CN113243943A - Intelligent oral mucosa sampling device and sampling method for gene detection - Google Patents
Intelligent oral mucosa sampling device and sampling method for gene detection Download PDFInfo
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- CN113243943A CN113243943A CN202110540101.8A CN202110540101A CN113243943A CN 113243943 A CN113243943 A CN 113243943A CN 202110540101 A CN202110540101 A CN 202110540101A CN 113243943 A CN113243943 A CN 113243943A
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- 238000005070 sampling Methods 0.000 title claims abstract description 138
- 210000002200 mouth mucosa Anatomy 0.000 title claims abstract description 35
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 34
- 238000001514 detection method Methods 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title abstract description 11
- 235000009161 Espostoa lanata Nutrition 0.000 claims abstract description 36
- 240000001624 Espostoa lanata Species 0.000 claims abstract description 36
- 230000000149 penetrating effect Effects 0.000 claims abstract description 6
- 230000002457 bidirectional effect Effects 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 210000000214 mouth Anatomy 0.000 abstract description 18
- 239000000523 sample Substances 0.000 description 19
- 210000004400 mucous membrane Anatomy 0.000 description 9
- 239000007788 liquid Substances 0.000 description 6
- 238000003825 pressing Methods 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
The invention relates to the technical field of gene detection, and discloses an oral mucosa intelligent sampling device and a sampling method for gene detection, which comprises a device base and a movable plate, wherein two sides of the upper surface of the device base are symmetrically provided with supporting side plates, one side of the upper surface of the device base is provided with a supporting column, the upper end of one side, close to the supporting side plates, of the supporting column is fixedly connected with a connecting column, the tail end of the connecting column is fixedly connected with a fixed shaft, the tail end of the fixed shaft is provided with a first limiting block, the side surface of one end of the movable plate is provided with a first circular through hole in a penetrating manner, the movable plate is rotatably connected with the fixed shaft, the other end of the movable plate is provided with a containing groove, the two-way electric telescopic rod drives a detachable sampling cotton ball to relatively move in an oral cavity to sample oral mucosa, the sampling is convenient to carry out, the sampling is controlled by a cylinder, the sampling connecting rod and the detachable sampling cotton ball extend out or retract into the containing groove, the collected oral mucosa cells are effectively protected, and pollution is avoided.
Description
Technical Field
The invention relates to the technical field of gene detection, in particular to an oral mucosa intelligent sampling device and a sampling method for gene detection.
Background
The gene detection is a technology for detecting DNA through blood, other body fluids or cells, which takes peripheral venous blood or other tissue cells of a detected person, amplifies the gene information, detects DNA molecular information in the cells of the detected person through a specific device, analyzes various conditions of the gene contained in the cells, and accordingly enables people to know the gene information of the people, and to determine the cause of disease or predict the risk of the body to suffer from certain diseases.
Some gene detection mechanisms sample and sample oral mucosa cells, generally use the oral mucosa spatula to stretch into the oral cavity, scrape the mucosa on both sides of the oral cavity respectively, need to scrape repeatedly to collect the appropriate sample, and use the spatula to exert force improperly and easily hurt people, the operation is inconvenient; gather the curette that has oral mucosa cell and need soak in the normal saline, wash the mucosa cell to the aquatic, collect, at the in-process that oral mucosa curette shifted, the sample exposes in the air, receives the pollution of bacterium in the air easily. The oral mucosa cell of drawing out is at the in-process of transportation, and the validity of cell sample can not be guaranteed, need add cell retaining fluid in sample solution, makes its intensive mixing, just can keep cell activity for a long time, all makes its misce bene through artificial shaking among the prior art, wastes time and energy.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the oral mucosa intelligent sampling device for gene detection, which has the advantages of no need of manually rotating a cotton ball to scrape a sample, effective protection of the sample, high-efficiency preservation of the sample and the like, and solves the problems that the manual scraping of the sample is inconvenient to operate, the sample is easily infected by external bacteria, and the sample is not easy to preserve.
(II) technical scheme
In order to solve the technical problems that the operation of manually scraping the sample is inconvenient, the sample is easily infected by external bacteria, and the sample is not easy to store, the invention provides the following technical scheme:
an oral mucosa intelligent sampling device for gene detection comprises a device base and a movable plate, wherein supporting side plates are symmetrically arranged on two sides of the upper surface of the device base, a supporting column is arranged on one side of the upper surface of the device base and is arranged at one end of the supporting side plates, a connecting column is fixedly connected to the upper end of one side, close to the supporting side plates, of the supporting side plates, a fixed shaft is fixedly connected to the tail end of the connecting column, a first limiting block is arranged at the tail end of the fixed shaft, a first circular through hole is formed in the side surface of one end of the movable plate in a penetrating mode, the fixed shaft penetrates through the first circular through hole, the movable plate is rotatably connected with the fixed shaft, a containing groove is formed in the other end of the movable plate, an air cylinder is fixedly installed inside the containing groove, a first arc-shaped plate is fixedly connected to the movable end of the air cylinder, and a fixed plate is respectively fixedly connected to the upper end and the lower end of the first arc-shaped plate, fixedly connected with fixed block between the fixed plate, it is provided with the circular through-hole of second to run through between the fixed block both sides, the inside fixed mounting of the circular through-hole of second has two-way electric telescopic handle, the expansion end of two-way electric telescopic handle both sides fixed mounting respectively has first connecting block, first connecting block end difference first traveller of fixedly connected with.
Preferably, the medial surface of first arc is provided with first T shape spout, the inside two second travelers that are provided with of first T shape spout, two the second traveller symmetry slidable mounting be in first T shape spout both sides, the equal fixedly connected with second connecting block in second traveller side, the equal fixedly connected with connecting plate in second connecting block one side, two a side surface that the connecting plate is close to each other all is provided with second T shape spout.
Preferably, two first traveller is slidable mounting respectively two inside the second T shape spout, two the connecting plate is kept away from one side difference fixedly connected with of second connecting block rotates the connecting block and rotates the connecting block down, it sets up to go up to rotate the connecting block and rotate the connecting block upper surface down, go up to rotate the connecting block with the circular through-hole department of rotating connecting block central authorities down rotates and installs the pivot.
Preferably, both ends difference fixedly connected with second stopper, two about the pivot the second stopper sets up respectively go up the upper surface of rotation connecting block with the lower surface of lower rotation connecting block, go up the rotation connecting block with lower rotation connecting block is kept away from one side difference fixedly connected with sampling connecting rod, two of connecting plate sampling connecting rod end is provided with respectively can dismantle the sampling cotton ball.
Preferably, a mounting groove is formed in one side of the device base, a detachable sealing plate is arranged on the outer side of the mounting groove, a hydraulic cylinder is fixedly mounted on the bottom surface inside the mounting groove, a movable end of the top of the hydraulic cylinder penetrates through the upper surface of the device base and is fixedly connected with a supporting circular plate, a supporting rod is uniformly arranged on the upper surface of the supporting circular plate, and a supporting sleeve is arranged at the top end of the supporting rod.
Preferably, support fixed mounting and have the sampling bottle between the cover inner wall, the sampling bottle bottom sets to coniform, the sampling bottle bottom is provided with the unloading valve, the first connecting piece of sampling bottle outer wall both sides fixedly connected with respectively, first connecting piece fixed surface is connected with T shape guide block, T shape guide block slidable mounting be in support the inside T shape guide way that curb plate surface set up.
Preferably, the sampling bottle top surface is provided with the rectangle opening, the rectangle opening sets up under the fixed axle, the rectangle opening with fly leaf side profile phase-match, the rectangle opening outside is provided with the spout, the outside one side of spout is provided with fixed stop, fixed stop fixed connection be in the sampling bottle top surface.
Preferably, spout surface movable mounting has the apron, fixed surface is connected with the connection ejector pad on the apron, connect ejector pad one side fixed mounting have first spring, the inside first flexible guide bar that is provided with of first spring, first spring with first flexible guide bar end all with fixed stop fixed connection.
Preferably, the fly leaf is close to the one end side fixedly connected with push pedal of accomodating the groove, fly leaf other end fixedly connected with second connecting piece, second connecting piece one side fixed mounting has fixed sleeve, fixed sleeve terminal surface with the support column is close to one side contactless each other of fly leaf.
Preferably, a second spring is fixedly mounted inside the fixed sleeve, a second telescopic guide rod is arranged inside the second spring, a positioning block is fixedly connected to the tail end of the second spring and is sleeved inside the fixed sleeve in a sliding mode, and a pressing column is arranged on one side of the positioning block.
(III) advantageous effects
Compared with the prior art, the invention provides an oral mucosa intelligent sampling device for gene detection, which has the following beneficial effects:
1. this an oral cavity mucous membrane intelligent sampling device for gene detection, it is flexible simultaneously to drive two first travellers through two-way electric telescopic handle is flexible, first traveller slides along second T shape spout, make two connecting plates keep away from each other or be close to round the pivot, and then drive two sampling connecting rods and rotate relatively, the sampling connecting rod drives can dismantle the sampling cotton ball and move relatively in the oral cavity, take a sample to the oral cavity mucous membrane, need not the artificial sampling cotton ball that can dismantle of rotating, the going on of convenient sampling, the sampling cotton ball can be dismantled, replace when being convenient for different personnel use, and use the cotton ball sampling can not make the people be injured.
2. This an oral cavity mucous membrane intelligence sampling device for gene detection, it is flexible to drive first arc through the cylinder is flexible, and then control sampling connecting rod with can dismantle the sampling cotton ball and stretch out or retract and accomodate the inslot portion, make the oral cavity mucous membrane cell that can dismantle the sampling cotton ball and gather effectively protected, avoid it by the bacterial contamination in the air.
3. This an oral cavity mucous membrane intelligence sampling device for gene detection connects the ejector pad through promoting, drives the apron and slides along the spout, opens the rectangle opening, and first spring and first flexible guide bar are compressed simultaneously, and the power that promotes to connect the ejector pad disappears the back, and first spring resets, drives the apron and resets, covers the rectangle opening again, can keep encapsulated situation constantly when making the sampling bottle not operated by the people, avoids inside to receive the pollution.
4. This an oral cavity mucous membrane intelligence sampling device for gene detection through pressing the compression leg, drives locating piece and the shrink of second spring, inside the locating piece retraction fixed sleeve, spacing relieving can rotate the fly leaf, and the fly leaf rotates when opening side level or the vertical of accomodating the groove, loosens the locating piece, and the extension of second spring resets, drives the locating piece and pops out and block the top surface or the side at the support column, fixes a position the fly leaf.
5. This an oral cavity mucous membrane intelligence sampling device for gene detection, through rotating the fly leaf, fly leaf pivoted in-process, the push pedal rotates thereupon, and the push pedal is slowly close to connecting the ejector pad, and the ejector pad is connected in final promotion, opens the rectangle opening, and the fly leaf resumes the in-process of normal position reversal, and the push pedal slowly keeps away from thereupon, and the power that the ejector pad was connected in the promotion slowly weakens until disappearing, and first spring drives the apron and resets, covers the rectangle opening again.
6. This an oral mucosa intelligence sampling device for gene detection makes through the cylinder can dismantle in the sampling cotton ball submerges the inside normal saline of sampling bottle completely, drives the sampling connecting rod and can dismantle sampling cotton ball relative rotation through two-way electric telescopic handle, reaches the stirring effect, makes the oral mucosa cell that can dismantle the sampling cotton ball and gather wash into in the normal saline completely.
7. This an oral cavity mucous membrane intelligent sampling device for gene detection drives through the cylinder and can dismantle the sampling cotton ball and rise to more than the liquid level, and the cylinder is reciprocal flexible, will dismantle that the solution of sampling cotton ball internal adsorption shakes off as far as possible, avoids extravagant, prevents the sample disappearance, and then influences gene testing result.
8. This an oral mucosa intelligence sampling device for gene detection drives through the pneumatic cylinder and supports the plectane and go up and down, and then drives the quick lift of sampling bottle, vibrates the inside normal saline, cell retaining fluid and the oral mucosa cell of sampling bottle, makes its intensive mixing for the oral mucosa cell can be high-efficient, stably preserve.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic view of the structure of the base of the apparatus of the present invention;
FIG. 3 is a schematic diagram of a movable plate structure according to the present invention;
FIG. 4 is a schematic view of the sampling mechanism of the present invention;
FIG. 5 is a schematic view of a first curved plate structure according to the present invention;
FIG. 6 is a schematic view of the two-way electric telescopic rod of the present invention;
FIG. 7 is a schematic view of a sampling connection rod according to the present invention;
FIG. 8 is a schematic view of a sample bottle of the present invention;
FIG. 9 is a schematic view of the cover plate structure of the present invention;
fig. 10 is a schematic view of the structure of the pressing column of the present invention.
In the figure: 1. a device base; 2. supporting the side plates; 3. a support pillar; 4. connecting columns; 5. a fixed shaft; 6. a first stopper; 7. a movable plate; 8. a first circular through hole; 9. a receiving groove; 10. a cylinder; 11. a first arc-shaped plate; 12. a fixing plate; 13. a fixed block; 14. a second circular through hole; 15. a bidirectional electric telescopic rod; 16. a first connection block; 17. a first traveler; 18. a first T-shaped chute; 19. a second strut; 20. a second connecting block; 21. a connecting plate; 22. a second T-shaped chute; 23. the connecting block is rotated upwards; 24. a lower rotating connecting block; 25. a rotating shaft; 26. a second limiting block; 27. a sampling connecting rod; 28. the sampling cotton ball can be disassembled; 29. mounting grooves; 30. a detachable sealing plate; 31. a hydraulic cylinder; 32. a supporting circular plate; 33. a support bar; 34. a support sleeve; 35. a sampling bottle; 36. a first connecting member; 37. a T-shaped guide block; 38. a T-shaped guide slot; 39. a rectangular opening; 40. a chute; 41. fixing a baffle plate; 42. a cover plate; 43. connecting the push block; 44. a first spring; 45. a first telescoping guide bar; 46. pushing the plate; 47. a second connecting member; 48. fixing the sleeve; 49. a second spring; 50. positioning blocks; 51. the column is pressed.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-10, an intelligent oral mucosa sampling device for gene detection comprises a device base 1 and a movable plate 7, wherein two sides of the upper surface of the device base 1 are symmetrically provided with supporting side plates 2, one side of the upper surface of the device base 1 is provided with a supporting column 3, the supporting column 3 is arranged at one end of the supporting side plate 2, the upper end of one side of the supporting column 3 close to the supporting side plate 2 is fixedly connected with a connecting column 4, the tail end of the connecting column 4 is fixedly connected with a fixed shaft 5, the tail end of the fixed shaft 5 is provided with a first limiting block 6, one end side of the movable plate 7 is provided with a first circular through hole 8 in a penetrating manner, the fixed shaft 5 is provided with a first circular through hole 8, the movable plate 7 is rotatably connected with the fixed shaft 5, the other end of the movable plate 7 is provided with an accommodating groove 9, a cylinder 10 is fixedly arranged inside the accommodating groove 9, the movable end of the cylinder 10 is fixedly connected with a first arc plate 11, and the upper end and the lower end of the first arc plate 11 are respectively and fixedly connected with a fixed plate 12, fixedly connected with fixed block 13 between fixed plate 12, run through between the fixed block 13 both sides and be provided with the circular through-hole 14 of second, the inside fixed mounting of the circular through-hole 14 of second has two-way electric telescopic handle 15, and the expansion end of two-way electric telescopic handle 15 both sides is fixed mounting respectively has first connecting block 16, and the first traveller 17 of 16 end difference fixedly connected with of first connecting block.
Further, the medial surface of first arc 11 is provided with first T shape spout 18, the inside two second travelers 19 that are provided with of first T shape spout 18, two 19 symmetrical slidable mounting of second travelers are in first T shape spout 18 both sides, the equal fixedly connected with second connecting block 20 in second traveler 19 side, the equal fixedly connected with connecting plate 21 in second connecting block 20 one side, a side surface that two connecting plates 21 are close to each other all is provided with second T shape spout 22, thereby two connecting plates 21 keep away from each other or be close to and can drive second traveler 19 respectively and slide along first T shape spout 18.
Further, two first travelers 17 are respectively slidable mounting inside two second T shape spouts 22, one side that second connecting block 20 was kept away from to two connecting plates 21 is fixedly connected with respectively and rotates connecting block 23 and lower rotation connecting block 24, it sets up rotates connecting block 24 upper surface under to rotate connecting block 23 to go up, it rotates and installs pivot 25 with the circular through-hole department rotation of lower rotation connecting block 24 central authorities to rotate connecting block 23, thereby two-way electric telescopic handle 15 is flexible to drive two first travelers 17 and stretch out or retract simultaneously, and then drive two connecting plates 21 and keep away from each other or be close to, two connecting plates 21 revolve the axle 25 rotation along last rotation connecting block 23 and lower rotation connecting block 24 respectively, make two second travelers 19 along the arc profile relative slip of first T shape spout 18.
Further, both ends difference fixedly connected with second stopper 26 about pivot 25, two second stoppers 26 set up the upper surface of rotating connecting block 23 at last and the lower surface of rotating connecting block 24 down respectively, it is last to rotate connecting block 23 and rotate connecting block 24 down and keep away from one side difference fixedly connected with sampling connecting rod 27 of connecting plate 21, two sampling connecting rod 27 ends are provided with respectively and can dismantle sampling cotton balls 28, thereby it can drive two sampling connecting rod 27 rotations respectively to rotate connecting block 23 and lower rotating connecting block 24 round pivot 25 rotation to go up to rotate, and then drive and to dismantle sampling cotton balls 28 relative rotation, take a sample to the oral cavity mucous membrane in the oral cavity. In addition, in specific application, when the cylinder 10 is at the maximum extension length, the sampling connecting rod 27 and the detachable sampling cotton ball 28 are completely extended out of the accommodating groove 9; with the cylinder 10 at the minimum extension, the sampling connection rod 27 and the detachable sampling cotton ball 28 are completely retracted inside the receiving groove 9.
Further, a mounting groove 29 is formed in one side of the device base 1, a detachable sealing plate 30 is arranged on the outer side of the mounting groove 29, a hydraulic cylinder 31 is fixedly mounted on the inner bottom surface of the mounting groove 29, a movable end of the top of the hydraulic cylinder 31 penetrates through the upper surface of the device base 1 and is fixedly connected with a supporting circular plate 32, a supporting rod 33 is uniformly arranged on the upper surface of the supporting circular plate 32, and a supporting sleeve 34 is arranged at the top end of the supporting rod 33, so that the hydraulic cylinder 31 can drive the supporting circular plate 32 to lift, and further the supporting rod 33 and the supporting sleeve 34 are sequentially driven to lift.
Further, fixed mounting has sampling bottle 35 between the 34 inner walls of support cover, sampling bottle 35 bottom sets to coniform, thereby make things convenient for the unloading, make the unloading thorough, sampling bottle 35 bottom is provided with the unloading valve, first connecting piece 36 of sampling bottle 35 outer wall both sides difference fixedly connected with, first connecting piece 36 fixed surface is connected with T shape guide block 37, T shape guide block 37 slidable mounting is inside the T shape guide way 38 that supports 2 surface settings of curb plate, thereby pneumatic cylinder 31 can drive sampling bottle 35 and go up and down fast, and then vibrate the inside solution of sampling bottle 35. In addition, in specific application, when the hydraulic cylinder 31 is at the maximum extension length, the T-shaped guide block 37 reaches the top end of the T-shaped guide groove 38, and the sampling bottle 35 rises to the highest position; when the hydraulic cylinder 31 is at the minimum extension length, the T-shaped guide block 37 reaches the bottom end of the T-shaped guide groove 38, the sampling bottle 35 descends to the lowest position, and the blanking valve at the bottom end of the sampling bottle 35 is not in contact with the upper surface of the device base 1.
Further, sampling bottle 35 top surface is provided with rectangle opening 39, and rectangle opening 39 sets up under fixed axle 5, and rectangle opening 39 and movable plate 7 side profile phase-match are provided with spout 40 outside the rectangle opening 39, and the outside one side of spout 40 is provided with fixed baffle 41, and fixed baffle 41 fixed connection is at sampling bottle 35 top surface to movable plate 7 can rotate to in the vertical space of rectangle opening 39 round fixed axle 5. In addition, when the sampling bottle 35 ascends to the highest position in specific application, the sampling bottle 35 does not block the rotation of the movable plate 7.
Further, the surface of the sliding groove 40 is movably provided with a cover plate 42, the cover plate 42 is fixedly connected with a connecting push block 43, one side of the connecting push block 43 is fixedly provided with a first spring 44, a first telescopic guide rod 45 is arranged inside the first spring 44, the tail ends of the first spring 44 and the first telescopic guide rod 45 are fixedly connected with a fixed baffle 41, so that the pushing connection push block 43 can drive the cover plate 42 to slide along the sliding groove 40, the rectangular opening 39 is opened, meanwhile, the first spring 44 and the first telescopic guide rod 45 are compressed, and when the force pushing the connecting push block 43 disappears, the first spring 44 resets and can drive the cover plate 42 to reset, and the rectangular opening 39 is covered again.
Further, a push plate 46 is fixedly connected to one side surface of the movable plate 7 close to the accommodating groove 9, a second connecting member 47 is fixedly connected to the other end of the movable plate 7, a fixing sleeve 48 is fixedly mounted on one side of the second connecting member 47, and the end surface of the fixing sleeve 48 is not in contact with one side of the supporting column 3 close to the movable plate 7, so that in the process that the movable plate 7 rotates downwards around the fixing shaft 5, the push plate 46 rotates along with the movable plate, the push plate 46 slowly approaches the connecting push block 43, and finally the connecting push block 43 is pushed to open the rectangular opening 39.
Further, a second spring 49 is fixedly installed inside the fixed sleeve 48, a second telescopic guide rod is arranged inside the second spring 49, a positioning block 50 is fixedly connected to the tail end of the second spring 49, the positioning block 50 is slidably sleeved inside the fixed sleeve 48, a pressing column 51 is arranged on one side of the positioning block 50, so that the pressing column 51 is pressed, the positioning block 50 retracts inside the fixed sleeve 48, and the movable plate 7 can be rotated after the limit is released. In addition, when the movable plate 7 rotates to the horizontal or vertical opening side of the accommodating groove 9 in specific application, when the second spring 49 is in a natural state, the surface of one side of the positioning block 50 close to the movable plate 7 is respectively attached to the top surface or the side surface of the supporting column 3 to limit the movable plate 7, and when the second spring 49 is completely compressed, the surface of the tail end of the positioning block 50 is flush with the surface of one side of the supporting column 3 close to the movable plate 7.
The working principle is as follows: when the sampling device is used, the connecting push block 43 is pushed, the connecting push block 43 drives the cover plate 42 to slide along the sliding groove 40, the rectangular opening 39 is opened, meanwhile, the first spring 44 and the first telescopic guide rod 45 are compressed, a proper amount of physiological saline is injected into the sampling bottle 35, the connecting push block 43 is loosened, the force for pushing the connecting push block 43 disappears, the first spring 44 resets to drive the cover plate 42 to reset, the rectangular opening 39 is covered again, the air cylinder 10 is started, the air cylinder 10 extends to drive the first arc-shaped plate 11 to extend out until the air cylinder 10 drives the sampling connecting rod 27 and the detachable sampling cotton balls 28 to completely extend out of the accommodating groove 9, the air cylinder 10 is closed, the sampling connecting rod 27 is sterilized, and the clean detachable sampling cotton balls 28 are replaced at the tail end of the sampling connecting rod 27;
when a person to be sampled opens the oral cavity, the two detachable sampling cotton balls 28 are contained in the oral cavity, the two detachable sampling cotton balls 28 are respectively attached to cheek parts on two sides of the oral cavity, the two-way electric telescopic rod 15 is started, the two-way electric telescopic rod 15 stretches and retracts to drive the two first sliding columns 17 to stretch and retract simultaneously, the first sliding columns 17 slide along the second T-shaped sliding grooves 22, the two connecting plates 21 are far away from or close to each other around the rotating shaft 25, the two sampling connecting rods 27 are driven to rotate relatively, the sampling connecting rods 27 drive the detachable sampling cotton balls 28 to move relatively in the oral cavity to sample oral mucosa, the connecting plates 21 simultaneously drive the two second sliding columns 19 to slide relatively along the arc-shaped profiles of the first T-shaped sliding grooves 18, and the stability of the assembly is improved;
after sampling of the oral mucosa is completed, when the distance between the two detachable sampling cotton balls 28 is the minimum, the two-way electric telescopic rod 15 is closed, the air cylinder 10 drives the sampling connecting rod 27 and the detachable sampling cotton balls 28 to be completely contracted into the containing groove 9, so that pollution to the collected oral mucosa is avoided, the pressing column 51 is pressed, the positioning block 50 drives the second spring 49 to be contracted, the positioning block 50 is contracted into the fixed sleeve 48, the limit is released, the movable plate 7 is rotated, in the rotating process of the movable plate 7, the push plate 46 rotates along with the sampling connecting rod, the push plate 46 slowly approaches the connecting push block 43, the connecting push block 43 is finally pushed, the rectangular opening 39 is opened, when the movable plate 7 rotates to the opening of the containing groove 9, the opening side of the containing groove 9 is positioned right above the rectangular opening 39, the positioning block 50 is released, the second spring 49 is extended and reset, and the positioning block 50 is driven to pop up and be clamped on the top surface of the supporting column 3, positioning the movable plate 7;
the sampling connecting rod 27 and the detachable sampling cotton ball 28 are driven by the air cylinder 10 to extend out of the storage groove 9, so that the detachable sampling cotton ball 28 is completely immersed into the physiological saline in the sampling bottle 35, the sampling connecting rod 27 and the detachable sampling cotton ball 28 are driven by the bidirectional electric telescopic rod 15 to rotate relatively to achieve a stirring effect, oral mucosa cells collected by the detachable sampling cotton ball 28 are completely washed into the physiological saline, after the stirring is carried out for a moment, the detachable sampling cotton ball 28 is driven by the air cylinder 10 to rise above the liquid level, the air cylinder 10 stretches and retracts in a reciprocating manner to drop the solution adsorbed in the detachable sampling cotton ball 28, after the shaking is carried out for a moment, the sampling connecting rod 27 and the detachable sampling cotton ball 28 are completely retracted into the storage groove 9, the movable plate 7 is rotated to restore the sampling position, and in the rotating process that the movable plate 7 is slowly far away from the sampling bottle 35, the push plate 46 is slowly far away with the movable plate, the force pushing the connecting push block 43 is gradually weakened until it disappears, and the first spring 44 drives the cover plate 42 to return, covering the rectangular opening 39.
Inject proper amount cell retaining liquid into sampling bottle 35, start hydraulic cylinder 31, pneumatic cylinder 31 drives support plectane 32 and goes up and down, and then drive sampling bottle 35 and go up and down fast, to the inside normal saline of sampling bottle 35, cell retaining liquid and oral mucosa cell vibrate, make its intensive mixing, when sampling bottle 35 rises to highest position, close hydraulic cylinder 31, open the unloading valve of sampling bottle 35 bottom and can draw out mixed liquid, can directly transport after the mixed liquid seal of extraction, send to the detection.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The utility model provides an oral mucosa intelligence sampling device for gene detection, includes device base (1) and fly leaf (7), its characterized in that: the device is characterized in that supporting side plates (2) are symmetrically arranged on the two sides of the upper surface of a base (1), a supporting column (3) is arranged on one side of the upper surface of the base (1), the supporting column (3) is arranged at one end of each supporting side plate (2), the supporting column (3) is close to a connecting column (4) fixedly connected to the upper end of one side of each supporting side plate (2), a fixing shaft (5) is fixedly connected to the tail end of each connecting column (4), a first limiting block (6) is arranged at the tail end of each fixing shaft (5), a first circular through hole (8) is arranged on the side face of one end of a movable plate (7) in a penetrating mode, the first circular through hole (8) is arranged in a penetrating mode through the fixing shaft (5), the movable plate (7) is rotatably connected with the fixing shaft (5), a containing groove (9) is arranged at the other end of the movable plate (7), a sampling connecting rod (27) is movably arranged in the containing groove (9), the tail end of the sampling connecting rod (27) is provided with a detachable sampling cotton ball (28).
2. The intelligent oral mucosa sampling device for gene detection according to claim 1, wherein: an air cylinder (10) is fixedly arranged inside the accommodating groove (9), a first arc-shaped plate (11) is fixedly connected to the movable end of the air cylinder (10), a fixing plate (12) is fixedly connected to the upper end and the lower end of the first arc-shaped plate (11) respectively, a fixing block (13) is fixedly connected between the fixing plates (12), a second circular through hole (14) is arranged between two sides of the fixing block (13) in a penetrating manner, a bidirectional electric telescopic rod (15) is fixedly arranged inside the second circular through hole (14), first connecting blocks (16) are fixedly arranged at the movable ends of two sides of the bidirectional electric telescopic rod (15) respectively, first sliding columns (17) are fixedly connected to the tail ends of the first connecting blocks (16) respectively, a first T-shaped sliding groove (18) is arranged on the inner side face of the first arc-shaped plate (11), two second sliding columns (19) are arranged inside the first T-shaped sliding groove (18), two second traveller (19) symmetry slidable mounting be in first T shape spout (18) both sides, the equal fixedly connected with second connecting block (20) in second traveller (19) side, equal fixedly connected with connecting plate (21) in second connecting block (20) one side, two a side surface that connecting plate (21) are close to each other all is provided with second T shape spout (22).
3. The intelligent oral mucosa sampling device for gene detection according to claim 2, wherein: two first traveller (17) slidable mounting is two respectively inside second T shape spout (22), two connecting plate (21) are kept away from one side difference fixedly connected with of second connecting block (20) is gone up and is rotated connecting block (23) and lower connecting block (24) of rotating, it sets up to go up to rotate connecting block (23) and is in rotate connecting block (24) upper surface down, go up rotate connecting block (23) with circular through-hole department of lower connecting block (24) central authorities rotates and installs pivot (25).
4. The intelligent oral mucosa sampling device for gene detection according to claim 3, wherein: both ends difference fixedly connected with second stopper (26), two about pivot (25) second stopper (26) set up respectively go up the upper surface of rotating connecting block (23) with the lower surface of lower rotation connecting block (24), sampling connecting rod (27) are provided with two, respectively fixed connection in go up rotation connecting block (23) with lower rotation connecting block (24) is kept away from one side of connecting plate (21), two sampling connecting rod (27) end is provided with respectively can dismantle sampling cotton ball (28).
5. The intelligent oral mucosa sampling device for gene detection according to claim 1, wherein: the device base is characterized in that a mounting groove (29) is formed in one side of the device base (1), a detachable sealing plate (30) is arranged on the outer side of the mounting groove (29), a hydraulic cylinder (31) is fixedly mounted on the inner bottom surface of the mounting groove (29), the movable end of the top of the hydraulic cylinder (31) penetrates through the upper surface of the device base (1) and a supporting circular plate (32) fixedly connected with the upper surface of the supporting circular plate (32), a supporting rod (33) is uniformly arranged on the upper surface of the supporting circular plate (32), and a supporting sleeve (34) is arranged on the top end of the supporting rod (33).
6. The intelligent oral mucosa sampling device for gene detection according to claim 5, wherein: support fixed mounting between cover (34) inner wall and have sampling bottle (35), sampling bottle (35) bottom sets to coniform, sampling bottle (35) bottom is provided with the unloading valve, sampling bottle (35) outer wall both sides are the first connecting piece of fixedly connected with (36) respectively, first connecting piece (36) fixed surface is connected with T shape guide block (37), T shape guide block (37) slidable mounting be in support inside T shape guide way (38) that curb plate (2) surface set up.
7. The intelligent oral mucosa sampling device for gene detection according to claim 6, wherein: sampling bottle (35) top surface is provided with rectangle opening (39), rectangle opening (39) set up under fixed axle (5), rectangle opening (39) with fly leaf (7) side profile phase-match, rectangle opening (39) outside is provided with spout (40), spout (40) outside one side is provided with fixed stop (41), fixed stop (41) fixed connection be in sampling bottle (35) top surface.
8. The intelligent oral mucosa sampling device for gene detection according to claim 7, wherein: spout (40) surface movable mounting has apron (42), fixed surface is connected with and connects ejector pad (43) on apron (42), it has first spring (44) to connect ejector pad (43) one side fixed mounting, first spring (44) inside is provided with first flexible guide bar (45), first spring (44) with first flexible guide bar (45) end all with fixed stop (41) fixed connection.
9. The intelligent oral mucosa sampling device for gene detection according to claim 8, wherein: fly leaf (7) are close to accomodate one end side fixedly connected with push pedal (46) of groove (9), when push pedal (46) rotated along with fly leaf (7), push pedal (46) with be connected ejector pad (43) to promote to connect ejector pad (43) and remove, fly leaf (7) other end fixedly connected with second connecting piece (47), second connecting piece (47) one side fixed mounting has fixed sleeve (48), fixed sleeve (48) terminal surface with support column (3) are contactless each other.
10. The intelligent oral mucosa sampling device for gene detection according to claim 9, wherein: fixed sleeve (48) inside fixed mounting has second spring (49), second spring (49) inside is provided with the flexible guide bar of second, second spring (49) end fixedly connected with locating piece (50), locating piece (50) slip cup joint inside fixed sleeve (48), locating piece (50) are right fly leaf (7) carry on spacingly, locating piece (50) one side is provided with and presses post (51).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110540101.8A CN113243943A (en) | 2021-05-18 | 2021-05-18 | Intelligent oral mucosa sampling device and sampling method for gene detection |
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| CN202110540101.8A CN113243943A (en) | 2021-05-18 | 2021-05-18 | Intelligent oral mucosa sampling device and sampling method for gene detection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114259264A (en) * | 2021-12-30 | 2022-04-01 | 云南中医药大学 | A quick sampling instrument of oral mucosa exudate for AIDS detects |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114259264A (en) * | 2021-12-30 | 2022-04-01 | 云南中医药大学 | A quick sampling instrument of oral mucosa exudate for AIDS detects |
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