CN113214503B - 一种氨基酸基聚氨酯超分子高黏性凝胶贴片的制备及应用 - Google Patents
一种氨基酸基聚氨酯超分子高黏性凝胶贴片的制备及应用 Download PDFInfo
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Abstract
一种氨基酸基聚氨酯超分子高黏性凝胶的制备方法及应用。通过选用不同的氨基酸和不同扩链剂制备得到了氨基酸基聚氨酯超分子,加大原料的投料比以提高体系聚合物所带基团的含量和丰富度,通过将其与制备好的改性生物大分子复合得到具有高粘性和优异生物相容性的凝胶贴片。本发明使用的生物活性材料为多种氨基酸化合物,对组织没有副作用,并且能促进受损部位的恢复。该复合材料能够不仅能与玻璃、金属和皮肤外表面等干态的界面形成强力的黏合,而且能在皮肤内表面和人体脏器血管等湿态界面组织等实现牢固的黏附,对软骨修复、止血敷料、神经导管支架、脏器修复等具有广阔的应用前景。本发明制备过程有非常好的调控性,易于加工制备方法绿色环保,有利于产业化生产。
Description
技术领域
本发明涉及一种基于氨基酸基聚氨酯超分子和改性天然生物大分子复合的高黏性凝胶的制备方法及应用,具体还涉及可控生物降解性生物基聚氨酯超分子的结构设计及复合组织贴片材料的制备技术。
技术背景
每年都有数百万人遭受需要修补的创伤,包括皮肤破损,肌肉组织撕裂,脏器破裂等极易诱发伤口感染、大出血和器官衰竭从而导致死亡的创伤。传统的伤口处理方法主要有包扎和缝合。因伤口包扎操作繁琐,且仅适用于体表的创伤,对伤口的止血和闭合效果较差使其应用场景受到大大的局限。伤口缝合是处理组织创伤的常用方法,但因其缝合过程耗时较长不利于伤口止血,特别是恢复过程皮肤缝合处可能因其局部组织酸聚集而不可避免地留下伤疤而有失美观。因此,开发具有良好伤口止血和闭合效果且能安全降解的伤口修复材料显得尤为迫切。
组织贴片因为具有能封闭伤口、止血和防止伤口感染的作用而备受科学家的青睐和追捧。随着科学技术的进步,越来越多的组织贴片得到了研究和开发。但是早期的组织贴片主要是聚氰基丙烯酸类,虽然粘合强度较高,但是其模量与组织不匹配在体内与组织发生摩擦容易造成组织二次损伤,且聚氰基丙烯酸类的生物相容性较差,对组织的恢复极其不利。后续报道的组织贴片有化学合成的聚丙烯酸类,天然化合物的明胶类。但是,天然化合物往往粘合强度较低,粘合效果不理想,而化学合成类大多生物相容性不理想,且在体内降解过程中很可能会产生酸聚集不利于伤口的恢复过程。
聚氨酯(Polyurethane,缩写PU)是聚氨基甲酸酯的简称。聚氨酯主要有软段和硬段构成,通过设计不同的软硬段结构,可以赋予材料优异的生物相容性、血液相容性,也能设计出具有良好的力学性能的材料,故在医用生物领域中得到了广泛的关注和应用,包括应用于人造皮肤、绷带、导管等。基于聚氨酯的结构可调控性,本发明所设计和制备的氨基酸基聚氨酯具有类生物大分子结构具有较好的生物相容性,且大量的有利于形成氢键的氨基和羧基等基团结构单元的存在,赋予了材料良好的机械性能和优异的粘合性能。为了进一步提高材料的生物相容性,以用于临床实验,本发明将其与改性生物大分子复合。生物大分子具有天然的良好的生物相容性,然而绝大多数生物大分子机械性能不理想,材料成型加工性较差,常常使其应用受到局限。将生物大分子进行改性再与氨基酸基聚氨酯进行复合,在进一步提高材料生物相容性的同时,其生物降解安全性也得到了很大的巩固,将有望进行临床实验。
发明内容
本发明以氨基酸基聚氨酯超分子为基体与改性天然生物大分子链段内部原位键合,目的是制备高粘性优异生物相容性和安全降解性的复合水凝胶,以用于黏附组织,闭合伤口,从而达到止血和组织修复的目的,并且优异的生物相容性能在伤口恢复过程具有促进作用。本发明设计的氨基酸基聚氨酯具有优异的粘附性,在干态和湿态的湿组织界面均能够形成高强度的互相作用而实现较为牢固的黏附效果。此外良好的生物相容性和安全的生物降解性将对组织的恢复具有良好的促进作用,这种能在各种场景中都能保持黏附性能的凝胶贴片,甚至能在各器官上例如;肝脏心脏和肺部,以及水中和血液中实现良好的黏附效果。
所制备的氨基酸基聚氨酯溶液稳定性好,能在室温下180天不沉淀,由于含有丰富的氨基和大量的羧基基团,能够在水溶液下充分浸润和分散从而实现不聚集的效果。除此之外,由于改性生物大分子的引入,不仅进一步提高了其生物相容性,还与聚氨酯分子链上的基团形成氢键和离子键,从而巩固了材料的力学性能。且该体系中的类生物大分子结构的聚氨酯具有可控的生物降解性能,采用此种复配的体系进一步制备的组织贴片材料同样具有优异的粘附性和生物相容性,以及可控的生物降解性。
一种氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于:
一种氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于:首先对DMPA、环糊精和扩链剂进行高温真空干燥过程处理,得到无水分的实验原料;同时,室温下在IPDI中加入活化好的4A分子筛进行除水处理;将IPDI、聚酯多元醇、DMPA、环糊精和氨基酸扩链剂按照先后顺序加入到容器中分别反应2-4小时,先后通过加入有机胺碱性物质进行盐化,旋转蒸馏除去有机溶剂操作得到氨基酸基聚氨酯粘溶液;将生物大分子明胶在PH为7.4缓冲液中加入甲基丙烯酸酐进行改性,先后进行了透析、冷冻干燥处理得到改性后的生物大分子。将其与聚氨酯粘溶液进行复配通过物理和化学交联得到高黏性凝胶。
本发明通过多次生物活性化合物扩链的聚氨酯超分子所制备的氨基酸基聚氨酯超分子-生物大分子的复合凝胶,通过进一步的固化所形成的以氢键和离子键以及共价键相结合的致密的交联网络结构稳定,并且具有高黏性特点,拥有互通的孔洞的三维交联网络结构特性,使其达到了良好的拉伸和压缩性能,并且对复合物的性能稳定性起到巩固作用;所涉及的氨基酸基聚氨酯结构包含大量的氨基酸结构,赋予了其丰富的官能团种类和含量。
一种如上所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于:所述高黏性凝胶成分为:
聚酯多元醇100份、DMPA30-60份、环糊精3-20份、异氰酸酯120-180份、三乙胺5-20份、改性明胶25-35份、扩链剂20-40份、催化剂0.5-1.0份、丙酮100-200份、医用蒸馏水200-300份;
具体制备步骤如下
步骤一:原料实验前预处理
将聚酯多元醇、DMPA原料经过80度真空干燥除水;用高温活化好的4A分子筛加入IPDI中,除去多余的杂质;
步骤二:氨基酸聚氨酯超分子的合成
在聚酯多元醇与异氰酸酯化合物中加入各种扩链剂、催化剂和稀释溶剂经预聚反应后得到预聚体,最后通过中和反应以及水化处理得到聚氨酯水溶液;
步骤三:天然大分子的改性
称取适量的A型明胶加入碳酸盐缓冲液中,加热使其溶解配置成5-10%质量分数的溶液,按照与明胶2%~10%质量比的比例滴加入甲基丙烯酸酐类化合物,反应3h后装入透析袋中透析三天并且每6h换一次去离子水,最后冻干得到改性生物大分子明胶;
步骤四:复配高粘性凝胶的制备
将一定质量分数的聚氨酯粘溶液与改性明胶按照5:1的比例混合,通过分散和充分接触,以提高分子层面的均匀度和互相作用力;倒入模具中,通过紫外均匀照射5-20min得到复合粘性凝胶。
进一步地,步骤二所述氨基酸聚氨酯超分子的合成步骤如下:
(1)将处理好的聚酯多元醇加入容器中;控制温度为79-81度,将其重新溶解,并对其进行搅拌;30min后分批加入一定量的环糊精,使其混合均匀充分;
(2)将异氰酸酯化合物分批次陆续加入容器中,并保持高速的搅拌;
(3)反应90min后,待体系稳定后加入DMPA粉末进行第一次扩链;
(4)反应60min后,降低体系温度,待稳定后陆续加入大部分氨基酸进行第二次扩链,继续反应30min;
(5)继续降低体系温度至室温,加入有机胺调节体系pH使其呈中性;
(6)称取氨基酸溶于去离子水中,在强剪切力快速搅拌下陆续滴入,直到体系出现相转变为止,此时已完成第三次扩链,过滤离心得到澄清的粘稠的氨基酸基聚氨酯溶液;
(7)通过离心和透析进一步的操作得到澄清透明的无杂质的聚氨酯浓溶液。
进一步地,所述的扩链剂选用1,4-丁二醇(BDO)、精氨酸(L-Arg)、新戊二醇(NPG)、赖氨酸、2,2-二羟甲基丙酸(DMPA)、三羟甲基丙烷(TMP)和一缩二乙二醇中一种或几种组合。
进一步地,所述的环糊精选用α-环糊精、β-环糊精或γ-环糊精中一种或几种组合。
进一步地,所述的聚酯多元醇选用聚乙二醇、聚四氢呋喃二醇、聚己内酯二元醇、聚己二酸己二醇酯二元醇、聚环氧丙烷二元醇、聚乙二醇醚二元醇、聚氧乙烯醚二元醇中一种或几种组合。
进一步地,所述的异氰酸酯单体选自不含苯环结构的脂肪族异氰酸酯化合物:L-赖氨酸三异氰酸酯(LDI)、4,4-二环己基甲烷二异氰酸酯(HMDI)、六亚甲基二异氰酸酯(HDI)和异佛尔酮二异氰酸酯(IPDI)中一种或几种组合。
进一步地,所述催化剂选自二月桂酸二丁基锡、辛酸亚锡中的任一种或两种组合。
进一步地,所述的稀释溶剂选自丙酮、氯仿、去离子水、二甲基亚砜(DMSO)、N-甲基吡咯烷酮(NMP)或N-乙基吡咯烷酮(NEP)的一种或几种。
本发明通过引入生物活性物质和富含羧基氨基等基团的化合物对聚氨酯进行设计和制备从而实现不同的功能化改性,从而改变其性能,如生物相容性、组织黏附性和降解性能等,但功能化改性不仅限于上述引入氨基酸物质以及引入大量的羧基氨基改性,其他能设计和制备以提高聚氨酯生物相容性和组织黏附性性能的改性同样适用,如引入壳聚糖和海藻酸钠等。该复配凝胶贴片的成型过程简单,且可塑性比较强,即能够面对不同的要求而制备不同形状的贴片,其制备复合材料的方法不仅限于上述方法和明胶生物大分子,由于该复配溶胶的特殊加工性能,使氨基酸基聚氨酯能够作为重要组分与不同材料复合,包括卡拉胶、细菌纤维素聚乙烯醇和海藻酸钠溶液等,使其能够作为生物胶水或组织工程支架在人体的各个部位得到应用,包括软骨修复、表皮止血、神经导管支架、心脏支架等,但不仅限于这几种应用。
本发明所使用的氨基酸化合物具有优异的生物活性且不会在体内产生酸碱聚集的组织毒性,这种氨基酸合成的聚氨酯具有高效的促进受损组织恢复的作用和特点;由于本发明是用生物相容性良好的聚氨酯超分子和具有优异生物活性的氨基酸设计的生物基聚氨酯超分子而得到的生物材料,且对干态和湿态的表面均能实现高强度的黏附效果,使其在组织工程中,例如:肺部修复、心脏补片、血管黏接等方面具有巨大的应用潜力。
本发明设计并制备了一种新型的氨基酸基聚氨酯超分子,并与改性天然大分子聚合物复配,制备具有优异生物相容性,良好血液相容性和无毒安全降解性的组织贴片。复合材料能够不仅与玻璃、金属和皮肤外表面等干态的界面形成强力的黏合,而且能在皮肤内表面和人体脏器如肝脏组织等湿态界面实现牢固的黏附,甚至在水中和血液均可迅速黏附并保持牢固粘合。该组织贴片有望应用于皮肤破损、肌肉撕裂和脏器损伤等出血环境以通过粘附性闭合伤口并且促进伤口的愈合。
本发明通过事先设计好的聚氨酯结构制备得到氨基酸基聚氨酯超分子溶液,之后对生物大分子进行改性得到可形成致密交联网络的生物大分子,将两者进行混合,通过分子链段间物理和化学的交联得到具有可控安全降解的、优异生物相容性和血液相容性的组织贴片,最后通过研究其生物降解性和降解过程的生物毒性对其生物降解性和生物相容性进行了全面的评估。
与现有技术相比,本发明具有如下优点和有益效果
1、本发明制备的具有高粘性的氨基酸基聚氨酯超分子与生物大分子复合的水凝胶具有非常好的生物组织黏附性,在与生物大分子复合的情况下,能与生物大分子之间形成稳定的静电作用和氢键作用,从而使所制备的组织贴片具有较柔韧的机械性能,此外,由于其优异的生物相容性以及在降解过程中不产生酸聚集的效应,可作为组织粘合剂的理想基底材料为后续的临床研究提供可操作性。
2、本发明所制备的具有优异组织粘性的氨基酸基聚氨酯超分子复合物,不仅对干性组织界面例如皮肤的外表面能稳定黏附,而且在湿性组织界面例如皮肤的内表面、肝脏和血管等组织表面具有很高的粘附性,甚至在水中和血液均可与界面迅速黏附并保持牢固粘合。该组织贴片在具有巨大的潜力应用于皮肤破损、肌肉撕裂和脏器损伤等出血环境以通过粘附性闭合伤口并且促进伤口的愈合。
3、本发明所制得的氨基酸基聚氨酯复合生物大分子的复配水凝胶中,聚氨酯经过不同条件下的聚合反应将氨基酸嵌入聚氨酯的分子链的链段中。此外通过引入大量的DMPA等化合物,赋予了聚氨酯不同的化学基团,此外,通过与生物大分子复合,使其成为具有可调控的力学性能和生物降解性,且降解产物安全无毒。
4、本发明制备的是以水为溶剂的聚氨酯溶液,具有绿色环保,易工业化大量生产。所采用的方法是将氨基酸基聚氨酯与改性生物大分子通过共混的方法,使其在分子层面上达到充分的混合,工艺过程可重复性强,有利于产业放大和过程控制。
该发明制备的氨基酸基聚氨酯复合粘性凝胶具有优异的生物相容性、安全可控的降解性和柔韧的力学性能,可作为医用补片应用于组织工程领域中的心脏、血管、肺和肝脏等软组织破损部位,在生物医用领域具有巨大的应用潜力。
附图说明
图1为氨基酸基聚氨酯的红外谱图,
图2为氨基酸基聚氨酯和改性生物大分子复合凝胶贴片的微观形貌。
具体实施方案
以下结合具体的实施案例,进一步阐述本发明的实施方式。这些实施案例仅用于说明本发明而不是用于限制本发明的范围,此外,本领域的技术人员在阅读了本发明讲述的内容之后,对本发明所做的各种等价形式的改动,同样落入本申请权利要求书所要求的范围之内。
实例1
本发明所制备的氨基酸基聚氨酯超分子复合组织粘合剂,由以下成分按重量份制备而成:聚乙二醇100份、DMPA 60份、环糊精5份、异氰酸酯150份、三乙胺8份、改性明胶30份、氨基酸25份、催化剂0.5份、丙酮100份、医用蒸馏水300份。
所设计的组织粘合剂的制备方法为:(1)称取含羟基的聚酯多元醇(包括但不限于聚乙二醇)置于研钵中,反复研磨成粉状,倒入烧杯中经过80度真空干燥除水;(2)将处理好的聚酯多元醇加入圆底烧瓶中。控制温度为80度,将其重新溶解,并对其进行搅拌,使其匀速搅动。30min后加入一定量的环糊精,使其混合均匀充分;(3)将异氰酸酯化合物分批次陆续加入圆底烧瓶中,并保持高速的搅拌;(4)反应60min后,待体系稳定后加入DMPA粉末进行扩链;(5)反应60-90min后,降低体系温度,待稳定后加入适量氨基酸,继续反应60min;(6)降至室温后加入三乙胺调节体系PH使其呈中性;(7)称取氨基酸溶于去离子水中,在强剪切力快速搅拌下陆续滴入,直到体系出现相反转为止,过滤离心得到澄清的粘稠的氨基酸基聚氨酯溶液;(8)称取明胶加入缓冲液中,溶解后加入甲基丙烯酸酐类化合物,反应3h后透析冻干得到改性明胶;(9)将聚氨酯粘溶液与改性明胶混合,通过分散和充分接触,使其达到分子层面的均匀度。(10)倒入模具中,通过紫外均匀照射10min得到复合粘性凝胶。
实例2
本发明所制备的氨基酸基聚氨酯组织粘合剂,由以下成分按重量份制备而成:聚乙二醇100份、DMPA 80份、环糊精3份、异氰酸酯180份、三乙胺10份、改性明胶35份、氨基酸20份、催化剂0.8份、丙酮120份、医用蒸馏水350份。
本发明的组织粘合剂的制备方法为:(1)称取含2-3个羟基的聚酯多元醇(包括但不限于聚己内酯)研磨成粉状,倒入烧杯中经过高温减压干燥除水12h;(2)将处理好的聚酯多元醇加入圆底烧瓶中,升温并恒温80度,将其溶解,溶解后分三次加入预定量的环糊精并对其进行匀速搅拌,使其混合均匀充分;(3)将异氰酸酯化合物分批次陆续加入圆底烧瓶中,保持高速的搅拌下通过适量加入丙酮溶剂以控制体系粘度;(4)反应30min后,待体系稳定后加入已溶于丙酮的DMPA溶液进行扩链;(5)反应60-90min后,降低体系温度至50度,待稳定后加入一部分氨基酸粉末,继续反应60min;(6)随后降至室温,滴加三乙胺调节体系pH使其呈中性;(7)称取剩余的氨基酸粉末溶于去离子水中,将其缓慢滴入体系中,并加快搅拌速度,直到体系完成相转变为止,通过离心机离心得到澄清的粘稠的氨基酸基聚氨酯溶液;(8)称取明胶加入碳酸盐缓冲液中,溶解后加入一定量甲基丙烯酸酐类化合物,接枝反应进行3h后,先后经过透析和冻干得到改性明胶;(9)将聚氨酯粘溶液与改性明胶混合并分散和充分接触,使其达到分子层面的均匀度。(10)倒入模具中,通过紫外均匀照射10min得到复合粘性凝胶贴片。
实例3
本发明所制备的氨基酸基聚氨酯组织粘合剂,由以下成分按重量份制备而成:聚乙二醇100份、DMPA 40份、环糊精15份、异氰酸酯130份、三乙胺5份、改性明胶35份、氨基酸35份、催化剂0.5份、丙酮120份、医用蒸馏水280份。
本发明的组织粘合剂的制备方法为:(1)称取含双官能团的聚酯多元醇(包括但不限于聚乳酸)研磨成粉状,倒入烧杯中经过加热和减压干燥除水24h;(2)将处理好的聚酯多元醇加入圆底烧瓶中并加热至80度直至将其溶解完全,分三次加入预定量的环糊精并对其进行匀速搅拌,使其混合均匀充分;(3)将异氰酸酯化合物分五次陆续加入圆底烧瓶中并且保持高速的搅拌下,必要时通过适量地加入丙酮溶剂以控制体系的粘度;(4)反应60min后,待体系稳定后加入已溶于丙酮的DMPA溶液进行扩链;(5)反应90min后,降低体系温度至50度,待稳定后加入一部分氨基酸粉末,继续反应60min,期间补充余下的异氰酸酯;(6)随后降至室温,滴加三乙胺调节体系pH使其呈中性;(7)称取剩余的氨基酸粉末溶于去离子水中,将其缓慢滴入体系中,并加快搅拌速度,直到体系完成相转变为止,通过离心机离心得到澄清的粘稠的氨基酸基聚氨酯溶液;(8)称取明胶加入碳酸盐缓冲液中,溶解后加入一定量甲基丙烯酸酐类化合物,接枝反应进行3h后,先后经过透析和冻干得到改性明胶;(9)将聚氨酯粘溶液与改性明胶混合并分散和充分接触,使其达到分子层面的均匀度。(10)倒入模具中,通过紫外均匀照射10min得到复合粘性凝胶贴片。
Claims (9)
1.一种氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于:首先对DMPA、环糊精和氨基酸扩链剂进行高温真空干燥过程处理,得到无水分的实验原料;同时,室温下在异氰酸酯中加入活化好的4A分子筛进行除水处理;将异氰酸酯、聚酯多元醇、DMPA、环糊精和氨基酸扩链剂按照先后顺序陆续加入到容器中分别反应2-4小时,先后通过加入有机胺碱性物质进行盐化,旋转蒸馏除去有机溶剂操作得到聚氨酯粘溶液;将生物大分子明胶在PH为7.4缓冲液中加入甲基丙烯酸酐进行改性,先后进行了透析、冷冻干燥处理得到改性后的生物大分子;将其与聚氨酯粘溶液进行复配通过物理和化学交联得到高黏性凝胶,所述化学交联通过紫外照射实现。
2.如权利要求1所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于:所述高黏性凝胶成分为:
聚酯多元醇100份、DMPA30-60份、环糊精3-20份、异氰酸酯120-180份、三乙胺5-20份、改性明胶25-35份、氨基酸扩链剂20-40份、催化剂0.5-1.0份、稀释溶剂100-200份、去离子水200-300份;
具体制备步骤如下
步骤一:原料实验前预处理
将聚酯多元醇、DMPA原料经过80度真空干燥除水;用高温活化好的4A分子筛加入异氰酸酯中,除去多余的杂质;
步骤二:氨基酸聚氨酯超分子的合成
在聚酯多元醇与异氰酸酯化合物中加入所述DMPA和所述氨基酸扩链剂、催化剂和稀释溶剂经预聚反应后得到预聚体,最后通过中和反应以及水化处理得到聚氨酯水溶液;
步骤三:天然大分子的改性
称取适量的A型明胶加入碳酸盐缓冲液中,加热使其溶解配置成5-10%质量分数的溶液,按照与明胶2%~10%质量比的比例滴加入甲基丙烯酸酐类化合物,反应3h后装入透析袋中透析三天并且每6h换一次去离子水,最后冻干得到改性生物大分子明胶;
步骤四:复配高黏性凝胶贴片的制备
将一定质量分数的聚氨酯粘溶液与改性明胶按照质量比为5~1的比例的混合,通过分散和充分接触,以提高分子层面的均匀度和互相作用力;倒入模具中,通过紫外均匀照射5-20 min得到复合黏性凝胶。
3.如权利要求2所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于:步骤二所述氨基酸聚氨酯超分子的合成步骤如下:
(1)将处理好的聚酯多元醇加入容器中;控制温度为79-81度,将其重新溶解,并对其进行搅拌;30min后分批加入一定量的环糊精,使其混合均匀充分;
(2)将异氰酸酯化合物分批次陆续加入容器中,并保持高速的搅拌;
(3)反应90min后,待体系稳定后加入DMPA粉末进行第一次扩链;
(4)反应60min后,降低体系温度,待稳定后陆续加入大部分氨基酸进行第二次扩链,继续反应30min;
(5)继续降低体系温度至室温,加入有机胺调节体系pH使其呈中性;
(6)称取氨基酸溶于去离子水中,在强剪切力快速搅拌下陆续滴入,直到体系出现相转变为止,此时已完成第三次扩链,过滤离心得到澄清的粘稠的聚氨酯溶液;
(7)通过离心和透析进一步的操作得到澄清透明的无杂质的聚氨酯浓溶液。
4.根据权利要求2中所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于所述的环糊精选用α-环糊精、β-环糊精或γ-环糊精中一种或几种组合。
5.根据权利要求2中所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于所述的聚酯多元醇选用聚乙二醇、聚四氢呋喃二醇、聚己内酯二元醇、聚己二酸己二醇酯二元醇、聚环氧丙烷二元醇中一种或几种组合。
6.根据权利要求2中所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于所述异氰酸酯的单体选自不含苯环结构的脂肪族异氰酸酯化合物:L-赖氨酸三异氰酸酯、4,4-二环己基甲烷二异氰酸酯、六亚甲基二异氰酸酯和异佛尔酮二异氰酸酯中一种或几种组合。
7.根据权利要求2所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于所述催化剂选自二月桂酸二丁基锡、辛酸亚锡中的任一种或两种组合。
8.根据权利要求2所述氨基酸基聚氨酯超分子高黏性凝胶的制备方法,其特征在于所述的稀释溶剂选自丙酮、氯仿、去离子水、二甲基亚砜、N-甲基吡咯烷酮或N-乙基吡咯烷酮的一种或几种。
9.采用权利要求2所述方法制备的氨基酸基聚氨酯超分子高黏性凝胶的应用,其特征在于,其应用于制备神经导管支架、心脏支架和心脏补片中的一种或几种。
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