2) fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process, wherein the direction of the barb short line is the z-axis direction of the textile-based conductive cardiac muscle patch (namely the direction of the barb short line vertical to the plane of the textile-based conductive cardiac muscle patch); all barbs are directed towards the textile-based conductive myocardial patch.
As shown in figure 1, the prepared suture-free three-dimensional textile-based conductive myocardial patch comprises a textile-based conductive myocardial patch and barb short threads fixed with the textile-based conductive myocardial patch.
The effect of fixing the myocardial patch of example 3 to myocardial tissue was explored, with the following steps:
(1) fixing the myocardial patch on a pig heart tissue sample with the thickness of 10mm, wherein the overlapping area is 10mm multiplied by 30 mm;
(2) one end of the cardiac tissue and one end of the myocardial patch were clamped using a shear tester, respectively, and then stretched at a constant speed of 50 mm/min. The patch was evaluated for bond strength at maximum peel force.
The experimental result shows that the maximum stripping force of the myocardial patch is 1N.
The influence of the myocardial patch of the embodiment 1-3 on myocardial repair is researched, and the method comprises the following steps:
(1) anesthetizing a rat with moderate ether, performing a left chest incision to expose the heart, and then ligating the left coronary artery with 8-0# suture 2mm below the left atrial appendage to establish a rat myocardial infarction model;
(2) dividing the myocardial infarction mice into two groups, wherein one group is implanted with a three-dimensional myocardial patch as an experimental group, and the other group without any operation is a control group;
(3) after 2 weeks, the rat heart function was observed using echocardiography, the rat was sacrificed, the heart was collected and fixed with 4% paraformaldehyde at 4 ℃ and dehydrated in ethanol, and the myocardial tissue sections were Masson trichrome stained for fibrotic tissue, infarct area, and left ventricular wall thickness changes;
the experimental result shows that the implantation of the myocardial patch can improve the ejection fraction of the infarcted heart of a rat and the short axis shortening rate of the left ventricle, and in addition, the internal size of the left ventricle in the contraction period is obviously reduced and is accompanied with the reduction of the fibrosis tissue and the infarct area.
Example 4
A preparation method of a stitch-free three-dimensional textile-based conductive myocardial patch comprises the following specific steps:
(1) preparing barb short lines;
(1.1) writing a barb short line printing program;
wherein the length of the short line is 4mm, the diameter is 30 μm, one end of the short line is in the shape of a bevel needle point, and the other end is a plane; the axial included angle between the inclined plane in the inclined plane needle point shape and the short line is 70 degrees; the cross section of the barb is wedge-shaped; the barbs are positioned on the peripheral surface of the short line; the distance between adjacent barbs on the barb short line is 0.4mm, and the included angle between the barbs and the short line (trunk axis) is 80 degrees; all barbs face one end where the plane of the short line is located; the barbs are distributed in a row along the axial direction of the short line, the number of the rows of the barbs is 4, and included angles between two adjacent rows of the barbs are equal;
(1.2) carrying out 3D printing by using polylactic acid as a raw material;
(2) a textile-based conductive myocardial patch;
preparing a textile-based conductive myocardial patch by using conductive fibers (stainless steel fiber wires) as warp and weft yarns through a weaving process; wherein the diameter of the conductive fiber is 50 μm, and the conductivity is 1S/m; the warp density is 125 pieces/cm, and the weft density is 400 pieces/cm; the weave structure is a plain weave;
(3) preparing a suture-free three-dimensional textile-based conductive myocardial patch;
(3.1) vertically placing a plurality of barb short threads on one side (corresponding to the warp and weft yarns) of the textile-based conductive myocardial patch, wherein one end of the plane of the barb short threads is in contact with the surface of the textile-based conductive myocardial patch; wherein the warp density of the barb short lines is 25/cm, and the weft density of the barb short lines is 200/cm;
(3.2) fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process, wherein the direction of the barb short line is the z-axis direction of the textile-based conductive cardiac muscle patch (namely the direction of the barb short line vertical to the plane of the textile-based conductive cardiac muscle patch); all barbs are directed towards the textile-based conductive myocardial patch.
The prepared stitching-free three-dimensional textile-based conductive cardiac muscle patch comprises a textile-based conductive cardiac muscle patch and barb short threads fixed with the textile-based conductive cardiac muscle patch.
Example 5
A preparation method of a stitch-free three-dimensional textile-based conductive myocardial patch comprises the following specific steps:
(1) preparing barb short lines;
(1.1) taking the existing commercial polycaprolactone barbed suture as a raw material; wherein the diameter of the barbed suture is 50 μm; the cross section of the barb is elliptical; the barbs are positioned on the peripheral surface of the barbed suture line (trunk axis) and are uniformly distributed along a single direction; the distance between adjacent barbs of the barb suture line (trunk axis) is 0.5mm, and the included angle between the barbs and the barb suture line (trunk axis) is 30 degrees;
(1.2) cutting the barbed suture into short threads with the length of 2 mm; two ends of the short line are planes; the barbs are distributed in a row along the axial direction of the short line, the number of the rows of the barbs is 4, and included angles between two adjacent rows of the barbs are equal;
(1.3) cutting one end of the short line into a bevel needle point shape by a laser cutting process, wherein the axial included angle between the bevel of the bevel needle point shape and the barb short line is 30 degrees; all barbs face one end where the plane of the short line is located;
(2) a textile-based conductive myocardial patch;
preparing a textile-based conductive myocardial patch by using conductive fibers (carbon coating conductive fibers) as warp and weft yarns through a weaving process; wherein the conductive fiber has a diameter of 70 μm and a conductivity of 10-5S/m; the density of warp yarns is 250 pieces/cm, and the density of weft yarns is 450 pieces/cm; the weave structure is twill;
(3) preparing a suture-free three-dimensional textile-based conductive myocardial patch;
(3.1) vertically placing a plurality of barb short lines on one side of the textile-based conductive cardiac muscle patch, wherein one end of the plane of the barb short lines is in contact with the surface of the textile-based conductive cardiac muscle patch; wherein the warp density of the barb short lines is 50/cm, and the weft density of the barb short lines is 450/cm;
(3.2) fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process, wherein the direction of the barb short line is the z-axis direction of the textile-based conductive cardiac muscle patch (namely the direction of the barb short line vertical to the plane of the textile-based conductive cardiac muscle patch); all barbs are directed towards the textile-based conductive myocardial patch.
The prepared stitching-free three-dimensional textile-based conductive cardiac muscle patch comprises a textile-based conductive cardiac muscle patch and barb short threads fixed with the textile-based conductive cardiac muscle patch.
Example 6
A preparation method of a stitch-free three-dimensional textile-based conductive myocardial patch comprises the following specific steps:
(1) preparing barb short lines;
and pouring the molten polypropylene solution into the barb short line die, and solidifying and molding. Wherein the length of the short line is 5mm, and the diameter is 66 μm; one end of the short line is in a bevel needle point shape, and the other end is a plane; the axial included angle between the inclined plane in the inclined plane needle point shape and the short line is 50 degrees; the cross section of the barb is octagonal; the barbs are positioned on the peripheral surface of the short line; the distance between adjacent barbs on the barb short line is 0.4mm, and the included angle between the barbs and the short line (trunk axis) is 50 degrees; all barbs face one end where the plane of the short line is located; the barbs are distributed in a row along the axial direction of the short line, the number of the rows of the barbs is 4, and included angles between two adjacent rows of the barbs are equal;
(2) a textile-based conductive myocardial patch;
preparing a textile-based conductive myocardial patch by using conductive fibers (silver fiber conductive wires) as warp and weft yarns through a weaving process; wherein the diameter of the conductive fiber is 80 μm, and the conductivity is 10-2S/m; the density of warp yarns is 200 pieces/cm, and the density of weft yarns is 500 pieces/cm; the weave structure is satin;
(3) preparing a suture-free three-dimensional textile-based conductive myocardial patch;
(3.1) vertically placing a plurality of barb short threads on one side (corresponding to the warp and weft yarns) of the textile-based conductive myocardial patch, wherein one end of the plane of the barb short threads is in contact with the surface of the textile-based conductive myocardial patch; wherein the warp density of the barb short lines is 40/cm, and the weft density of the barb short lines is 500/cm;
(3.2) fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process, wherein the direction of the barb short line is the z-axis direction of the textile-based conductive cardiac muscle patch (namely the direction of the barb short line vertical to the plane of the textile-based conductive cardiac muscle patch); all barbs are directed towards the textile-based conductive myocardial patch.
The prepared stitching-free three-dimensional textile-based conductive cardiac muscle patch comprises a textile-based conductive cardiac muscle patch and barb short threads fixed with the textile-based conductive cardiac muscle patch.
Example 7
A preparation method of a stitch-free three-dimensional textile-based conductive myocardial patch comprises the following specific steps:
(1) preparing barb short lines;
(1.1) writing a barb short line printing program;
wherein the length of the short line is 1mm, the diameter is 100 μm, one end of the short line is in the shape of an inclined needle point, and the other end is a plane; the axial included angle between the inclined plane in the inclined plane needle point shape and the short line is 60 degrees; the cross section of the barb is rectangular or flat, and the number ratio is 1: 1; the two barbs are uniformly and alternately positioned on the peripheral surface of the short line; the distance between adjacent barbs on the barb short line is 0.3mm, and the included angle between the barbs and the short line (trunk axis) is 60 degrees; all barbs face one end where the plane of the short line is located; the barbs are distributed in a row along the axial direction of the short line, the number of the rows of the barbs is 4, and included angles between two adjacent rows of the barbs are equal;
(1.2) respectively taking polylactic acid and polypropylene as raw materials to perform 3D printing;
(2) a textile-based conductive myocardial patch;
preparing a textile-based conductive myocardial patch by using conductive fibers (carbon fiber yarns) as warp and weft yarns through a weaving process; wherein the conductive fiber has a diameter of 100 μm and a conductivity of 101S/m; the warp density is 500 pieces/cm, and the weft density is 500 pieces/cm; tissue ofThe structure is a plain weave;
(3) preparing a suture-free three-dimensional textile-based conductive myocardial patch;
(3.1) vertically placing a plurality of barb short threads on one side (corresponding to the warp and weft yarns) of the textile-based conductive myocardial patch, wherein one end of the plane of the barb short threads is in contact with the surface of the textile-based conductive myocardial patch; wherein the warp density of the barb short lines is 500 pieces/cm, the weft density of the barb short lines is 250 pieces/cm, and the ratio of the number of the barb short lines made of polylactic acid to the number of the barb short lines made of polypropylene is 1: 1;
(3.2) fixing the barb short line on one side of the textile-based conductive cardiac muscle patch by adopting a hot melting process, wherein the direction of the barb short line is the z-axis direction of the textile-based conductive cardiac muscle patch (namely the direction of the barb short line vertical to the plane of the textile-based conductive cardiac muscle patch); all barbs are directed towards the textile-based conductive myocardial patch.
The prepared stitching-free three-dimensional textile-based conductive cardiac muscle patch comprises a textile-based conductive cardiac muscle patch and barb short threads fixed with the textile-based conductive cardiac muscle patch.
Claims (10)
1. A stitch-free three-dimensional textile-based conductive myocardial patch is characterized in that: comprises a textile-based conductive cardiac muscle patch and a plurality of barb short lines fixed with the textile-based conductive cardiac muscle patch;
the plurality of barb short lines are uniformly distributed on the same side of the textile-based conductive cardiac muscle patch;
the barb short line is a short line with barbs, the barbs are positioned on the peripheral surface of the short line, and the axial direction of the short line is perpendicular to the plane of the textile-based conductive myocardial patch; all barbs are directed towards the textile-based conductive myocardial patch.
2. The stitch-free three-dimensional textile-based conductive myocardial patch according to claim 1, wherein the cross-sectional shape of the barbs is one or more of circular, triangular, square, wedge, oval, octagonal, rectangular, and flat.
3. The stitch-free three-dimensional textile-based conductive myocardial patch according to claim 1, wherein the distance between adjacent barbs on the short line of the barbs is 0.1-0.5 mm, and the included angle between the barbs and the short line is greater than 0 and less than or equal to 80 degrees; and the barbs are distributed in rows along the axial direction of the short line, and the number of the rows is 1-4.
4. The stitch-free three-dimensional textile-based conductive myocardial patch according to claim 1, wherein one end of the short line is in a shape of a bevel needle point, the other end of the short line is a plane, and one end of the plane is fixed with the textile-based conductive myocardial patch; the axial included angle between the inclined plane of the inclined plane needle point shape and the short line is 10-70 degrees.
5. The stitch-free three-dimensional textile-based conductive myocardial patch according to claim 1, wherein the warp density of the textile-based conductive myocardial patch is an integral multiple of the warp density of the barb stubs, and the weft density of the textile-based conductive myocardial patch is an integral multiple of the weft density of the barb stubs; the diameter of the short wire is 0.5-1 time of the diameter of the fiber in the textile-based conductive myocardial patch; the length of the short line is 1-5 mm; the barb short line is made of more than one of polylactic acid, polycaprolactone and polypropylene.
6. The stitch-free three-dimensional textile-based conductive myocardial patch according to claim 1, wherein the yarn raw material of the textile-based conductive myocardial patch is conductive fiber, and the weave structure is plain, twill or satin.
7. The stitch-free three-dimensional textile-based conductive myocardial patch according to claim 6, wherein the conductive fibers have a diameter of 20-100 μm and an electrical conductivity of 10-5～101S/m; the warp density of the textile-based conductive myocardial patch is 10-500 pieces/cm, and the weft density is 10-500 pieces/cm.
8. The method for preparing the suture-free three-dimensional textile-based conductive myocardial patch as claimed in any one of claims 1 to 7, which is characterized in that: vertically placing a plurality of barb short lines on one side of the textile-based conductive cardiac muscle patch, wherein one end of each barb short line is in contact with the surface of the textile-based conductive cardiac muscle patch; and fixing the barb short line on one side of the textile-based conductive myocardial patch by adopting a hot melting process.
9. The method of claim 8, wherein the barbed stub is prepared by: the barbed suture is cut into short threads of desired length, which are then beveled at one end by a mechanical cutting or laser cutting process.
10. The method of claim 8, wherein the barbed stub is prepared by: the preparation method is characterized by preparing in a pouring or 3D printing mode.
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