CN113116586A

CN113116586A - Quantitative damage device for optic nerve tube

Info

Publication number: CN113116586A
Application number: CN201911387865.7A
Authority: CN
Inventors: 吴文灿; 张逸夔
Original assignee: Wenzhou Medical University
Current assignee: Wenzhou Medical University
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2021-07-16

Abstract

The optic nerve tube quantitative damage device provided by the invention can give quantitative damage to optic nerves through adjustable physical impact, so that the model establishment of TON animal research becomes accurate, efficient and controllable, thereby better controlling variables and achieving the purpose of improving the reliability of research results. The structure includes: 1 gas cylinder, 2 charging connectors, 3 gas cylinder valves, 4 constant pressure meters, 5 gas cylinder pressure meters, 6 snap switches and 7 constant pressure valves.

Description

Quantitative damage device for optic nerve tube

Technical Field

The invention relates to the field of damaged optic nerves, in particular to a device for quantitatively damaging an optic nerve tube.

Background

With the change and development of traffic ways, traffic accidents are increased. The head trauma caused by traffic accidents is the main cause of traumatic optic neuropathy, in particular to motorcycle accidents; the second is high fall, and the head of a bicycle falls to the ground first.

At present, there is no well-established gold standard treatment scheme for TON, and the selection of treatment mode and operation time are still controversial. In the animal research of TON, the damage which is effective and more suitable for the actual condition is caused to the optic nerve of the animal, and the important role is to improve the reliability of the research result. At present, the aim of quantitatively damaging the optic nerve is achieved by clamping the optic nerve with certain clamping force and continuously clamping the optic nerve for a certain time. However, in the existing method, the optic nerve clip is required to clamp the optic nerve continuously for a period of time to achieve the purpose of damaging the optic nerve, the required time is long, the efficiency is low, and the optic nerve clamping cannot accurately simulate the optic nerve damage caused by external force impact such as traffic accidents. Therefore, it is necessary to invent a device for quantitatively damaging the optic nerve tube, which can adjust the quantitative damage to the optic nerve by physical impact, so that the model establishment of TON animal research becomes accurate, efficient and controllable, thereby better controlling variables and achieving the purpose of improving the reliability of research results.

Disclosure of Invention

In order to solve the problems mentioned in the background technology, the adjustable physical impact provided by the invention can be used for quantitatively damaging the optic nerve, so that the model establishment of TON animal research becomes accurate, efficient and controllable, thereby better controlling the variable and achieving the purpose of improving the reliability of the research result.

The gas cylinder be used for adorning high-pressure gas's bottle, the charging connector toward the gas cylinder inside gas filled connecting device, the gas cylinder valve be used for controlling the gaseous valve in the gas cylinder, the constant pressure gauge be used for showing the manometer of constant voltage room air, the gas cylinder manometer be used for showing the manometer of the air in the gas cylinder, the snap switch be used for the percussion device of shooting usefulness, the constant pressure valve be used for controlling the gaseous valve in the constant voltage room.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.

FIG. 1 is a schematic view of an apparatus for quantitative damage of optic nerve tube according to the present invention;

FIG. 2 is a schematic front view of an apparatus for quantitative damage of optic nerve tube according to the present invention;

FIG. 3 is a schematic side-view, back-view of the apparatus for quantitative damage of optic nerve tube according to the present invention;

FIG. 4 is a schematic diagram of the inclined plane of the apparatus for quantitative damage of optic nerve tube provided by the present invention;

reference numerals:

1 gas cylinder, 2 charging connectors, 3 gas cylinder valves, 4 constant pressure meters, 5 gas cylinder pressure meters, 6 snap switches and 7 constant pressure valves; Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Preferably, the device for quantitative damage of optic nerve tube is characterized in that: the fracture pen is of sufficient length to reach the optic nerve canal directly through the nasal cavity, whereas traditional methods require the optic nerve to be exposed. In contrast, the fracture pen is more convenient, and avoids causing additional damage to the optic nerve when the optic nerve is exposed in an operation.

Preferably, the device for quantitative damage of optic nerve tube is characterized in that: the quantitative damage to the optic nerve can be caused by adjusting the air pressure, and the method is convenient and accurate.

Preferably, the device for quantitative damage of optic nerve tube is characterized in that: the optic nerve at the intraductal segment runs in the optic nerve tube, the strength of the fracture pen is large, the fracture of the optic nerve tube can be directly caused, and the optic nerve can only be damaged in the traditional mode.

Preferably, the device for quantitative damage of optic nerve tube is characterized in that: aiming at the establishment of the TON animal model, the optic nerve is quantitatively damaged in a short time through adjustable physical impact, and the method has the advantages of accuracy, high efficiency and controllability. Meanwhile, the damage caused by physical impact is closer to the condition of optic nerve damage in traffic accidents.

When in use;

1. the cylinder pressure gauge 5 is checked to ensure that the value cannot be below 6 Mpa. (the working range of the gas cylinder pressure gauge 5 is 6MPa to 30 MPa);

2. the constant pressure gauge 4 was checked to ensure that the value could not be higher than 5 Mpa. (constant pressure gauge 4 working range: 2MPa to 5 MPa);

3. opening the gas cylinder valve 3, and if the pressure value of the constant pressure gauge 4 is lower than 5Mpa, the operation can be normally carried out;

4. opening the gas cylinder valve 3, if the pressure value of the constant pressure gauge 4 is higher than 5Mpa, firstly locking the gas cylinder valve 3 clockwise, and then exhausting by pressing the snap switch 6;

5. how to adjust the constant voltage table 4: the constant pressure valve 7 is locked clockwise, the cylinder valve 3 is opened, the value of the constant pressure meter 4 is 0 at the moment, and the working pressure required to be used can be slowly adjusted from bottom to top. (Note that only slow adjustments are possible)

6. Note that: the pressure of the constant pressure gauge 4 can be adjusted only from low to high and cannot be adjusted from high to low. If the pressure adjustment exceeds the working pressure range, the operations of

items

4 and 5 must be repeated. If the pressure of the constant pressure gauge 4 is lower than the normal working range, the pressure can be directly adjusted.

7. After use, the cylinder valve is locked immediately to avoid air leakage.

These terms are used merely to more conveniently describe and explain the nature of the present invention; they are to be construed as being without limitation to any additional limitations that may be imposed by the spirit of the present invention.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An apparatus for quantifying damage to an optic nerve tube, comprising: the optic nerve tube quantitative damage device provided by the invention gives optic nerve quantitative damage through adjustable physical impact, so that model establishment of TON animal research becomes accurate, efficient and controllable, thereby better controlling variables and achieving the purpose of improving the reliability of research results, and the structure comprises: 1 gas cylinder, 2 charging connectors, 3 gas cylinder valves, 4 constant pressure meters, 5 gas cylinder manometer, 6 clap switches, 7 constant pressure valves, the gas cylinder be used for adorning high-pressure gas's bottle, the charging connectors toward the gas cylinder inside gas filled connecting device, the gas cylinder valve be used for controlling the gaseous valve in the gas cylinder, the constant pressure meter be used for showing the manometer of constant pressure room air, the gas cylinder manometer be used for showing the manometer of the air in the gas cylinder, the clap switch be used for the percussion device of shooting usefulness, the constant pressure valve be used for controlling the gaseous valve in the constant pressure room.

2. The device for quantitative damage of the optic nerve tube according to claim 1, wherein: to the establishment of TON animal model, give the optic nerve quantitative damage in the short time through adjustable physical striking, have accuracy, high efficiency, controllability, the damage that the physical striking caused simultaneously more is close to the condition of optic nerve damage in the traffic accident.

3. The device for quantitative damage of the optic nerve tube according to claim 1, wherein: the length of the pen is enough to reach the optic nerve tube directly through the nasal cavity, and the traditional method needs to expose the optic nerve.

4. The device for quantitative damage of the optic nerve tube according to claim 1, wherein: the quantitative damage to the optic nerve can be caused by adjusting the air pressure, and the method is convenient and accurate.

5. The device for quantitative damage of the optic nerve tube according to claim 1, wherein: the optic nerve at the intraductal segment runs in the optic nerve tube, the strength of the fracture pen is large, the fracture of the optic nerve tube can be directly caused, and the optic nerve can only be damaged in the traditional mode.