CN113210347A - Amorphous alloy antibacterial surface and manufacturing method thereof - Google Patents
Amorphous alloy antibacterial surface and manufacturing method thereof Download PDFInfo
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- CN113210347A CN113210347A CN202110318507.1A CN202110318507A CN113210347A CN 113210347 A CN113210347 A CN 113210347A CN 202110318507 A CN202110318507 A CN 202110318507A CN 113210347 A CN113210347 A CN 113210347A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
- B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/70—Cleaning devices specially adapted for surgical instruments
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
Abstract
The invention relates to the technical field of medical instruments, in particular to a manufacturing method of an amorphous alloy antibacterial surface, which comprises the following steps of S1: polishing the surface of the amorphous alloy; s2: irradiating the polished surface of the amorphous alloy by using laser S1 to induce the surface of the amorphous alloy microstructure; s3: firstly, ultrasonically cleaning the surface of the amorphous alloy microstructure prepared by S2 with ethanol, and then cleaning the surface of the amorphous alloy microstructure with deionized water; s4: sequentially carrying out silver nitrate solution treatment, hydrogen peroxide solution treatment and sterile deionized soaking on the surface of the amorphous alloy microstructure cleaned in the step S3; s5: the manufacturing method of the amorphous alloy antibacterial surface can effectively manufacture the amorphous alloy antibacterial surface which is formed by compounding the structural antibacterial property and the chemical component antibacterial property and can stably sterilize.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a manufacturing method of an amorphous alloy antibacterial surface.
Background
In the clinical treatment process, the patients can be infected due to the unclean disinfection of medical instruments or the pollution in the transportation and storage processes, and even the patients can die in serious cases. Meanwhile, for the implantation operation, the tissue infection near the implant body usually occurs after the operation, and the serious patient may cause the failure of the implantation operation. The medical instrument with the antibacterial function can effectively reduce the infection risk in the clinical treatment process. The amorphous alloy has the characteristics of high strength, strong wear resistance and corrosion resistance, good biocompatibility and the like by virtue of a unique amorphous structure, and compared with the traditional medical stainless steel and titanium alloy, the strength of the amorphous alloy can be increased by about 2 times, and the hardness can be increased by about 1.5 times, so that the amorphous alloy is known as one of the most ideal materials for surgical instruments and implant materials, and has a wide application prospect in the field of biomedicine.
From the surface antibacterial mechanism of medical materials, the current amorphous surface antibacterial form can be divided into structural antibacterial, component antibacterial and composite antibacterial. The structural antibiosis mainly utilizes the surface microstructure to realize the reduction of the adhesion rate of bacteria. The component antibacterial mainly utilizes the reaction of bacterial cell membranes and DNA with specific chemical elements/functional groups to kill bacteria, such as metal elements such as Ag, Cu and the like with strong antibacterial property, active oxygen and organic functional groups to destroy the protein structure and DNA structure of bacterial cells adhered to the surface of a material. The composite antibacterial is to combine the structural antibacterial and the component antibacterial, and kill the adhered bacterial cell bodies while realizing the reduction of the adhesion rate of bacteria on the surface of the material. However, the above-mentioned antibacterial surface only has antibacterial effect by reducing the adhesion rate of bacteria and additional components, and its antibacterial approach is single, which is not favorable for efficiently realizing the antibacterial function of the surface of amorphous alloy.
Disclosure of Invention
The first purpose of the invention is to provide a manufacturing method of an amorphous alloy antibacterial surface, which can effectively manufacture an amorphous alloy antibacterial surface which has the antibacterial combination of structure and chemical components and can stably sterilize, and the defects in the prior art are avoided.
The first purpose of the invention is realized by the following technical scheme:
provides a manufacturing method of amorphous alloy antibacterial surface, which is characterized by comprising the following steps,
s1: polishing the surface of the amorphous alloy;
s2: irradiating the polished surface of the amorphous alloy by using laser S1 to induce the surface of the amorphous alloy microstructure;
s3: firstly, ultrasonically cleaning the surface of the amorphous alloy microstructure prepared by S2 by using ethanol, and then cleaning the surface of the amorphous alloy microstructure by using deionized water;
s4: sequentially carrying out silver nitrate solution treatment, hydrogen peroxide solution treatment and sterile deionized soaking on the surface of the amorphous alloy microstructure cleaned in the step S3;
s5: firstly, ultrasonically cleaning the surface of the amorphous alloy microstructure processed by S4 by using ethanol, and then cleaning the surface of the amorphous alloy microstructure by using deionized water to obtain the amorphous alloy antibacterial surface.
Further, in the S1, the roughness Ra of the polished amorphous alloy surface is less than 0.1 μm.
Further, diamond with the grain size of 0.25-5 microns is adopted to polish abrasive grains, and then the surface of the amorphous alloy is polished at the linear velocity of 0.5-10 m/s and the pressure of 0.3-10 MPa, wherein the polishing time is 20-40 min.
Further, in S2, the amorphous alloy microstructure surface is an ordered submicron structure surface or an unordered nanoparticle structure surface, and a structure gap of the amorphous alloy microstructure surface is less than 0.7 μm.
Further, in the step S2, the polished surface of the amorphous alloy is irradiated with ultrafast laser once or for multiple times, the ultrafast laser has a wavelength of 300nm to 1200nm and a pulse width of<10ps, fluence of 0.1J/mm2～2J/mm2The scanning interval is 10-50 μm.
Further, in the step S3, the cleaning time of the ethanol is 5min to 20min, and the cleaning time of the deionized water is 5min to 20 min.
Further, in the S4, the silver nitrate solution is used for treating the surface of the amorphous alloy microstructure for 0.5 to 5 hours at the temperature of 18 to 100 ℃, and the concentration of the silver nitrate solution is 0.1 to 3 mol/L; treating the surface of the amorphous alloy microstructure for 0.5-5 h at 18-100 ℃ by using a hydrogen peroxide solution, wherein the concentration of the hydrogen peroxide solution is 0.3-30%; and treating the surface of the amorphous alloy microstructure for 10-30 min at 18-100 ℃ by using the sterile deionized water.
Further, in the step S5, the cleaning time of the ethanol is 5min to 20min, and the cleaning time of the deionized water is 5min to 20 min.
Further, the ethanol in S3 is absolute ethanol, and the ethanol in S5 is absolute ethanol.
The manufacturing method of the amorphous alloy antibacterial surface has the beneficial effects that:
(1) the manufacturing method of the invention combines the structural antibiosis and the chemical component antibiosis, thereby not only reducing the bacteria adhesion rate on the surface of the amorphous alloy, but also killing the adhered bacteria cell body, thereby greatly improving the antibacterial efficiency on the surface of the amorphous alloy; the chemical components can be stably adhered to the surface of the amorphous alloy by the microstructure surface of the amorphous alloy, so that the antibacterial durability of the surface of the amorphous alloy is effectively improved; and the microstructure on the surface of the amorphous alloy can ensure that bacteria and chemical components are adhered more stably, thereby further improving the antibacterial performance of the surface of the amorphous alloy.
(2) The manufacturing method of the invention firstly uses silver nitrate solution to deposit silver ions on the surface of the amorphous alloy microstructure, and then uses hydrogen peroxide to oxidize the deposited silver ions and copper ions on the surface of the amorphous alloy, so that a layer of chemical components with remarkable antibacterial effect is attached to the surface of the amorphous alloy.
(3) The manufacturing method not only can manufacture the microstructure capable of reducing the adhesion rate of bacteria, but also adopts ethanol for multiple times of cleaning, so that the surface of the amorphous alloy has super-hydrophilic characteristics, the adhered bacteria can be in close contact with chemical components on the microstructure, and the sterilization effect of the chemical components is improved.
The second purpose of the invention is to provide an amorphous alloy antibacterial surface, which is manufactured by the manufacturing method of the amorphous alloy antibacterial surface and can efficiently, stably and durably resist bacteria.
Drawings
The invention is further illustrated by means of the attached drawings, but the embodiments in the drawings do not constitute any limitation to the invention, and for a person skilled in the art, other drawings can be derived on the basis of the following drawings without inventive effort.
FIG. 1 is a comparison graph of the surface topography of zirconium-based amorphous alloys after different treatments;
FIG. 2 is a fluorescence contrast graph of the bacterial adhesion properties of zirconium based amorphous alloy surfaces after different treatments;
FIG. 3 is a graph comparing the antibacterial effect of the zirconium based amorphous alloy surfaces after different treatments.
Detailed Description
The invention is further described with reference to the following examples.
A method for manufacturing an amorphous alloy antibacterial surface comprises the following steps,
s1: polishing the surface of the amorphous alloy;
s2: irradiating the polished surface of the amorphous alloy by using laser S1 to induce the surface of the amorphous alloy microstructure so as to obtain the surface microstructure of the amorphous alloy;
s3: firstly ultrasonically cleaning the surface of the amorphous alloy microstructure prepared by S2 by using ethanol, and then cleaning the surface of the amorphous alloy microstructure by using deionized water, wherein the ethanol can endow the surface of the amorphous alloy microstructure with certain hydrophilic property;
s4: sequentially carrying out silver nitrate solution treatment, hydrogen peroxide solution treatment and sterile deionized soaking on the surface of the amorphous alloy microstructure cleaned in the S3 manner, so that the surface of the amorphous alloy microstructure has chemical components, and the hydrogen peroxide can oxidize silver ions and copper ions on the surface of the amorphous alloy microstructure, thereby improving the antibacterial effect of the chemical components;
s5: firstly, ultrasonically cleaning the surface of the amorphous alloy microstructure processed by S4 by using ethanol, and then cleaning the surface of the amorphous alloy microstructure by using deionized water to prepare the amorphous alloy antibacterial surface.
Wherein, in the S1, the roughness Ra of the polished amorphous alloy surface is less than 0.1 μm, and the roughness is small, so that the microstructure surface has relative smoothness and prevents bacteria from adhering. Preferably, the polishing is carried out by a mechanical method, which comprises the following steps: on a wool polishing pad (or other pads), diamond polishing abrasive particles with the granularity of 0.25-5 mu m are adopted, and then the surface of the amorphous alloy is polished at the linear speed of 0.5-10 m/s and the pressure of 0.3-10 MPa, wherein the polishing time is 20-40 min.
In the step S2, the surface of the amorphous alloy microstructure is a surface with a ordered submicron scale structure or a surface with a disordered nanoparticle structure, and the structural gap of the surface of the amorphous alloy microstructure is less than 0.7 μm, so that the density of the surface microstructure of the amorphous alloy is higher, and a better antibacterial effect is achieved.
Wherein in S2, the polished surface of the amorphous alloy is irradiated by ultrafast laser once or for many times, the wavelength of the ultrafast laser is 300-1200 nm, and the pulse width of the ultrafast laser is<10ps, fluence of 0.1J/mm2～2J/mm2The scanning interval is 10-50 μm, so that the required microstructure can be induced.
Wherein in the step S3, the cleaning time of the ethanol is 5min to 20min, and the cleaning time of the deionized water is 5min to 20 min.
In the S4, the silver nitrate solution is used for treating the surface of the amorphous alloy microstructure for 0.5-5 h at the temperature of 18-100 ℃, and the concentration of the silver nitrate solution is 0.1-3 mol/L; treating the surface of the amorphous alloy microstructure for 0.5-5 h at 18-100 ℃ by using a hydrogen peroxide solution, wherein the concentration of the hydrogen peroxide solution is 0.3-30%; the sterile deionized water is used for treating the surface of the amorphous alloy microstructure for 10min to 30min at the temperature of 18 ℃ to 100 ℃, silver ions are stably deposited on the amorphous alloy microstructure by the process, and the silver ions and copper ions can be thoroughly oxidized.
Wherein in the step S5, the cleaning time of the ethanol is 5min to 20min, and the cleaning time of the deionized water is 5min to 20 min.
The ethanol in the S3 is absolute ethanol, the ethanol in the S5 is absolute ethanol, and the absolute ethanol can provide a good cleaning effect and can also endow certain hydrophilic performance.
Example 1
The embodiment discloses a manufacturing method of a zirconium-based amorphous alloy antibacterial surface, which comprises the following steps,
s1: polishing the surface of a zirconium-based amorphous alloy medical instrument by a mechanical method, and polishing at a linear speed of 3.5m/s by using a resin polishing pad and diamond polishing abrasive particles with the granularity of 0.25 mu m for 30min at the polishing pressure of 0.5MPa, wherein the surface roughness Ra of the polished amorphous alloy is less than 0.1 mu m;
s2: the manufacturing of the amorphous alloy microstructure antibacterial surface is realized by adopting an ultrafast laser, wherein the laser wavelength is 1030nm, the pulse width is 300fs, and the energy flux density is 0.23J/mm2Carrying out single irradiation on the surface of the amorphous alloy under the condition, wherein the irradiation scanning interval is 10 mu m, and inducing an ordered submicron line array structure, and the structure gap is 0.6 mu m;
s3: firstly, ultrasonically cleaning the surface of the amorphous alloy by using absolute ethyl alcohol for 10min, and then cleaning the surface of the amorphous alloy by using deionized water for 10 min;
s4: improving the antibacterial property of amorphous alloy components by using a chemical treatment method, firstly treating with a silver nitrate solution with the concentration of 0.1mol/L for 0.5h at the treatment temperature of 80 ℃, then treating with a hydrogen peroxide solution with the concentration of 5% for 1h at the treatment temperature of 80 ℃, soaking the amorphous alloy in sterile deionized water after treatment for 10min at the temperature of 25 ℃;
s5: and ultrasonically cleaning the surface of the amorphous alloy by using absolute ethyl alcohol for 20min, and then cleaning the surface of the amorphous alloy by using deionized water for 20 min.
Example 2
The embodiment discloses a manufacturing method of a zirconium-based amorphous alloy antibacterial surface, which comprises the following steps,
s1: polishing the surface of a zirconium-based amorphous alloy medical instrument by a mechanical method, polishing at a linear speed of 10m/s by using a wool polishing pad and diamond polishing abrasive particles with the granularity of 5 mu m, wherein the polishing pressure is 10MPa, the polishing time is 40min, and the surface roughness Ra of the polished amorphous alloy is less than 0.1 mu m;
s2: the manufacturing of the amorphous alloy microstructure antibacterial surface is realized by adopting ultrafast laser, wherein the laser wavelength is 1200nm, the pulse width is 900fs, and the energy flux density is 2J/mm2Under the condition, single irradiation is carried out on the surface of the amorphous alloy, the irradiation scanning interval is 50 mu m, an ordered submicron line array structure is induced, and the structure gap is 0.5 mu m;
s3: firstly, ultrasonically cleaning the surface of the amorphous alloy by using absolute ethyl alcohol for 5min, and then cleaning the surface of the amorphous alloy by using deionized water for 5 min;
s4: improving the antibacterial property of the components of the amorphous alloy by using a chemical treatment method, firstly treating the amorphous alloy by using a silver nitrate solution with the concentration of 3mol/L for 5 hours at the treatment temperature of 100 ℃, then treating the amorphous alloy by using a hydrogen peroxide solution with the concentration of 30 percent for 5 hours at the treatment temperature of 100 ℃, soaking the amorphous alloy in sterile deionized water after treatment for 30 minutes at the temperature of 100 ℃;
s5: and ultrasonically cleaning the surface of the amorphous alloy by using absolute ethyl alcohol for 5min, and then cleaning the surface of the amorphous alloy by using deionized water for 5 min.
Example 3
The embodiment discloses a manufacturing method of a zirconium-based amorphous alloy antibacterial surface, which comprises the following steps,
s1: polishing the surface of the zirconium-based amorphous alloy medical instrument by a mechanical method, and polishing at a linear speed of 0.5m/s by using a wool polishing pad and diamond polishing abrasive particles with the granularity of 0.25 mu m, wherein the polishing pressure is 0.3 MPa-10 MP, the polishing time is 20min, and the surface roughness Ra of the polished amorphous alloy is less than 0.1 mu m;
s2: the manufacturing of the amorphous alloy microstructure antibacterial surface is realized by adopting ultrafast laser, wherein the laser wavelength is 300nm, the pulse width is 800ps, and the energy flux density is 0.1J/mm2Under the condition, the surface of the amorphous alloy is irradiated for multiple times, the irradiation scanning interval is 40 mu m, the disordered nanoparticle structure is induced, and the structure gap is 0.5 mu m;
s3: firstly, ultrasonically cleaning the surface of the amorphous alloy by using absolute ethyl alcohol for 10min, and then cleaning the surface of the amorphous alloy by using deionized water for 10 min;
s4: improving the antibacterial property of amorphous alloy components by using a chemical treatment method, firstly treating with a silver nitrate solution with the concentration of 1.5mol/L for 3 hours at the treatment temperature of 18 ℃, then treating with a hydrogen peroxide solution with the concentration of 0.3 percent for 3 hours at the treatment temperature of 18 ℃, soaking the amorphous alloy in sterile deionized water after treatment for 10 minutes at the temperature of 18 ℃;
s5: and ultrasonically cleaning the surface of the amorphous alloy by using absolute ethyl alcohol for 10min, and then cleaning the surface of the amorphous alloy by using deionized water for 10 min.
Example 4
The difference between the present embodiment and embodiment 1 is that the present embodiment is to manufacture an antibacterial surface on the surface of a titanium-based amorphous composite medical device, and in S1, polishing is performed on a wool polishing pad; at a fluence of 0.23J/mm in S22Under the condition, the surface of the amorphous alloy is irradiated once, and other parameters are the same as those of the embodiment 1, and are not described again.
Example 5
The difference between the present example and example 1 is that the antibacterial surface is manufactured on the surface of the copper-based amorphous composite medical device, and in S1, the polishing pressure is 0.5 MPa; at an energy flow density of 0.67J/mm in S22Carrying out single irradiation on the surface of the amorphous alloy under the condition; in S4, the concentration of the silver nitrate solution is 0.5mol/L, the treatment time is 1h, the treatment time of the hydrogen peroxide is 2h, and other parameters are the same as those in example 1 and are not repeated herein.
Performance testing
And (3) morphology characterization: the surface of the zirconium-based amorphous alloy which is not polished and treated by the laser, the surface of the zirconium-based amorphous alloy which is treated by the laser and chemically treated in the embodiment 1 are respectively characterized by scanning by an electron microscope, as shown in fig. 1, the surface of the zirconium-based amorphous alloy which is not polished and treated by the laser is smooth, the surface of the zirconium-based amorphous alloy which is treated by the laser can induce an ordered microstructure surface, the microstructure is induced by the laser, the surface color of the zirconium-based amorphous alloy which is treated by the laser and chemically treated is deepened, and the chemical components are successfully deposited on the surface of the zirconium-based amorphous alloy.
And (3) verifying bacterial adhesion rate: bacteria are respectively paved on the polished untreated zirconium-based amorphous alloy surface, the laser treated zirconium-based amorphous alloy surface and the laser and chemical treated zirconium-based amorphous alloy surface prepared in the embodiment 1, then the amorphous alloy surfaces are washed by deionized water, then DAPI (4, 6-diamino-2-phenylindole) is used for dyeing the amorphous alloy surfaces, and the number of bacteria is observed under a fluorescence microscope, as can be seen from figure 2, the number of bacteria on the polished untreated zirconium-based amorphous alloy surface is the largest, the laser treated zirconium-based amorphous alloy surface is the second, and the laser and chemical treated zirconium-based amorphous alloy surface is the last, so that the amorphous alloy surface prepared by the technical scheme can effectively reduce the adhesion rate to the bacteria.
And (3) verification of sterilization characteristics: preparing three groups of bacteria solutions with the same bacteria number, respectively placing the medical equipment with the polished untreated zirconium-based amorphous alloy surface, the medical equipment with the laser treated zirconium-based amorphous alloy surface and the medical equipment with the laser and chemical treated zirconium-based amorphous alloy surface, which are prepared in the embodiment 1, in the corresponding three groups of bacteria solutions, standing for 3 hours, removing the corresponding amorphous alloy medical equipment, standing the bacteria solutions for 30 minutes, then sucking the upper layer solution of each group of bacteria solutions, placing the upper layer solution on a culture plate, culturing bacteria for 1 week, and according to the culture plate shown in fig. 3, the bacteria number of the equipment with the polished untreated zirconium-based amorphous alloy surface is the largest, the bacteria number of the equipment with the laser treated zirconium-based amorphous alloy surface is the second, and the bacteria number of the equipment with the laser and chemical treated zirconium-based amorphous alloy surface is finally proved to be capable of effectively sterilizing the amorphous alloy surface prepared by the technical scheme of the application.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A manufacturing method of an amorphous alloy antibacterial surface is characterized in that: comprises the following steps of (a) carrying out,
s1: polishing the surface of the amorphous alloy;
s2: irradiating the polished surface of the amorphous alloy by using laser S1 to induce the surface of the amorphous alloy microstructure;
s3: firstly, ultrasonically cleaning the surface of the amorphous alloy microstructure prepared by S2 by using ethanol, and then cleaning the surface of the amorphous alloy microstructure by using deionized water;
s4: sequentially carrying out silver nitrate solution treatment, hydrogen peroxide solution treatment and sterile deionized soaking on the surface of the amorphous alloy microstructure cleaned in the step S3;
s5: firstly, ultrasonically cleaning the surface of the amorphous alloy microstructure processed by S4 by using ethanol, and then cleaning the surface of the amorphous alloy microstructure by using deionized water to obtain the amorphous alloy antibacterial surface.
2. The method of claim 1, wherein the step of forming the antimicrobial amorphous alloy surface comprises: in the step S1, the roughness Ra of the polished amorphous alloy surface is less than 0.1 μm.
3. The method of claim 2, wherein the step of forming the amorphous alloy antimicrobial surface comprises: diamond with the granularity of 0.25-5 mu m is adopted to polish abrasive particles, and then the surface of the amorphous alloy is polished under the conditions of the linear velocity of 0.5-10 m/s and the pressure of 0.3-10 MPa, wherein the polishing time is 20-40 min.
4. The method of claim 1, wherein the step of forming the antimicrobial amorphous alloy surface comprises: in the step S2, the amorphous alloy microstructure surface is an ordered submicron structure surface or an unordered nanoparticle structure surface, and the structural gap of the amorphous alloy microstructure surface is less than 0.7 μm.
5. The amorphous alloy antibacterial surface of claim 4The manufacturing method is characterized in that: in the step S2, the polished surface of the amorphous alloy is irradiated by ultrafast laser once or for many times, the wavelength of the ultrafast laser is 300-1200 nm, and the pulse width is<10ps, fluence of 0.1J/mm2～2J/mm2The scanning interval is 10-50 μm.
6. The method of claim 1, wherein the step of forming the antimicrobial amorphous alloy surface comprises: in the step S3, the cleaning time of the ethanol is 5min to 20min, and the cleaning time of the deionized water is 5min to 20 min.
7. The method of claim 1, wherein the step of forming the antimicrobial amorphous alloy surface comprises: in the S4, the silver nitrate solution is used for treating the surface of the amorphous alloy microstructure for 0.5 to 5 hours at the temperature of between 18 and 100 ℃, and the concentration of the silver nitrate solution is between 0.1 and 3 mol/L; treating the surface of the amorphous alloy microstructure for 0.5-5 h at 18-100 ℃ by using a hydrogen peroxide solution, wherein the concentration of the hydrogen peroxide solution is 0.3-30%; and treating the surface of the amorphous alloy microstructure for 10-30 min at 18-100 ℃ by using the sterile deionized water.
8. The method of claim 1, wherein the step of forming the antimicrobial amorphous alloy surface comprises: in the step S5, the cleaning time of the ethanol is 5min to 20min, and the cleaning time of the deionized water is 5min to 20 min.
9. The method of claim 1, wherein the step of forming the antimicrobial amorphous alloy surface comprises: the ethanol in the S3 is absolute ethanol, and the ethanol in the S5 is absolute ethanol.
10. An amorphous alloy antibacterial surface, which is characterized in that: an amorphous alloy antibacterial surface prepared by the method for manufacturing an amorphous alloy antibacterial surface according to any one of claims 1 to 9.
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