CN113144375A - Anti-wall-sticking double-resistance nano hemodialysis catheter - Google Patents
Anti-wall-sticking double-resistance nano hemodialysis catheter Download PDFInfo
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- CN113144375A CN113144375A CN202110413637.3A CN202110413637A CN113144375A CN 113144375 A CN113144375 A CN 113144375A CN 202110413637 A CN202110413637 A CN 202110413637A CN 113144375 A CN113144375 A CN 113144375A
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- 238000001631 haemodialysis Methods 0.000 title claims abstract description 242
- 230000000322 hemodialysis Effects 0.000 title claims abstract description 230
- 239000008280 blood Substances 0.000 claims description 43
- 210000004369 blood Anatomy 0.000 claims description 43
- 239000003814 drug Substances 0.000 claims description 36
- 238000013268 sustained release Methods 0.000 claims description 32
- 239000012730 sustained-release form Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 25
- 229940079593 drug Drugs 0.000 claims description 23
- 230000008093 supporting effect Effects 0.000 claims description 22
- 230000003014 reinforcing effect Effects 0.000 claims description 14
- 238000010041 electrostatic spinning Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 230000002924 anti-infective effect Effects 0.000 claims description 11
- 229940127217 antithrombotic drug Drugs 0.000 claims description 8
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 5
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
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- Health & Medical Sciences (AREA)
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- Biophysics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
The invention provides a wall-sticking-proof double-resistance nano hemodialysis catheter, which is characterized in that: comprises a hemodialysis catheter body, an input unit and an output unit; wherein, the hemodialysis catheter body comprises an input tube and an output tube; the input unit is communicated with one end of the input pipe; the output unit is communicated with one end of the output pipe; the hemodialysis catheter body consists of a hemodialysis catheter main body, a hemodialysis catheter outer slow release layer and a hemodialysis catheter inner slow release layer; the hemodialysis catheter main body is internally nested with an input tube and an output tube; the outer slow release layer of the hemodialysis catheter is positioned on the outer surface of the hemodialysis catheter main body; the slow release layer in the hemodialysis catheter is positioned on the inner surface of the input tube. The deep venous catheter can resist infection and thrombus, prolongs the catheter placing time, and can reduce the damage to the body of a patient by reducing infection and thrombus formation of the patient. And can avoid the occurrence of the condition of adherence.
Description
Technical Field
The invention relates to a medical appliance, in particular to a nano double-resistance deep venous catheter.
Background
Clinical hemodialysis pipe mainly used needs the patient of bedside blood purification treatment, this kind of patient often the state of an illness is critical, self immunity is low, easily infects, including the pipe bore is bigger than general venous line pipe bore, should form the thrombus after lasting bedside blood purification treatment to it is bigger to bleed and infect the risk during puncture, but itself is difficult for remaining the time overlength, generally 7-10 days also need to be changed, to the patient that needs to use this equipment for a long time, undoubtedly need face the misery of repeated puncture and undertake the risk that this process probably produced.
And current dialysis tube is at the in-process of drawing blood, often because the reason that frequent adherence appears in the cause of vascular wall pressure leads to the equipment to shut down, and then causes patient's blood to pass through the in-process and need the special staff to pay close attention to constantly and frequently open the condition of opening the start-stop equipment, has wasted a large amount of manpower and materials and treatment time on the one hand, and on the other hand also causes the not good problem of blood effect of passing through
Disclosure of Invention
The invention aims to overcome the defects and provides a hemodialysis catheter with dual functions of infection resistance and thrombus resistance, which not only can prolong the catheter placing time, but also can reduce the infection and the thrombus formation of a patient and simultaneously reduce the damage to the body of the patient to the greatest extent. The anti-infection and anti-thrombosis medicine has a slow release effect and cannot be quickly flushed away by blood at the moment of entering a human body or by external injection in the using process. In addition, the invention can effectively avoid the shutdown problem caused by flattening the tube wall in the hemodialysis process by a mode of constructing the side wall opening or the reinforcing mechanism.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter which is characterized in that: comprises a hemodialysis catheter body, an input unit and an output unit;
wherein, the hemodialysis catheter body comprises an input tube and an output tube;
the input unit is communicated with one end of the input tube and inputs blood or other liquid;
the output unit is communicated with one end of the output tube and outputs blood or other liquid;
the hemodialysis catheter body consists of a hemodialysis catheter main body, a hemodialysis catheter outer slow release layer and a hemodialysis catheter inner slow release layer;
the hemodialysis catheter main body is internally nested with an input tube and an output tube;
the outer slow release layer of the hemodialysis catheter is positioned on the outer surface of the main body of the hemodialysis catheter;
the slow release layer in the hemodialysis catheter is positioned on the inner surface of the input tube;
the outer slow release layer of the hemodialysis catheter slowly releases medicaments with anti-infection and/or anti-thrombosis functions;
the slow release layer in the hemodialysis catheter slowly releases the medicament with anti-infection and/or anti-thrombosis functions.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the hemodialysis catheter body is provided with one or more side backflow holes;
the side backflow holes are communicated with the output pipe.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the output pipe is provided with a reinforcing structure;
and auxiliary backflow holes are formed around the reinforcing structure.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the inner side of the output pipe is provided with a supporting mechanism;
the supporting mechanism and the inner space of the output pipe allow liquid to pass through;
and auxiliary backflow holes are formed around the reinforcing structure.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the outer slow release layer of the hemodialysis catheter is a sleeve structure nested outside the main body of the hemodialysis catheter;
nanometer through holes are densely distributed on the external visual surface of the outer sustained-release layer of the hemodialysis catheter;
anti-infection and/or antithrombotic drugs are filled between the outer slow release layer of the hemodialysis catheter and the hemodialysis catheter main body;
and/or
The slow release layer in the hemodialysis catheter is a sleeve structure nested in the infusion tube;
nanometer through holes are densely distributed on the inner visual surface of the slow release layer in the hemodialysis catheter;
anti-infection and/or antithrombotic drugs are filled between the slow release layer and the input tube in the hemodialysis catheter.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the hemodialysis catheter outer sustained-release layer comprises a first hemodialysis catheter outer sustained-release layer and a second hemodialysis catheter outer sustained-release layer;
the first hemodialysis catheter outer sustained-release layer and the second hemodialysis catheter outer sustained-release layer are independently arranged on the outer surface of the hemodialysis catheter main body;
the first hemodialysis catheter outer slow-release layer and the second hemodialysis catheter outer slow-release layer are filled with different medicines;
and/or
The slow release layer in the hemodialysis catheter comprises a first slow release layer in the hemodialysis catheter and a second slow release layer in the hemodialysis catheter;
the first hemodialysis catheter inner slow-release layer and the second hemodialysis catheter inner slow-release layer are independently arranged on the inner surface of the input tube;
the slow release layer in the first hemodialysis catheter and the slow release layer in the second hemodialysis catheter are filled with different medicines.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the first hemodialysis catheter outer slow-release layer and the second hemodialysis catheter outer slow-release layer are independent from each other and are spirally arranged on the outer surface of the hemodialysis catheter main body;
or
The first hemodialysis catheter outer sustained-release layer and the second hemodialysis catheter outer sustained-release layer are independent from each other and are arranged on the outer surface of the hemodialysis catheter main body in a staggered manner.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the slow release layer in the first hemodialysis catheter and the slow release layer in the second hemodialysis catheter are independent from each other and are spirally arranged on the inner surface of the input tube;
or
The slow release layer in the first hemodialysis catheter and the slow release layer in the second hemodialysis catheter are independent from each other and are arranged on the inner surface of the input tube in a staggered manner.
The invention provides a wall-sticking-prevention double-resistance nano hemodialysis catheter, which is further characterized in that: the outer slow release layer of the hemodialysis catheter is of a net drug-carrying structure;
the reticular drug-loaded structure is manufactured by adopting an electrostatic spinning process;
and/or
The slow release layer in the hemodialysis catheter is of a net drug-carrying structure;
the reticular drug-loaded structure is manufactured by adopting an electrostatic spinning process.
In addition, the invention also provides a wall-sticking-proof double-resistance nano hemodialysis catheter assembly, which is characterized in that:
comprises the anti-sticking double-resistance nano hemodialysis catheter and a supporting device;
the support device comprises a telescopic element and a support element;
the telescopic element has the functions of swelling and shrinking;
the supporting element is nested outside the telescopic element and forms a barrel-shaped net surface structure along with the expansion of the telescopic element;
the hemodialysis catheter body of the anti-blocking double-anti-hemodialyzer catheter is also connected with a third channel;
the third passage is communicated with the output pipe;
the third channel can accommodate the inlet and outlet of the supporting element;
a sealing mechanism is also detachably arranged on the third channel;
the sealing mechanism seals the outlet end of the third channel;
the tail end of the output pipe of the anti-blocking double-anti-hemodialysis catheter is provided with a limiting ring which is hooked inwards;
after the supporting element is unfolded, one end surface of the supporting element is just embedded into the limit ring;
the outer surfaces of the telescopic element and the hemodialysis catheter body are provided with scales. .
Drawings
Fig. 1 is a schematic structural diagram of an anti-blocking double-anti-hemodialysis catheter provided in this embodiment 1;
FIG. 2 is a schematic structural view of the interior of the main body of the anti-blocking double-hemodialysis catheter according to the embodiment 1;
fig. 3 is a schematic structural view of a tube body portion of the anti-clogging double anti-hemodialysis catheter according to the embodiment 2;
fig. 4 is a schematic structural diagram of a tube body portion of the anti-blocking double-anti-hemodialysis catheter provided in this embodiment 3.
Fig. 5 is a schematic structural diagram of a tube body portion of the anti-blocking dual-anti-hemodialysis catheter provided in this embodiment 4.
Fig. 6 is a schematic structural view of the outlet tube body of the anti-blocking double anti-hemodialysis catheter according to the embodiment 5.
Fig. 7 is a schematic structural diagram of the outlet tube body of the anti-blocking double anti-hemodialysis catheter according to the embodiment 6.
Fig. 8 is a schematic structural view of the delivery tube body portion of the anti-clogging double anti-hemodiafiltration catheter provided in this embodiment 7.
Detailed Description
Example 1
As shown in fig. 1, the present embodiment 1 provides an anti-wall-sticking double-resistance nano hemodialysis catheter, which includes an anti-blocking double-resistance hemodialysis catheter body 100 and an input/output assembly;
in this embodiment, the input/output assembly includes a connection pipe, an input pipe 200 and an output pipe 300;
one end of the connecting pipe is connected with the anti-blocking double-antibody hemodialysis catheter body 100 through a rubber pipe;
the other end of the connecting pipe is connected with an input pipe 200 and an output pipe 300 in a Y shape, and the input pipe 200 and the output pipe 300 are respectively used for outputting blood in the blood exsanguination process; the partial structure can be replaced by any existing blood dialysis tube model.
The anti-blocking double-resistance hemodialysis catheter body 100 consists of a hemodialysis catheter main body 110, a hemodialysis catheter outer slow release layer 120 and a hemodialysis catheter inner slow release layer 130;
as shown in FIG. 2, the hemodialysis catheter body 110 is nested with an efferent vessel 110-2, both of which are a central passage;
the input pipe 110-1 is communicated with the input pipe 200;
the output pipe 110-2 is communicated with the output pipe 300;
the hemodialysis catheter outer sustained release layer 120 is positioned on the outer surface of the hemodialysis catheter main body 110;
the slow release layer 130 in the hemodialysis catheter is positioned on the inner surface of the input tube 110-1;
wherein, the slow release layer 120 outside the hemodialysis catheter is filled with slow release drugs with anti-infection and/or anti-thrombosis functions, such as: anti-inflammatory drugs such as minocycline, rifampicin and the like, antithrombotic drugs such as heparin and the like, which can be mixed and filled according to the conventional dosage proportion;
the slow release layer 130 in the hemodialysis catheter is filled with slow release drugs with anti-infection and/or anti-thrombosis effects, such as: anti-inflammatory drugs such as minocycline, rifampicin and the like, antithrombotic drugs such as heparin and the like, and the drugs can be mixed and filled according to the conventional dosage proportion.
In addition, nanometer through holes (the actual size of the through holes is determined) are densely distributed on the external visual surface of the outer slow release layer of the hemodialysis catheter, when the catheter is placed in a vein, the medicine in the outer slow release layer of the hemodialysis catheter is slowly pressed out through the nanometer holes due to the pressing effect formed by natural expansion and contraction of the wall of the vein, so that the slow release effect is formed, and meanwhile, after the catheter body is placed in the vein, the blood in the catheter enters and exits the outer slow release layer of the hemodialysis catheter through the nanometer holes, so that the medicine can be gradually washed out, and the medicine is gradually and slowly released at an acting part.
Through, in addition, also densely distributed has nanometer through-hole on the interior sight of this hemodialysis catheter in slow-release layer, after the pipe is put into the vein, because the leading-in of injection and blood of medicine produces the oppression to the pipe wall, press and come out the medicine in the hemodialysis catheter in slow-release layer slowly empty nanopore oppression to form the effect of slowly-releasing, simultaneously, because the body is put into the vein after, blood wherein passes in and out the hemodialysis catheter in slow-release layer through the nanopore can realize gradually passing through the mode of erodeing with the medicine, is gone out slowly by the slowly-releasing gradually at the position of action.
In addition, as shown in fig. 1 and 2, the problem of shutdown caused by the adhesion of the pipe wall after some part of the body is pressed is avoided. In this embodiment, still have a plurality of through-hole 111 on this hemodialysis catheter body, on the one hand, through the mode of addding the multiple-ported hole, after partial pipe wall laminating, blood still can flow in and flow out the body through other holes, just so can avoid the condition that the adherence shut down, because partly pipeline still is in under unblocked circumstances, thereby can effective patient by partial pipeline pressure of adherence make it wash the in-process by blood and can resume the original shape. On the other hand, the problem of multiple local pressures can be avoided by multi-channel liquid circulation due to the existence of the multi-channel holes.
Example 2
The embodiment 2 provides an anti-wall-sticking double-resistance nano hemodialysis catheter, which comprises an anti-blocking double-resistance hemodialysis catheter body 100 and an input/output assembly;
in this embodiment, the input/output assembly includes a connection pipe, an input pipe 200 and an output pipe 300;
one end of the connecting pipe is connected with the anti-blocking double-antibody hemodialysis catheter body 100 through a rubber pipe;
the other end of the connecting pipe is connected with an input pipe 200 and an output pipe 300 in a Y shape, and the input pipe 200 and the output pipe 300 are respectively used for outputting blood in the blood exsanguination process; the partial structure can be replaced by any existing blood dialysis tube model.
The anti-blocking double-resistance hemodialysis catheter body 100 consists of a hemodialysis catheter main body 110, a hemodialysis catheter outer slow release layer 120 and a hemodialysis catheter inner slow release layer 130;
as shown in FIG. 2, the hemodialysis catheter body 110 is nested with an efferent vessel 110-2, both of which are a central passage;
the input pipe 110-1 is communicated with the input pipe 200;
the output pipe 110-2 is communicated with the output pipe 300;
the hemodialysis catheter outer sustained release layer 120 is positioned on the outer surface of the hemodialysis catheter main body 110;
the slow release layer 130 in the hemodialysis catheter is positioned on the inner surface of the input tube 110-1;
still have a plurality of through-hole 111 on this hemodialysis pipe body, on the one hand, through the mode of addding the multiple-pass hole, after partial pipe wall laminating, blood still can flow in and flow out the body through other holes, just so can avoid the condition of adherence shut down, because partly pipeline still is in under the unblocked condition, thereby can effective patient by the partial pipeline pressure of adherence make it wash by blood and get the in-process and can resume the original shape. On the other hand, the problem of multiple local pressures can be avoided by multi-channel liquid circulation due to the existence of the multi-channel holes.
In this embodiment, it is considered that there may occur a problem that the drug effects are mutually cancelled or the drug effects are deteriorated due to mixed storage between different drugs.
Therefore, in this embodiment, a structure in which different drugs are independently released is proposed on the basis of the above embodiments.
As shown in fig. 3, in this embodiment, taking two drugs as an example, the structure of the outer sustained-release layer of the deep venous catheter includes a first outer sustained-release layer 131 of the deep venous catheter and a second outer sustained-release layer 132 of the deep venous catheter;
the first deep venous catheter outer sustained-release layer 131 and the second deep venous catheter outer sustained-release layer 132 are independent from each other and spirally wound on the outer surface of the deep venous catheter main body 110;
one or a mixture of more of minocycline, rifampicin and other anti-inflammatory drugs is filled in the outer slow release layer of the first deep venous catheter;
heparin is filled in the outer slow release layer of the second deep venous catheter.
Similarly, the first deep ductus venosus outer sustained release layer 131 and the second deep ductus venosus outer sustained release layer 132 are uniformly distributed with nano-pores on the external visual surface, so as to be beneficial to the exudation of the medicine.
Also, the structure of the slow release layer in the deep venous catheter can be the same as that of the slow release layer outside the deep venous catheter.
Example 3
The embodiment 3 provides an anti-wall-sticking double-resistance nano hemodialysis catheter, which comprises an anti-blocking double-resistance hemodialysis catheter body 100 and an input/output assembly;
in this embodiment, the input/output assembly includes a connection pipe, an input pipe 200 and an output pipe 300;
one end of the connecting pipe is connected with the anti-blocking double-antibody hemodialysis catheter body 100 through a rubber pipe;
the other end of the connecting pipe is connected with an input pipe 200 and an output pipe 300 in a Y shape, and the input pipe 200 and the output pipe 300 are respectively used for outputting blood in the blood exsanguination process; the partial structure can be replaced by any existing blood dialysis tube model.
The anti-blocking double-resistance hemodialysis catheter body 100 consists of a hemodialysis catheter main body 110, a hemodialysis catheter outer slow release layer 120 and a hemodialysis catheter inner slow release layer 130;
as shown in FIG. 2, the hemodialysis catheter body 110 is nested with an efferent vessel 110-2, both of which are a central passage;
the input pipe 110-1 is communicated with the input pipe 200;
the output pipe 110-2 is communicated with the output pipe 300;
the hemodialysis catheter outer sustained release layer 120 is positioned on the outer surface of the hemodialysis catheter main body 110;
the slow release layer 130 in the hemodialysis catheter is positioned on the inner surface of the input tube 110-1;
still have a plurality of through-hole 111 on this hemodialysis pipe body, on the one hand, through the mode of addding the multiple-pass hole, after partial pipe wall laminating, blood still can flow in and flow out the body through other holes, just so can avoid the condition of adherence shut down, because partly pipeline still is in under the unblocked condition, thereby can effective patient by the partial pipeline pressure of adherence make it wash by blood and get the in-process and can resume the original shape. On the other hand, the problem of multiple local pressures can be avoided by multi-channel liquid circulation due to the existence of the multi-channel holes.
In this embodiment, it is considered that there may occur a problem that the drug effects are mutually cancelled or the drug effects are deteriorated due to mixed storage between different drugs.
Therefore, in this embodiment, a structure in which different drugs are independently released is proposed on the basis of the above embodiments.
As shown in fig. 4, in this embodiment, taking two drugs as an example, the structure of the outer sustained-release layer of the deep venous catheter includes a first outer sustained-release layer 131 of the deep venous catheter and a second outer sustained-release layer 132 of the deep venous catheter;
the first deep venous catheter outer sustained-release layer 131 and the second deep venous catheter outer sustained-release layer 132 are independently arranged on the outer surface of the deep venous catheter main body 110 in a staggered manner;
one or a mixture of more of minocycline, rifampicin and other anti-inflammatory drugs is filled in the outer slow release layer of the first deep venous catheter;
heparin is filled in the outer slow release layer of the second deep venous catheter.
Similarly, the first deep ductus venosus outer sustained release layer 131 and the second deep ductus venosus outer sustained release layer 132 are uniformly distributed with nano-pores on the external visual surface, so as to be beneficial to the exudation of the medicine.
Also, the structure of the slow release layer in the deep venous catheter can be the same as that of the slow release layer outside the deep venous catheter.
Example 4
The embodiment 4 provides an anti-wall-sticking double-resistance nano hemodialysis catheter, which comprises an anti-blocking double-resistance hemodialysis catheter body 100 and an input/output assembly;
in this embodiment, the input/output assembly includes a connection pipe, an input pipe 200 and an output pipe 300;
one end of the connecting pipe is connected with the anti-blocking double-antibody hemodialysis catheter body 100 through a rubber pipe;
the other end of the connecting pipe is connected with an input pipe 200 and an output pipe 300 in a Y shape, and the input pipe 200 and the output pipe 300 are respectively used for outputting blood in the blood exsanguination process; the partial structure can be replaced by any existing blood dialysis tube model.
The anti-blocking double-resistance hemodialysis catheter body 100 consists of a hemodialysis catheter main body 110, a hemodialysis catheter outer slow release layer 120 and a hemodialysis catheter inner slow release layer 130;
as shown in FIG. 2, the hemodialysis catheter body 110 is nested with an efferent vessel 110-2, both of which are a central passage;
the input pipe 110-1 is communicated with the input pipe 200;
the output pipe 110-2 is communicated with the output pipe 300;
the hemodialysis catheter outer sustained release layer 120 is positioned on the outer surface of the hemodialysis catheter main body 110;
the slow release layer 130 in the hemodialysis catheter is positioned on the inner surface of the input tube 110-1;
still have a plurality of through-hole 111 on this hemodialysis pipe body, on the one hand, through the mode of addding the multiple-pass hole, after partial pipe wall laminating, blood still can flow in and flow out the body through other holes, just so can avoid the condition of adherence shut down, because partly pipeline still is in under the unblocked condition, thereby can effective patient by the partial pipeline pressure of adherence make it wash by blood and get the in-process and can resume the original shape. On the other hand, the problem of multiple local pressures can be avoided by multi-channel liquid circulation due to the existence of the multi-channel holes.
In this embodiment, a novel structure for sustained release of a drug is also provided.
As shown in fig. 5, the drug sustained release layer is realized by an outer membrane layer manufactured by an electrostatic spinning process, and the specific manufacturing method of the outer membrane layer is as follows: dissolving equivalent polyvinyl alcohol, collagen sugar and rifampicin (the mass ratio of the total concentration of the polymer to the anti-inflammatory drug is 10:0.5-1, the drug can be replaced by other anti-inflammatory drugs or antithrombotic drugs or a mixture thereof) in 6 ml of HFIP, and magnetically stirring at normal temperature until the drug is completely dissolved to obtain the electrospinning solution with the concentration of 5% (g/ml). Placing the obtained electrostatic spinning solution in an injector, and carrying out electrostatic spinning: the voltage is 12 kilovolts, the advancing speed of the injector is 0.8 ml/h, the receiving distance is 150 mm, the composite nano-fiber loaded with the anti-inflammatory drug is obtained after the aluminum foil paper is received and vacuum-dried, and then the composite nano-fiber is covered on the outer surface of the deep venous catheter main body 110 in a blanching way.
If the double-layer electrostatic spinning effect is required to be achieved, the drug slow-release inner layer is also realized by adopting an inner film layer manufactured by an electrostatic spinning process, and the specific manufacturing method of the outer film layer comprises the following steps: dissolving equal amount of polyvinyl alcohol, collagen sugar and heparin (the mass ratio of the total concentration of the polymer to the anti-inflammatory drug is 10:0.5-1, the drug can be replaced by other anti-inflammatory drugs or antithrombotic drugs or the mixture thereof) in 6 ml of HFIP, and magnetically stirring at normal temperature until the mixture is completely dissolved to obtain the electrostatic spinning solution with the concentration of 5% (g/ml). Placing the obtained electrostatic spinning solution in an injector, and carrying out electrostatic spinning: the voltage was 12 kv, the syringe advancing speed was 0.8 ml/hr, the receiving distance was 150 mm, and the composite nanofibers carrying the anti-inflammatory drug were obtained after receiving in aluminum foil paper and vacuum drying, and then covered on the inner surface of the deep intravenous catheter main body 110 in a thermoplastic manner.
Also, the structure of the slow release layer in the deep venous catheter can be the same as that of the slow release layer outside the deep venous catheter.
Example 5
This embodiment 5 provides a wall-sticking-proof double-resistance nano hemodialysis catheter, which includes a blocking-proof double-resistance hemodialysis catheter body 100 and an input/output assembly;
in this embodiment, the input/output assembly includes a connection pipe, an input pipe 200 and an output pipe 300;
one end of the connecting pipe is connected with the anti-blocking double-antibody hemodialysis catheter body 100 through a rubber pipe;
the other end of the connecting pipe is connected with an input pipe 200 and an output pipe 300 in a Y shape, and the input pipe 200 and the output pipe 300 are respectively used for outputting blood in the blood exsanguination process; the partial structure can be replaced by any existing blood dialysis tube model.
The anti-blocking double-resistance hemodialysis catheter body 100 consists of a hemodialysis catheter main body 110, a hemodialysis catheter outer slow release layer 120 and a hemodialysis catheter inner slow release layer 130;
as shown in FIG. 2, the hemodialysis catheter body 110 is nested with an efferent vessel 110-2, both of which are a central passage;
the input pipe 110-1 is communicated with the input pipe 200;
the output pipe 110-2 is communicated with the output pipe 300;
the hemodialysis catheter outer sustained release layer 120 is positioned on the outer surface of the hemodialysis catheter main body 110;
the slow release layer 130 in the hemodialysis catheter is positioned on the inner surface of the input tube 110-1;
still have a plurality of through-hole 111 on this hemodialysis pipe body, on the one hand, through the mode of addding the multiple-pass hole, after partial pipe wall laminating, blood still can flow in and flow out the body through other holes, just so can avoid the condition of adherence shut down, because partly pipeline still is in under the unblocked condition, thereby can effective patient by the partial pipeline pressure of adherence make it wash by blood and get the in-process and can resume the original shape. On the other hand, the problem of multiple local pressures can be avoided by multi-channel liquid circulation due to the existence of the multi-channel holes.
In the embodiment, in order to further reduce the condition that the pipe wall is completely attached;
as shown in FIG. 6, the delivery tube 110-2 in the hemodialysis catheter body 110 is further modified as follows:
namely, the hemodialysis catheter main body 110 is embedded with the reinforcing rib 112 in a subsection manner, and the reinforcing rib 112 is of a net surface structure or a thickened structure and is used for reinforcing part of the strength of the catheter body so that the catheter body can resist pressure;
further, a through hole 111 is provided above the rib 112.
Example 6
This embodiment 6 provides a wall-sticking-proof double-resistance nano hemodialysis catheter, which includes a blocking-proof double-resistance hemodialysis catheter body 100 and an input/output assembly;
in this embodiment, the input/output assembly includes a connection pipe, an input pipe 200 and an output pipe 300;
one end of the connecting pipe is connected with the anti-blocking double-antibody hemodialysis catheter body 100 through a rubber pipe;
the other end of the connecting pipe is connected with an input pipe 200 and an output pipe 300 in a Y shape, and the input pipe 200 and the output pipe 300 are respectively used for outputting blood in the blood exsanguination process; the partial structure can be replaced by any existing blood dialysis tube model.
The anti-blocking double-resistance hemodialysis catheter body 100 consists of a hemodialysis catheter main body 110, a hemodialysis catheter outer slow release layer 120 and a hemodialysis catheter inner slow release layer 130;
as shown in FIG. 2, the hemodialysis catheter body 110 is nested with an efferent vessel 110-2, both of which are a central passage;
the input pipe 110-1 is communicated with the input pipe 200;
the output pipe 110-2 is communicated with the output pipe 300;
the hemodialysis catheter outer sustained release layer 120 is positioned on the outer surface of the hemodialysis catheter main body 110;
the slow release layer 130 in the hemodialysis catheter is positioned on the inner surface of the input tube 110-1;
still have a plurality of through-hole 111 on this hemodialysis pipe body, on the one hand, through the mode of addding the multiple-pass hole, after partial pipe wall laminating, blood still can flow in and flow out the body through other holes, just so can avoid the condition of adherence shut down, because partly pipeline still is in under the unblocked condition, thereby can effective patient by the partial pipeline pressure of adherence make it wash by blood and get the in-process and can resume the original shape. On the other hand, the problem of multiple local pressures can be avoided by multi-channel liquid circulation due to the existence of the multi-channel holes.
In the embodiment, in order to further reduce the condition that the pipe wall is completely attached;
as shown in FIG. 7, the delivery tube 110-2 in the hemodialysis catheter body 110 is further modified as follows:
namely, the hemodialysis catheter main body 110 is embedded with the reinforcing rib 112 in a segmented manner, the reinforcing rib 112 is of a barrel-shaped net surface structure or a thickened structure, and a plurality of reinforcing support rods which are arranged in parallel or in a staggered manner are arranged at the cross section of the structure and are used for reinforcing partial strength of the catheter body, so that the catheter body can resist pressure;
further, a through hole 111 is provided above the rib 112.
Example 7
This example 7 provides a wall-attachment-resistant, double-resistant, nano-hemodialysis catheter assembly comprising the wall-attachment-resistant, double-resistant, nano-hemodialysis catheter and a support apparatus of any of examples 1-6 above;
as shown in fig. 8, the supporting apparatus includes a telescopic member and a supporting member 500;
the telescopic element consists of an air pipe/water pipe 410, an air bag/water bag 420 and a swelling/water injection device 430, and has the functions of swelling and shrinking, namely, the air bag/water bag 420 is swelled under the action of air swelling, and the air bag/water bag 420 is shrunk under the mode of air releasing or water pumping, so that the air bag/water bag can enter and exit from the branch pipe 140;
the support member 500 is similar to the structure of a vascular stent (commonly used, such as a heart stent), and has a contracted structure when not in use, and is nested outside the telescopic member;
when the air bag/water bag 420 is expanded, the air bag/water bag is expanded to form a barrel-shaped net surface structure, so that a supporting effect is realized;
the hemodialysis catheter body of the anti-blocking double-anti-hemodialysis catheter is also connected with a branch pipe 140;
the pipe 140 is communicated with the output pipe 110-2;
the branch pipe 140 may accommodate the ingress and egress of the support member;
the end of the branch pipe 140 has a clip or bulkhead or similar device that can close the outlet end of the branch pipe when the telescoping member exits the branch pipe after the support structure 500 enters the pipeline and is installed in place;
in addition, the tail end of an output tube 110-2 in the hemodialysis catheter body of the anti-blocking double-anti-hemodialytic catheter is provided with a limiting ring 101 which is hooked inwards;
when the supporting element is unfolded, the lower end surface of the supporting element can be just embedded into the limit ring;
in addition, the outer surfaces of the telescopic element and the hemodialysis catheter body are provided with scales, so that the depth of the telescopic element can be predicted.
The specific use method is that after the hemodialysis tube body is installed in place, the hemodialysis tube body is guided into the supporting equipment from the branch tube, whether the hemodialysis tube body is guided in place (generally, 1-2mm is reserved) is judged according to the scales, and after the hemodialysis tube body is installed in place, the supporting element is slightly pushed inwards to be clamped into the limiting ring 101 after being expanded by air blowing or water filling. Deflation or pumping will then withdraw the telescoping member through the manifold and close the manifold outlet, initiating the hemodialysis procedure.
Claims (10)
1. The utility model provides a prevent two anti nanometer hemodialysis pipes of wall pasting which characterized in that: comprises a hemodialysis catheter body, an input unit and an output unit;
wherein the hemodialysis catheter body comprises an input tube and an output tube;
the input unit is communicated with one end of the input tube and inputs blood or other liquid;
the output unit is communicated with one end of the output tube and outputs blood or other liquid;
the hemodialysis catheter body consists of a hemodialysis catheter main body, a hemodialysis catheter outer slow release layer and a hemodialysis catheter inner slow release layer;
the hemodialysis catheter main body is internally nested with an input tube and an output tube;
the outer slow release layer of the hemodialysis catheter is positioned on the outer surface of the main body of the hemodialysis catheter;
the slow release layer in the hemodialysis catheter is positioned on the inner surface of the input tube;
the outer slow release layer of the hemodialysis catheter slowly releases medicaments with anti-infection and/or anti-thrombosis functions;
the slow release layer in the hemodialysis catheter slowly releases the medicine with anti-infection and/or anti-thrombosis functions.
2. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 1, wherein:
the hemodialysis catheter body is provided with one or more side backflow holes;
the side backflow hole is communicated with the output pipe.
3. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 1, wherein:
the output pipe is provided with a reinforcing structure;
and auxiliary backflow holes are formed around the reinforcing structure.
4. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 1, wherein:
the inner side of the output pipe is provided with a supporting mechanism;
the supporting mechanism is the inner space of the output pipe and allows liquid to pass through;
and auxiliary backflow holes are formed around the reinforcing structure.
5. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 1, wherein:
the outer slow release layer of the hemodialysis catheter is a sleeve structure nested outside the main body of the hemodialysis catheter;
nanometer through holes are densely distributed on the external visual surface of the outer slow release layer of the hemodialysis catheter;
anti-infection and/or antithrombotic drugs are filled between the outer slow release layer of the hemodialysis catheter and the hemodialysis catheter main body;
and/or
The slow release layer in the hemodialysis catheter is a sleeve structure nested in the infusion tube;
nanometer through holes are densely distributed on the inner visual surface of the slow release layer in the hemodialysis catheter;
anti-infection and/or antithrombotic drugs are filled between the slow release layer and the input tube in the hemodialysis catheter.
6. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 1, wherein:
the hemodialysis catheter outer slow-release layer comprises a first hemodialysis catheter outer slow-release layer and a second hemodialysis catheter outer slow-release layer;
the first hemodialysis catheter outer sustained-release layer and the second hemodialysis catheter outer sustained-release layer are independently arranged on the outer surface of the hemodialysis catheter main body;
the first hemodialysis catheter outer slow-release layer and the second hemodialysis catheter outer slow-release layer are filled with different medicines;
and/or
The slow release layer in the hemodialysis catheter comprises a first slow release layer in the hemodialysis catheter and a second slow release layer in the hemodialysis catheter;
the first hemodialysis catheter inner slow release layer and the second hemodialysis catheter inner slow release layer are independently arranged on the inner surface of the input tube;
the slow release layer in the first hemodialysis catheter and the slow release layer in the second hemodialysis catheter are filled with different medicines.
7. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 6, wherein:
the first hemodialysis catheter outer slow-release layer and the second hemodialysis catheter outer slow-release layer are independent from each other and are spirally arranged on the outer surface of the hemodialysis catheter main body;
or
The first hemodialysis catheter outer slow-release layer and the second hemodialysis catheter outer slow-release layer are independent from each other and are arranged on the outer surface of the hemodialysis catheter main body in a staggered mode.
8. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 6, wherein:
the slow release layer in the first hemodialysis catheter and the slow release layer in the second hemodialysis catheter are independent from each other and are spirally arranged on the inner surface of the input tube;
or
The slow release layer in the first hemodialysis catheter and the slow release layer in the second hemodialysis catheter are independent from each other and are arranged on the inner surface of the input tube in a staggered mode.
9. The anti-paring double-anti-nano hemodialysis catheter as set forth in claim 1, wherein:
the outer slow release layer of the hemodialysis catheter is of a net drug-carrying structure;
the reticular drug-loaded structure is manufactured by adopting an electrostatic spinning process;
and/or
The slow release layer in the hemodialysis catheter is of a net drug-carrying structure;
the reticular drug-loaded structure is manufactured by adopting an electrostatic spinning process.
10. The utility model provides a prevent that wall subsides dual resistance nanometer hemodialysis catheter subassembly which characterized in that:
comprising a adherence-resistant double-resistant nano hemodialysis catheter of any one of claims 1 to 9, and a support device;
the supporting device comprises a telescopic element and a supporting element;
the telescopic element has the functions of expanding and contracting;
the supporting element is nested outside the telescopic element and forms a barrel-shaped net surface structure along with the expansion of the telescopic element;
the hemodialysis catheter body of the anti-blocking double-anti-hemodialytic catheter is also connected with a third channel;
the third passage is communicated with the output pipe;
the third channel can accommodate the in and out of the supporting element;
a sealing mechanism is detachably arranged on the third channel;
the sealing mechanism seals the outlet end of the third channel;
the tail end of the output tube of the anti-blocking double-anti-hemodialysis catheter is provided with a limiting ring hooked inwards;
after the supporting element is unfolded, one end surface of the supporting element is just embedded into the limit ring;
the outer surfaces of the telescopic element and the hemodialysis catheter body are provided with scales.
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| CN202110413637.3A CN113144375B (en) | 2021-04-16 | 2021-04-16 | Wall-sticking-preventing double-resistance nano hemodialysis catheter |
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| CN202110413637.3A CN113144375B (en) | 2021-04-16 | 2021-04-16 | Wall-sticking-preventing double-resistance nano hemodialysis catheter |
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| CN113144375B (en) | 2024-04-02 |
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