CN113117269A - Focused ultrasound medium gasket and using method thereof - Google Patents
Focused ultrasound medium gasket and using method thereof Download PDFInfo
- Publication number
- CN113117269A CN113117269A CN202110577779.3A CN202110577779A CN113117269A CN 113117269 A CN113117269 A CN 113117269A CN 202110577779 A CN202110577779 A CN 202110577779A CN 113117269 A CN113117269 A CN 113117269A
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- focused ultrasound
- medium
- pad
- gasket
- dielectric
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- 238000002604 ultrasonography Methods 0.000 title claims abstract description 82
- 238000000034 method Methods 0.000 title claims abstract description 22
- 239000000523 sample Substances 0.000 claims abstract description 17
- 125000006850 spacer group Chemical group 0.000 claims abstract description 17
- 229920000936 Agarose Polymers 0.000 claims abstract description 13
- 230000000149 penetrating effect Effects 0.000 claims abstract description 4
- 239000011543 agarose gel Substances 0.000 claims description 18
- 230000009471 action Effects 0.000 description 3
- 239000007822 coupling agent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000002679 ablation Methods 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004007 neuromodulation Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000021715 photosynthesis, light harvesting Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
Abstract
The invention discloses a focused ultrasound dielectric gasket which comprises a dielectric gasket body, wherein the dielectric gasket body contains 1-10 wt% of agarose. The invention also discloses a using method of the focusing ultrasonic medium gasket, which comprises the following steps: placing a focused ultrasound dielectric spacer on a target; using a probe of a focused ultrasound system, which emits a sound beam to penetrate through the focused ultrasound medium pad and focuses the sound beam on a specific position of a target object; and focusing the sound beam at different specific positions of the target object by means of the sound beam penetrating through the focusing ultrasonic medium gaskets with different thicknesses or different agarose contents. The focused ultrasound medium gasket is not easy to slide when being attached to a target object, and can focus an acoustic beam at a specific position with high precision by matching with a probe of a focused ultrasound system.
Description
Technical Field
The invention relates to a gasket and a using method thereof, in particular to a focused ultrasound medium gasket for a focused ultrasound system and a using method thereof.
Background
Focused ultrasound originated in the 30's of the 19 th century and was generated by mechanical vibrations with frequencies above 20 kHz. By periodic mechanical vibration, focused ultrasound can be transmitted in air, liquid and solid tissues, and thus has good penetration. In addition, focused ultrasound can also focus the acoustic beam at a target point deep in the tissue.
By utilizing the focusing property and penetrability of ultrasonic sound waves, focused ultrasound can focus energy at a target point on the premise of generating minimum influence on surrounding tissues, and non-invasively generates local biological effect on deep tissues, thereby playing multiple roles in tissues such as brain and the like. Ranging from transient blood brain barrier opening and neuromodulation to permanent thermal ablation. The use of focused ultrasound has increased dramatically over the past 5 years, with the growing academic and public interest in such techniques.
In order to achieve the focusing effect of ultrasound, energy is focused at a certain point in space, and a focused ultrasound transducer is provided in a focused ultrasound system. However, each focused ultrasound transducer has only one specific focal depth and cannot exert biological effects in tissues of different depths. If the ultrasonic transducer is applied to tissues with different depths, the ultrasonic transducer with different focusing depths needs to be replaced, and the technical cost is too high. At present, the action site of focused ultrasound can be changed by adopting a method of thickening an ultrasonic coupling agent between an ultrasonic probe and tissues, however, the ultrasonic coupling agent is aqueous polymer gel, the probe is easy to slide on the aqueous polymer gel, and the high-precision regulation and control effect of the focused ultrasound cannot be realized. Therefore, on the premise of ensuring that the focused ultrasound probe does not slide, how to change the action site of the focused ultrasound transducer is a problem which needs to be solved urgently at present.
In view of the above-mentioned shortcomings of the prior art, the present inventors have developed a focused ultrasound dielectric spacer and a method for using the same to solve the problems of the prior art, such as high cost for replacing ultrasound transducers with different focusing depths, and difficulty in sliding the probe on the ultrasound coupling agent, thereby failing to achieve high-precision control of focused ultrasound.
Disclosure of Invention
The invention aims to provide a focused ultrasound medium gasket and a using method thereof, which have the advantages of low cost, convenient use and capability of realizing high-precision regulation and control of focused ultrasound.
The invention provides the following technical scheme:
a focused ultrasound medium gasket comprises a medium gasket body, wherein the medium gasket body contains 1-10 wt% of agarose.
The thickness of the medium gasket is 0.1-6.0 cm.
Preferably, the medium gasket body contains 5-10 wt% of agarose.
The invention provides a focused ultrasound medium gasket, wherein a medium gasket body is agarose gel.
The invention also provides a using method of the focused ultrasound medium gasket, which comprises the steps of placing the focused ultrasound medium gasket on a target object; using a probe of a focused ultrasound system, emitting an acoustic beam to penetrate through the focused ultrasound medium pad, and focusing the acoustic beam on a specific position of the target object; and focusing the sound beam on different specific positions of the target object by means of the sound beam penetrating through the focused ultrasonic medium gaskets with different agarose contents or/and different thicknesses.
The invention provides a using method of a focused ultrasound medium gasket, wherein the focused ultrasound medium gasket is fixedly attached to a target object.
The invention provides a using method of a focused ultrasound medium gasket, wherein the relative positions of the probe and the focused ultrasound medium gasket are adjusted, and the probe contacts the focused ultrasound medium gasket to focus the sound beam on different specific positions of the target object.
The invention provides a using method of a focused ultrasound medium gasket, wherein the target organism is biological tissue.
Compared with the prior art, the focusing ultrasonic medium gasket provided by the invention forms a regulation effect by focusing and emitting sound waves, and the contained components can avoid energy dissipation and consumption in the penetrating process; therefore, the focused ultrasound at different positions of the target object can be realized by using the focused ultrasound medium gaskets with different thicknesses or/and different component contents and adjusting the positions of the probe and the focused ultrasound medium gaskets without replacing the ultrasonic transducers with different focusing depths.
Drawings
FIG. 1 is a perspective view of a focused ultrasound dielectric spacer according to an embodiment of the invention.
FIG. 2 is a graph showing the relationship between the acoustic power attenuation and the thickness of a focused ultrasound dielectric spacer according to an embodiment of the present invention.
FIG. 3 is a graph showing the relationship between the acoustic power attenuation and the thickness of a focused ultrasound dielectric spacer according to another embodiment of the present invention.
FIG. 4 is a flow chart illustrating steps of an embodiment of a method of using a focused ultrasound dielectric spacer in accordance with the present invention.
Detailed Description
Referring to fig. 1, a focused ultrasound dielectric spacer 1 according to an embodiment of the present invention includes: a dielectric gasket body 11 containing 1-10 wt% of agarose; wherein the thickness of the dielectric spacer is 0.1-6.0 cm. The dielectric gasket body preferably contains 5 to 10 wt% of agarose. The medium gasket body is agarose gel, and air bubbles can not be generated in the medium gasket when the medium gasket is prepared. The focused ultrasound medium pad 1 shown in fig. 1 has a circular shape, but the present invention is not limited thereto, and the shape and size of the focused ultrasound medium pad 1 can be appropriately adjusted according to the attached target.
The preparation of the focused ultrasound dielectric spacer according to an embodiment of the present invention is first illustrated by comparing the thicknesses of 0.5cm, 1.0cm and 1.5cm, and the scope of the present invention is not limited thereby. In practice, the thickness of the focused ultrasound medium pad can be extended up to 6cm or more, which is as follows:
1. mixing agarose and water to prepare 5 wt% agarose gel, and cutting the agarose gel into dielectric gasket bodies with the thickness of 0.5cm, 1.0cm and 1.5 cm;
2. fixing the 5 wt% agarose gel with different thicknesses on a 500kHz focused ultrasonic transducer, and respectively measuring the output sound power of the agarose gel for 7 times in total;
3. the relationship between the average attenuation rate of the acoustic power and the thickness of the focused ultrasound dielectric spacer according to an embodiment of the present invention is obtained, as shown in FIG. 2.
The preparation and measurement results of the focused ultrasound dielectric spacer according to another embodiment of the present invention are as follows:
1. mixing agarose and water to prepare 10 wt% agarose gel, and cutting the agarose gel into dielectric gasket bodies with the thickness of 0.5cm, 1.0cm and 1.5 cm;
2. fixing the 10 wt% agarose gel with different thicknesses on a 500kHz focused ultrasonic transducer, and measuring the output sound power of the agarose gel respectively for 7 times in total;
3. the relationship between the average attenuation rate of the acoustic power and the thickness of the focused ultrasound dielectric spacer according to another embodiment of the present invention is obtained, as shown in FIG. 3.
The results of the experiments shown in fig. 2 and 3, comparing the focused ultrasound medium pad of one embodiment and another embodiment of the present invention, are as follows:
1. the variation of the mean decay rate of acoustic power of 5 wt% agarose gels of different thickness in FIG. 2 is closer to the exponential distribution.
2. Comparing 5 wt% and 10 wt% agarose gels of the same thickness, 10 wt% agarose gel produced a greater average attenuation of acoustic power.
The 5 wt% agarose gel and the 10 wt% agarose gel with the thickness of 3.0.5-1.0 cm have approximate changes of the average attenuation rate of the sound power, and are suitable for changing the action site of the focused ultrasonic transducer.
The change degree of the sound power average attenuation rate of 10 wt% agarose gel with the thickness of 4.1.0-1.5 cm is far larger than that of 5% agarose gel.
Referring to fig. 4 again, the application method of the focused ultrasound medium pad of the embodiment of the invention includes the steps of:
1. placing the focused ultrasound medium pad on a target object; and
2. using a probe of a focused ultrasound system, which emits a sound beam to penetrate through the focused ultrasound medium pad and focuses the sound beam on a specific position of the target object; and
3. the sound beam penetrates through the focused ultrasonic medium gaskets with different thicknesses or different agarose contents to focus the sound beam on different specific positions of the target object.
The invention relates to a using method of a focused ultrasound medium gasket, wherein the focused ultrasound medium gasket is fixedly attached to a target object and is not easy to slide. In addition, the relative positions of the probe and the focused ultrasound medium pad are adjusted, and the probe contacts the focused ultrasound medium pad to focus the sound beam on different specific positions of the target object. In addition, the target object is a biological tissue.
In summary, the focused ultrasound dielectric spacer of the present invention is not easy to slide when attached to the target, and has low manufacturing cost, and the probe of the focused ultrasound system can focus the acoustic beam on the specific position of the target with high precision.
Although the present invention has been described with reference to the above embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention.
Claims (8)
1. The focused ultrasound dielectric gasket is characterized by comprising a dielectric gasket body, wherein the dielectric gasket body contains 1-10 wt% of agarose.
2. The focused ultrasound dielectric spacer of claim 1, wherein the thickness of the dielectric spacer is 0.1-6.0 cm.
3. The focused ultrasound dielectric spacer of claim 1, wherein the dielectric spacer body comprises 5-10 wt% agarose.
4. The focused ultrasound media pad of claim 1, wherein the media pad body is agarose gel.
5. A method of using the focused ultrasound media pad of any of claims 1-4, wherein the steps of the method of using comprise:
placing the focused ultrasound dielectric pad on a target; using a probe of a focused ultrasound system, emitting an acoustic beam to penetrate through the focused ultrasound medium pad, and focusing the acoustic beam on a specific position of the target object;
wherein the sound beams are focused on different specific positions of the target object by penetrating the sound beams through the focused ultrasound medium gaskets with different agarose contents or/and different thicknesses.
6. The method of using a focused ultrasound media pad as recited in claim 5, wherein the focused ultrasound media pad is affixed to a target.
7. The method of using a focused ultrasound medium pad as claimed in claim 6, wherein the relative positions of the probe and the focused ultrasound medium pad are adjusted, and the probe contacts the focused ultrasound medium pad, to focus the acoustic beam at different specific positions of the target.
8. The method of using a focused ultrasound media pad as recited in claim 5, wherein the target is a biological tissue.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110577779.3A CN113117269A (en) | 2021-05-26 | 2021-05-26 | Focused ultrasound medium gasket and using method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110577779.3A CN113117269A (en) | 2021-05-26 | 2021-05-26 | Focused ultrasound medium gasket and using method thereof |
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| CN113117269A true CN113117269A (en) | 2021-07-16 |
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| US20110172591A1 (en) * | 2010-01-13 | 2011-07-14 | Bacoustics Llc | Portable topical hyperbaric skin therapy and wound treatment system |
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| US20150135840A1 (en) * | 2012-08-29 | 2015-05-21 | Thync, Inc. | Systems and devices for coupling ultrasound energy to a body |
| US20150320394A1 (en) * | 2014-05-12 | 2015-11-12 | University Of Washington | Toric focusing for radiation force applications |
| US20160242736A1 (en) * | 2015-02-25 | 2016-08-25 | Decision Sciences Medical Company, LLC | Acoustic signal transmission couplants and coupling mediums |
| CN108471944A (en) * | 2015-10-16 | 2018-08-31 | 玛多拉公司 | The ultrasonic device restored for vulvovaginal |
| US20190038262A1 (en) * | 2017-08-07 | 2019-02-07 | Utah Valley University | Apparatus, system and method for diagnostic imaging forceps |
| JP2019111330A (en) * | 2017-12-22 | 2019-07-11 | 株式会社デントロケミカル | Acoustic coupling material |
| CN209574731U (en) * | 2018-05-22 | 2019-11-05 | 昆明市儿童医院 | A kind of superficial foci ultrasonic examination coupling pad |
| WO2021067754A1 (en) * | 2019-10-04 | 2021-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Creation of a flexible ultrasound system for real time acquisition of large fields of view |
-
2021
- 2021-05-26 CN CN202110577779.3A patent/CN113117269A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58142254A (en) * | 1982-02-19 | 1983-08-24 | Nippon Steel Corp | Ultrasonic flaw detection |
| US20110172591A1 (en) * | 2010-01-13 | 2011-07-14 | Bacoustics Llc | Portable topical hyperbaric skin therapy and wound treatment system |
| CN102568287A (en) * | 2010-12-24 | 2012-07-11 | 中国科学院深圳先进技术研究院 | Multimodality bionic body model |
| US20130006114A1 (en) * | 2011-06-30 | 2013-01-03 | Paolo Pellegretti | Apparatus for ultrasound imaging |
| US20150135840A1 (en) * | 2012-08-29 | 2015-05-21 | Thync, Inc. | Systems and devices for coupling ultrasound energy to a body |
| US20150320394A1 (en) * | 2014-05-12 | 2015-11-12 | University Of Washington | Toric focusing for radiation force applications |
| US20160242736A1 (en) * | 2015-02-25 | 2016-08-25 | Decision Sciences Medical Company, LLC | Acoustic signal transmission couplants and coupling mediums |
| CN108471944A (en) * | 2015-10-16 | 2018-08-31 | 玛多拉公司 | The ultrasonic device restored for vulvovaginal |
| US20190060675A1 (en) * | 2015-10-16 | 2019-02-28 | Madorra Inc. | Ultrasound device for vulvovaginal rejuvenation |
| US20190038262A1 (en) * | 2017-08-07 | 2019-02-07 | Utah Valley University | Apparatus, system and method for diagnostic imaging forceps |
| JP2019111330A (en) * | 2017-12-22 | 2019-07-11 | 株式会社デントロケミカル | Acoustic coupling material |
| CN209574731U (en) * | 2018-05-22 | 2019-11-05 | 昆明市儿童医院 | A kind of superficial foci ultrasonic examination coupling pad |
| WO2021067754A1 (en) * | 2019-10-04 | 2021-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Creation of a flexible ultrasound system for real time acquisition of large fields of view |
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