CN113105655A - Cartilage bionic hydrogel capable of swelling and enhancing mechanical property and preparation method and application thereof - Google Patents

Cartilage bionic hydrogel capable of swelling and enhancing mechanical property and preparation method and application thereof Download PDF

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CN113105655A
CN113105655A CN202110412805.7A CN202110412805A CN113105655A CN 113105655 A CN113105655 A CN 113105655A CN 202110412805 A CN202110412805 A CN 202110412805A CN 113105655 A CN113105655 A CN 113105655A
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hydrogel
swelling
cartilage
mechanical property
crosslinking
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李建树
俞鹏
谢婧
潘哲宇
徐心源
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Sichuan University
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Sichuan University
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/38—Esters containing sulfur
    • C08F220/382—Esters containing sulfur and containing oxygen, e.g. 2-sulfoethyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
    • C08F220/585—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine and containing other heteroatoms, e.g. 2-acrylamido-2-methylpropane sulfonic acid [AMPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters
    • C08J2333/14—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
    • C08J2333/24—Homopolymers or copolymers of amides or imides

Abstract

The invention belongs to the field of high molecular functional materials, and particularly relates to cartilage bionic water capable of swelling and enhancing mechanical propertyGel, preparation method and application thereof, anion hydrogel rich in sulfonic acid and carboxylic acid groups is prepared, and Fe is enhanced through swelling behavior of anion hydrogel3+Secondary crosslinking of the hydrogel. The swelling property of the hydrogel can increase Fe3+Permeability in hydrogels, and providing sufficient space for Fe3+and-COO‑Chelation between them. The hydrogel designed by cartilage bionics has a large-pore-small-pore alternate structure, and is prepared by using a method of preparing a hydrogel3+And after crosslinking has a compressive modulus of 2.88 MPa. At the same time, the hydrogel has a consumption of H2O2Not only does not generate OH during the process, but also can remove H2O2Self-decomposing the generated free radicals. The cartilage bionic hydrogel with the mechanical property enhanced by swelling has wide application prospect in cartilage tissue engineering.

Description

Cartilage bionic hydrogel capable of swelling and enhancing mechanical property and preparation method and application thereof
Technical Field
The invention belongs to the field of high-molecular functional materials, and relates to a cartilage bionic hydrogel capable of swelling and enhancing mechanical properties, a preparation method and application thereof, which can be used for cartilage replacement, has high mechanical properties and anti-inflammatory properties, and has a wide biological application scene.
Background
Osteoarthritis is one of the concentrated common diseases threatening human health at present, and the main clinical manifestation of osteoarthritis is cartilage damage[1]. Healthy articular cartilage mainly comprises molecules such as type II collagen, phospholipid molecular layers, chondroitin sulfate, hyaluronic acid and the like, provides excellent lubricating property and mechanical property for cartilage, but along with osteoarthritis or other mechanical cartilage injuries, cartilage matrix can be gradually lost, so that the lubricating property and the mechanical property of cartilage are weakened[2]. In addition, in the course of development of osteoarthritis, inflammation-related molecules (e.g., H)2O2And active oxygen) can further cause the cartilage to lose normal physiological functions[3,4]. Therefore, a material with both mechanical property and H is constructed2O2The articular cartilage substitute material with ROS removing capability has great scientific significance for cartilage repair and osteoarthritis treatment.
The cartilage replacement materials commonly used at present are mainly hydrogels, but most of the hydrogels gradually weaken or even lose the mechanical properties along with the generation of swelling behavior, so that the cartilage replacement materials cannot achieve long-term effects on the aspect of mechanical support.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a cartilage bionic hydrogel with swelling enhanced mechanical property and a preparation method and application thereof2O2ROS scavenging ability and lubricating properties, provides a solution for cartilage replacement hydrogel materials.
The specific technical scheme is as follows:
a preparation method of cartilage bionic hydrogel with swelling enhanced mechanical property is provided, anion hydrogel rich in sulfonic acid and carboxylic acid groups is prepared, and Fe is enhanced through swelling behavior of the anion hydrogel3+Secondary crosslinking of the hydrogel.
The method specifically comprises the following steps: dissolving a sulfonic acid monomer, a carboxylic acid monomer, a cross-linking agent and a photoinitiator in ultrapure water, and performing ultraviolet crosslinking to obtain hydrogel; after removal of unreacted monomer, with 0.1M Fe3+And co-culturing the solution to obtain the cartilage bionic hydrogel with swelling enhanced mechanical property.
The sulfonic acid monomer is SPMK or AMPS; the carboxylic acid monomer is acrylic acid or 1-butenoic acid; the cross-linking agent is N, N' -bis (methacrylamide); the photoinitiator is I2959.
Further, the method specifically comprises the following steps according to the following material ratio:
s1, preparing PSPMK/PAA hydrogel
Accurately weighing 3-sulfopropyl methacrylate potassium Salt (SPMK), acrylic acid (AAc), a cross-linking agent (N, N' -bismethacrylamide) (MBA) and a photoinitiator in a 15mL sterile centrifuge tube, adding ultrapure water, and then ultrasonically dissolving, wherein the final liquid volume is controlled to be 15 mL; adding the prepared monomer solution into a 48-pore plate, and crosslinking into gel by ultraviolet irradiation;
s2, preparing Fe-PSPMK/PAA hydrogel
Step 1The prepared hydrogel is taken out and placed in 0.1M FeCl3In aqueous solution, to be Fe3+And (3) completely crosslinking to obtain the Fe-PSPMK/PAA hydrogel.
The hydrogel obtained by the invention has a large-pore-small-pore alternate structure; enhancement of Fe by swelling behavior3+The permeability in the hydrogel further improves the crosslinking and enhances the mechanical property of the hydrogel; also, the hydrogel has a hydrogen peroxide (H) consumption2O2) And the ability to scavenge hydroxyl radicals (. OH). The cartilage bionic hydrogel can be used as a cartilage replacement material.
Compared with the prior art, the invention has the following beneficial technical effects:
1. the invention provides a cartilage bionic hydrogel with swelling enhanced mechanical property, which is prepared by the following specific steps of preparing anion hydrogel rich in sulfonic acid/carboxylic acid, and enhancing Fe in the swelling process of the hydrogel3+The permeability in the hydrogel is increased, so that the physical crosslinking sites are increased, and the mechanical property of the hydrogel is enhanced.
2. The invention proves the mechanical property, the lubricating property and the H resistance of the Fe-PSPMK/PAA hydrogel through experiments2O2And hydroxyl radical scavenging ability. Therefore, the hydrogel can meet the requirements of cartilage repair in an osteoarthritis environment. Meanwhile, the hydrogel preparation process is simple in flow, does not need special equipment and equipment, and is easy to realize batch production and application and popularization.
Drawings
FIG. 1 is a scanning electron micrograph of the hydrogel prepared in example 1.
FIG. 2 is an infrared spectrum of the PSPMK/PAA hydrogel prepared in example 1.
FIG. 3 is a scanning electron micrograph of the Fe-PSPMK/PAA hydrogel of example 2 showing different degrees of crosslinking.
FIG. 4 is the change in swelling ratio of PSPMK/PAA hydrogel in pure water in example 4.
FIG. 5a is a PSPMK/PAA hydrogel at 0.1MFe as in example 43+One of the swelling-crosslinking relationships in solution.
FIG. 5b is PS in example 4PMK/PAA hydrogel at 0.1MFe3+The second relationship of swelling-crosslinking in solution.
FIG. 6a is the stress-strain curve of the PSPMK/PAA hydrogel in example 5.
FIG. 6b is the stress-strain curve of the Fe-PSPMK/PAA hydrogel in example 5.
FIG. 6c is a comparison of the compressive elastic modulus of the PSPMK/PAA and Fe-PSPMK/PAA hydrogels of example 5.
FIG. 7 is a graph of the different Fe-PSPMK/PAA hydrogel pairs H of example 62O2And comparing the consumption capacity.
FIG. 8 is a comparison of OH scavenging ability of different Fe-PSPMK/PAA hydrogels of example 7.
Detailed Description
The cartilage biomimetic hydrogel with swelling enhanced mechanical property and the preparation method thereof provided by the invention are further explained by the following examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and those skilled in the art can make certain insubstantial modifications and adaptations of the present invention based on the above disclosure and still fall within the scope of the present invention.
Example 1
In this embodiment, a method for preparing a PSPMK/PAA hydrogel is provided, which includes the following steps:
accurately weighing 3-sulfopropyl methacrylate potassium Salt (SPMK), acrylic acid (AAc), a cross-linking agent N, N' -bis (methacrylamide) (MBA) and a photoinitiator I2959 into a 15mL sterile centrifuge tube, adding ultrapure water, and dissolving by ultrasonic waves to control the final liquid volume to be 15 mL. Wherein, the using amount (10mmol/L) of MBA is 0.5 percent of the molar concentration of the monomer, and the using amount of the photoinitiator is 1 percent by weight. Adding the prepared monomer solution into a 48-pore plate, and crosslinking into gel by ultraviolet irradiation. The amounts of each component of each design group are shown in table 1:
TABLE 1
Figure BDA0003024577350000031
Example 1 hydrogel preparation scanning electron micrographs are shown in fig. 1, and the infrared spectra of the hydrogels are shown in fig. 2.
Example 2
In this embodiment, a method for preparing an Fe-PSPMK/PAA hydrogel is provided, which includes the following steps:
the PSPMK/PAA hydrogel obtained in example 1 was taken out, and the unreacted monomer was thoroughly washed with ultrapure water. Next, 0.1M Fe was prepared3+The solution comprises the following specific steps: 13.515g of ferric chloride hexahydrate (FeCl) were correctly weighed3·6H2O) dissolved in ultrapure water and finally brought to a constant volume of 100mL by means of a volumetric flask, in which case Fe is present3+The concentration of (A) is 0.5M, and the concentration of (B) is 0.1M Fe after being diluted by 5 times each time3+And (3) solution. And (3) placing each gel in 10mL of solution, and obtaining the Fe-PSPMK/PAA hydrogel after iron ions are fully crosslinked.
Scanning electron micrographs of the obtained Fe-PSPMK/PAA hydrogel of different crosslinking degrees are shown in FIG. 3.
Example 3
In this example, the preparation of hydrogel, which is designated as Fe-PAMPS/PAA, was substantially the same as in example 1 except that the ester bond in the sulfonic acid monomer in example 1 was replaced with an amide bond. Wherein, the chemical structure of the sulfonic acid monomer used as the main structure of the hydrogel is shown as the formula (I):
Figure BDA0003024577350000032
example 4
In this example, the preparation of a hydrogel was substantially the same as in examples 1 and 2, except that the acrylic acid monomer in example 1 was replaced with 1-butenoic acid, and this hydrogel was designated as Fe-PSPMK/PBA.
The swelling ratio of the PSPMK/PAA hydrogel in pure water in example 4 changes as shown in FIG. 4. PSPMK/PAA hydrogel at 0.1MFe3+The swelling-crosslinking relationship in solution is shown in fig. 5a and 5 b.
Example 5
In this example, a preparation scheme of a hydrogel was substantially the same as that of example 1 and example 2, except that the sulfonic acid monomer and the acrylic acid monomer in example 1 were replaced with AMPS monomer and 1-butenoic acid monomer, respectively, and the hydrogel was referred to as Fe-PAMPS/PBA.
The stress-strain curve of the PSPMK/PAA hydrogel is shown in FIG. 6 a. The stress-strain curve of the Fe-PSPMK/PAA hydrogel is shown in FIG. 6 b. The compressive modulus of elasticity for the PSPMK/PAA and Fe-PSPMK/PAA hydrogels is plotted in FIG. 6 c.
Example 6
In this example, swelling of hydrogel and Fe by weighing3+The relationship between crosslinks was tested. The specific test steps are as follows:
the hydrogel was prepared substantially the same as in example 1, except that the mold used was changed to a 96-well plate and the liquid volume per well was 200. mu.L. Respectively placing the prepared hydrogel in ultrapure water and 0.1M Fe3+The total volume of the solution was 10 mL. At a predetermined time point, the hydrogel was taken out, rinsed 3 times with ultrapure water, and then the hydrogel surface was wiped dry with filter paper and weighed, and the swelling ratio of the hydrogel was calculated by the formula (II).
Figure BDA0003024577350000041
Wherein, WtIs the wet weight of the hydrogel at time t, W0Is the wet weight of the hydrogel at the initial time.
FIG. 4 reflects that the introduction of the PSPMK component in aqueous solution can increase the swelling ratio of the hydrogel. FIGS. 5a and 5b show PSPMK/PAA in Fe3+The mass change in the solution mainly goes through 3 stages, the stage I is dominated by the swelling behavior of the hydrogel, and the mass is mainly increased; stage II from Fe3+The crosslinking is dominant, mainly reflected in reduced quality; in stage III, swelling and crosslinking are substantially balanced and the quality of the hydrogel is substantially maintained.
Example 7
In this example, a universal tensile testing machine was used to test the mechanical properties of the hydrogel. The hydrogel was prepared substantially the same as in examples 1 and 2, except that the volume of liquid added to the well plate in the examples was changed to 800. mu.L. The mechanical test is mainly a compression test, the compression speed is set to be 2mm/min, and the test can be stopped when the strain reaches 50%. FIG. 7 illustrates that the mechanical properties of the hydrogel are significantly increased after Fe ion crosslinking.
Example 8
In this example, the absorbance method was used to detect H in hydrogel pairs2O2The consumption capability of (c). The method comprises the following specific steps: the Fe-PSPMK/PAA hydrogel prepared in step 2 was mixed with 5mL of 1mMH2O2Co-culturing the solution under the following culture conditions: protected from light at 37 ℃. At the prescribed time point, 50. mu.L of the culture broth was taken out into a 96-well plate, cocultured with 100. mu.L of a titanium sulfate solution for half an hour, and the absorbance at 405nm was measured with a microplate reader. FIG. 8 shows the hydrogel after Fe crosslinking for H2O2There are different levels of consumption.
Example 9
In this example, a fluorescence spectrophotometer was used to test the H consumption of Fe-PSPMK/PAA hydrogel2O2Whether or not a hydroxyl radical (. OH) is generated in the process of (1). The specific test steps are as follows: reacting the hydrogel prepared in step 2 with H2O2Co-culturing in solution and terephthalic acid solution, wherein H2O2The solution concentration was 1mM, and the culture conditions were: protected from light, water bath at 37 ℃ for 12 hours. After the co-culture was completed, the fluorescence value was measured using a fluorescence spectrophotometer with an excitation wavelength of 345nm and an emission wavelength of 450 nm. FIG. 9 shows the consumption of H for Fe-PSPMK/PAA hydrogel2O2Does not generate OH and can scavenge H2O2OH produced by spontaneous decomposition.

Claims (6)

1. The preparation method of the cartilage bionic hydrogel with swelling enhanced mechanical property is characterized in that the anion hydrogel rich in sulfonic acid and carboxylic acid groups is prepared, and Fe is enhanced through the swelling behavior of the anion hydrogel3+Secondary crosslinking of the hydrogel.
2. The method for preparing cartilage bionic hydrogel with swelling enhanced mechanical property according to claim 1, which comprises the following steps: dissolving a sulfonic acid monomer, a carboxylic acid monomer, a cross-linking agent and a photoinitiator in ultrapure water, and performing ultraviolet crosslinking to obtain hydrogel; after removal of unreacted monomer, with 0.1M Fe3+And co-culturing the solution to obtain the cartilage bionic hydrogel with swelling enhanced mechanical property.
3. The method for preparing cartilage biomimetic hydrogel with swelling enhanced mechanical property according to claim 2, wherein the sulfonic acid monomer is SPMK or AMPS; the carboxylic acid monomer is acrylic acid or 1-butenoic acid; the cross-linking agent is N, N' -bis (methacrylamide); the photoinitiator is I2959.
4. The method for preparing the cartilage bionic hydrogel with swelling enhanced mechanical property according to claim 1, which is characterized by comprising the following steps according to the following ratio:
s1, preparing PSPMK/PAA hydrogel
Accurately weighing 3-sulfopropyl methacrylate potassium Salt (SPMK), acrylic acid (AAc), a cross-linking agent (N, N' -bismethacrylamide) (MBA) and a photoinitiator in a 15mL sterile centrifuge tube, adding ultrapure water, and then ultrasonically dissolving, wherein the final liquid volume is controlled to be 15 mL; adding the prepared monomer solution into a 48-pore plate, and crosslinking into gel by ultraviolet irradiation;
s2, preparing Fe-PSPMK/PAA hydrogel
Taking out the hydrogel prepared in the step 1 and placing the hydrogel in 0.1M FeCl3In aqueous solution, to be Fe3+And (3) completely crosslinking to obtain the Fe-PSPMK/PAA hydrogel.
5. A biomimetic hydrogel of cartilage with enhanced mechanical properties by swelling, obtained by the method of any one of claims 1 to 4.
6. Use of a biomimetic hydrogel of cartilage with swelling enhancing mechanical properties, wherein the biomimetic hydrogel of cartilage according to claim 5 is used as a cartilage replacement material.
CN202110412805.7A 2021-04-16 2021-04-16 Cartilage bionic hydrogel capable of swelling and enhancing mechanical property and preparation method and application thereof Pending CN113105655A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107737370A (en) * 2017-11-20 2018-02-27 西南交通大学 It is a kind of to be used for the high-strength of repair of cartilage, superlastic, the preparation method of conductive hydrogel
CN108976350A (en) * 2018-06-01 2018-12-11 南京理工大学 A kind of bionic joint cartilage polyion complex compound hydrogel and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107737370A (en) * 2017-11-20 2018-02-27 西南交通大学 It is a kind of to be used for the high-strength of repair of cartilage, superlastic, the preparation method of conductive hydrogel
CN108976350A (en) * 2018-06-01 2018-12-11 南京理工大学 A kind of bionic joint cartilage polyion complex compound hydrogel and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHOWDHURY NOMAN, ET AL: "Role of Ionic Moieties in Hydrogel Networks to Remove Heavy Metal Ions from Water", 《ACS OMEGA》 *
LIN PENG,ET AL: "Molecularly Engineered Dual-Crosslinked Hydrogel with Ultrahigh Mechanical Strength, Toughness, and Good Self-Recovery", 《ADVANCED MATERIALS》 *
余娜: "P（AA/AMPS）及PVA-P（AA/AMPS）智能水凝胶的研究", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技Ⅰ辑》 *

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Application publication date: 20210713