CN113128685A - Natural selection classification and population scale change analysis system based on neural network - Google Patents
Natural selection classification and population scale change analysis system based on neural network Download PDFInfo
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Abstract
The invention discloses a natural selection classification and population scale change analysis system based on a neural network, which comprises the following steps: an input module for obtaining genome sequence data; the data processing module is used for processing the genome sequence data acquired by the input module and outputting summary statistics of the genome sequence data; the classification fitting module is used for constructing a population genetic classification and parameter fitting model by combining a cyclic neural network with a convolutional neural network, and performing natural selection classification and fitting population change on the population by using data output by the data processing module; the input module is connected with the data processing module, and the data processing module is connected with the classification fitting module. The invention can simultaneously analyze the scale change of the population and the natural selection classification, thereby eliminating the influence of the population scale change on the classification judgment of the natural selection, and automatically extracting and analyzing various summary statistics of the population through the neural network, thereby obtaining a result with high accuracy and reliability.
Description
Technical Field
The invention relates to the field of biological population genomes, in particular to a natural selection classification and population scale change analysis system based on a neural network.
Background
Group genetics is the life science of studying the genetic characteristics and rules of biological groups. In agricultural production, the method has great economic value for pest and disease management and seed selection breeding; in medical treatment, the medicine has great contribution to the infection law of diseases; has great scientific significance for biodiversity protection and research.
At present, some natural selection classification systems appear at home and abroad, but the influence of population scale change on natural selection judgment is not considered, and the population scale change may leave signals similar to natural selection on a population genome, so that the judgment of natural selection classification is influenced.
Disclosure of Invention
The invention aims to provide a natural selection classification and population scale change analysis system based on a neural network, so as to overcome the defects in the prior art.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a neural network based natural choice classification and population scale variation analysis system, comprising:
an input module for obtaining genome sequence data;
the data processing module is used for processing the genome sequence data acquired by the input module and outputting summary statistics of the genome sequence data;
the classification fitting module is used for constructing a population genetic classification and parameter fitting model by combining a cyclic neural network with a convolutional neural network, and performing natural selection classification and fitting population change on the population by using data output by the data processing module;
the input module is connected with the data processing module, and the data processing module is connected with the classification fitting module.
Further, the data processing module comprises,
the data preprocessing unit is used for dividing and cleaning the genome sequence data;
the data summarizing statistic generation unit is used for dividing each piece of output data of the data preprocessing unit into a set number of windows and calculating the population genetics summarizing statistic of each window;
the data preprocessing unit is connected with the data summarizing statistic generation unit.
Further, the number of the windows is 3.
Further, the statistics of genetic summary for each window population include number of loci, locus folding spectrum, length distribution among loci, length distribution of state identification region, linkage disequilibrium distribution, Tajima's D statistics.
Further, the data preprocessing unit includes,
the data slice divider is used for dividing the genome sequence into a plurality of segments with equal size;
a data position calculator for calculating the relative position of a site in a gene fragment at the fragment;
a data converter for converting the divided genome fragment data into binary data;
the data cleaner is used for deleting data with length less than a first set length and data with length greater than a second set length, combining the data of the repeated sites and carrying out OR operation on the data of the repeated sites to obtain a result, wherein the second set length is greater than the first set length;
the data slice divider, the data position calculator, the data converter and the data cleaner are sequentially connected.
Further, 0 in the binary data represents an ancestor gene and 1 represents a variant gene.
Further, the class fitting module includes,
the model building unit is used for building a natural selection classification and population change parameter fitting model by adopting a gate control cycle unit in a cyclic neural network (RNN) and combining a convolutional neural network;
the model prediction unit is used for inputting the group genetic summary statistic sequence obtained by the data processing module into the natural selection classification and group change parameter fitting model constructed by the model construction unit, training the model by using training set data, and reading the test set into the trained model to perform natural selection classification and group change parameter fitting;
the model building unit is connected with the model prediction unit.
Further, the model construction unit constructs a natural selection classification and group change parameter fitting model according to the following sequence, firstly calls an Input layer, a BilSTM layer, a CNN layer and a Dropout layer, and constructs a natural selection classification and group change parameter fitting model; the BiLSTM layer and the CNN layer are used for vector characterization learning, and the Dropout layer is used for preventing overfitting of the model; then adjusting the weight according to the correlation of each characteristic and the population genetic variable; and finally, multiplying the weight and the characteristic value vector, and summing and outputting.
Further, the calculation process of the gating cycle unit is,
ft＝σ(Wf·[ht-1,xt]+bf)
it＝σ(Wi·[ht-1,xt]+bi)
ot＝σ(Wo·[ht-1,xt]+bo)
ht＝ot*tanh(Ct)；
wherein f istIs a forgetting gate, itIs a memory door, and the memory door is provided with a memory,
is in a temporary state, CtIs the current time state, otIs an input gate, htIs a hidden state, σ is an activation function, Wf、Wi、WC、WoAre different weight matrices, bf、bi、bC、boAre different offsets, ht-1Is a concealment of the upper layerState, xtIs the current input, '-' stands for point product, and tanh is the tangent function. (ii) a
V＝conv(W,X)+b
The calculation process of the CNN layer is as follows:
w is the weight matrix, X is the BiLSTM layer output, b is the offset,
is an activation function.
Further, the natural choice prediction classification process in the model prediction unit proceeds in the following order: firstly, reading a group genetic summary statistic sequence output by a data processing module, and dividing the read data into a training set and a test set according to a set proportion; then, coding the dispersed type data by adopting a single-hot coding mode to obtain vector representation of a group genetic summary statistical sequence; secondly, inputting training set data converted into vector representation into a model for model training; and finally, reading in test set data by using the trained model, and performing natural selection classification and population scale change parameter fitting.
Compared with the prior art, the invention has the advantages that: the invention can simultaneously analyze the scale change of the population and the natural selection classification, thereby eliminating the influence of the population scale change on the natural selection classification judgment, and automatically extracting and analyzing various summary statistics of the population through the neural network, thereby obtaining a beneficial result with high accuracy and reliability.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a block diagram of a neural network-based natural choice classification and population-scale variation analysis system of the present invention.
Detailed Description
The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, and the scope of the present invention will be more clearly and clearly defined.
Referring to fig. 1, the present invention discloses a natural selection classification and population scale change analysis system based on neural network, comprising: an input module for obtaining genome sequence data; the data processing module is used for processing the genome sequence data acquired by the input module and outputting summary statistics of the genome sequence data; the classification fitting module is used for constructing a population genetic classification and parameter fitting model by combining a cyclic neural network with a convolutional neural network, and performing natural selection classification and fitting population change on the population by using data output by the data processing module; the input module is connected with the data processing module, and the data processing module is connected with the classification fitting module.
In this embodiment, the data processing module includes: the data preprocessing unit is used for dividing and cleaning the genome sequence data; the data summarizing statistic generation unit is used for dividing each piece of output data of the data preprocessing unit into a set number of windows (3 in the embodiment) and calculating the population genetics summarizing statistic of each window; the data preprocessing unit is connected with the data summarizing statistic generation unit.
Preferably, the genetic summary statistics of each window population include site number, site fold spectra, site-to-site length distribution, state signature region length distribution, linkage disequilibrium distribution, Tajima's D statistics.
In this embodiment, the data preprocessing unit includes: the data slice divider is used for dividing the genome sequence into a plurality of segments with equal size; a data position calculator for calculating the relative position of a site in a gene fragment at the fragment; a data converter for converting the divided genome fragment data into 0, 1 binary data (0 in the binary data represents an ancestor gene, 1 represents a variant gene); the data cleaner is used for deleting data with length less than a first set length and data with length greater than a second set length, combining the data of the repeated sites and carrying out OR operation on the data of the repeated sites to obtain a result, wherein the second set length is greater than the first set length; the data slice divider, the data position calculator, the data converter and the data cleaner are connected in sequence.
In this embodiment, the classification fitting module includes: the model building unit is used for building a natural selection classification and population change parameter fitting model by adopting a gate control cycle unit in a cyclic neural network (RNN) and combining a convolutional neural network; the model prediction unit is used for inputting the group genetic summary statistic sequence obtained by the data processing module into the natural selection classification and group change parameter fitting model constructed by the model construction unit, training the model by using training set data, and reading the test set into the trained model to perform natural selection classification and group change parameter fitting; the model building unit is connected with the model prediction unit.
The model construction unit constructs a natural selection classification and group change parameter fitting model according to the following sequence, firstly, an Input layer, a BilSTM layer, a CNN layer and a Dropout layer are called, and the natural selection classification and group change parameter fitting model is constructed; the BiLSTM layer and the CNN layer are used for vector characterization learning, and the Dropout layer is used for preventing overfitting of the model; then adjusting the weight according to the correlation of each characteristic and the population genetic variable; and finally, multiplying the weight and the characteristic value vector, and summing and outputting.
The calculation process of the gating cycle unit is that,
ft＝σ(Wf·[ht-1,xt]+bf)
it＝σ(Wi·[ht-1,xt]+bi)
ot＝σ(Wo·[ht-1,xt]+bo)
ht＝ot*tanh(Ct)；
wherein f istIs a forgetting gate, itIs a memory door, and the memory door is provided with a memory,
is in a temporary state, CtIs the current time state, otIs an input gate, htIs a hidden state, σ is an activation function, Wf、Wi、WC、WoAre different weight matrices, bf、bi、bC、boAre different offsets, ht-1Is a hidden state of the previous layer, xtIs the current input, '-' stands for point product, and tanh is the tangent function. (ii) a
V＝conv(W,X)+b
The calculation process of the CNN layer is as follows:
w is the weight matrix, X is the BiLSTM layer output, b is the offset,
is an activation function.
In this embodiment, the natural selection prediction classification process in the model prediction unit is performed in the following order: firstly, reading a group genetic summary statistic sequence output by a data processing module, and dividing the read data into a training set and a test set according to a set proportion; then, coding the dispersed type data by adopting a single-hot coding mode to obtain vector representation of a group genetic summary statistical sequence; secondly, inputting training set data converted into vector representation into a model for model training; and finally, reading in test set data by using the trained model, and performing natural selection classification and population scale change parameter fitting.
The invention provides a natural selection classification and group scale change analysis system based on a neural network, which utilizes the characteristic that the neural network can have multiple outputs, simultaneously outputs a group scale change parameter and a natural selection classification result, and can simultaneously analyze the group scale change and the natural selection classification, thereby eliminating the influence of the group scale change on the natural selection classification judgment, and automatically extracting and analyzing various summary statistics of the group through the neural network, thereby obtaining a beneficial result with high accuracy and reliability.
Although the embodiments of the present invention have been described with reference to the accompanying drawings, various changes or modifications may be made by the patentees within the scope of the appended claims, and within the scope of the invention, as long as they do not exceed the scope of the invention described in the claims.
Claims (10)
1. A natural selection classification and population scale change analysis system based on a neural network is characterized in that: comprises the steps of (a) preparing a mixture of a plurality of raw materials,
an input module for obtaining genome sequence data;
the data processing module is used for processing the genome sequence data acquired by the input module and outputting summary statistics of the genome sequence data;
the classification fitting module is used for constructing a population genetic classification and parameter fitting model by combining a cyclic neural network with a convolutional neural network, and performing natural selection classification and fitting population change on the population by using data output by the data processing module;
the input module is connected with the data processing module, and the data processing module is connected with the classification fitting module.
2. The neural network-based natural choice classification and population-scale variation analysis system of claim 1, wherein: the data processing module comprises a data processing module and a data processing module,
the data preprocessing unit is used for dividing and cleaning the genome sequence data;
the data summarizing statistic generation unit is used for dividing each piece of output data of the data preprocessing unit into a set number of windows and calculating the population genetics summarizing statistic of each window;
the data preprocessing unit is connected with the data summarizing statistic generation unit.
3. The neural network-based natural choice classification and population-scale variation analysis system of claim 2, wherein: the number of the windows is 3.
4. The neural network-based natural choice classification and population-scale variation analysis system of claim 2, wherein: the statistics of genetics summary of each window group comprise the number of sites, site folding frequency spectrum, length distribution among the sites, length distribution of state identification regions, linkage disequilibrium distribution and Tajima's D statistics.
5. The neural network-based natural choice classification and population-scale variation analysis system of claim 2, wherein: the data pre-processing unit comprises a data pre-processing unit,
the data slice divider is used for dividing the genome sequence into a plurality of segments with equal size;
a data position calculator for calculating the relative position of a site in a gene fragment at the fragment;
a data converter for converting the divided genome fragment data into binary data;
the data cleaner is used for deleting data with length less than a first set length and data with length greater than a second set length, combining the data of the repeated sites and carrying out OR operation on the data of the repeated sites to obtain a result, wherein the second set length is greater than the first set length;
the data slice divider, the data position calculator, the data converter and the data cleaner are sequentially connected.
6. The neural network-based natural choice classification and population-scale variation analysis system of claim 2, wherein: in the binary data, 0 represents an ancestral gene and 1 represents a mutated gene.
7. The neural network-based natural choice classification and population-scale variation analysis system of claim 1, wherein: the class-fitting module includes a class-fitting module,
the model building unit is used for building a natural selection classification and population change parameter fitting model by adopting a gate control cycle unit in a cyclic neural network (RNN) and combining a convolutional neural network;
the model prediction unit is used for inputting the group genetic summary statistic sequence obtained by the data processing module into the natural selection classification and group change parameter fitting model constructed by the model construction unit, training the model by using training set data, and reading the test set into the trained model to perform natural selection classification and group change parameter fitting;
the model building unit is connected with the model prediction unit.
8. The neural network-based natural choice classification and population-scale variation analysis system of claim 7, wherein: the model construction unit constructs a natural selection classification and group change parameter fitting model according to the following sequence, firstly calls an Input layer, a BilSTM layer, a CNN layer and a Dropout layer, and constructs the natural selection classification and group change parameter fitting model; the BiLSTM layer and the CNN layer are used for vector characterization learning, and the Dropout layer is used for preventing overfitting of the model; then adjusting the weight according to the correlation of each characteristic and the population genetic variable; and finally, multiplying the weight and the characteristic value vector, and summing and outputting.
9. The neural network-based natural choice classification and population-scale variation analysis system of claim 8, wherein: the calculation process of the gating cycle unit is that,
ft＝σ(Wf·[ht-1,xt]+bf)
it＝σ(Wi·[ht-1,xt]+bi)
ot＝σ(Wo·[ht-1,xt]+bo)
ht＝ot*tanh(Ct)；
wherein f istIs a forgetting gate, itIs a memory door, and the memory door is provided with a memory,
is in a temporary state, CtIs the current time state, otIs an input gate, htIs a hidden state, σ is an activation function, Wf、Wi、WC、WoAre different weight matrices, bf、bi、bC、boAre different offsets, ht-1Is a hidden state of the previous layer, xtIs the current input, '-' stands for point product, and tanh is the tangent function. (ii) a
The calculation process of the CNN layer is as follows:
w is the weight matrix, X is the BiLSTM layer output, b is the offset,
is an activation function。
10. The neural network-based natural choice classification and population-scale variation analysis system of claim 7, wherein: the natural selection prediction classification process in the model prediction unit is carried out according to the following sequence: firstly, reading a group genetic summary statistic sequence output by a data processing module, and dividing the read data into a training set and a test set according to a set proportion; then, coding the dispersed type data by adopting a single-hot coding mode to obtain vector representation of a group genetic summary statistical sequence; secondly, inputting training set data converted into vector representation into a model for model training; and finally, reading in test set data by using the trained model, and performing natural selection classification and population scale change parameter fitting.
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