CN113107931B - Fluid pattern reconstruction system based on microfluid technology - Google Patents
Fluid pattern reconstruction system based on microfluid technology Download PDFInfo
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- CN113107931B CN113107931B CN202110378536.7A CN202110378536A CN113107931B CN 113107931 B CN113107931 B CN 113107931B CN 202110378536 A CN202110378536 A CN 202110378536A CN 113107931 B CN113107931 B CN 113107931B
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C4/00—Circuit elements characterised by their special functions
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D1/00—Pipe-line systems
- F17D1/02—Pipe-line systems for gases or vapours
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D1/00—Pipe-line systems
- F17D1/08—Pipe-line systems for liquids or viscous products
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D3/00—Arrangements for supervising or controlling working operations
- F17D3/01—Arrangements for supervising or controlling working operations for controlling, signalling, or supervising the conveyance of a product
Abstract
The invention relates to a fluid pattern reconstruction system based on a microfluid technology. The system comprises: a microfluidic device comprising a microfluidic pattern area for providing a patterned space for a fluid; and the micro-fluid driving device is used for driving and controlling the fluid to flow in the micro-fluid device to obtain the reconstructed micro-fluid pattern. The micro-flow pattern reconstruction system provides a pattern reconstruction design for a general micro-flow channel, reconstructs micro-flow patterns through an external micro-flow driving system, does not add new devices such as valves and the like to the original micro-flow channel, and maintains the original structure of the micro-flow channel; the microfluidic pattern reconstruction system can generate various geometric patterns for the microfluid in the microfluidic channel, and has stronger adaptability and universality compared with the prior art that a control component needs to be additionally added in the microfluidic channel.
Description
Technical Field
The invention belongs to the technical field of microfluid, and particularly relates to a system for reconstructing a microfluidic pattern by using microfluid technology to control fluid in a microfluidic channel.
Background
In recent years, with the rapid development of the universal flexible materials, many unique properties exhibited by the universal flexible materials, such as softness, deformation, lightness, thinness, and good biocompatibility, have been widely applied in the fields of biology, chemistry, medicine, electronics, and the like. In the field of microfluidics, great progress has also been made in the past few years, numerous applications have emerged including flexible displays, flexible sensors, flexible actuators, and the like, and integrated platforms with hybrid sensing and driving mechanisms have been developed. The microfluidics technology in this field is a technology for processing a small amount of fluid by using channels of a micro size (typically several tens to several hundreds of micrometers). It is mainly composed of fluid and various components for controlling fluid. Microfluidic technology has the characteristics of stably controlling fluids, performing automatic analysis through microfluidic devices, and using a small amount of fluid.
The flow path of the microfluid in the microfluidic channel is referred to as a microfluidic pattern. Manipulation of the microfluidic channel by microfluidic technology allows patterning of the already designed microfluidic channel, but since the microfluidic channel is often fixed, the pattern of the microfluidic channel formed by the microfluidic channel is often not variable. The reconstruction of the micro-flow pattern can effectively expand the application range of the micro-flow, and the micro-flow can be more effectively screened, classified, shaped and the like in the micro-flow channel. The reconstruction of microfluidic patterns will have a positive effect in the biomedical and flexible electronics fields.
In the related art, methods capable of realizing microfluidic pattern reconstruction are mainly classified into two methods: one is to reconstruct the micro-flow pattern in the relatively open micro-flow channel by the physical features of the micro-flow, such as guiding the micro-flow to a designated area by using gravitational potential energy, or changing the flowing direction of the micro-flow by the attraction of a magnet, or influencing the micro-flow pattern by electric effect and thermal effect. Although the method can flexibly control the flow of the micro-fluid, the micro-fluid channel is relatively open, and is often influenced by the external environment, particularly gravity, and has certain limitations. The second method is to actively control the flow of a micro-fluid in a micro-fluid channel by providing a micro-fluid valve in a fixed micro-fluid channel. When the micro-fluid flows in the micro-fluid channel, the opening and closing of the micro-fluid valve can determine whether the micro-fluid passes through the channel or not, so that the pattern reconstruction of the micro-fluid is realized. In such controllers, since current microfluidic valves are mostly manufactured based on mechanical actuators or microfluidic actuator designs, this inevitably results in a heavy and complex control system, which often has a great influence on the structure of the device compared to flexible and thin microfluidic channels. Therefore, designing and developing a micro-scale, flexible, simple and reliable micro-flow pattern reconstruction system will be of great significance to the development of micro-flow technology.
Disclosure of Invention
The invention aims to provide a microflow pattern reconstruction system based on a microfluid technology, which realizes the microflow pattern reconstruction of the whole microflow channel by controlling the flow speed at the inlet and the outlet of a fluid in the microflow channel.
In order to achieve the above object, the present invention provides a fluid pattern reconstruction system based on microfluidics technology, which comprises:
a microfluidic device comprising a microfluidic pattern area providing a patterned space for a fluid;
and the micro-fluid driving device is used for driving and controlling fluid to flow in the micro-fluid device to obtain the reconstructed micro-fluid pattern.
Further, the microfluidic device includes an elastomer layer and a channel layer. The elastomer layer is located outside the device and has mainly a fixing and supporting function. The channel layer is located inside the microfluidic device and is primarily responsible for the flow of the microfluidic fluid in the channel. The channel layer is provided with a micro-flow inlet, a micro-flow outlet and a micro-flow pattern area; the microfluidic inlet and the microfluidic outlet are positioned at the edge of the microfluidic channel, and the microfluidic pattern region is positioned between the microfluidic inlet and the microfluidic outlet.
Further, the structure of the micro-flow inlet and the micro-flow outlet is circular or rectangular. Optionally, the microfluidic flow inlet and the microfluidic flow outlet are on the order of micrometers or millimeters in size.
Furthermore, the micro-flow inlet and the micro-flow outlet are respectively connected with the micro-flow pattern area, and micro-flow can flow to the micro-flow pattern area through the micro-flow inlet and then flow to the micro-flow outlet area. The microflow inflow port and the microflow outflow port are opposite and can be interchanged according to the actual flowing direction.
Furthermore, the micro-flow inlet and the micro-flow outlet can be connected with an external micro-flow driving device, micro-flow can flow in at different speeds through the micro-flow inlet, and micro-flow can flow out at different speeds through the micro-flow outlet.
Further, the micro-flow patterns in the micro-flow pattern area comprise various geometric patterns, and particularly, the patterns in the micro-flow pattern area at least comprise at least two patterns. The microfluidic pattern area is composed of at least two microfluidic pattern channels, the microfluidic pattern channels are communicated with each other, and a microfluidic can flow or be static in each microfluidic pattern channel. Optionally, the microfluidic pattern channel has a dimension on the order of micrometers or millimeters.
Further, the material of the elastomer layer and the channel layer of the microfluidic device is a silicone elastomer material.
Further, the microfluidic class of microfluidic devices is any fluid (including gases and liquids) that does not react with silicone elastomers.
Further, the channels of the microfluidic device may be concurrently present with one or more fluids; the state of motion of the fluid in the device may be flowing or stationary. When the external microfluidic driving device is not driven, the fluid is in a static state in the device; when the external micro-fluid driving device starts to drive, the micro-fluid is in a flowing state in the device.
Further, the structure of the micro-fluid driving device comprises a push-in end and a pull-out end. The push-in end is connected with a micro-flow inlet of the micro-fluid device, and the pull-out end is connected with a micro-flow outlet of the micro-fluid device.
Further, the microfluidic driving device may push in a fluid from the push-in end and pull out a fluid from the pull-out end; both the push-in and the pull-out pressures can be independently controlled by the microfluidic driving device. The maximum pressure of pushing in the micro-fluid driving device is 2Pa, and the maximum pressure of pulling out the micro-fluid driving device is-1 Pa.
Furthermore, a pushing end and a drawing end of the microfluid driving device are respectively provided with a valve; the valve may be a solenoid valve or a microfluidic valve. When the valve at the pushing end is opened, the fluid can flow into the microflow inflow port of the microflow device through the pushing end; when the valve at the push-in end is closed, the micro-flow stops pushing the fluid into the micro-flow inlet of the micro-fluid device; when the valve at the extraction end is opened, the fluid can be extracted to the extraction end through the micro-fluid outflow port of the micro-fluid device; when the valve at the withdrawal end is closed, the microflow stops discharging fluid to the microflow outlet of the microfluidic device.
Further, through the control of the microfluid driving device, a plurality of reconstruction states of the fluid pattern are realized; the reconfiguration state includes: a full filling state in which all the microfluidic patterns are filled, a full emptying state in which all the microfluidic patterns are emptied, and a microfluidic pattern filling state in which various microfluidic patterns are separately filled.
Compared with the prior art, the invention has the following positive effects:
the micro-flow pattern reconstruction system provides a pattern reconstruction design for a general micro-flow channel, reconstructs micro-flow patterns through an external micro-flow driving system, does not add new devices such as valves and the like to the original micro-flow channel, and maintains the original structure of the micro-flow channel; the microfluidic pattern reconstruction system can generate various geometric patterns for the microfluid in the microfluidic channel, and has stronger adaptability and universality compared with the prior art that a control component needs to be additionally added in the microfluidic channel.
Drawings
FIG. 1 is a schematic view of a fluid pattern reconstruction system of the present invention.
FIG. 2 is a schematic diagram of a microfluidic device of the fluid pattern reconstruction system of the present invention.
Fig. 3a, 3b and 3c are schematic views illustrating the driving principle of the fluid pattern reconstruction system according to the present invention.
Detailed Description
In order to make the aforementioned features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below.
The embodiment provides a system for reconstructing a microfluidic pattern by manipulating a fluid in a microfluidic channel by using a microfluidic technology, which comprises a microfluidic device and a microfluidic driving device, as shown in fig. 1, wherein 7 is the microfluidic device, and 1-6 constitute the microfluidic driving device. The micro-fluid driving device comprises a pushing end and a pulling end, in the embodiment, the micro-fluid driving device 1, the micro-fluid pipeline 3 and the micro-fluid valve 5 are used as the pushing end, and the micro-fluid driving device 2, the micro-fluid pipeline 4 and the micro-fluid valve 6 are used as the pulling end. In other embodiments, 1, 3, and 5 may be used as the extraction end, and 2, 4, and 6 may be used as the push-in end.
Wherein the microfluidic device 7 comprises an elastomer layer and a channel layer. The elastomer layer is positioned outside and mainly has the functions of fixing and supporting; the channel layer is located inside and is mainly responsible for the flow of the microflows in the channel. The channel layer is provided with a micro-flow inlet, a micro-flow outlet and a micro-flow pattern area; the micro-flow inlet and the micro-flow outlet are positioned at the edge of the micro-flow channel, and the micro-flow pattern area is positioned between the micro-flow inlet and the micro-flow outlet.
Here, the present invention is not limited to a specific configuration form for the micro flow driving devices 1, 2. The micro-fluidic drive device 1 can stably and controllably push fluid into the micro-fluidic tubing 3; the micro-fluidic drive device 2 can stably and controllably withdraw fluid from the micro-fluidic tubing 4.
Wherein the fluid movement state in the channel can be realized by controlling the fluid pushing-in of the micro-fluid driving device 1 and the fluid pulling-out of the micro-fluid driving device 2.
Because the invention does not limit the specific content form of the microfluidic pipeline, the material and the size of the microfluidic pipeline only need to be matched with the equipment at the connecting part. In particular, the flexibility of the microfluidic conduit needs to be moderate, not to deform the walls of the tube due to the pressure of the fluid.
The microfluidic valve 5 is provided with at least one microfluidic inlet channel and one microfluidic outlet channel, and the microfluidic inlet channel is connected with the microfluidic driving device 1 through the microfluidic pipeline 3; the microfluidic outlet channel is connected to a microfluidic inlet port of a microfluidic device 7 via a microfluidic channel 3.
Wherein, the fluid can only flow from the micro-flow inlet to the micro-flow outlet of the micro-flow valve 5; the microfluidic valve 5 can control the on-off of the microfluidic. When the microfluidic valve 5 is in passage, the fluid can be pushed into the microfluidic inlet of the microfluidic device 7 directly by the microfluidic driving device 1 and flows into the microfluidic device 7; when the microfluidic valve 5 is open, fluid is no longer pushed into the microfluidic flow inlet of the microfluidic device 7 by the microfluidic driving device 1, i.e. no fluid enters the microfluidic flow inlet of the microfluidic device 7.
The microfluidic valve 6 is provided with at least one microfluidic inlet channel and one microfluidic outlet channel, and a microfluidic outlet of the microfluidic device 7 is connected with the microfluidic inlet channel through the microfluidic pipeline 4; the microfluidic outlet channel is connected to the microfluidic drive device 2 via a microfluidic channel 4.
Wherein, the fluid can only flow from the micro-flow inlet to the micro-flow outlet of the micro-flow valve 6; the microfluidic valve 6 can control the on-off of the microfluidic. When the microfluidic valve 6 is open, the fluid can be directly pumped out from the microfluidic outlet of the microfluidic device 7 and flow into the microfluidic driving device 2; when the microfluidic valve 6 is open, fluid is no longer drawn out to the microfluidic drive device 2 by the microfluidic outlet of the microfluidic device 7, i.e. no fluid is drawn out by the microfluidic outlet of the microfluidic device 7.
The micro-flow inlet and outlet of the micro-fluid device 7 are connected to external equipment through micro-flow pipes 3 and 4, respectively.
The content form of the schematic structural diagram of the microfluidic device shown in fig. 2 is not specifically limited, and the microfluidic pattern region of the channel layer of the microfluidic device is composed of at least two microfluidic patterns. A typical pattern is shown in the schematic diagram:
1) the micro flow pattern 21 is a pie-shaped micro flow pattern.
2) The microfluidic pattern 22 is a linear microfluidic pattern.
Wherein, the micro-flow pattern 21 and the micro-flow pattern 22 are communicated with each other, and the fluid can enter the micro-flow pattern of each other from the communication channel; the fluid needs to be composed of two different types of fluid, fluid a being the fill fluid and fluid B being the make-up fluid.
The fluid pattern reconstruction system of the present embodiment has a total of four reconstruction states, and the specific states are shown in table 1.
TABLE 1 four reconstitution states
| The |
The |
|
| The microfluidic pattern 22 is fluid A | Full fill | Linear type microflow pattern |
| The microfluidic pattern 22 is fluid B | Patty-shaped microflow pattern | Full emptying |
When the microfluidic patterns 21 and 22 are all filled with the fluid a, a full-filling state is presented; when the microfluidic patterns 21 and 22 are completely supplemented by the fluid B, a completely empty state is presented; when the micro-flow pattern 21 is filled with the fluid A and the micro-flow pattern 22 is supplemented with the fluid B, a cake-shaped micro-flow pattern state is presented; when the microfluidic pattern 22 is filled with the fluid a and the microfluidic pattern 21 is supplemented with the fluid B, a linear microfluidic pattern state is presented.
The driving process of the present embodiment is explained in detail in the driving principle diagram of fig. 3. Fig. 3a shows the process of fluid full extraction, fig. 3b shows the process of fluid full filling, and fig. 3c shows the process of fluid filling in the microfluidic pattern 22. For ease of understanding, a brief implementation thereof is now described as follows:
in fig. 3a, the microfluidic valve at the push-in end is closed, the microfluidic valve at the pull-out end is opened, and the device of the microfluidic driving system at the pull-out end performs fluid extraction, so that the fluid in the microfluidic patterns 21 and 22 can be extracted.
In fig. 3b, the whole fluid pumping process as shown in fig. 3a is performed, and then the microfluidic valve at the push-in end is opened, the microfluidic valve at the pump-out end is closed, and the device of the microfluidic driving system at the push-in end performs fluid pushing. After full filling, the microfluidic valve at the push-in end and the microfluidic valve at the pull-out end are both closed. In particular, if the filling is not complete, the above operation is repeated.
In fig. 3c, the microfluidic valve at the push-in end and the microfluidic valve at the pull-out end are both open, the device of the microfluidic driving system at the push-in end performs fluid push-in, and the device of the microfluidic driving system at the pull-out end performs fluid pull-out; wherein the speed of the push-in and the pull-out are substantially the same, the underlying microfluidic pattern 22 may be filled.
The implementation of the two patterns for the fluid pattern reconstruction system of the present embodiment is as follows.
1) Microfluidic pattern 21 reconstruction process: the micro-flow pattern 21 is obtained by performing the whole extraction in the process shown in fig. 3a, then performing the whole filling of the liquid a, i.e. the filling liquid, in the process shown in fig. 3B, and finally performing the supplement of the liquid B, i.e. the supplement liquid, to the micro-flow pattern 22 in the process shown in fig. 3 c.
2) Microfluidic pattern 22 reconstruction process: the micro-flow pattern 22 can be obtained by performing the whole extraction in the process shown in fig. 3a, then performing the whole filling of the liquid B, i.e., the supplementary liquid, in the process shown in fig. 3B, and finally performing the filling of the liquid a, i.e., the filling liquid, in the micro-flow pattern 22 in the process shown in fig. 3 c.
The method of the present invention has been described in detail by way of the form expression and examples, but the specific embodiment of the present invention is not limited thereto. Various obvious changes and modifications can be made therein by one skilled in the art without departing from the spirit and principles of the process of the invention. The protection scope of the present invention shall be subject to the claims.
Claims (5)
1. A fluid pattern reconstruction system based on microfluidic technology, comprising:
a microfluidic device comprising a microfluidic pattern region providing patterned spaces for fluid;
the microfluid driving device is positioned outside the microfluid device and used for driving and controlling fluid to flow in the microfluid device to obtain a reconstructed microfluid pattern;
the microfluidic device comprises an elastomer layer for supporting and a channel layer for fluid flow; the channel layer comprises a micro-flow inlet, a micro-flow outlet and a micro-flow pattern area, and the micro-flow pattern area is positioned between the micro-flow inlet and the micro-flow outlet; the microfluidic driving device is connected with the microfluidic inlet and the microfluidic outlet;
the microfluidic pattern area comprises at least two microfluidic pattern channels, and the microfluidic pattern channels are communicated with each other;
the microfluid driving device comprises a pushing end and a pulling end, the pushing end is connected with a microfluid inflow port of the microfluid device, the pulling end is connected with a microfluid outflow port of the microfluid device, fluid is pushed into the microfluid device from the pushing end, and the fluid is pulled out of the microfluid device from the pulling end;
the push-in end and the pull-out end of the microfluid driving device are respectively provided with a valve; when the valve at the pushing end is opened, the fluid flows into the microflow inflow port of the microflow device through the pushing end; when the valve of the push-in end is closed, stopping pushing the fluid into the microflow inflow port of the microfluid device; when the valve at the extraction end is opened, the fluid is extracted to the extraction end through the micro-fluid outflow port of the micro-fluid device; stopping the discharge of fluid to the microfluidic flow outlet of the microfluidic device when the valve at the withdrawal end is closed;
through the control of the microfluid driving device, realizing a plurality of reconstruction states of a fluid pattern in the microfluid device; the reconfiguration state includes: a full filling state in which all the microfluidic patterns are filled, a full emptying state in which all the microfluidic patterns are emptied, and a microfluidic pattern filling state in which various microfluidic patterns are individually filled.
2. The system of claim 1, wherein one or more fluids are present in each microfluidic pattern channel, and the microfluidic channels are capable of flowing or standing still; when the micro-fluid driving device is not driven, the fluid is in a static state; when the microfluid driving device is driven, the microfluid is in a flowing state.
3. The microfluidic technology based fluid pattern reconstruction system of claim 1, wherein the microfluidic flow inlet and outlet are circular or rectangular in configuration; the sizes of the micro-flow inlet and the micro-flow outlet are in a micron scale or a millimeter scale.
4. The microfluidic based fluid pattern reconstruction system of claim 1, wherein the microfluidic flow inlet and the microfluidic flow outlet are opposite and interchangeable according to actual flow direction.
5. The microfluidic based fluid pattern reconstruction system of claim 1, wherein the pressures of fluid push-in and pull-out are independently controlled by the microfluidic driving device, the maximum pressure for push-in is 2Pa and the maximum pressure for pull-out is-1 Pa.
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Citations (4)
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| CN102124259A (en) * | 2008-05-16 | 2011-07-13 | 哈佛大学 | Valves and other flow control in fluidic systems including microfluidic systems |
| CN102896005A (en) * | 2011-07-25 | 2013-01-30 | 罗伯特·博世有限公司 | Micro-fluidic device having chambers for storing liquid |
| CN106459869A (en) * | 2014-03-11 | 2017-02-22 | 伊鲁米那股份有限公司 | Disposable, integrated microfluidic cartridge and methods of making and using same |
| CN107937270A (en) * | 2017-11-17 | 2018-04-20 | 清华大学深圳研究生院 | A kind of micro-fluidic chip nozzle and biological 3D printer |
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| ATE432420T1 (en) * | 2003-03-10 | 2009-06-15 | Univ Michigan | INTEGRATED MICROFLUIDIC CONTROL DEVICE WITH PROGRAMMABLE TACTILE ACTUATORS |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102124259A (en) * | 2008-05-16 | 2011-07-13 | 哈佛大学 | Valves and other flow control in fluidic systems including microfluidic systems |
| CN102896005A (en) * | 2011-07-25 | 2013-01-30 | 罗伯特·博世有限公司 | Micro-fluidic device having chambers for storing liquid |
| CN106459869A (en) * | 2014-03-11 | 2017-02-22 | 伊鲁米那股份有限公司 | Disposable, integrated microfluidic cartridge and methods of making and using same |
| CN107937270A (en) * | 2017-11-17 | 2018-04-20 | 清华大学深圳研究生院 | A kind of micro-fluidic chip nozzle and biological 3D printer |
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