CN113105019A - Method for decomposing morphine in pharmaceutical factory waste liquid - Google Patents

Method for decomposing morphine in pharmaceutical factory waste liquid Download PDF

Info

Publication number
CN113105019A
CN113105019A CN202110378509.XA CN202110378509A CN113105019A CN 113105019 A CN113105019 A CN 113105019A CN 202110378509 A CN202110378509 A CN 202110378509A CN 113105019 A CN113105019 A CN 113105019A
Authority
CN
China
Prior art keywords
waste liquid
morphine
pharmaceutical factory
decomposing
exchange resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110378509.XA
Other languages
Chinese (zh)
Inventor
陆西颖
陆红羽
黎均宝
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangxi Guorui Engineering Consulting Co ltd
Original Assignee
Guangxi Guorui Engineering Consulting Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangxi Guorui Engineering Consulting Co ltd filed Critical Guangxi Guorui Engineering Consulting Co ltd
Priority to CN202110378509.XA priority Critical patent/CN113105019A/en
Publication of CN113105019A publication Critical patent/CN113105019A/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F9/00Multistage treatment of water, waste water or sewage
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/52Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities
    • C02F1/5236Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities using inorganic agents
    • C02F1/5245Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities using inorganic agents using basic salts, e.g. of aluminium and iron
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/72Treatment of water, waste water, or sewage by oxidation
    • C02F1/722Oxidation by peroxides
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/72Treatment of water, waste water, or sewage by oxidation
    • C02F1/76Treatment of water, waste water, or sewage by oxidation with halogens or compounds of halogens
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/42Treatment of water, waste water, or sewage by ion-exchange
    • C02F2001/425Treatment of water, waste water, or sewage by ion-exchange using cation exchangers
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2101/00Nature of the contaminant
    • C02F2101/30Organic compounds
    • C02F2101/38Organic compounds containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2103/00Nature of the water, waste water, sewage or sludge to be treated
    • C02F2103/34Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32
    • C02F2103/343Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32 from the pharmaceutical industry, e.g. containing antibiotics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Hydrology & Water Resources (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Removal Of Specific Substances (AREA)

Abstract

The invention belongs to the technical field of pharmaceutical factory sewage treatment, and particularly relates to a method for decomposing morphine in pharmaceutical factory waste liquid. A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps: (1) adding a decomposer into the morphine-containing pharmaceutical factory waste liquid, stirring and mixing, and fully reacting; (2) adding a flocculating agent into the mixed solution after the reaction, stirring and mixing, and standing for 1-3 h; (3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate; (4) and (4) adding cation exchange resin into the filtrate obtained in the step (3) for adsorption, detecting waste liquid, and discharging after the waste liquid reaches the standard. The method can effectively decompose morphine in the pharmaceutical factory waste liquid, and has the advantages of simple operation, high efficiency and low cost.

Description

Method for decomposing morphine in pharmaceutical factory waste liquid
Technical Field
The invention belongs to the technical field of pharmaceutical factory sewage treatment, and particularly relates to a method for decomposing morphine in pharmaceutical factory waste liquid.
Background
Morphine (Morphine), an opioid receptor agonist, is present in an amount of 4-21% in the opioid, averaging about 10%. The IUPAC name is 7,8-Didehydro-4, 5-epoxy-17-methyl-morphine-3, 6-diol. Molecular formula C17H19NO3And the molecular weight is 285.3.
In 1806 German chemist Zeerdina first isolated it from opium and named morphine using the name Greek dream Morpheus. Morphine hydrochloride which is a derivative thereof is a common anesthetic in clinic, has extremely strong analgesic effect, has better selectivity of the analgesic effect, is used for treating severe pain caused by trauma, operation, burn and the like, is also used for treating angina caused by myocardial infarction, and can be used as an analgesic, antitussive and antidiarrheal agent; the diacetate of morphine is also known as heroin. But the biggest disadvantage is the high addiction. The method can lead a long-term smoker to have serious dependence on morphine from both physical and psychological aspects, and cause serious toxicomania, thereby causing great harm to the smoker and the society.
According to the prejudicial Law of the people's republic of China, drugs include opium, heroin, methamphetamine (methamphetamine), morphine, marijuana, cocaine, and other narcotics and psychotropic drugs regulated by the state of medicine that can induce cravings.
At present, due to the production process, a small amount of morphine needs to be added in the production process of cough syrup in some domestic pharmaceutical factories, but the morphine remains in the waste liquid, and if the morphine is not removed, the morphine enters a water body or is absorbed by crops along with the discharge of the waste liquid and enters a food chain, so that the morphine influences the human body.
Therefore, it is urgent to develop a method for decomposing morphine in the waste liquid of pharmaceutical factory.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
Disclosure of Invention
The invention provides a method for decomposing morphine in pharmaceutical factory waste liquid, which can effectively decompose morphine in the pharmaceutical factory waste liquid and has the advantages of simple operation, high efficiency and low cost.
In order to achieve the purpose, the invention adopts the following technical scheme:
a method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding a decomposer into the morphine-containing pharmaceutical factory waste liquid, stirring and mixing, and fully reacting to obtain a mixed solution;
(2) adding a flocculating agent into the mixed solution after the reaction, stirring and mixing, and standing for 1-3 h;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) and (4) adding cation exchange resin into the filtrate obtained in the step (3) for adsorption, detecting waste liquid, and discharging after the waste liquid reaches the standard.
Preferably, the decomposing agent in step (1) is chlorine dioxide or hydrogen peroxide.
Preferably, the flocculant in the step (2) is polyaluminium chloride or ferrous sulfate.
Preferably, the cation exchange resin in step (4) is a macroporous strongly acidic styrene cation exchange resin.
Preferably, the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
Compared with the prior art, the invention has the following beneficial effects:
the method can effectively decompose morphine in the pharmaceutical factory waste liquid, and has the advantages of simple operation, high efficiency and low cost.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. It is intended that all modifications or alterations to the methods, procedures or conditions of the present invention be made without departing from the spirit or essential characteristics thereof.
Example 1
A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding 200mL of 20% chlorine dioxide solution into 200mL of pharmaceutical factory waste liquid, and fully stirring and mixing;
(2) 50g of polyaluminum chloride (content Al) were added2O3More than or equal to 28 percent), stirring and mixing, flocculating and settling, and standing for 1-3 hours;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) after 20 g of macroporous strong-acid styrene cation exchange resin is added into the filtrate for adsorption, the wastewater can reach the standard and is discharged;
the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
Example 2
A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding 50mL of 30% chlorine dioxide solution into 200mL of pharmaceutical factory waste liquid, and fully stirring and mixing;
(2) 50g of ferrous sulfate FeSO are added4·7H2More than or equal to 98 percent of O, stirring and mixing, and standing for 1-3 hours by flocculation and precipitation;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) after 100 g of macroporous strong-acid styrene cation exchange resin is added into the filtrate for adsorption, the wastewater can reach the standard and is discharged;
the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
Example 3
A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding 20mL of hydrogen peroxide disinfectant into 200mL of pharmaceutical factory waste liquid, and fully stirring and mixing; the content of hydrogen peroxide in the hydrogen peroxide solution disinfectant is 2.8-3.5% (W/W);
(2) 50g of polyaluminum chloride (content Al) were added2O3More than or equal to 28 percent), stirring and mixing, flocculating and settling, and standing for 1-3 hours;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) after 20 g of macroporous strong-acid styrene cation exchange resin is added into the filtrate for adsorption, the wastewater can reach the standard and is discharged;
the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
The morphine content before and after the decomposition treatment of the waste liquid of the pharmaceutical factory in examples 1 to 3 was measured, and the results are shown in Table 1.
TABLE 1 determination of decomposed morphine content by decomposition method of morphine in pharmaceutical factory waste liquid according to the present invention
Figure BDA0003012195460000041
As can be seen from Table 1, the method of the present invention can effectively remove the residual morphine from the pharmaceutical factory waste liquid, and no morphine is detected after the waste liquid is treated by the method of the present invention.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.

Claims (5)

1. A method for decomposing morphine in pharmaceutical factory waste liquid is characterized by comprising the following steps:
(1) adding a decomposer into the morphine-containing pharmaceutical factory waste liquid, stirring and mixing, and fully reacting to obtain a mixed solution;
(2) adding a flocculating agent into the mixed liquid obtained in the step (1), stirring and mixing, and standing for 1-3 h;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) and (4) adding cation exchange resin into the filtrate obtained in the step (3) for adsorption, detecting waste liquid, and discharging after the waste liquid reaches the standard.
2. The method according to claim 1, wherein the decomposition agent in step (1) is chlorine dioxide or hydrogen peroxide.
3. The method for decomposing morphine in waste liquor of pharmaceutical factory according to claim 1, wherein said flocculant in step (2) is polyaluminium chloride or ferrous sulfate.
4. The method of claim 1, wherein the cation exchange resin in step (4) is a macroporous strongly acidic styrene cation exchange resin.
5. The method of claim 4, wherein the macroporous strongly acidic styrene cation exchange resin is D061, manufactured by Zhengzhou Hecheng New Material science and technology Ltd.
CN202110378509.XA 2021-04-08 2021-04-08 Method for decomposing morphine in pharmaceutical factory waste liquid Pending CN113105019A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110378509.XA CN113105019A (en) 2021-04-08 2021-04-08 Method for decomposing morphine in pharmaceutical factory waste liquid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110378509.XA CN113105019A (en) 2021-04-08 2021-04-08 Method for decomposing morphine in pharmaceutical factory waste liquid

Publications (1)

Publication Number Publication Date
CN113105019A true CN113105019A (en) 2021-07-13

Family

ID=76715377

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110378509.XA Pending CN113105019A (en) 2021-04-08 2021-04-08 Method for decomposing morphine in pharmaceutical factory waste liquid

Country Status (1)

Country Link
CN (1) CN113105019A (en)

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901657A (en) * 1974-04-29 1975-08-26 Sun Scient Inc Device for testing solutions and body fluids
DE2905468A1 (en) * 1978-02-15 1979-08-16 Inst Chemii Przemyslowej METHOD FOR THE ISOLATION OF MORPHINE FROM PLANT RAW MATERIAL EXTRACT
JPS5821633A (en) * 1981-07-30 1983-02-08 Mitsubishi Chem Ind Ltd Preparation of bisphenol a
DE3524529A1 (en) * 1985-02-23 1986-08-28 Stenger Eugen Dipl Kaufm Process for detoxifying and upgrading plants and parts of plants of the species Papaver
CN1597039A (en) * 2003-09-16 2005-03-23 中国医药集团总公司四川抗菌素工业研究所 Method of extracting and separating morphine using cation exchange resin
AU2001281599B2 (en) * 2000-08-25 2007-07-12 Glaxo Wellcome Australia Ltd Chemical methods
WO2010066203A1 (en) * 2008-12-10 2010-06-17 Anhui Zhongren Technology Co., Ltd. Controlled releasing composition
US20160159812A1 (en) * 2013-07-26 2016-06-09 Siegfried Ag Novel synthesis of noroxymorphone from morphine
CN107304213A (en) * 2016-04-20 2017-10-31 中国医药工业有限公司 A kind of opium poppy extract-treated method and apparatus
US20190046567A1 (en) * 2014-04-17 2019-02-14 ImMutriX Therapeutics, Inc. Therapeutic Detoxification Compositions and Methods of Making and Using Same
CN111039481A (en) * 2019-12-04 2020-04-21 浙江德强科技有限公司 Method for treating glyphosate wastewater
CN111170497A (en) * 2019-11-29 2020-05-19 南京大学 Method for promoting Fenton oxidation efficiency by resin regulation and control
CN111514513A (en) * 2020-05-06 2020-08-11 中国农业科学院农业资源与农业区划研究所 Harmless treatment method for drugs

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901657A (en) * 1974-04-29 1975-08-26 Sun Scient Inc Device for testing solutions and body fluids
DE2905468A1 (en) * 1978-02-15 1979-08-16 Inst Chemii Przemyslowej METHOD FOR THE ISOLATION OF MORPHINE FROM PLANT RAW MATERIAL EXTRACT
JPS5821633A (en) * 1981-07-30 1983-02-08 Mitsubishi Chem Ind Ltd Preparation of bisphenol a
DE3524529A1 (en) * 1985-02-23 1986-08-28 Stenger Eugen Dipl Kaufm Process for detoxifying and upgrading plants and parts of plants of the species Papaver
AU2001281599B2 (en) * 2000-08-25 2007-07-12 Glaxo Wellcome Australia Ltd Chemical methods
CN1597039A (en) * 2003-09-16 2005-03-23 中国医药集团总公司四川抗菌素工业研究所 Method of extracting and separating morphine using cation exchange resin
WO2010066203A1 (en) * 2008-12-10 2010-06-17 Anhui Zhongren Technology Co., Ltd. Controlled releasing composition
US20160159812A1 (en) * 2013-07-26 2016-06-09 Siegfried Ag Novel synthesis of noroxymorphone from morphine
US20190046567A1 (en) * 2014-04-17 2019-02-14 ImMutriX Therapeutics, Inc. Therapeutic Detoxification Compositions and Methods of Making and Using Same
CN107304213A (en) * 2016-04-20 2017-10-31 中国医药工业有限公司 A kind of opium poppy extract-treated method and apparatus
CN111170497A (en) * 2019-11-29 2020-05-19 南京大学 Method for promoting Fenton oxidation efficiency by resin regulation and control
CN111039481A (en) * 2019-12-04 2020-04-21 浙江德强科技有限公司 Method for treating glyphosate wastewater
CN111514513A (en) * 2020-05-06 2020-08-11 中国农业科学院农业资源与农业区划研究所 Harmless treatment method for drugs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
康诺等: "《药物的化学稳定性》", 30 May 1983, 人民卫生出版社 *
李建国等: "吗啡烷型生物碱类药物的化学发光分析法研究", 《分析试验室》 *

Similar Documents

Publication Publication Date Title
CN101327976B (en) Efficient water treatment flocculant
CN100537457C (en) Combined treating method for reclaimed water reuse
CN105859052B (en) A kind of environmental purification method of sanitary sewage
CN102276097B (en) Processing method of high density organic process wastewater in production of amprolium hydrochloride
Mahdavi et al. Removal of different NOM fractions from spent filter backwash water by polyaluminum ferric chloride and ferric chloride
CN104291538A (en) Cyanide waste residue leaching solution treating method
CN103232121A (en) Method for removing soluble organic nitrogen in slightly polluted water source water
CN110697934A (en) Method for reducing disinfection by-products of drinking water
CN102765796B (en) Preparation method of loose type polyaluminum ferric chloride flocculants
Feng Research progress in pharmaceutical wastewater treatment technology
CN103466902A (en) High-concentration ammonia nitrogen wastewater treatment method
Wang et al. Interaction-sedimentation strategy for highly efficient removal of refractory humic substances in biologically treated wastewater effluent: From mechanistic investigation to full-scale application
Trapido et al. Fenton treatment efficacy for the purification of different kinds of wastewater
CN113105019A (en) Method for decomposing morphine in pharmaceutical factory waste liquid
CN213060470U (en) Sulfuric acid process titanium dioxide effluent treatment plant
CN104058489A (en) Cellulose compound water-treatment flocculant and application method thereof
Song et al. Floc aging: Crystallization and improving low molecular weight organic removal in re-coagulation
García-Fayos et al. Alternatives to the use of synthetic organic coagulant aids in drinking water treatment: improvements in the application of the crude extract of Moringa oleifera seed
CN110790426A (en) Method for treating cyclization wastewater generated in folic acid production process
CN108503130A (en) A kind of novel environment friendly sewage treatment process
CN107162335A (en) A kind of method for handling chitin pharmaceutical wastewater
CN113117680A (en) Nano ferrous metatitanate-silica gel particle Fenton catalyst, and preparation method and use method thereof
CN104710073B (en) A kind of processing method of vitamin leaf acid producing waste water
CN1330583C (en) Method for removing ammonia and nitrogen in raw water with powdery zeolite
CN114426348A (en) High-salinity wastewater treatment system and treatment method

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20210713

RJ01 Rejection of invention patent application after publication