CN113200825A - Preparation method of 2- (4-benzyloxy phenyl) ethanol - Google Patents

Preparation method of 2- (4-benzyloxy phenyl) ethanol Download PDF

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CN113200825A
CN113200825A CN202110458469.XA CN202110458469A CN113200825A CN 113200825 A CN113200825 A CN 113200825A CN 202110458469 A CN202110458469 A CN 202110458469A CN 113200825 A CN113200825 A CN 113200825A
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曾海峰
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SHANGHAI RECORDCHEM TECHNOLOGY CO LTD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
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Abstract

The invention provides a preparation method of 2- (4-benzyloxy phenyl) ethanol, which comprises the following steps: 1) reacting phenol with chloroacetyl chloride under the catalysis of aluminum trichloride to obtain a compound shown as a formula II; 2) reacting the compound shown in the formula II with benzyl halide under an alkaline condition to obtain a compound shown in a formula III; wherein, the benzyl halide is one of benzyl bromide or benzyl chloride; 3) after the compound shown in the formula III is subjected to reduction treatment, regulating a reaction system to be an alkaline system to obtain a compound shown in a formula IV; 4) the compound of formula IV is reduced under the action of a catalyst under the condition of hydrogen to obtain the 2- (4-benzyloxy phenyl) ethanol shown in the formula I.
Figure DDA0003041366020000011

Description

Preparation method of 2- (4-benzyloxy phenyl) ethanol
Technical Field
The invention belongs to the field of synthesis of drug intermediates, and relates to a preparation method of 2- (4-benzyloxy phenyl) ethanol.
Background
Levobetaxolol hydrochloride (a compound shown as formula A) is first marketed in the United states in 2 months in 2000, and is mainly used for treating chronic open-angle glaucoma or reducing intraocular pressure of patients with high intraocular pressure. The medicine has small side effect and high curative effect, and is expected to become the first choice medicine for treating chronic angle glaucoma.
Figure BDA0003041364000000011
2- (4-benzyloxy phenyl) ethanol (a compound shown as a formula I) is an important intermediate for synthesizing levobetaxolol hydrochloride.
Figure BDA0003041364000000012
Currently, there are several methods for preparing 2- (4-benzyloxyphenyl) ethanol:
1. WO2007/139923a1 discloses a method for preparing 2- (4-benzyloxy phenyl) ethanol by condensation reaction of methyl p-hydroxyphenylacetate serving as a starting material with benzyl chloride and reduction of the reaction product with lithium aluminum hydride, which can be represented by the following synthetic route:
Figure BDA0003041364000000013
however, the raw materials used in the preparation method are expensive and high in cost, and meanwhile, lithium aluminum hydride with high risk is used as a reducing agent, so that the preparation method has strict operation requirements and high potential safety hazard, and a large amount of three wastes generated by post-treatment can pollute the environment, so that the preparation method is not suitable for industrial production.
2. WO2004/113282A1 discloses a method for preparing 2- (4-benzyloxy phenyl) ethanol by condensation of p-hydroxybenzene ethanol as raw material and benzyl bromide under alkaline condition, which can be represented by the following synthetic route:
Figure BDA0003041364000000021
the preparation method has short synthetic route, but the raw materials are expensive and high in cost, and meanwhile, the benzyl bromide is easy to react with the alcoholic hydroxyl, so that the reaction selectivity is poor and the product purity is low.
3. CN108689810A discloses a method for preparing 2- (4-benzyloxy-phenyl) ethanol by using p-chlorophenol as a raw material and reacting the p-chlorophenol with benzyl chloride to prepare a Grignard reagent and reacting the Grignard reagent with ethylene oxide, wherein the specific synthetic route is as follows:
Figure BDA0003041364000000022
the reaction raw materials used in the preparation method have low cost, but ethylene oxide is used in the preparation process, is flammable and explosive, has high use risk and has great limitation in industrial production.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a preparation method of 2- (4-benzyloxy phenyl) ethanol, which takes phenol which is cheap and easy to obtain as an initial raw material, and prepares the 2- (4-benzyloxy phenyl) ethanol with high selectivity through the steps of Friedel-crafts acylation, nucleophilic substitution, reductive cyclization, hydrogenation ring opening and the like.
The invention provides a preparation method of 2- (4-benzyloxy phenyl) ethanol, which comprises the following steps:
1) reacting phenol with chloroacetyl chloride under the catalysis of aluminum trichloride to obtain a compound shown as a formula II;
2) reacting the compound shown in the formula II with benzyl halide under an alkaline condition to obtain a compound shown in a formula III; wherein, the benzyl halide is one of benzyl bromide or benzyl chloride;
3) after the compound shown in the formula III is subjected to reduction treatment, regulating a reaction system to be an alkaline system to obtain a compound shown in a formula IV;
4) reducing the compound shown in the formula IV under the action of a catalyst under the condition of hydrogen to obtain 2- (4-benzyloxy phenyl) ethanol shown in the formula I;
Figure BDA0003041364000000031
in a specific embodiment, the solvent in step 1) is selected from one or more of dichloromethane, 1, 2-dichloroethane, chloroform, benzene, toluene, ethylbenzene, xylene, chlorobenzene.
In one embodiment, in step 1), the ratio of the amounts of phenol, aluminum trichloride, and chloroacetyl chloride is 1: (1.0-5.0): (1.0-5.0).
In a specific embodiment, the base in step 2) is selected from one or more of potassium carbonate, sodium carbonate, potassium hydroxide, sodium bicarbonate, potassium bicarbonate, sodium ethoxide, potassium ethoxide, sodium hydride.
In a specific embodiment, the solvent in step 2) is selected from one or more of N, N-dimethylformamide, dimethylsulfoxide, toluene, tetrahydrofuran, acetonitrile, N-methylpyrrolidone, hexamethylphosphoric triamide, acetone.
In a particular embodiment, in step 2), the mass ratio of the compound of formula II, the benzyl halide and the base is 1: (1.0-3.0): (1.0-5.0).
In a specific embodiment, in step 3), the reducing agent for reduction treatment is selected from one or more of sodium borohydride, potassium borohydride, sodium cyanoborohydride, sodium triacetoxyborohydride, lithium aluminum hydride, and borane.
In a particular embodiment, in step 3), the ratio of the amounts of the compound of formula III, the reducing agent and the base is 1: (1.0-3.0): (1.0-5.0).
In a specific embodiment, in step 4), the catalyst is selected from one or more of palladium on carbon, ruthenium on carbon, platinum on carbon, and raney nickel.
In a specific embodiment, in the step 4), the reduction reaction is performed under a pressure of 0.1 to 1.0 Mpa.
The preparation method of 2- (4-benzyloxy phenyl) ethanol provided by the invention takes cheap and easily available phenol as an initial raw material, and prepares the 2- (4-benzyloxy phenyl) ethanol with high selectivity through the steps of Friedel-crafts acylation, nucleophilic substitution, reductive cyclization, hydrogenation ring opening and the like.
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FIG. 1 shows the preparation of 2- (4-benzyloxyphenyl) ethanol according to example 1 of the present invention1H NMR chart.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a preparation method of 2- (4-benzyloxy phenyl) ethanol, which comprises the following steps:
1) reacting phenol with chloroacetyl chloride under the catalysis of aluminum trichloride to obtain a compound shown as a formula II;
2) reacting the compound shown in the formula II with benzyl halide under an alkaline condition to obtain a compound shown in a formula III; wherein, the benzyl halide is one of benzyl bromide or benzyl chloride;
3) after the compound shown in the formula III is subjected to reduction treatment, regulating a reaction system to be an alkaline system to obtain a compound shown in a formula IV;
4) reducing the compound shown in the formula IV under the action of a catalyst under the condition of hydrogen to obtain 2- (4-benzyloxy phenyl) ethanol shown in the formula I;
Figure BDA0003041364000000051
the preparation method takes phenol as an initial raw material, and the 2- (4-phenyl methoxyphenyl) ethanol is prepared by the steps of Friedel-crafts acylation, nucleophilic substitution, reductive cyclization, hydrogenation ring opening and the like, the raw material used in the method is cheap and easy to obtain, other expensive and high-risk auxiliary reagents are not used in the preparation process, and the method has the advantages of high selectivity, low cost, mild conditions, simple operation and less three-waste pollution.
The solvent used in each step of the production process of 2- (4-benzyloxyphenyl) ethanol according to the present invention is not particularly limited as long as it can dissolve the substrate, utilize the progress of the reaction, and be easily removed in the post-treatment process.
For example, the solvent in step 1) may be selected from one or more of dichloromethane, 1, 2-dichloroethane, chloroform, benzene, toluene, ethylbenzene, xylene, chlorobenzene, and more preferably dichloromethane.
The solvent in step 2) may be one or more selected from N, N-dimethylformamide, dimethyl sulfoxide, toluene, tetrahydrofuran, acetonitrile, N-methylpyrrolidone, hexamethylphosphoric triamide, and acetone, and is more preferably N, N-dimethylformamide.
The solvent in step 3) may be one or more selected from tetrahydrofuran, water, acetonitrile, methanol, ethanol, and isopropanol, and is more preferably methanol.
The solvent in step 4) may be one or more selected from ethyl acetate, methanol, ethanol, isopropanol, and tetrahydrofuran, and is more preferably methanol.
It will be appreciated that the amount of material between the individual starting components is suitably controlled during the reaction so that at least equimolar proportions of the starting components are maintained for complete conversion of the substrate, and that depending on the reaction requirements, for example, the amount of material for one or more substrates may be suitably increased to increase the reaction speed, shorten the reaction time and increase the preparation efficiency.
For example, in step 1), the ratio of the amounts of phenol, aluminum trichloride and chloroacetyl chloride is 1: (1.0-5.0): (1.0-5.0).
In step 2), the mass ratio of the compound represented by formula II, the benzyl halide and the base is 1: (1.0-3.0): (1.0-5.0).
In step 3), the ratio of the amounts of the compound represented by formula III, the reducing agent and the base is 1: (1.0-3.0): (1.0-5.0).
The reaction temperature is also an important factor for determining whether the reaction can be carried out or not, and influencing the reaction speed and the amount of side reactions. The inventor finds that all the reactions in the preparation process of the 2- (4-benzyloxy phenyl) ethanol can be carried out at 0-100 ℃.
The temperature of each step reaction is further optimized by the inventor according to different reactivity of each step. When the reaction temperature in the step 1) is 20-30 ℃, and/or the reaction temperature in the step 2) is 30-40 ℃, and/or the reaction temperature in the step 3) is 20-30 ℃, and/or the reaction temperature in the step 4) is 40 ℃, the reaction speed is suitable, the side reaction is less, and the yield of the target product 2- (4-benzyloxy-phenyl) ethanol is high.
Further, when the benzyl halide in step 2) is benzyl bromide, it is more advantageous to obtain the compound of formula III, probably because bromide is a better leaving group to facilitate the nucleophilic substitution reaction in step 2).
In the step 2), a proper amount of alkali needs to be added, and under the action of the alkali, the phenolic hydroxyl group in the compound shown in the formula II loses proton and becomes an oxyanion, so that the compound is a better nucleophilic reagent and is favorable for reacting with benzyl halide to prepare the compound shown in the formula III.
The base used in step 2) is not particularly limited in the present invention as long as it is basic enough to deprive a proton on a phenolic hydroxyl group. For example, the base in step 2) may be selected from one or more of potassium carbonate, sodium carbonate, potassium hydroxide, sodium bicarbonate, potassium bicarbonate, sodium ethoxide, potassium ethoxide, and sodium hydride.
In step 3), it is necessary to reduce the carbonyl group in the compound represented by formula III to a hydroxyl group, and then perform intramolecular nucleophilic substitution reaction under alkaline conditions. The reducing agent for reduction treatment in step 3) may be one or more selected from sodium borohydride, potassium borohydride, sodium cyanoborohydride, sodium triacetoxyborohydride, lithium aluminum hydride and borane, and when sodium borohydride is further preferred, on the basis of a better reduction effect, excess sodium borohydride is more easily removed in the post-treatment process, and the reducing agent is cheaper and easily available, which is beneficial to reducing the reaction cost.
In the present invention, the base used after the reduction in step 3) is not particularly limited, and an organic base or an inorganic base may be used as long as it can ensure that the intramolecular cyclization is promoted to generate an oxirane ring after the reduction of the carbonyl group, and in a specific embodiment, the base used after the reduction may be one or more selected from potassium hydroxide, sodium bicarbonate, potassium bicarbonate, sodium ethoxide, potassium ethoxide, calcium hydroxide, and lithium hydroxide, and is more preferably sodium methoxide.
In the step 4), under the action of a catalyst, an oxirane three-membered ring in the compound shown in the formula IV is opened and reduced to obtain a target product 2- (4-benzyloxy phenyl) ethanol, a reducing agent is hydrogen, the hydrogen serving as gas and the compound shown in the formula IV are in a multiphase reaction, the reaction difficulty is high, and the reaction is carried out under the pressurization condition of 0.1-1.0 Mpa.
The catalyst in step 4) may be selected from catalysts commonly used in hydrogenation reactions, for example, one or more selected from palladium carbon, ruthenium carbon, platinum carbon, and raney nickel. When the catalyst is palladium carbon, and more preferably 5% palladium carbon, the catalyst has a good catalytic effect and is beneficial to reducing the reaction cost.
In one embodiment, when the catalyst is selected from 5% palladium on carbon, the mass ratio of the compound of formula IV to 5% palladium on carbon is 1: (0.1-1.0), and the reduction reaction in the step 4) can be ensured to have a better reduction effect in the range.
The following will further describe the preparation method of 2- (4-benzyloxyphenyl) ethanol according to the present invention with reference to specific examples.
In the following examples, unless otherwise specified, all the raw materials and auxiliary materials used in the examples of the present invention are industrial grade materials, and can be prepared by a commercially available or conventional method.
Example 1
The preparation method of 2- (4-benzyloxy-phenyl) ethanol of this example comprises the following steps:
1) preparation of 2-chloro-1- (4-hydroxyphenyl) ethan-1-one (compound represented by formula II)
Figure BDA0003041364000000071
Adding phenol (47g, 0.5mol) and dichloromethane (100mL) into a 1000mL four-mouth reaction bottle, cooling to 0-5 ℃ in an ice water bath, slowly adding aluminum trichloride powder (166.70g, 1.25mol, 2.5equiv) into a phenol solution, maintaining the temperature at 0-5 ℃, slowly dropwise adding chloroacetyl chloride solution after the aluminum trichloride powder is added, slowly heating chloroacetyl chloride (124.23g, 1.1mol, 2.2equiv) to dichloromethane (150mL) after the chloroacetyl chloride solution is added, after dropwise adding is finished, slowly heating the temperature to 20-30 ℃, continuously stirring for reaction for 6.0 hours, detecting the reaction by HPLC, adding hydrochloric acid and ice water for quenching reaction, filtering to obtain a solid, adding water, pulping and washing, and drying to obtain 80.1g of 2-chloro-1- (4-hydroxyphenyl) ethane-1-ketone (the compound shown in formula II), the yield is 94.0 percent, and the purity is 98.2 percent.
2) Preparation of 1- (4- (benzyloxy) phenyl) -2-chloroethan-1-one (compound shown in formula III)
Figure BDA0003041364000000081
Adding 2-chloro-1- (4-hydroxyphenyl) ethane-1-ketone (the compound shown in the formula II) (17g, 0.1mol), potassium carbonate (41.4g, 0.3mol, 3.0equiv), N, N-dimethylformamide (85mL) into a 500mL four-mouth reaction bottle, stirring for 0.5 hour at 20-30 ℃, adding benzyl bromide (17.3g, 0.101mol, 1.01equiv), slowly heating to 30-40 ℃ for reaction for 4.0 hours, reducing the temperature to room temperature after HPLC tracking the conversion of raw materials, adding ethyl acetate (170mL) and water (170mL) into the reaction system, stirring for dissolving, separating, back-extracting the aqueous phase with ethyl acetate (35mL), combining organic phases, sequentially adding water, washing with saturated saline water respectively 85mL, drying with anhydrous sodium sulfate, filtering, concentrating under reduced pressure to obtain 25.33g of 1- (4- (benzyloxy) phenyl) -2-chloroethane-1-ketone (the compound shown in the formula III), the yield is 97.5 percent, and the purity is 98.8 percent.
3) Preparation of (4-benzyloxyphenyl) -oxirane (Compound represented by formula IV)
Figure BDA0003041364000000082
Adding 1- (4- (benzyloxy) phenyl) -2-chloroethane-1-ketone (a compound shown in a formula III) (26.0g, 0.1mol) and methanol (260mL) into a reaction bottle, cooling to 0-10 ℃, adding sodium borohydride (3.97g, 0.105mol, 1.05equiv) in batches, heating to room temperature after the sodium borohydride is added, stirring for 0.5-1.0 hour after the sodium borohydride is added, tracking the conversion of raw materials by HPLC to be complete, dropwise adding a sodium methoxide solution, wherein the sodium methoxide solution is prepared by dissolving sodium methoxide (8.10g, 0.15mol, 1.50equiv) in methanol (20mL), continuing to stir and react for 2.0 hours at 20-30 ℃ after the dropwise adding is finished, tracking the conversion of the raw materials by HPLC to be complete, concentrating to remove the solvent, adding methyl tert-butyl ether (150mL) and water (150mL), stirring and dissolving, standing for liquid separation, adding methyl tert-butyl ether (50mL) into an aqueous phase for back extraction, the organic phases were combined, washed with water and saturated brine in this order, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 20.8g of (4-benzyloxyphenyl) -oxirane (the compound represented by formula IV), yield 92.0%, purity 97.82%.
4) Preparation of 2- (4-benzyloxy-phenyl) ethanol (compound shown in formula I)
Figure BDA0003041364000000091
Adding (p-benzyloxyphenyl) -ethylene oxide (a compound shown in formula IV) (10g) into a 500mL autoclave, adding methanol (150mL), sodium hydroxide (0.2g) and 5% palladium carbon (0.1 g and 10 wt%), heating to 40 ℃, maintaining the hydrogen pressure at 0.5MPa, reacting, cooling to room temperature, filtering and recovering the palladium carbon, concentrating the filtrate under reduced pressure to recover methanol, adding ethyl acetate (100mL) and water (100mL) into the residue, stirring and dissolving, standing, adding saturated saline solution into the organic phase, washing, drying with anhydrous sodium sulfate, filtering, and concentrating under reduced pressure to obtain 9.67g of 2- (4-benzyloxy phenyl) ethanol, wherein the yield is 97.8%, and the purity is 99.0%.
The total reaction yield was calculated to be 82.5% by multiplying the reaction yields of steps 1) to 4). FIG. 1 shows the preparation of 2- (4-benzyloxyphenyl) ethanol according to example 1 of the present invention1H NMR as shown in FIG. 1,2- (4-benzyloxyphenyl) ethanol was purified by1H NMR characterization:1H NMR(400MHz，CDCl3)δ：7.32～7.44(m，5H),7.14(d，2H),6.93(d，2H),5.05(s，2H),3.82(t，2H),2.81(t，2H),1.42(s，1H).
example 2
This example, 2- (4-Benzyloxyphenyl) ethanol, was prepared in substantially the same manner as in example 1, except that the methylene chloride in step 1) was replaced with toluene and passed through1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in a total yield of 76.5% and a purity of 98.4%.
Example 3
This example, 2- (4-Benzyloxyphenyl) ethanol, was prepared in substantially the same manner as in example 1, except that N, N-dimethylformamide in step 2) was replaced with tetrahydrofuran1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in a total yield of 71.4% and a purity of 98.1%.
Example 4
This example, 2- (4-Benzyloxyphenyl) ethanol, was prepared in substantially the same manner as in example 1, except that the potassium carbonate in step 2) was replaced with sodium hydroxide and the solution was passed through1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in a total yield of 64.6% and a purity of 98.6%.
Example 5
The preparation method of 2- (4-benzyloxy-phenyl) ethanol in this example is substantially the same as that in example 1, except that the potassium borohydride in step 3) is replaced by sodium cyanoborohydride, which is passed through1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in 78.7% overall yield and 98.7% purity.
Example 6
This example, 2- (4-Benzyloxyphenyl) ethanol preparation method and example 1 basically consistent, the difference is, in step 4) 5% palladium carbon replaced by Raney nickel, through1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in a total yield of 75.8% and a purity of 98.8%.
Example 7
This example, 2- (4-Benzyloxyphenyl) ethanol, was prepared in substantially the same manner as in example 1, except that benzyl bromide in step 2) was replaced with benzyl chloride, followed by1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in 68.4% overall yield and 98.5% purity.
Example 8
The preparation method of 2- (4-benzyloxy-phenyl) ethanol in this example is substantially the same as that in example 1, except that the molar ratio of phenol, aluminum trichloride and chloroacetyl chloride in step 1) is 1: 3.0: 2.5, by1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in a total yield of 80.11% and a purity of 99.0%.
Example 9
The preparation method of 2- (4-benzyloxy-phenyl) ethanol in this example is substantially the same as that in example 1, except that the molar ratio of phenol, benzyl bromide and potassium carbonate in step 2) is 1: 3.0: 1.1, by1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in a total yield of 81.2% and a purity of 98.80%.
Example 10
The preparation method of 2- (4-benzyloxy-phenyl) ethanol in this example is substantially the same as in example 1, except that, in step 3), the molar ratio of the compound represented by formula III, sodium borohydride and sodium methoxide is 1: 1.0: 1.5, by1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in 79.66% overall yield and 98.60% purity.
Example 11
This example, 2- (4-Benzyloxyphenyl) ethanol, was prepared in substantially the same manner as in example 1, except that in step 4), the pressure of the reduction reaction was changedThe force was changed from 0.5MPa to 0.8MPa by1H NMR confirmed that 2- (4-benzyloxyphenyl) ethanol was finally obtained in a total yield of 75.76% and a purity of 98.72%.
The above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (10)

1. A preparation method of 2- (4-benzyloxy phenyl) ethanol is characterized by comprising the following steps:
1) reacting phenol with chloroacetyl chloride under the catalysis of aluminum trichloride to obtain a compound shown as a formula II;
2) reacting the compound shown in the formula II with benzyl halide under an alkaline condition to obtain a compound shown in a formula III; wherein, the benzyl halide is one of benzyl bromide or benzyl chloride;
3) after the compound shown in the formula III is subjected to reduction treatment, regulating a reaction system to be an alkaline system to obtain a compound shown in a formula IV;
4) reducing the compound shown in the formula IV under the action of a catalyst under the condition of hydrogen to obtain 2- (4-benzyloxy phenyl) ethanol shown in the formula I;
Figure FDA0003041363990000011
2. the method according to claim 1, wherein the solvent in step 1) is one or more selected from the group consisting of dichloromethane, 1, 2-dichloroethane, chloroform, benzene, toluene, ethylbenzene, xylene, and chlorobenzene.
3. The production method according to claim 1 or 2, wherein in the step 1), the ratio of the amounts of phenol, aluminum trichloride and chloroacetyl chloride is 1: (1.0-5.0): (1.0-5.0).
4. The method according to any one of claims 1 to 3, wherein the base in step 2) is selected from one or more of potassium carbonate, sodium carbonate, potassium hydroxide, sodium bicarbonate, potassium bicarbonate, sodium ethoxide, potassium ethoxide, and sodium hydride.
5. The method according to any one of claims 1 to 4, wherein the solvent in step 2) is one or more selected from the group consisting of N, N-dimethylformamide, dimethylsulfoxide, toluene, tetrahydrofuran, acetonitrile, N-methylpyrrolidone, hexamethylphosphoric triamide, and acetone.
6. The process according to any one of claims 1 to 5, wherein in step 2), the ratio of the amounts of the compound represented by formula II, the benzyl halide and the base is 1: (1.0-3.0): (1.0-5.0).
7. The preparation method according to any one of claims 1 to 6, wherein in the step 3), the reducing agent for reduction treatment is selected from one or more of sodium borohydride, potassium borohydride, sodium cyanoborohydride, sodium triacetoxyborohydride, lithium aluminum hydride and borane.
8. The production method according to any one of claims 1 to 7, wherein in step 3), the ratio of the amounts of the compound represented by the formula III, the reducing agent and the base is 1: (1.0-3.0): (1.0-5.0).
9. The method according to any one of claims 1 to 8, wherein in step 4), the catalyst is selected from one or more of palladium on carbon, ruthenium on carbon, platinum on carbon, and Raney nickel.
10. The method according to any one of claims 1 to 9, wherein the reduction reaction is performed at a pressure of 0.1 to 1.0Mpa in the step 4).
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