CN113105019A - Method for decomposing morphine in pharmaceutical factory waste liquid - Google Patents
Method for decomposing morphine in pharmaceutical factory waste liquid Download PDFInfo
- Publication number
- CN113105019A CN113105019A CN202110378509.XA CN202110378509A CN113105019A CN 113105019 A CN113105019 A CN 113105019A CN 202110378509 A CN202110378509 A CN 202110378509A CN 113105019 A CN113105019 A CN 113105019A
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- Prior art keywords
- waste liquid
- morphine
- pharmaceutical factory
- decomposing
- exchange resin
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F9/00—Multistage treatment of water, waste water or sewage
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/52—Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities
- C02F1/5236—Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities using inorganic agents
- C02F1/5245—Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities using inorganic agents using basic salts, e.g. of aluminium and iron
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/72—Treatment of water, waste water, or sewage by oxidation
- C02F1/722—Oxidation by peroxides
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/72—Treatment of water, waste water, or sewage by oxidation
- C02F1/76—Treatment of water, waste water, or sewage by oxidation with halogens or compounds of halogens
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/42—Treatment of water, waste water, or sewage by ion-exchange
- C02F2001/425—Treatment of water, waste water, or sewage by ion-exchange using cation exchangers
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2101/00—Nature of the contaminant
- C02F2101/30—Organic compounds
- C02F2101/38—Organic compounds containing nitrogen
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/34—Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32
- C02F2103/343—Nature of the water, waste water, sewage or sludge to be treated from industrial activities not provided for in groups C02F2103/12 - C02F2103/32 from the pharmaceutical industry, e.g. containing antibiotics
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- Life Sciences & Earth Sciences (AREA)
- Hydrology & Water Resources (AREA)
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Removal Of Specific Substances (AREA)
Abstract
The invention belongs to the technical field of pharmaceutical factory sewage treatment, and particularly relates to a method for decomposing morphine in pharmaceutical factory waste liquid. A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps: (1) adding a decomposer into the morphine-containing pharmaceutical factory waste liquid, stirring and mixing, and fully reacting; (2) adding a flocculating agent into the mixed solution after the reaction, stirring and mixing, and standing for 1-3 h; (3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate; (4) and (4) adding cation exchange resin into the filtrate obtained in the step (3) for adsorption, detecting waste liquid, and discharging after the waste liquid reaches the standard. The method can effectively decompose morphine in the pharmaceutical factory waste liquid, and has the advantages of simple operation, high efficiency and low cost.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical factory sewage treatment, and particularly relates to a method for decomposing morphine in pharmaceutical factory waste liquid.
Background
Morphine (Morphine), an opioid receptor agonist, is present in an amount of 4-21% in the opioid, averaging about 10%. The IUPAC name is 7,8-Didehydro-4, 5-epoxy-17-methyl-morphine-3, 6-diol. Molecular formula C17H19NO3And the molecular weight is 285.3.
In 1806 German chemist Zeerdina first isolated it from opium and named morphine using the name Greek dream Morpheus. Morphine hydrochloride which is a derivative thereof is a common anesthetic in clinic, has extremely strong analgesic effect, has better selectivity of the analgesic effect, is used for treating severe pain caused by trauma, operation, burn and the like, is also used for treating angina caused by myocardial infarction, and can be used as an analgesic, antitussive and antidiarrheal agent; the diacetate of morphine is also known as heroin. But the biggest disadvantage is the high addiction. The method can lead a long-term smoker to have serious dependence on morphine from both physical and psychological aspects, and cause serious toxicomania, thereby causing great harm to the smoker and the society.
According to the prejudicial Law of the people's republic of China, drugs include opium, heroin, methamphetamine (methamphetamine), morphine, marijuana, cocaine, and other narcotics and psychotropic drugs regulated by the state of medicine that can induce cravings.
At present, due to the production process, a small amount of morphine needs to be added in the production process of cough syrup in some domestic pharmaceutical factories, but the morphine remains in the waste liquid, and if the morphine is not removed, the morphine enters a water body or is absorbed by crops along with the discharge of the waste liquid and enters a food chain, so that the morphine influences the human body.
Therefore, it is urgent to develop a method for decomposing morphine in the waste liquid of pharmaceutical factory.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
Disclosure of Invention
The invention provides a method for decomposing morphine in pharmaceutical factory waste liquid, which can effectively decompose morphine in the pharmaceutical factory waste liquid and has the advantages of simple operation, high efficiency and low cost.
In order to achieve the purpose, the invention adopts the following technical scheme:
a method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding a decomposer into the morphine-containing pharmaceutical factory waste liquid, stirring and mixing, and fully reacting to obtain a mixed solution;
(2) adding a flocculating agent into the mixed solution after the reaction, stirring and mixing, and standing for 1-3 h;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) and (4) adding cation exchange resin into the filtrate obtained in the step (3) for adsorption, detecting waste liquid, and discharging after the waste liquid reaches the standard.
Preferably, the decomposing agent in step (1) is chlorine dioxide or hydrogen peroxide.
Preferably, the flocculant in the step (2) is polyaluminium chloride or ferrous sulfate.
Preferably, the cation exchange resin in step (4) is a macroporous strongly acidic styrene cation exchange resin.
Preferably, the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
Compared with the prior art, the invention has the following beneficial effects:
the method can effectively decompose morphine in the pharmaceutical factory waste liquid, and has the advantages of simple operation, high efficiency and low cost.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. It is intended that all modifications or alterations to the methods, procedures or conditions of the present invention be made without departing from the spirit or essential characteristics thereof.
Example 1：
A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding 200mL of 20% chlorine dioxide solution into 200mL of pharmaceutical factory waste liquid, and fully stirring and mixing;
(2) 50g of polyaluminum chloride (content Al) were added2O3More than or equal to 28 percent), stirring and mixing, flocculating and settling, and standing for 1-3 hours;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) after 20 g of macroporous strong-acid styrene cation exchange resin is added into the filtrate for adsorption, the wastewater can reach the standard and is discharged;
the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
Example 2：
A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding 50mL of 30% chlorine dioxide solution into 200mL of pharmaceutical factory waste liquid, and fully stirring and mixing;
(2) 50g of ferrous sulfate FeSO are added4·7H2More than or equal to 98 percent of O, stirring and mixing, and standing for 1-3 hours by flocculation and precipitation;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) after 100 g of macroporous strong-acid styrene cation exchange resin is added into the filtrate for adsorption, the wastewater can reach the standard and is discharged;
the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
Example 3：
A method for decomposing morphine in pharmaceutical factory waste liquid comprises the following steps:
(1) adding 20mL of hydrogen peroxide disinfectant into 200mL of pharmaceutical factory waste liquid, and fully stirring and mixing; the content of hydrogen peroxide in the hydrogen peroxide solution disinfectant is 2.8-3.5% (W/W);
(2) 50g of polyaluminum chloride (content Al) were added2O3More than or equal to 28 percent), stirring and mixing, flocculating and settling, and standing for 1-3 hours;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) after 20 g of macroporous strong-acid styrene cation exchange resin is added into the filtrate for adsorption, the wastewater can reach the standard and is discharged;
the macroporous strong-acid styrene cation exchange resin is produced by Zhengzhou Hecheng new material science and technology limited, and the model is D061.
The morphine content before and after the decomposition treatment of the waste liquid of the pharmaceutical factory in examples 1 to 3 was measured, and the results are shown in Table 1.
TABLE 1 determination of decomposed morphine content by decomposition method of morphine in pharmaceutical factory waste liquid according to the present invention
As can be seen from Table 1, the method of the present invention can effectively remove the residual morphine from the pharmaceutical factory waste liquid, and no morphine is detected after the waste liquid is treated by the method of the present invention.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (5)
1. A method for decomposing morphine in pharmaceutical factory waste liquid is characterized by comprising the following steps:
(1) adding a decomposer into the morphine-containing pharmaceutical factory waste liquid, stirring and mixing, and fully reacting to obtain a mixed solution;
(2) adding a flocculating agent into the mixed liquid obtained in the step (1), stirring and mixing, and standing for 1-3 h;
(3) filtering the mixed solution after standing, removing the precipitate, and reserving filtrate;
(4) and (4) adding cation exchange resin into the filtrate obtained in the step (3) for adsorption, detecting waste liquid, and discharging after the waste liquid reaches the standard.
2. The method according to claim 1, wherein the decomposition agent in step (1) is chlorine dioxide or hydrogen peroxide.
3. The method for decomposing morphine in waste liquor of pharmaceutical factory according to claim 1, wherein said flocculant in step (2) is polyaluminium chloride or ferrous sulfate.
4. The method of claim 1, wherein the cation exchange resin in step (4) is a macroporous strongly acidic styrene cation exchange resin.
5. The method of claim 4, wherein the macroporous strongly acidic styrene cation exchange resin is D061, manufactured by Zhengzhou Hecheng New Material science and technology Ltd.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110378509.XA CN113105019A (en) | 2021-04-08 | 2021-04-08 | Method for decomposing morphine in pharmaceutical factory waste liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110378509.XA CN113105019A (en) | 2021-04-08 | 2021-04-08 | Method for decomposing morphine in pharmaceutical factory waste liquid |
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| Publication Number | Publication Date |
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| CN113105019A true CN113105019A (en) | 2021-07-13 |
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| CN202110378509.XA Pending CN113105019A (en) | 2021-04-08 | 2021-04-08 | Method for decomposing morphine in pharmaceutical factory waste liquid |
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Citations (13)
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|---|---|---|---|---|
| US3901657A (en) * | 1974-04-29 | 1975-08-26 | Sun Scient Inc | Device for testing solutions and body fluids |
| DE2905468A1 (en) * | 1978-02-15 | 1979-08-16 | Inst Chemii Przemyslowej | METHOD FOR THE ISOLATION OF MORPHINE FROM PLANT RAW MATERIAL EXTRACT |
| JPS5821633A (en) * | 1981-07-30 | 1983-02-08 | Mitsubishi Chem Ind Ltd | Preparation of bisphenol a |
| DE3524529A1 (en) * | 1985-02-23 | 1986-08-28 | Stenger Eugen Dipl Kaufm | Process for detoxifying and upgrading plants and parts of plants of the species Papaver |
| CN1597039A (en) * | 2003-09-16 | 2005-03-23 | 中国医药集团总公司四川抗菌素工业研究所 | Method of extracting and separating morphine using cation exchange resin |
| AU2001281599B2 (en) * | 2000-08-25 | 2007-07-12 | Glaxo Wellcome Australia Ltd | Chemical methods |
| WO2010066203A1 (en) * | 2008-12-10 | 2010-06-17 | Anhui Zhongren Technology Co., Ltd. | Controlled releasing composition |
| US20160159812A1 (en) * | 2013-07-26 | 2016-06-09 | Siegfried Ag | Novel synthesis of noroxymorphone from morphine |
| CN107304213A (en) * | 2016-04-20 | 2017-10-31 | 中国医药工业有限公司 | A kind of opium poppy extract-treated method and apparatus |
| US20190046567A1 (en) * | 2014-04-17 | 2019-02-14 | ImMutriX Therapeutics, Inc. | Therapeutic Detoxification Compositions and Methods of Making and Using Same |
| CN111039481A (en) * | 2019-12-04 | 2020-04-21 | 浙江德强科技有限公司 | Method for treating glyphosate wastewater |
| CN111170497A (en) * | 2019-11-29 | 2020-05-19 | 南京大学 | Method for promoting Fenton oxidation efficiency by resin regulation and control |
| CN111514513A (en) * | 2020-05-06 | 2020-08-11 | 中国农业科学院农业资源与农业区划研究所 | Harmless treatment method for drugs |
-
2021
- 2021-04-08 CN CN202110378509.XA patent/CN113105019A/en active Pending
Patent Citations (13)
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| US3901657A (en) * | 1974-04-29 | 1975-08-26 | Sun Scient Inc | Device for testing solutions and body fluids |
| DE2905468A1 (en) * | 1978-02-15 | 1979-08-16 | Inst Chemii Przemyslowej | METHOD FOR THE ISOLATION OF MORPHINE FROM PLANT RAW MATERIAL EXTRACT |
| JPS5821633A (en) * | 1981-07-30 | 1983-02-08 | Mitsubishi Chem Ind Ltd | Preparation of bisphenol a |
| DE3524529A1 (en) * | 1985-02-23 | 1986-08-28 | Stenger Eugen Dipl Kaufm | Process for detoxifying and upgrading plants and parts of plants of the species Papaver |
| AU2001281599B2 (en) * | 2000-08-25 | 2007-07-12 | Glaxo Wellcome Australia Ltd | Chemical methods |
| CN1597039A (en) * | 2003-09-16 | 2005-03-23 | 中国医药集团总公司四川抗菌素工业研究所 | Method of extracting and separating morphine using cation exchange resin |
| WO2010066203A1 (en) * | 2008-12-10 | 2010-06-17 | Anhui Zhongren Technology Co., Ltd. | Controlled releasing composition |
| US20160159812A1 (en) * | 2013-07-26 | 2016-06-09 | Siegfried Ag | Novel synthesis of noroxymorphone from morphine |
| US20190046567A1 (en) * | 2014-04-17 | 2019-02-14 | ImMutriX Therapeutics, Inc. | Therapeutic Detoxification Compositions and Methods of Making and Using Same |
| CN107304213A (en) * | 2016-04-20 | 2017-10-31 | 中国医药工业有限公司 | A kind of opium poppy extract-treated method and apparatus |
| CN111170497A (en) * | 2019-11-29 | 2020-05-19 | 南京大学 | Method for promoting Fenton oxidation efficiency by resin regulation and control |
| CN111039481A (en) * | 2019-12-04 | 2020-04-21 | 浙江德强科技有限公司 | Method for treating glyphosate wastewater |
| CN111514513A (en) * | 2020-05-06 | 2020-08-11 | 中国农业科学院农业资源与农业区划研究所 | Harmless treatment method for drugs |
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Application publication date: 20210713 |
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