CN113163806A - Granular feed additive - Google Patents
Granular feed additive Download PDFInfo
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- CN113163806A CN113163806A CN201880099965.7A CN201880099965A CN113163806A CN 113163806 A CN113163806 A CN 113163806A CN 201880099965 A CN201880099965 A CN 201880099965A CN 113163806 A CN113163806 A CN 113163806A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
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Abstract
The present disclosure relates to a granulated feed supplement capable of reducing hygroscopicity, caking, and caking, the supplement comprising a basic amino acid and an anion represented by formula 1, wherein a molar ratio of the anion to the basic amino acid is greater than 0.1 and equal to or less than 0.52.
Description
Technical Field
The present invention relates to a granulated feed supplement comprising a basic amino acid (basic amino acid) and an anion represented by formula 1, and capable of reducing hygroscopicity (hygroscopicity), lumping (lumping), and caking (calking) phenomena, wherein a molar ratio of the anion to the basic amino acid is greater than 0.1 and equal to or less than 0.52.
Background
Feed supplements are products intended to be consumed as a supplement to a regular diet to overcome the problem of insufficient daily intake of certain compounds. In order to improve the livestock performance of livestock, amino acids are commonly used to enhance the feed additives of livestock.
Since amino acids for feed supplements produced by microbial fermentation are present in fermentation broth (broth) together with other by-products, various methods of increasing the amino acid content have been used. For example, to increase the amino acid content, the particles can be prepared by mixing a purified high amino acid content aqueous solution with the fermentation broth. However, in the case of aqueous solutions with high content of basic amino acids, their hydrophilicity and polarity lead to high hygroscopicity, caking and caking phenomena in the final granulated product. This caking and caking phenomenon is not suitable for the processing process technically required by the mixed-feed mill. In addition, in order to increase the content of basic amino acids, various purification processes for removing impurities in the fermentation broth and crystallization processes with addition of hydrochloric acid may be used. Although high content feed supplements can be prepared in this way, numerous purification processes are required and the necessary reagents need to be discharged into waste after use, leading to economic and environmental problems.
Therefore, there is a need for an economical method of developing a granulated feed supplement containing a high content of basic amino acids and having low hygroscopicity.
Disclosure of Invention
Technical object of the invention
The present disclosure provides a granulated feed supplement comprising a basic amino acid and an anion represented by the following formula 1, and having an effect of preventing hygroscopicity, caking, and caking phenomena, wherein a molar ratio of the anion to the basic amino acid is greater than 0.1 and equal to or less than 0.52.
[ formula 1]
HnCO3 (2-n)-
(wherein, in formula 1, n is 0 or 1).
Means for achieving the technical aim
Embodiments of the present disclosure may provide a granulated feed supplement comprising a basic amino acid and an anion represented by the following formula 1, wherein a molar ratio of the anion to the basic amino acid is greater than 0.1 and equal to or less than 0.52.
[ formula 1]
HnCO3 (2-n)-
(wherein, in formula 1, n is 0 or 1).
The granulated feed additive according to the embodiment may include a high content of the basic amino acid, and may also include an anion represented by formula 1 by injecting carbon dioxide to reduce the polarity of the basic amino acid. Therefore, the problems of hygroscopicity, caking and caking (etc.) caused by the polarity of the basic amino acid can be effectively reduced.
As used herein, the term "feed additives" refers to substances added to feed to increase productivity or promote the health of a target organism. The feed supplement may be prepared in various forms known in the art, and may be used alone or in combination with conventionally known feed supplements. The feed supplement may be added to the feed in a composition ratio (composition ratio) that is readily determined in view of common knowledge and experience in the art. The feed supplement may be added to the feed of animals such as chickens, pigs, monkeys, dogs, cats, rabbits, cows, sheep, goats, etc., but the embodiments of the present disclosure are not limited thereto.
In one embodiment, the feed supplement may be in the form of pellets.
In one embodiment, such a granular feed supplement may comprise a basic amino acid. The term "basic amino acids" as used herein may include at least one selected from lysine, arginine and histidine. The basic amino acid may include at least one selected from the group consisting of L-lysine, L-arginine, and L-histidine. The basic amino acids may be in the form of salts of each of lysine, arginine and histidine or free amino acids (free amino acids). The salt may be a sulfate, a hydrochloride, or a carbonate, but embodiments of the present disclosure are not limited thereto.
Basic amino acids can readily bind to water and can be polar. Therefore, in general, when a basic amino acid is contained in a granular feed supplement at a high content, the polarity of granules may increase, resulting in an increase in the occurrence of problems such as hygroscopicity, caking, and caking phenomena. The granular feed supplement may comprise a basic amino acid in a range of about 50 wt% to about 90 wt%, such as about 55 wt% to about 89.5 wt%, about 60 wt% to about 89 wt%, about 65 wt% to about 88.5 wt%, about 70 wt% to about 88 wt%, about 75 wt% to about 87 wt%, about 76 wt% to about 86 wt%, about 77 wt% to about 85 wt%, about 78 wt% to about 84 wt%, or about 79 wt% to about 80 wt%, based on the total weight of the granular feed supplement. That is, the granular feed supplement may contain a high content of basic amino acids, and by including basic amino acids within the above range, advantages in transportation and storage may be produced. Granular feed additives can achieve this high content property using aqueous solutions of amino acids prepared by purification and concentration of fermentation broths. In addition, by mixing the aqueous amino acid solution with the concentrated fermentation broth, the content of amino acids in the resulting solution can be adjusted, and thus, the content of amino acids contained in the feed supplement can also be adjusted to be within an appropriate range.
In one embodiment, the granular feed supplement may comprise an anion represented by formula 1 below:
[ formula 1]
HnCO3 (2-n)-
(wherein, in formula 1, n is 0 or 1).
The anion represented by formula 1 may specifically include bicarbonate ion (HCO)3 -) Or carbonate ion (CO)3 2-)。
The anion can be generated by adding carbon dioxide to an aqueous solution containing a basic amino acid. The carbon dioxide can react with hydrogen ions in the aqueous solution to produce carbonate ions, which can then be converted to bicarbonate ions. In this process, the pH (alkalinity or acidity) of the granulated feed supplement can be lowered or neutralized. Thus, in one embodiment, the granular feed supplement may comprise carbonate ions, bicarbonate ions, or a mixture thereof.
In one embodiment, the molar ratio of anion to basic amino acid can be greater than 0.1 and equal to or less than 0.52. The term "mole ratio of anion to basic amino acid" as used herein may refer to the mole ratio of bicarbonate ion or carbonate ion to basic amino acid, and may be derived from HCO3 -Basic amino acids or CO3 2-Basic amino acid.
The molar ratio of bicarbonate or carbonate ions to basic amino acid in the feed supplement may be greater than 0.1 and equal to or less than 0.52.
When the molar ratio is about 0.1 or less than 0.1, the content of bicarbonate ions or carbonate ions in the particles is low so that the effect of neutralizing the basic amino acid can be weakened, resulting in problems of hygroscopicity or curability of the particles. When the molar ratio is greater than about 0.52, the amino acid content of the granules may be reduced, resulting in a reduction in product value. That is, the granular feed supplement may have improved hygroscopicity (hygroscopicity) compared to a granular feed supplement that does not contain bicarbonate ions or carbonate ions. The term "hygroscopic" as used herein refers to the tendency to absorb or retain moisture. Typical granular feed supplements (in particular, granular feed supplements comprising a basic amino acid) can exhibit high hygroscopicity, which leads to increased caking and caking phenomena, resulting in low product value. However, according to the present disclosure, the product value of the feed supplement may be increased.
The molar ratio may specifically be in the range of about 0.15 to about 0.5, or about 0.2 to about 0.45.
The molar ratio can be calculated from the results obtained by HPLC (high performance liquid chromatography) after dissolving the particles in water. However, embodiments of the present disclosure are not so limited.
The size of the particles comprised in the granulated feed supplement may be determined according to the animal husbandry use.
In one embodiment, the average particle diameter of the granulated feed supplement can be in a range of about 0.1 millimeters (mm) to about 3.0 mm. In one or more embodiments, the average particle diameter may be in a range from about 0.5 millimeters to about 3.0 millimeters. However, various modifications may be made within a scope not exceeding the object of the present disclosure. When the average particle diameter of the granulated feed supplement is less than about 0.1 mm, the degree of solidification may increase, or dust may be generated. When the average particle diameter of the granulated feed supplement is greater than about 3.0 mm, the particles may not be uniformly mixed during feed preparation.
The particles of the granulated feed supplement may have an irregular shape and may, for example, have a spherical shape.
In one embodiment, when the molar ratio of bicarbonate ion or carbonate ion to basic amino acid is greater than 0.1 and equal to or less than 0.52, hygroscopicity may be improved while agglomeration and caking phenomena may be reduced. Therefore, by adjusting the molar ratio to be more than 0.1 and equal to or less than 0.52, a granulated feed supplement with improved hygroscopicity can be provided.
In one embodiment, the ph of the granulated feed supplement can be in the range of about 8.5 to about 9.5. In one or more embodiments, the ph of the granular feed supplement may be in the range of about 8.5 to about 9.2. The ph can be reduced by injecting carbon dioxide during the fermentation process.
In one embodiment, the moisture content (moisture content) of the granular feed supplement may be less than about 7 wt% based on the total weight of the granular feed supplement. For example, the moisture content of the granulated feed supplement can be from about 0.1% to about 7% by weight. The present disclosure provides a granular feed supplement comprising a basic amino acid and an anion represented by formula 1, wherein the molar ratio of anion to basic amino acid is set to be greater than about 0.1 and equal to or less than 0.52, thereby improving hygroscopicity, and thus only contains a small amount of moisture within the above moisture content range.
The granular feed supplement of the present disclosure can be prepared according to the following method. In one embodiment, the granular feed supplement may be prepared by: preparing a basic amino acid aqueous solution; preparing a neutralized aqueous amino acid solution; concentrating the broth (broth); preparing a mixed amino acid solution containing a neutralized amino acid aqueous solution and a concentrated fermentation broth; and granulating the mixed amino acid solution.
In one or more embodiments, the granular feed supplement may be prepared by: preparing a basic amino acid aqueous solution; concentrating the broth (broth); preparing a neutralized aqueous amino acid solution; preparing a mixed amino acid solution containing a neutralized amino acid aqueous solution and a concentrated fermentation broth; and granulating the mixed amino acid solution.
In one embodiment, the term "aqueous amino acid solution" as used herein may refer to a purified fermentation broth (broth) containing a basic amino acid. In detail, the aqueous amino acid solution can be obtained through processes of filtering, purifying and concentrating a fermentation product obtained by culturing a basic amino acid-producing strain (basic amino acid-producing strain).
The fermentation product can be achieved by culturing while the strain is fermenting, and can be performed by a fed-batch process (fed-batch process), a batch process (also known as batch culture), or a repeated fed-batch process (also known as a repeated fed-batch process). The fermentation medium used in this context can be optimized according to the requirements of the production strain. The aqueous amino acid solution may have the following characteristics: a concentration of about 560 grams/liter (g/L) to 640 grams/liter, a pH of about 10.2 to about 10.7, a weight of about 1.13 to about 1.14, and a purity of about 95 wt% to about 99 wt%.
In this production method, the basic amino acid-producing strain is not particularly limited as long as it is a strain that produces a basic amino acid within a range that does not exceed the object of the present disclosure. For example, the basic amino acid-producing strain may comprise a strain of Corynebacterium (genus Corynebacterium).
Further, the conditions under which the strain produces the basic amino acid may include such conditions that the amount of the basic amino acid produced is high but the accumulated amount of the strain is small.
The fermentation product may be filtered or, in particular, a membrane may be used to separate the microorganisms therein. The microorganism-removed fermentation broth (broth) can then be passed through, for example, an ion exchange resin column (ion exchange resin tower), in order to remove impurities and purify the basic amino acid, among other things. The concentration process of the purified amino acid may be performed on the fermentation broth containing the basic amino acid by, for example, a vacuum and/or a drying process.
The term "neutralized aqueous amino acid solution" as used herein may refer to a form in which the aqueous amino acid solution is neutralized. In particular, the neutralized aqueous amino acid solution may further contain HCO in the aqueous amino acid solution3 -Or CO3 2-. That is, the aqueous solution of the neutralized amino acid may be one in which the aqueous solution of the amino acid is HCO3 -Or CO3 2-A neutralized form.
In the step of neutralizing the aqueous amino acid solution, the neutralization may be performed by adding carbon dioxide to the aqueous amino acid solution. Carbon dioxide may be produced during the fermentation process of the microorganisms. When carbon dioxide is injected into an aqueous solution of amino acids, HCO may be generated in the aqueous solution3 -Or CO3 2-So that basic amino acids can be neutralized. According to this method, carbon dioxide generated during fermentation can be used, and thus emission of carbon dioxide is reduced, and resources can be recovered.
In addition, since the conventional process of neutralizing the aqueous solution of amino acid with hydrochloric acid can be omitted, the purification process can be simplified.
The aqueous neutralized amino acid solution may have the following characteristics: a pH of about 8.9 to about 9.5, a weight of about 1.18 to about 1.20, and a purity of about 82 wt% to about 89 wt%.
The "step of concentrating the fermentation broth (broth)" may refer to concentrating the fermentation broth of the fermentation medium after isolating the basic amino acid from the fermentation medium. In one embodiment, "concentrated fermentation broth" may refer to a fermentation broth (broth) containing a basic amino acid and concentrated by a vacuum and/or drying process. The concentrated fermentation broth may be obtained by a process of concentrating a fermentation product, which is obtained by culturing a basic amino acid-producing strain, under vacuum and heating without a purification process, such that the total solid content in the fermentation product is set in the range of about 50 wt% to about 60 wt%, i.e., the solid content is set in the range of about 50 wt% to about 60 wt%. "solids content" may refer to the mass of solids remaining after complete removal of liquid.
In one embodiment, the step of preparing a mixed amino acid solution containing an aqueous amino acid solution and a concentrated fermentation broth may be performed by mixing the aqueous amino acid solution with the concentrated fermentation broth at room temperature. When mixed, the molar ratio of anion to mixed solution may be about 0.15 or greater than 0.15 and about 0.65 or less than 0.65. In one embodiment, the step of granulating the mixed amino acid solution may be performed, for example, by: an aqueous amino acid solution or a concentrated fermentation broth is continuously sprayed into the granulator, and hot air is continuously supplied to the granulator to form a fluidized bed (fluidized bed) of particles formed by spraying in a constant size range. For this process, a conventional fluidized bed circulation granulator (circulation granulator) or the like may be used. Conditions for granulation may include, for example: the injection rate is about 5 milliliters (mL)/minute to about 10 milliliters/minute, and the nozzle pressure is about 1.2 kilograms per square centimeter (kg/cm)2) And a temperature of from about 75 ℃ to about 80 ℃. However, embodiments of the present disclosure are not so limited.
The granulated feed supplement is suitable for the preparation of animal feed. For example, the feed supplement may be part of an animal feed premix (premix) or a precursor to an animal feed, and the feed supplement itself may be mixed with the feed material.
The granulated feed supplement can be administered to the animal alone or in combination with other feed supplements in an edible carrier. In addition, the feed supplement can be administered to the animal as a topdressing material, can be mixed directly with the animal feed, or can be administered to the animal in an oral formulation separate from the feed.
ADVANTAGEOUS EFFECTS OF INVENTION
The granulated feed additive according to the embodiment contains a high content of the basic amino acid, and is also capable of preventing hygroscopicity, caking, and caking caused by the basic amino acid.
In addition, with respect to the granulated feed supplement according to the embodiment, a process using hydrochloric acid, which is generally used to neutralize basic amino acids, may be omitted. Therefore, the process can be simplified and the process problems caused by the use of hydrochloric acid can be solved.
Drawings
Fig. 1 is a drawing showing the steps of preparing a granulated feed supplement according to an embodiment.
Detailed Description
Hereinafter, the present disclosure will be explained in more detail with reference to examples. However, these examples are for illustrative purposes only, and the scope of the present disclosure is not limited to these examples.
Examples 1 to 6 and comparative examples 1 to 6
Fig. 1 is a drawing showing the steps of preparing a granulated feed supplement containing a high content of basic amino acid according to an embodiment. Hereinafter, each step will be explained in detail with reference to fig. 1.
1. Preparation of Mixed amino acid solution
An aqueous amino acid solution and a concentrated fermentation broth were prepared according to the compositions shown in tables 1 and 2, and then mixed to prepare a mixed solution. In this example, L-lysine was used as an example of the basic amino acid. Except that an aqueous solution of L-lysine is used instead of the aqueous solution of neutralized L-lysineExcept that, comparative examples 1 to 6 were performed in the same manner as example 1. First, an aqueous amino acid solution is prepared by purifying a fermentation broth containing L-lysine. To prepare the fermentation broth, a starter culture of an L-lysine-producing strain of Corynebacterium (Corynebacterium) was performed at a speed of 200 revolutions per minute (rpm) in 25 milliliters (mL) of seed medium at pH 7.0 for 20 hours at a temperature of 30 ℃. Here, the seed medium was supplemented with 20 g (g) of glucose, 10 g of peptone, 5 g of yeast extract, 1.5 g of urea, 4 g of KH in terms of 1 liter (L) of distilled water2PO48 g of K2HPO40.5 g MgSO4·7H2O, 100 micrograms (μ g) of biotin, 1 milligram (mg) of thiamine hydrochloride (thiamine HCl), 2 mg of calcium pantothenate, and 2 mg of nicotinamide. A starter obtained by seed culture (seed culture) was inoculated into a production medium having a pH of 7.0 at 4% (volume/volume (v/v)), and the medium was cultured until glucose added thereto was completely consumed while sufficiently ventilating and stirring the medium, thereby obtaining a final fermentation broth. Here, the production medium was supplemented with 100 g of glucose and 40 g of (NH) in terms of 1 liter of distilled water4)2SO42.5 grams soy protein, 5 grams corn steep liquor solids, 3 grams urea, 1 gram KH2PO40.5 g MgSO4·7H2O, 100. mu.g biotin, 1 mg thiamine hydrochloride, 2 mg calcium pantothenate, 3 mg nicotinamide and 30 g CaCO3. After completion of the culture, the fermentation broth was analyzed for the concentration of L-lysine by HPLC (Waters Company, 2478). The use of a membrane with a size of 0.1 micron removed the microorganisms from the fermentation broth. The fermentation broth from which the microorganisms are removed is passed through a cation exchange resin column to absorb L-lysine in the fermentation broth and separate the L-lysine from other impurities. The absorbed L-lysine was desorbed from the resin tower using an ammonia solution of about 2N (equivalent concentration), recovered, and then heated and concentrated in vacuo, thereby preparing an L-lysine aqueous solution. After concentration, the concentration of the aqueous solution of L-lysine was 560 g/L (g/L), pH was 10.2, weight was 1.13, and purity was 99 wt%. Dissolving 35 kg (kg) of L-lysine in waterAfter the solution was added to the neutralization tank, a gas containing 5 vol.% carbon dioxide was injected at a rate of 1000 liters per minute (L/min) and at a rate of 500 revolutions per minute (rpm) for 10 hours at a temperature of 50 c in a neutralized aqueous L-lysine solution. The concentrations of L-lysine and bicarbonate ion or carbonate ion neutralized after carbon dioxide injection were analyzed by HPLC (Waters corporation, 2478). The neutralized L-lysine aqueous solution further contains HCO3 -Or CO3 2-The solution of (1). The neutralized L-lysine aqueous solution had a pH of 8.9, a specific gravity of 1.20, and a purity of 89 wt%.
The concentrated fermentation broth was prepared by heating and concentrating the fermentation broth prepared as described above in vacuo without performing a purification process. Then, the total solid content in the concentrated fermentation broth was set to 56% by weight.
A mixed solution was prepared by mixing an L-lysine aqueous solution or a neutralized L-lysine aqueous solution with the concentrated fermentation broth at the ratio specified in tables 1 and 2. The mixed solution was analyzed for L-lysine and HCO by HPLC (Waters, 2478)3 -Or CO3 2-The concentration of (c). Referring to the results of the concentration analysis, calculation of HCO in the mixed solution in each of examples 1 to 6 and comparative examples 1 to 6 is shown in table 1 and table 23 -Results of the molar ratio to L-lysine.
[ Table 1]
[ Table 2]
As shown in Table 1, HCO in the mixed solution increased with the increase in the ratio of the L-lysine aqueous solution3 -The molar ratio/L-lysine decreases. As shown in Table 2, according to the L-lysine solubilityChange of liquid ratio, HCO in the mixed solution3 -The molar ratio/L-lysine did not vary significantly.
2. Preparation of the granules
The mixed solutions detailed in tables 1 and 2 were then granulated. In detail, at a temperature of 80 ℃ at a rate of 5 milliliters per minute (mL/min) and 1.2 kilograms per square centimeter (kg/cm)2) The prepared mixed solution was pressure-sprayed to inject it into the fluidized-bed circulation granulator. The prepared particles were selected by separation according to a size of about 0.5 millimeters (mm) to about 3.0 mm.
2.1. Analysis of HCO in particles3 -Molar ratio to L-lysine and content of L-lysine
To analyze HCO in the particles of each of examples 1 to 6 and comparative examples 1 to 63 -For the molar ratio of L-lysine and the content of L-lysine, a small amount of particles was dissolved in 1 liter of ultrapure water. Then, HPLC (Waters corporation, 2478) was performed on the sample, and the molar ratio was calculated from the results. The calculation results are shown in tables 3 and 4.
[ Table 3]
[ Table 4]
As shown in tables 3 and 4, it was confirmed that HCO was contained in the pellets3 -The molar ratio to L-lysine was in the range of 0.1 to 0.52 in examples 1 to 6, and in the range of 0.02 to 0.03 in comparative examples 1 to 6. Further, in all of examples 1 to 6 and comparative examples 1 to 6, the content of L-lysine was confirmed to be 78% or more than 78%, and thus the content was confirmed to be high.
2.2 evaluation of hygroscopicity and curability
To evaluate the hygroscopicity and curability of the pellets of examples 1 to 6 and comparative examples 1 to 6, 3 grams of each pellet was placed in a disposable mass tray (mass plate) and stored at a temperature of 40 ℃ and a relative humidity of 60% for one week. The change in moisture in the pellets was then measured by the change in mass.
In addition, in order to quantitatively evaluate the caking and caking phenomenon (i.e., solidification) of the water-absorbent particles, the particles were placed on a sieve having a mesh size of 1.7 mm, and then the mass of the particles filtered out of the sieve was measured after vibration (50 hertz (Hz), 5 minutes (min)) using a vibrator to determine the degree of caking and caking. The degree of caking and caking was calculated by the following equation.
The results are shown in tables 5 and 6.
[ Table 5]
[ Table 6]
As shown in tables 5 and 6, the moisture content and the degree of agglomeration and caking of the pellets of examples 1 to 6 were significantly low as compared with the pellets of comparative examples 1 to 6. Specifically, it was confirmed that the highest hygroscopicity was obtained in the case of using only the L-lysine aqueous solution (comparative example 1). Further, it was found that the polarity of purified L-lysine increases the hygroscopicity of the particles based on the fact that the hygroscopicity of the particles increases as the proportion of the L-lysine aqueous solution in the compositions of comparative examples 1 to 6 increases. Meanwhile, it was also confirmed that in the pellets of examples 1 to 6, the moisture content and the degree of agglomeration and caking increased as the ratio of the neutralized L-lysine aqueous solution decreasedAnd (4) adding. That is, with HCO in the particles3 -The polarity of L-lysine is decreased, thereby improving the hygroscopicity of the granule. In particular, when HCO is present in the particles3 -When the molar ratio/L-lysine is reduced to 0.1 or less than 0.1, the curability is remarkably increased. In this regard, it was confirmed that HCO was used to solve the problem of solidification3 -The molar ratio of/L-lysine is set to be greater than 0.1.
Thus, it was confirmed that HCO was contained in the granules3 -When the molar ratio of (b) is more than 0.1 and equal to or less than 0.52 in the compositions of examples 1 to 6, the hygroscopicity of the particles can be reduced, and thus the caking and agglomeration phenomena caused by the hygroscopicity can also be reduced.
Claims (6)
1. A granulated feed supplement comprising a basic amino acid and an anion represented by the following formula 1,
wherein the molar ratio of the anion to the basic amino acid is greater than 0.1 and equal to or less than 0.52:
[ formula 1]
HnCO3 (2-n)-
(wherein, in formula 1, n is 0 or 1).
2. The granular feed supplement of claim 1 wherein the basic amino acid is one or more selected from the group consisting of lysine, arginine and histidine.
3. The granulated feed supplement of claim 1 wherein the average particle diameter of the granulated feed supplement is from 0.1 to 3.0 mm.
4. The granulated feed supplement of claim 1 wherein the pH of the granulated feed supplement is from 8.5 to 9.5.
5. The granulated feed supplement of claim 1 wherein the moisture content of the granulated feed supplement is less than 7 wt% based on the total weight of the granulated feed supplement.
6. The granulated feed supplement of claim 1, wherein the basic amino acid is present in an amount of 50 to 90 wt. -%, based on the total weight of the granulated feed supplement.
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| KR1020180156900A KR102209821B1 (en) | 2018-12-07 | 2018-12-07 | Granular feed additives |
| PCT/KR2018/015539 WO2020116697A1 (en) | 2018-12-07 | 2018-12-07 | Granular feed additive |
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| CN113163806A true CN113163806A (en) | 2021-07-23 |
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| US (1) | US20220030914A1 (en) |
| EP (1) | EP3892108A4 (en) |
| KR (1) | KR102209821B1 (en) |
| CN (1) | CN113163806A (en) |
| AR (1) | AR117278A1 (en) |
| BR (1) | BR112021010719A2 (en) |
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| CN115279195A (en) * | 2020-03-13 | 2022-11-01 | Cj第一制糖株式会社 | Production method of granular feed additive |
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| BR112021010719A2 (en) * | 2018-12-07 | 2021-08-31 | Cj Cheiljedang Corporation | GRANULAR FOOD ADDITIVE |
| KR102380678B1 (en) * | 2020-10-29 | 2022-04-01 | 씨제이제일제당 주식회사 | Manufacturing method for solid state amino acids mixture and manufacturing system for solid state amino acids mixture |
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| Publication number | Priority date | Publication date | Assignee | Title |
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Also Published As
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|---|---|
| US20220030914A1 (en) | 2022-02-03 |
| KR20200073298A (en) | 2020-06-24 |
| TWI720714B (en) | 2021-03-01 |
| KR102209821B1 (en) | 2021-01-29 |
| TW202021469A (en) | 2020-06-16 |
| BR112021010719A2 (en) | 2021-08-31 |
| EP3892108A1 (en) | 2021-10-13 |
| EP3892108A4 (en) | 2022-06-22 |
| AR117278A1 (en) | 2021-07-28 |
| WO2020116697A1 (en) | 2020-06-11 |
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