CN113211666A - Progesterone suppository's machine-shaping equipment - Google Patents

Progesterone suppository's machine-shaping equipment Download PDF

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Publication number
CN113211666A
CN113211666A CN202110526268.9A CN202110526268A CN113211666A CN 113211666 A CN113211666 A CN 113211666A CN 202110526268 A CN202110526268 A CN 202110526268A CN 113211666 A CN113211666 A CN 113211666A
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CN
China
Prior art keywords
cavity
progesterone
suppository
processing
main shaft
Prior art date
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Granted
Application number
CN202110526268.9A
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Chinese (zh)
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CN113211666B (en
Inventor
贾瑞巧
何井亮
吕国强
肖凤轩
戴丽萍
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Jiangsu Yuanheng Pharmaceutical Co ltd
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Jiangsu Yuanheng Pharmaceutical Co ltd
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Priority to CN202110526268.9A priority Critical patent/CN113211666B/en
Publication of CN113211666A publication Critical patent/CN113211666A/en
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Publication of CN113211666B publication Critical patent/CN113211666B/en
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29BPREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00Mixing; Kneading
    • B29B7/02Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type
    • B29B7/06Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type with movable mixing or kneading devices
    • B29B7/10Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type with movable mixing or kneading devices rotary
    • B29B7/12Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type with movable mixing or kneading devices rotary with single shaft
    • B29B7/14Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type with movable mixing or kneading devices rotary with single shaft with screw or helix
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29BPREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00Mixing; Kneading
    • B29B7/02Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type
    • B29B7/22Component parts, details or accessories; Auxiliary operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29BPREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00Mixing; Kneading
    • B29B7/02Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type
    • B29B7/22Component parts, details or accessories; Auxiliary operations
    • B29B7/24Component parts, details or accessories; Auxiliary operations for feeding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29BPREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00Mixing; Kneading
    • B29B7/02Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type
    • B29B7/22Component parts, details or accessories; Auxiliary operations
    • B29B7/26Component parts, details or accessories; Auxiliary operations for discharging, e.g. doors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29BPREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00Mixing; Kneading
    • B29B7/02Mixing; Kneading non-continuous, with mechanical mixing or kneading devices, i.e. batch type
    • B29B7/22Component parts, details or accessories; Auxiliary operations
    • B29B7/28Component parts, details or accessories; Auxiliary operations for measuring, controlling or regulating, e.g. viscosity control

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention discloses processing and forming equipment for a progesterone suppository, which comprises a shell and an inverted T-shaped partition plate arranged in an inner cavity of the shell, wherein the partition plate divides the inner cavity of the shell into a progesterone cavity, a matrix cavity on one side of the progesterone cavity and a mixing cavity below the progesterone cavity; the processing and forming equipment for the progesterone suppository realizes the integrated processing of the progesterone suppository, and the matrix and the progesterone are added in a successive quantitative manner, so that the mixing and dissolving speed is high, and the yield is high.

Description

Progesterone suppository's machine-shaping equipment
Technical Field
The invention relates to the field of processing of progesterone suppositories, and particularly relates to processing and forming equipment of a progesterone suppository.
Background
In the process of processing and forming the progesterone suppository, the matrix needs to be melted and then dissolved in the matrix and then mixed, a plurality of devices are generally needed for processing, and when raw materials are transferred from the devices, the pollution is easily caused, and the continuous production of the suppository is not facilitated. In addition, progesterone is generally added into the matrix in a powder state, long time is required for completely dissolving the progesterone powder, and the time limit for the progesterone suppository to melt in the prior art is more than 70 minutes, which exceeds the regulation that the time limit for the water-soluble matrix to melt is less than 60 minutes under the suppository item in the Chinese pharmacopoeia, and thus, the progesterone powder may bring adverse effects to users as a medicament.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an integrated processing and forming device for progesterone suppository, which can further add progesterone and a matrix in a successive quantitative manner to help the progesterone to be dissolved as soon as possible. The technical scheme of the invention is as follows:
a processing and forming device for progesterone suppository comprises a shell and an inverted T-shaped partition plate arranged in an inner cavity of the shell, wherein the partition plate divides the inner cavity of the shell into a progesterone cavity, a matrix cavity on one side of the progesterone cavity and a mixing cavity below the progesterone cavity; a feeding port is respectively arranged on the shell above the progesterone cavity and the matrix cavity; a discharge port communicated with an external filling machine is arranged on the shell at the bottom of the mixing cavity;
the lower end opening of the partition board for separating the progesterone cavity and the matrix cavity forms a first feeding hole; a feeding mechanism is arranged at the first feeding port; the partition plate at the bottom of the progesterone cavity is also provided with an opening to form a second feeding port.
Furthermore, a plurality of baffle plates are sequentially arranged on the first feeding port and in the progesterone cavity from top to bottom, and one side of each baffle plate, which is close to the partition plate, can be connected with the partition plate in an upward rotating manner; when the baffle rotates to the horizontal, the periphery of the baffle is tightly attached to the inner wall of the progesterone cavity.
Further, a first spiral stirring paddle is vertically arranged in the matrix cavity, and an electric heating wire is arranged in a blade of the first spiral stirring paddle; and a temperature sensor is fixed in the partition plate at the bottom of the substrate cavity.
Further, the feeding mechanism comprises a rotating shaft vertically arranged at the center of the first feeding port, a plurality of stirring pieces are symmetrically arranged on the periphery of the rotating shaft, and the heights of the stirring pieces are matched with the height of the first feeding port; when the two symmetrical poking pieces rotate into the first feeding port, the distance between the outer ends of the two poking pieces is matched with the length of the first feeding port.
Furthermore, a material containing groove is formed in the surface, facing the base material, of the poking piece when the poking piece rotates.
Furthermore, a main shaft is arranged in the mixing cavity, a plurality of separating sheets which are attached to each other are arranged on the outer edge of the top of the main shaft, the separating sheets which are spaced from each other can be arranged on the main shaft in an upward rotating mode, and a driving mechanism for driving the separating sheets which can rotate upwards to move upwards is arranged on the main shaft below the separating sheets which can rotate upwards;
and the mixing cavity above the separation sheet and the shell at the positions of the progesterone cavity and the matrix cavity are internally provided with heat-insulating layers.
Furthermore, an electromagnet is arranged inside one side of the separation sheet close to the main shaft, a limiting plate is arranged above the separation sheet corresponding to one side of the electromagnet far from the main shaft, and through holes are uniformly distributed in the limiting plate;
a plurality of magnetic stirrers capable of freely moving are arranged above the separating sheets; when the upward rotatable separating sheets rotate to the uppermost end, the distance between each upward rotatable separating sheet and the limiting plate of the adjacent separating sheet is smaller than the width of the magnetic stirrer;
and a silica gel sheet is fixed on the outer edge of the separation sheet.
Furthermore, the driving mechanism comprises a fixed plate fixed on the side wall below the separating sheet, and a supporting plate is rotatably arranged below the fixed plate; a lifting cavity is arranged in the main shaft below each separation sheet, and a screw rod is vertically arranged in the lifting cavity; one end of the supporting plate, which is far away from the separating sheet, can be connected with the nut seat of the screw rod in a vertically rotating manner; the side wall of the lifting cavity at the position of each supporting plate is provided with a through groove for each supporting plate to pass through and move up and down.
Furthermore, a second spiral stirring paddle is arranged between the upper end of the main shaft and the bottom of the partition plate above the main shaft, and electric heating wires are arranged in blades of the second spiral stirring paddle.
Furthermore, a plurality of stirring rods are arranged on the periphery of the outer wall of the lower end of the main shaft, a plurality of stirring hammers are arranged on the outer wall below each stirring rod along the length direction, and the outer ends of the stirring hammers are expanded outwards to form spherical hammers.
The method for preparing the progesterone suppository by adopting the processing and forming equipment comprises the following raw materials in parts by weight: 25 parts of progesterone, 292 parts of polyoxyl (40) stearate, 488 parts of polyethylene glycol 1500 and 195 parts of polyethylene glycol 400;
the production method of the progesterone suppository comprises the following steps:
a. melting the polyoxyl (40) stearate, polyethylene glycol 1500 and polyethylene glycol 400 at 70-80 ℃ to obtain a matrix;
b. mixing and stirring progesterone and a preset amount of matrix until the progesterone is completely dissolved, simultaneously adding the rest matrix one by one, and keeping the temperature for 30 minutes;
c. stirring, cooling to 30-40 deg.C, and packaging.
Based on the technical scheme, the invention can realize the following technical effects:
1. the processing and forming equipment for the progesterone suppository integrates melting of the matrix, mixing with the progesterone, stirring and cooling into one equipment, and reduces raw material waste and pollution caused by connection of multiple equipment.
2. According to the processing and forming equipment for the progesterone suppository, the progesterone and part of the matrix are mixed firstly, and then the rest matrix is added gradually, so that the progesterone is easy to disperse and dissolve, layering and chromatography phenomena of the progesterone in the suppository are reduced, the uniformity of the medicament is improved, the time required by stirring and mixing is reduced, the melting time limit of the progesterone suppository is reduced, the progesterone suppository is within 40 minutes, the shape is smooth and uniform, and the hardness is moderate.
3. According to the processing and forming equipment for the progesterone suppository, the feeding mechanism can be used for shifting the matrix in the matrix cavity into the progesterone cavity one by one and quantitatively and enabling the matrix to flow into the mixing cavity from the second discharge hole, so that the adding amount, adding times and adding speed of the matrix are accurately controlled.
4. According to the processing and forming equipment for the progesterone suppository, when the shifting pieces rotate into the first feeding port, the distance between the outer ends of the two shifting pieces is matched with the length of the first feeding port, so that the first feeding port can be blocked, a valve of the first feeding port is closed when a matrix is not required to be added, and the addition controllability of the matrix is ensured.
5. According to the processing and forming equipment for the progesterone suppository, progesterone with the formula amount is sequentially arranged on each baffle in a progesterone cavity, the progesterone can be sequentially added by sequentially turning the baffles downwards, and the baffles are completely lifted and then sequentially put down from bottom to top in a processing gap, so that the sequential addition of the progesterone can be realized, the continuous processing of the suppository is realized without stopping after each batch of suppository is made, and additional feeding is performed, and the production efficiency is improved.
6. According to the processing and forming equipment for the progesterone suppository, the magnetic stirrer and the electromagnet are arranged on the partition plate and are sequentially electrified, so that the magnetic stirrer moves relative to the partition plate along the electrifying direction of the electromagnet, materials sinking in the lower layer are stirred in a more targeted manner, and uneven stirring caused by sinking of progesterone powder is prevented.
7. According to the processing and forming equipment for the progesterone suppository, the driving mechanism realizes upward supporting and lowering of the separating sheet, the separating sheet is upwards supported when the nut seat of the screw rod moves to the uppermost direction, the mixed raw materials flow down from the gap of the separating sheet, the separating sheet is lowered and mutually closed when the nut seat moves to the lowermost direction, the separating sheet realizes switching between separation and opening, the separating effect is good, and the raw materials are not easy to retain when the separating sheet moves downwards.
Drawings
Fig. 1 is a schematic front view of a progesterone suppository processing and forming apparatus according to the present invention;
fig. 2 is a sectional view a-a of fig. 1 of the apparatus for processing and molding a progesterone suppository according to the present invention;
fig. 3 is an enlarged view B of fig. 2 of the machine-shaping apparatus for progesterone suppositories of the present invention;
fig. 4 is a sectional view B-B of fig. 1 of the progesterone suppository processing and forming apparatus of the present invention;
fig. 5 is an enlarged view a of fig. 1 of the machine-shaping equipment for progesterone suppositories of the present invention;
in the figure: 1-a shell; 11-a heat-insulating layer; 12-a separator; 13-a first feed port; 2-progesterone cavity; 21-a baffle plate; 22-a second feed port; 23-a stromal cavity; 24-a first helical mixing paddle; 25-a feeding mechanism; 26-a toggle sheet; 27-a material containing groove; 3-a mixing chamber; 31-a separator; 32-second helical paddles; 33-a limiting plate; 34-a silica gel sheet; 35-an electromagnet; 36-a fixed plate; 37-a supporting plate; 38-a lifting chamber; 39-a screw rod; 4-a main shaft; 41-a stirring rod; 42-a stirring hammer; .
Detailed Description
The present invention will be further described with reference to the accompanying drawings, and it is to be understood that the described embodiments are merely illustrative of some, but not all, embodiments of the invention.
As shown in fig. 1-5, the present embodiment provides a processing and forming apparatus for progesterone suppository, which comprises a housing 1 and an inverted T-shaped partition 12 disposed in the inner cavity of the housing 1, wherein the partition 12 divides the inner cavity of the housing 1 into a progesterone cavity 2, a matrix cavity 23 on one side of the progesterone cavity 2 and a mixing cavity 3 below;
the shell 1 above the progesterone cavity 2 and the matrix cavity 23 is respectively provided with a feeding port. A discharge port communicated with an external filling machine is arranged on the shell 1 at the bottom of the mixing cavity 3;
the lower end of the partition plate 12 separating the progesterone cavity 2 from the matrix cavity 23 is open, forming a first feed port 13. The first feeding port 13 is provided with a feeding mechanism 25. The partition 12 at the bottom of the progesterone cavity 2 is also provided with an opening forming a second feeding port 22.
Preferably, a plurality of baffle plates 21 are sequentially arranged on the first feeding port 13 and in the progesterone cavity 2 from top to bottom, and one side of each baffle plate 21, which is close to the partition plate 12, can be connected with the partition plate 12 in an upward rotating manner; when the shutter 21 is rotated to the horizontal, the periphery of the shutter 21 abuts against the inner wall of the progesterone cavity 2.
Preferably, a first helical stirring paddle 24 is vertically arranged in the substrate cavity 23, and a heating wire is arranged in a blade of the first helical stirring paddle 24. A temperature sensor is fixed in the partition 12 at the bottom of the substrate chamber 23.
Preferably, the feeding mechanism 25 includes a rotating shaft vertically arranged at the center of the first feeding port 13, a plurality of stirring pieces 26 are symmetrically arranged on the periphery of the rotating shaft, and the heights of the stirring pieces 26 are matched with the height of the first feeding port 13; when the two symmetrical stirring pieces 26 rotate into the first feeding port 13, the distance between the outer ends of the two stirring pieces 26 is matched with the length of the first feeding port 13.
Preferably, the side of the poking sheet 26 facing the base material when rotating is provided with a material containing groove 27.
Preferably, a main shaft 4 is arranged in the mixing cavity 3, a plurality of separating sheets 31 which are attached to each other are arranged on the outer edge of the top of the main shaft 4, wherein the separating sheets which are spaced from each other are arranged on the main shaft 4 in an upward rotating manner, and a driving mechanism for driving the separating sheets 31 which rotate upward to move upward is arranged on the main shaft 4 below the separating sheets 31 which rotate upward;
the heat-insulating layer 11 is arranged in the shell 1 at the positions of the mixing cavity 3, the progesterone cavity 2 and the matrix cavity 23 above the separation plate 31.
Preferably, an electromagnet 35 is arranged inside one side of the separating sheet 31 close to the main shaft 4, a position of the electromagnet 35 far away from the main shaft 4 is provided with a limit plate 33 above the corresponding separating sheet 31, and through holes are uniformly distributed on the limit plate 33;
a plurality of magnetic stirrers capable of freely moving are arranged above the separating sheet 31; when the upward rotatable separating sheets 31 rotate to the uppermost end, the distance between each upward rotatable separating sheet and the limiting plate 33 of the adjacent separating sheet 31 is smaller than the width of the magnetic stirrer;
a silicon sheet 34 is fixed on the outer edge of the separating sheet 31.
Preferably, the driving mechanism comprises a fixing plate 36 fixed on the lower side wall of the separating plate 31, and a supporting plate 37 is rotatably arranged below the fixing plate 36; a lifting cavity 38 is arranged in the main shaft 4 below each separation plate 31, and a screw rod 39 is vertically arranged in the lifting cavity 38. One end of the supporting plate 37 far away from the separating sheet 31 can be connected with the nut seat of the screw rod 39 in a way of rotating up and down; the side wall of the lifting cavity 38 at the position of each supporting plate 37 is provided with a through groove for each supporting plate 37 to pass through and move up and down.
Preferably, a second helical stirring paddle 32 is arranged between the upper end of the main shaft 4 and the bottom of the partition board 12 above, and a heating wire is arranged in a blade of the second helical stirring paddle 32. Preferably, a plurality of stirring rods 41 are arranged on the periphery of the outer wall of the lower end of the main shaft 4, a plurality of stirring hammers 42 are arranged on the outer wall below each stirring rod 41 along the length direction, and the outer ends of the stirring hammers 42 are expanded outwards to form spherical hammers.
Based on the structure, the processing and forming equipment for the progesterone suppository disclosed by the invention lifts all the baffles 21 in the progesterone cavity 2 before processing, and then sequentially puts down the baffles from bottom to top to be horizontal, and each next baffle 21 is put into the progesterone with the formula amount from the feeding port on the progesterone cavity 2, and each progesterone falls onto the baffles 21 sequentially. Meanwhile, the matrix raw materials with the formula amount are poured into the matrix cavity 23, and the first spiral stirring paddle 24 is used for stirring and heating the matrix raw materials to 70-80 ℃ for melting. Then the second screw propeller 32 rotates, the rotating shaft of the feeding mechanism 25 rotates, and the stirring plate 26 gradually stirs the melted matrix from the first feeding port 13 into the progesterone cavity 2 and flows from the second discharging port 22 into the mixing cavity 3. The quantity of the substrate stirred by each stirring plate 26 is fixed, and the adding quantity, adding times and adding speed of the substrate are accurately controlled. When stirring matrix to mixing chamber 3, the baffle 21 of lower floor overturns downwards, and progesterone falls gradually from the gap that produces between baffle 21 and casing 1, flows gradually to the matrix homogeneous mixing in the mixing chamber, once only adds progesterone among the prior art and carries out the mixing stirring again with the matrix and compare, and progesterone and matrix are all more dispersed, and it is easier to mix, can hold process time, reduce the defective percentage.
When the second spiral stirring paddle 32 rotates, the electromagnets 35 arranged on the separating plate 31 are sequentially powered according to the rotating direction of the second spiral stirring paddle 32, so that the magnetic stirrers move relative to the separating plate 31 along the power-on sequence of the electromagnets 35, the stirring speed is higher than that of the second spiral stirring paddle 32 above, and therefore materials sinking in the lower layer are stirred more specifically, and uneven stirring caused by sinking of progesterone powder is prevented. The limiting plate 33 prevents the stirrer from moving to the outer side of the limiting plate 33 during stirring. After mixing and heat preservation are completed, the screw rod 39 rotates to move the nut seat upwards, so that the supporting plate 37 lifts the partition plates 31 which can rotate upwards, and the mixed materials flow downwards from the gaps between the partition plates 31, are decelerated and stirred by the stirring rod 41 and the stirring hammer 42, and then flow to an external filling machine from the discharge port. And finishing the processing and forming.
The embodiments of the present invention have been described in detail with reference to the drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention.

Claims (10)

1. A processing and forming device for a progesterone suppository comprises a shell (1) and an inverted T-shaped partition plate (12) arranged in the inner cavity of the shell (1), wherein the partition plate (12) divides the inner cavity of the shell (1) into a progesterone cavity (2), a matrix cavity (23) on one side of the progesterone cavity (2) and a mixing cavity (3) below the progesterone cavity;
a feeding port is respectively arranged on the shell (1) above the progesterone cavity (2) and the matrix cavity (23); a discharge hole communicated with an external filling machine is formed in the shell (1) at the bottom of the mixing cavity (3);
the lower end of a partition plate (12) for separating the progesterone cavity (2) and the matrix cavity (23) is opened to form a first feeding port (13) which can communicate the progesterone cavity (2) and the matrix cavity (23); a feeding mechanism (25) is arranged at the first feeding port (13); the partition plate (12) at the bottom of the progesterone cavity (2) is also provided with an opening to form a second feeding port (22) which can be communicated with the mixing cavity (3).
2. The processing and forming equipment for the progesterone suppository, according to claim 1, wherein a plurality of baffle plates (21) are sequentially arranged above the first feeding port (13) and in the progesterone cavity (2) from top to bottom, and one side of each baffle plate (21) close to the partition plate (12) is connected with the partition plate (12) in an upward rotatable manner; when the baffle plate (21) rotates to the horizontal position, the periphery of the baffle plate (21) is tightly attached to the inner wall of the progesterone cavity (2).
3. The processing and forming equipment for the progesterone suppository, according to the claim 1, characterized in that a first spiral stirring paddle (24) is vertically arranged in the matrix cavity (23), and a heating wire is arranged in a blade of the first spiral stirring paddle (24); a temperature sensor is fixed in the clapboard (12) at the bottom of the substrate cavity (23).
4. The processing and forming equipment for the progesterone suppository, according to claim 1, wherein the feeding mechanism (25) comprises a rotating shaft vertically arranged at the center of the first feeding port (13), a plurality of stirring sheets (26) are symmetrically arranged on the periphery of the rotating shaft, and the height of each stirring sheet (26) is matched with that of the first feeding port (13); when the two symmetrical poking sheets (26) rotate into the first feeding port (13), the distance between the outer ends of the two poking sheets (26) is matched with the length of the first feeding port (13).
5. The processing and forming equipment for the progesterone suppository, according to claim 1, characterized in that the side of the poking piece (26) facing the base material is provided with a material containing groove (27) when rotating.
6. The processing and forming equipment for the progesterone suppository, according to claim 1, wherein a main shaft (4) is arranged in the mixing cavity (3), a plurality of separating sheets (31) attached to each other are arranged on the outer edge of the top of the main shaft (4), the separating sheets spaced from each other are rotatably arranged on the main shaft (4), and a driving mechanism for driving the separating sheets (31) rotatable upwards to move upwards is arranged on the main shaft (4) below the separating sheets (31) rotatable upwards;
and a heat-insulating layer (11) is arranged in the shell (1) at the positions of the mixing cavity (3) above the separation sheet (31), the progesterone cavity (2) and the matrix cavity (23).
7. The processing and forming equipment for the progesterone suppository, according to claim 6, wherein an electromagnet (35) is arranged inside one side of all the spacers (31) close to the main shaft (4), a limiting plate (33) is arranged above the corresponding spacer (31) at one side of the electromagnet (35) far away from the main shaft (4), and through holes are uniformly distributed on the limiting plate (33);
a plurality of magnetic stirrers capable of freely moving are arranged above the separating sheet (31); when the separating sheets (31) which can rotate upwards rotate to the uppermost end, the distance between each separating sheet which can rotate upwards and the position of the limiting plate (33) of the adjacent separating sheet (31) is less than the width of the magnetic stirrer;
and a silica gel sheet (34) is fixed on the outer edge of the separation sheet (31).
8. The processing and forming equipment for progesterone suppository according to claim 6, wherein the driving mechanism comprises a fixing plate (36) fixed on the lower side wall of the partition plate (31) capable of rotating upwards, and a supporting plate (37) is rotatably arranged below the fixing plate (36); a lifting cavity (38) is arranged in the main shaft (4) below each separating sheet (31), and a screw rod (39) is vertically arranged in the lifting cavity (38); one end of the supporting plate (37) far away from the separating sheet (31) can be connected with the nut seat of the screw rod (39) in a vertically rotating manner; the side wall of the lifting cavity (38) at the position of each supporting plate (37) is provided with a through groove for each supporting plate (37) to pass through and move up and down.
9. The processing and forming equipment for the progesterone suppository, according to claim 6, wherein a second spiral stirring paddle (32) is arranged between the upper end of the main shaft (4) and the bottom of the upper partition plate (12), and electric heating wires are arranged in blades of the second spiral stirring paddle (32).
10. The processing and forming equipment for the progesterone suppository, according to claim 6, wherein a plurality of stirring rods (41) are arranged on the periphery of the outer wall of the lower end of the main shaft (4), a plurality of stirring hammers (42) are arranged below each stirring rod (41) along the length direction, and the outer ends of the stirring hammers (42) are expanded outwards to form spherical hammers.
CN202110526268.9A 2021-05-14 2021-05-14 Progesterone suppository's machine-shaping equipment Active CN113211666B (en)

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CN113211666B CN113211666B (en) 2021-12-10

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