CN113083198A - Convenient reation kettle for captopril midbody production who observes - Google Patents
Convenient reation kettle for captopril midbody production who observes Download PDFInfo
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- CN113083198A CN113083198A CN202110414928.4A CN202110414928A CN113083198A CN 113083198 A CN113083198 A CN 113083198A CN 202110414928 A CN202110414928 A CN 202110414928A CN 113083198 A CN113083198 A CN 113083198A
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- Prior art keywords
- rotating rod
- shell
- working groove
- captopril
- fixedly connected
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0073—Sealings
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/14—Production of inert gas mixtures; Use of inert gases in general
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
- B01J4/007—Feed or outlet devices as such, e.g. feeding tubes provided with moving parts
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/008—Feed or outlet control devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/002—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the feeding side being of particular interest
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a conveniently observed captopril intermediate production reaction kettle, which comprises a shell, wherein the upper end of the shell is provided with a working groove, and a device cover is arranged at the notch of the working groove; the trigger mechanism comprises a first rotating rod vertically arranged in the working groove, the lower end of the shell is provided with a motor, and the tail end of an output shaft of the motor extends into the working groove and is fixedly connected with the lower end of the first rotating rod; the stirring mechanism comprises a plurality of stirring rods fixedly connected to the first rotating rod. Can let in nitrogen gas through the intake pipe before the reaction, get rid of the air in the work groove, prevent that medicine and oxygen from taking place oxidation reaction to the staff can carry out the ration through rotating the handle and add to the raw materials, reduces staff's burden, still rotates through the stirring rod, thereby promotes the quick reaction of medicine.
Description
Technical Field
The invention relates to the field of medicine production, in particular to a reaction kettle for producing a captopril intermediate, which is convenient to observe.
Background
Captopril is an angiotensin converting enzyme inhibitor and is applied to the treatment of hypertension and certain types of congestive heart failure, and as a first ACEI drug, captopril is considered as a breakthrough in drug therapy due to a new action mechanism and a revolutionary development process;
the raw materials need to be added in the reaction process during the production and processing of captopril, most of the manual feeding adopted at present needs workers to control the amount of the raw materials firstly and then add the raw materials, so that the burden of the workers can be greatly increased, and in the reaction, if the medicines and oxygen in the air generate oxidation reaction, the medicine property of the medicines can be reduced, and how to solve the problems needs to be considered.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides the reaction kettle for producing the captopril intermediate, which is convenient to observe.
In order to achieve the purpose, the invention adopts the following technical scheme:
a reaction kettle convenient for observation and used for producing a captopril intermediate comprises a shell, wherein the upper end of the shell is provided with a working groove, and a device cover is arranged at the notch of the working groove; the trigger mechanism comprises a first rotating rod vertically arranged in the working groove, the lower end of the shell is provided with a motor, and the tail end of an output shaft of the motor extends into the working groove and is fixedly connected with the lower end of the first rotating rod; rabbling mechanism, rabbling mechanism includes a plurality of puddlers of fixed connection on first bull stick, and first bull stick drives a plurality of puddlers and rotates, stirs the raw materials to promote the medicine fast reaction.
Preferably, still include quantitative mechanism, quantitative mechanism includes fixed block of fixed connection on the casing left side wall, the pan feeding groove has been seted up to the upper end of fixed block, the right side inner wall in pan feeding groove passes through pan feeding mouth intercommunication with the left side inner wall in work groove, the level is equipped with the second bull stick in the pan feeding mouth, the rear end of second bull stick rotates with the rear side inner wall of pan feeding mouth to be connected, the front end of second bull stick extends to the external world to fixedly connected with handle, the second bull stick is located a plurality of baffles of part fixedly connected with of pan feeding mouth, keeps apart the raw materials through the baffle, and in the baffle pivoted, the raw materials is filled between per two baffles, makes the fixed raw materials of adding at every turn, is convenient for control the volume of adding.
Preferably, the anti-oxidation mechanism comprises an air inlet pipe communicated with the inner wall of the right side of the working groove, nitrogen is discharged into the working groove through the air inlet pipe, the air inlet pipe is sealed, the sealing performance in the working groove is guaranteed, and only nitrogen and no oxygen exist in the working groove.
Preferably, the inner wall of the left side of the working tank is communicated with the outside through a discharge port, a manual valve is mounted on the discharge port, and after the use is finished, a finished product after the reaction is taken out by manually opening the manual valve.
Preferably, a power supply is mounted on the right side wall of the housing.
Preferably, the power supply is electrically connected to the motor.
Compared with the prior art, the invention has the beneficial effects that:
1. be provided with rabbling mechanism, first bull stick drives a plurality of puddlers and rotates, stirs the raw materials to promote the medicine fast reaction, guaranteed the quality of finished product medicine.
2. Be provided with quantitative mechanism, keep apart the raw materials through the baffle, when the baffle rotated, the raw materials was filled between per two baffles, made at every turn add fixed raw materials, the volume of being convenient for control addition, also do not need the staff when adding the raw materials, need measure or control the raw materials volume to reduce staff's burden.
3. Be provided with anti-oxidation mechanism, earlier discharge into nitrogen gas to the work inslot through the intake pipe, seal the intake pipe, guarantee the leakproofness of work inslot to only nitrogen gas in the work inslot, oxygen does not have, and the effectual oxidation reaction that has prevented medicine and oxygen from taking place can reduce the condition emergence of the property of a medicine of medicine.
Drawings
FIG. 1 is a schematic structural view of a captopril intermediate production reactor provided by the invention, which is convenient for observation;
FIG. 2 is a left side view of FIG. 1;
fig. 3 is a perspective view of fig. 1.
In the figure: the device comprises a shell 1, a working groove 2, a device cover 3, a discharge hole 4, a first rotating rod 5, a motor 6, a stirring rod 7, a fixed block 8, a feeding groove 9, a feeding hole 10, a second rotating rod 11, a partition plate 12, a handle 13, an air inlet pipe 14 and a power supply 15.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1-3, a conveniently observed reactor for producing a captopril intermediate comprises a shell 1, wherein the upper end of the shell 1 is provided with a working groove 2, and a device cover 3 is arranged at the notch of the working groove 2;
the trigger mechanism comprises a first rotating rod 5 vertically arranged in the working tank 2, a motor 6 is installed at the lower end of the shell 1, the tail end of an output shaft of the motor 6 extends into the working tank 2 and is fixedly connected with the lower end of the first rotating rod 5, the inner wall of the left side of the working tank 2 is communicated with the outside through a discharge port 4, a manual valve is installed on the discharge port 4, and after the trigger mechanism is used, a finished product after reaction is taken out by manually opening the manual valve;
rabbling mechanism, rabbling mechanism include a plurality of puddlers 7 of fixed connection on first bull stick 5, and the right side wall mounting of casing 1 has power 15, and power 15 and 6 electric connection of motor, first bull stick 5 drive a plurality of puddlers 7 and rotate, stir the raw materials to promote the quick reaction of medicine, guaranteed the quality of finished product medicine.
Wherein, the quantitative mechanism comprises a fixed block 8 fixedly connected on the left side wall of the shell 1, the upper end of the fixed block 8 is provided with a feeding groove 9, the right side inner wall of the feeding groove 9 is communicated with the left side inner wall of the working groove 2 through a feeding port 10, a second rotating rod 11 is horizontally arranged in the feeding port 10, the rear end of the second rotating rod 11 is rotatably connected with the rear side inner wall of the feeding port 10, the front end of the second rotating rod 11 extends to the outside, a handle 13 is fixedly connected, a plurality of clapboards 12 are fixedly connected to the part of the second rotating rod 11 positioned at the feeding hole 10, the raw materials are isolated by the clapboards 12, when the baffle 12 rotates, the raw materials are filled between every two baffle 12, so that the fixed raw materials are added at every time, the adding amount is convenient to control, namely, the raw material amount is required to be measured or controlled when the raw materials are added by workers, and the burden of the workers is reduced.
Wherein, still include anti-oxidation mechanism, anti-oxidation mechanism include with the intake pipe 14 of the 2 right side inner walls intercommunication of work groove, earlier through intake pipe 14 to the interior nitrogen gas that emits into of work groove 2, seal intake pipe 14, guarantee the leakproofness in the work groove 2 to only nitrogen gas in the work groove 2 does not have oxygen, and the effectual oxidation reaction that takes place with oxygen has prevented medicine, can reduce the condition emergence of the property of a medicine of medicine.
When the reaction kettle is used, firstly, a manual valve on a discharge port 4 is opened, nitrogen is discharged into a working tank 2 through an air inlet pipe 14, the working tank 2 is filled with the nitrogen, air in the working tank 2 is discharged into the outside through the discharge port 4, the manual valve on the discharge port 4 is closed, a device cover 3 is opened, a part of raw materials are placed into the working tank 2, the device cover 3 is closed, the air inlet pipe 14 always keeps the state of discharging the nitrogen, namely, no air enters the working tank 2 in the process of placing the raw materials, after the device cover 3 is closed, the nitrogen is not continuously introduced, the air inlet pipe 14 is sealed, the sealing property in the working tank 2 is ensured, only nitrogen exists in the working tank 2, no oxygen exists, the oxidation reaction of the medicine and the oxygen is effectively prevented, and the medicine property can be reduced;
the raw materials to be added are placed into the feeding groove 9, the handle 13 is rotated, the handle 13 drives the second rotating rod 11 to rotate, the second rotating rod 11 drives the partition plates 12 to rotate, the raw materials are isolated through the partition plates 12, the raw materials are filled between every two partition plates 12 when the partition plates 12 rotate, so that the fixed raw materials are added each time, the adding amount is convenient to control, namely, the raw material amount does not need to be measured or controlled when a worker adds the raw materials, and the burden of the worker is reduced;
after adding the raw materials that need add, can switch on 15, the electric current of power 15 passes through motor 6, and motor 6 drives first bull stick 5 and rotates, and first bull stick 5 drives a plurality of puddlers 7 and rotates, stirs the raw materials to promote the medicine fast reaction, guaranteed the quality of finished product medicine, after the use, can take out the finished product after the reaction is accomplished through manual opening manual valve.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. A reation kettle is used in captopril midbody production that conveniently observes, characterized by, includes:
the device comprises a shell (1), wherein a working groove (2) is formed in the upper end of the shell (1), and a device cover (3) is installed at the notch of the working groove (2);
the trigger mechanism comprises a first rotating rod (5) vertically arranged in the working groove (2), a motor (6) is installed at the lower end of the shell (1), and the tail end of an output shaft of the motor (6) extends into the working groove (2) and is fixedly connected with the lower end of the first rotating rod (5);
the stirring mechanism comprises a plurality of stirring rods (7) fixedly connected to the first rotating rod (5).
2. The reaction kettle for producing captopril intermediates convenient to observe as claimed in claim 1, further comprising a quantifying mechanism, wherein the quantifying mechanism comprises a fixed block (8) fixedly connected to the left side wall of the shell (1), a feeding groove (9) is formed in the upper end of the fixed block (8), the right side inner wall of the feeding groove (9) is communicated with the left side inner wall of the working groove (2) through a feeding port (10), a second rotating rod (11) is horizontally arranged in the feeding port (10), the rear end of the second rotating rod (11) is rotatably connected with the rear side inner wall of the feeding port (10), the front end of the second rotating rod (11) extends to the outside and is fixedly connected with a handle (13), and the second rotating rod (11) is located on a part of the feeding port (10) and is fixedly connected with a plurality of partition plates (12).
3. The easy-to-observe captopril intermediate production reaction kettle according to claim 1, further comprising an anti-oxidation mechanism, wherein the anti-oxidation mechanism comprises an air inlet pipe (14) communicated with the inner wall of the right side of the working groove (2).
4. The easy-to-observe captopril intermediate production reaction kettle as claimed in claim 1, wherein the left inner wall of the working tank (2) is communicated with the outside through a discharge port (4), and a manual valve is mounted on the discharge port (4).
5. An easy-to-observe captopril intermediate production reaction kettle according to claim 1, wherein a power supply (15) is mounted on the right side wall of the shell (1).
6. The easy-to-observe captopril intermediate production reaction kettle according to claim 5, wherein the power supply (15) is electrically connected with the motor (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110414928.4A CN113083198A (en) | 2021-04-17 | 2021-04-17 | Convenient reation kettle for captopril midbody production who observes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110414928.4A CN113083198A (en) | 2021-04-17 | 2021-04-17 | Convenient reation kettle for captopril midbody production who observes |
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| Publication Number | Publication Date |
|---|---|
| CN113083198A true CN113083198A (en) | 2021-07-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110414928.4A Pending CN113083198A (en) | 2021-04-17 | 2021-04-17 | Convenient reation kettle for captopril midbody production who observes |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684873A (en) * | 2017-09-11 | 2018-02-13 | 浦江县宏创科技开发有限公司 | A kind of injectable dextrose monohydrate solution preparation liquid mixing oscillating uniform device |
| CN208742505U (en) * | 2018-09-17 | 2019-04-16 | 金溪斯普瑞药业有限公司 | In a kind of captopril intermediate reaction into charging mechanism |
| CN208742570U (en) * | 2018-09-17 | 2019-04-16 | 金溪斯普瑞药业有限公司 | A kind of hypertension drug captopril intermediate reaction device |
| CN209423565U (en) * | 2018-10-29 | 2019-09-24 | 郑州网知汇信息科技有限公司 | A kind of automatic ration charging mechanism of pharmaceutical intermediate reaction kettle |
| CN111715119A (en) * | 2020-06-30 | 2020-09-29 | 湖南艾凯环保科技有限公司 | Comprehensive deodorant blending system |
| CN212284033U (en) * | 2020-08-20 | 2021-01-05 | 山东东科化工科技有限公司 | Anti-oxidation reaction kettle |
| CN112473546A (en) * | 2020-12-20 | 2021-03-12 | 天门楚天精细化工有限公司 | Production of intermediate is with throwing material device |
| CN113083127A (en) * | 2021-04-26 | 2021-07-09 | 金溪斯普瑞药业有限公司 | Mixing apparatus is used in production of captopril midbody of convenient feeding |
| CN215050749U (en) * | 2021-06-03 | 2021-12-07 | 福建浩达智能科技股份有限公司 | Efficient salt feeding machine for sodium hypochlorite generator |
-
2021
- 2021-04-17 CN CN202110414928.4A patent/CN113083198A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107684873A (en) * | 2017-09-11 | 2018-02-13 | 浦江县宏创科技开发有限公司 | A kind of injectable dextrose monohydrate solution preparation liquid mixing oscillating uniform device |
| CN208742505U (en) * | 2018-09-17 | 2019-04-16 | 金溪斯普瑞药业有限公司 | In a kind of captopril intermediate reaction into charging mechanism |
| CN208742570U (en) * | 2018-09-17 | 2019-04-16 | 金溪斯普瑞药业有限公司 | A kind of hypertension drug captopril intermediate reaction device |
| CN209423565U (en) * | 2018-10-29 | 2019-09-24 | 郑州网知汇信息科技有限公司 | A kind of automatic ration charging mechanism of pharmaceutical intermediate reaction kettle |
| CN111715119A (en) * | 2020-06-30 | 2020-09-29 | 湖南艾凯环保科技有限公司 | Comprehensive deodorant blending system |
| CN212284033U (en) * | 2020-08-20 | 2021-01-05 | 山东东科化工科技有限公司 | Anti-oxidation reaction kettle |
| CN112473546A (en) * | 2020-12-20 | 2021-03-12 | 天门楚天精细化工有限公司 | Production of intermediate is with throwing material device |
| CN113083127A (en) * | 2021-04-26 | 2021-07-09 | 金溪斯普瑞药业有限公司 | Mixing apparatus is used in production of captopril midbody of convenient feeding |
| CN215050749U (en) * | 2021-06-03 | 2021-12-07 | 福建浩达智能科技股份有限公司 | Efficient salt feeding machine for sodium hypochlorite generator |
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Application publication date: 20210709 |
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| RJ01 | Rejection of invention patent application after publication |