CN113082536A - Wireless closed-loop control system and method - Google Patents
Wireless closed-loop control system and method Download PDFInfo
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- CN113082536A CN113082536A CN202110358502.1A CN202110358502A CN113082536A CN 113082536 A CN113082536 A CN 113082536A CN 202110358502 A CN202110358502 A CN 202110358502A CN 113082536 A CN113082536 A CN 113082536A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
- A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
Abstract
The present disclosure provides a wireless closed-loop control system, which includes: photoelectrode module (101) for detect the EEG signal, signal processing module (102) for with EEG signal processing and categorised, acquire the control signal who corresponds with the classification, wireless energy supply module (103) for provide the electric energy for photoelectrode module (101) according to control signal, photoelectrode module (101) still is used for receiving the electric energy, makes LED lamp (32) in photoelectrode module (101) luminous. The present disclosure also provides a wireless closed-loop control method: the electroencephalogram signals are detected, processed and classified, control signals corresponding to the classification are obtained, and power supply is controlled according to the control signals, so that the LED lamp (32) emits light. The wireless closed-loop control system and the wireless closed-loop control method can realize the control of the light intensity of the photoelectrode by detecting the electroencephalogram signal, and can be applied to the treatment of brain diseases.
Description
Technical Field
The invention relates to the field of epilepsy disease treatment in brain science, in particular to a wireless closed-loop control method and system
Background
Epilepsy is a common neurological disorder, and is a chronic brain disease with transient central nervous system dysfunction caused by abnormal firing of cerebral neurons, and is clinically manifested by different symptoms of motor, sensory, consciousness and neurological dysfunction. About 5000 million people are affected globally, about 900 million patients with epilepsy in China, and 20 percent of the patients with epilepsy are intractable epilepsy.
The current effective means for treating epilepsy are mainly two types: firstly, the method achieves certain effect in the aspect of refractory epilepsy treatment, but under the influence of a functional structure, the cut part is limited, the medicine assistance cannot be got rid of, and sequelae are easy to generate; secondly, the epilepsy of most patients can be controlled by the method, and the epilepsy drug therapy is the most effective, most convenient, most safe and most common treatment method at present, but for intractable epilepsy patients, a large dose of drugs are required to be used for inhibiting the epilepsy, and the drugs are absorbed and accumulated by the organ tubes of the whole body to generally cause remarkable side effects.
Disclosure of Invention
In view of the above, the present disclosure provides a wireless closed-loop control system and method that solves, or at least partially solves, the above-mentioned problems
One aspect of the present disclosure provides a wireless closed-loop control system, comprising: the photoelectrode module is used for detecting an electroencephalogram signal; the signal processing module is used for processing and classifying the electroencephalogram signals and acquiring control signals corresponding to the classification; the wireless energy supply module is used for supplying electric energy to the photoelectrode module according to the control signal; and the photoelectrode module is also used for receiving electric energy to enable the LED lamp in the photoelectrode module to emit light.
Optionally, the photoelectrode module comprises: the detection electrode is used for detecting an electroencephalogram signal; the transmission interface is used for transmitting the electroencephalogram signals to the signal processing module; the receiving coil is used for receiving the electric energy provided by the wireless energy supply module; and the LED lamp is used for emitting light through electric energy.
Optionally, the detection electrode and the LED lamp constitute a photoelectrode.
Optionally, the signal processing module comprises: the signal processing unit is used for filtering and amplifying the electroencephalogram signals; and the signal classification unit is used for classifying the electroencephalogram signals and acquiring control signals corresponding to the classification.
Optionally, the signal classification unit is specifically configured to: judging whether the electroencephalogram signal exceeds a preset threshold value according to the intensity of the electroencephalogram signal; when the strength of the electroencephalogram signal is larger than a preset threshold value, acquiring a first control signal; when the strength of the electroencephalogram signal is smaller than a preset threshold value, acquiring a second control signal; the first control signal controls the wireless energy supply module to start energy supply, and the second control signal controls the wireless energy supply module to end energy supply.
Optionally, the wireless closed-loop control system further includes a wireless recording module, connected to the photoelectrode module, for storing the electroencephalogram signal and forwarding the electroencephalogram signal to the signal processing module.
Optionally, the wireless closed-loop control system further comprises a wireless recording module, a signal processing module, and the wireless energy supply module is in wireless communication with each other.
Another aspect of the present disclosure provides a wireless closed-loop control method, including: detecting an electroencephalogram signal; processing and classifying the electroencephalogram signals to obtain control signals corresponding to the classification; and controlling power supply according to the control signal so that the LED lamp emits light.
Optionally, processing and classifying the electroencephalogram signals, and acquiring control signals corresponding to the classification, further comprising: filtering and amplifying the electroencephalogram signals; and classifying the electroencephalogram signals, and acquiring control signals corresponding to the classification.
Optionally, classifying the electroencephalogram signals, and acquiring control signals corresponding to the classification, further comprising: judging whether the electroencephalogram signal exceeds a preset threshold value according to the intensity of the electroencephalogram signal; when the strength of the electroencephalogram signal is larger than a preset threshold value, acquiring a first control signal; when the strength of the electroencephalogram signal is smaller than a preset threshold value, acquiring a second control signal; the first control signal controls the wireless energy supply module to start energy supply, and the second control signal controls the wireless energy supply module to end energy supply.
The wireless closed-loop control system and method provided by the present disclosure have at least the following beneficial effects:
(1) the wireless closed-loop control system can timely and accurately control energy supply to adjust illumination intensity according to the electroencephalogram signals, can be applied to treating brain diseases, for example, epilepsy real-time detection and treatment of photosensitive medicines are matched, the light intensity of the photoelectrode is controlled through detecting the electroencephalogram signals, the action degree of the photosensitive medicines is controlled, accordingly, real-time and quick epilepsy treatment is achieved, and side effects caused by excessive epilepsy treatment medicines are prevented.
(2) The detection electrode and the LED lamp are respectively prepared and then assembled into the photoelectrode, and the effect of low noise can be achieved.
(3) According to the wireless connection type experimental animal experiment device, each module is in wireless connection, so that the influence of connection lines is eliminated, and the experimental animal can perform normal physiological activities.
Drawings
Fig. 1 schematically illustrates a wireless closed-loop control system according to an embodiment of the present disclosure, which may be applied to detection and suppression of epilepsy in an epileptic mouse;
FIG. 2A schematically illustrates a photoelectrode module block diagram, according to an embodiment of the present disclosure;
FIG. 2B schematically illustrates a block diagram of a photoelectrode 3 according to an embodiment of the present disclosure;
FIG. 3 schematically shows a block diagram of a signal processing module according to an embodiment of the disclosure;
FIG. 4 schematically illustrates a wireless closed-loop control system according to another embodiment of the present disclosure;
FIG. 5 schematically illustrates a wireless closed-loop control method according to an embodiment of the disclosure;
fig. 6 schematically shows a flow chart of a method for signal processing and classification according to an embodiment of the present disclosure.
Description of reference numerals:
brain region of brain focus of 100-epileptic mouse
101-photoelectrode module
102-Signal processing Module
103-wireless energy supply module
104-Wireless recording Module
700-epileptic mouse
800, 900-wireless closed loop control system;
1-inductor
2-interface
3-photo electrode
31-detecting electrode
32-LED lamps;
201-Signal processing Unit
202-signal classification unit.
Detailed Description
Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. It should be understood that the description is illustrative only and is not intended to limit the scope of the present disclosure. In the following detailed description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of the embodiments of the disclosure. It may be evident, however, that one or more embodiments may be practiced without these specific details. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present disclosure.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. The terms "comprises," "comprising," and the like, as used herein, specify the presence of stated features, steps, operations, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, or components.
All terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art unless otherwise defined. It is noted that the terms used herein should be interpreted as having a meaning that is consistent with the context of this specification and should not be interpreted in an idealized or overly formal sense.
Fig. 1 schematically illustrates a wireless closed-loop control system according to an embodiment of the present disclosure, which may be applied to detection and suppression of epilepsy in an epileptic rat.
As shown in fig. 1, the closed-loop control system 800 includes: the system comprises a photoelectrode module 101, a signal processing module 102 and a wireless energy supply module 103.
And the photoelectrode module 101 is used for detecting an electroencephalogram signal. The photoelectrode module 101 includes a detection electrode 31, a transmission interface 2, a receiving coil 1, and an LED lamp 32. Wherein, the detecting electrode 31 and the LED lamp 32 form the photoelectrode 3.
And the signal processing module 102 is used for processing and classifying the electroencephalogram signals and acquiring control signals corresponding to the classification. The signal processing module 102 may be a computer or the like. When the detection electrode 31 detects the electroencephalogram signal, there is strong interference, and the detected electroencephalogram signal is very weak, so that the electroencephalogram signal needs to be filtered and amplified. The method is beneficial to improving the accuracy of the electroencephalogram signals, facilitates further classification of the electroencephalogram signals, and obtains control signals corresponding to the classification.
And the wireless energy supply module 103 is used for supplying electric energy to the photoelectrode module 101 according to the control signal. The wireless power supply module 103 is used for supplying electric energy to the photoelectrode module 101 according to the control signal. After the wireless energy supply module 103 receives the control signal, the electric energy is transmitted to the receiving coil 1 of the photoelectrode module 101 by using the principle of electromagnetic coupling, so that the LED lamp 32 is lighted. The illumination intensity of the LED lamp 32 is controlled by controlling the electric energy generated by the wireless energy supply module 103
The photoelectrode module 101 is also used for receiving electric energy to make the LED lamp 32 in the photoelectrode module 101 emit light. The receiver coil 32 receives power to cause the LED lamp 32 to emit light. The LED lamp 32 may vary the intensity of illumination according to the amount of power received by the power source.
In the disclosed embodiment, the wireless closed-loop system 800 may be applied to the detection and treatment of brain diseases such as epilepsy. As shown in fig. 1, epileptic mice 700 were injected with caged compounds containing therapeutic components for epilepsy in brain areas of epileptic mice brain lesions. The caged compounds have light-sensitive properties. The process of photolyzing the cage-lock by the cage-lock compound is as follows: when the caged compound is exposed to light, the cryptic group of the caged compound is released, releasing the active ingredient therein.
In the working process of the wireless closed-loop control system 800 for detecting and treating the epileptic mouse 700, the detection electrode 31 sends the detected electroencephalogram signals to the signal processing module 102 in real time. When the signal processing module 102 determines that the epileptic mouse is in an epileptic state, the signal processing module sends a control signal to the wireless energy supply module 103 in real time, and the LED lamp 32 starts to be supplied with electric energy. When the LED lamp 32 starts to illuminate, the caged compounds already existing in the focal zone of the brain are subjected to photocaging, and the epilepsy treating component is released to inhibit the seizure of epilepsy. Meanwhile, the signal processing module 102 analyzes the electroencephalogram signals in real time, when the electroencephalogram signals are recovered to be normal, the signal processing module 102 sends control signals to the wireless energy supply module 103, the wireless energy supply module 103 stops supplying energy, the LED lamp 32 stops illuminating, and the epileptic treatment ingredients are not released any more.
Fig. 2A to 2B schematically show the photo-electrode module 101 in this embodiment. The photoelectrode module 101 includes: photoelectrode 3, transmission interface 2 and receiving coil 1.
The photoelectrode 3 is composed of a detection electrode 31 and an LED lamp 32. As shown in fig. 2B, the photoelectrode 3 is composed of a probe electrode 31 prepared by EMS process and an LED lamp 32 epitaxial on sapphire sheet. The detection electrode 31 and the LED lamp 32 are respectively prepared and then assembled into the photoelectrode 3, so that the effect of low noise can be achieved.
The detection electrode 31, the LED lamp 32, the transmission interface 2 and the receiving coil 1 are respectively welded on the PCB board by gold wire pressure welding. The PCB is also provided with a signal transmission circuit and an energy receiving circuit. The detection electrode 31 is communicated with the transmission interface 2 through a signal transmission circuit, the detection electrode 31 detects an electroencephalogram signal of a focus brain area of the epileptic mouse, and the electroencephalogram signal is transmitted to the signal processing module 102 through the transmission interface 2. The LED lamp 32 is in communication with the receiving coil 1 through an energy receiving circuit. The receiving coil 1 receives the electric energy provided by the wireless energy supply module 103 in an electromagnetic coupling mode, and transmits the electric energy to the LED lamp 32, so that the LED lamp 32 emits light.
Fig. 4 schematically shows the signal processing module 102 of the present embodiment. The signal processing module 102 includes a signal processing unit 201 and a signal classification unit 202.
The signal processing unit 201 is used for filtering and amplifying the electroencephalogram signals;
because strong interference exists when the detection electrode 31 detects the electroencephalogram signal, and the detected electroencephalogram signal is very weak, the electroencephalogram signal needs to be filtered and amplified. The method is beneficial to improving the accuracy of the electroencephalogram signals and is convenient for further processing.
And the signal classification unit 202 is used for classifying the electroencephalogram signals and acquiring control signals corresponding to the classification.
When the signal classification unit 201 classifies the electroencephalogram signal, it first determines whether the electroencephalogram signal exceeds a preset threshold according to the intensity of the detected electroencephalogram signal. When the strength of the electroencephalogram signal is larger than a preset threshold value, acquiring a first control signal; and when the strength of the electroencephalogram signal is smaller than a preset threshold value, acquiring a second control signal. The first control signal controls the wireless energy supply module (103) to start energy supply, and the second control signal controls the wireless energy supply module (103) to end energy supply.
Fig. 3 schematically illustrates another wireless closed-loop control system 900. The closed-loop control system 900 includes: photoelectrode module 101, wireless record module 104, signal processing module 102 and wireless energy supply module 103. The functions of the photoelectrode module 101, the signal processing module 102 and the wireless power supply module 103 are as above, and are not described herein again.
And the wireless recording module 104 is connected with the photoelectrode module 101 and used for storing the electroencephalogram signals and forwarding the electroencephalogram signals to the signal processing module 102.
The wireless recording module 104, the signal processing module 102 and the wireless energy supply module 103 are in wireless communication. The wireless communication mode can be Bluetooth, WIFE, relay and the like.
The wireless closed-loop control system can automatically adjust the illumination in time and accurately according to the strength of the electroencephalogram signal. The method can be applied to matching photosensitive drugs, monitoring seizure and treatment of epilepsy in real time, and controlling the light intensity of the photoelectrode by detecting the electroencephalogram signals, so that epilepsy can be treated quickly in real time, and side effects caused by excessive epilepsy treatment drugs can be prevented. According to the wireless closed-loop control system, each module adopts a wireless connection mode, so that the influence of connection lines is eliminated, and the experimental animal can perform normal physiological activities.
Fig. 5 is a flow chart of a wireless closed-loop control method.
And S100, detecting the electroencephalogram signals.
Specifically, the photoelectrode 3 is implanted into the brain region of the brain by a surgical operation. The detection electrode 31 in the photoelectrode 3 detects the electroencephalogram signal, and the electroencephalogram signal is stored in the wireless recording module 104 through the transmission interface 2. The wireless recording module 104 stores the electroencephalogram signal and transmits the electroencephalogram signal to the signal processing module 102 in a wireless communication mode. The frequency of signal transmission can be transmitted once every 1 second or every 2 seconds, so that the effect that the signal processing equipment can process the electroencephalogram signals in real time is achieved.
And S200, processing and classifying the electroencephalogram signals, and acquiring control signals corresponding to the classification.
The electroencephalogram signal processing is to filter and amplify the electroencephalogram signal. And filtering the received electroencephalogram signal data, and improving the accuracy of the acquired electroencephalogram signal data. And then amplifying the EEG signal data obtained after filtering, thereby facilitating further classification of the EEG signals. Whether the electroencephalogram signal exceeds a preset threshold value is judged according to the intensity of the electroencephalogram signal during classification of the electroencephalogram signal, when the intensity of the electroencephalogram signal is larger than the preset threshold value, a first control signal is obtained, when the intensity of the electroencephalogram signal is smaller than the preset threshold value, a second control signal is obtained, wherein the first control signal is used for controlling the wireless energy supply module (103) to start energy supply, and the second control signal is used for controlling the wireless energy supply module (103) to end energy supply.
S300, controlling power supply according to the control signal to enable the LED lamp 32 to emit light
Specifically, the wireless power supply system is controlled according to the control signal to supply electric energy to the photoelectrode module 101. After the wireless energy supply module 103 receives the control signal, the electric energy is transmitted to the receiving coil 1 of the photoelectrode module 101 by using the principle of electromagnetic coupling, so that the LED lamp 32 is lighted. The illumination intensity of the LED lamp 32 is controlled by controlling the electric energy generated by the wireless energy supply module 103.
The wireless closed-loop control method can be applied to treatment of brain diseases, such as detection and treatment of epilepsy of epileptic mice. And implanting the photoelectrode 3 into a brain focus brain area of the epileptic mouse to detect an electroencephalogram signal. When the epileptic mouse is judged to be in the epileptic state, a control signal is sent in real time, and the LED lamp 32 starts to be supplied with electric energy. When the LED lamp 32 starts to illuminate, the caged compounds already existing in the focal zone of the brain are subjected to photocaging, and the epilepsy-inhibiting component is released to inhibit the seizure of epilepsy. Meanwhile, the signal processing module 102 analyzes the electroencephalogram signals in real time, when the electroencephalogram signals are recovered to be normal, the signal processing module 102 sends control signals, the LED lamp 32 stops illuminating, and the epilepsy treatment components are not released any more.
Fig. 6 is a flow chart of a specific method for processing and classifying electroencephalogram signals and obtaining control signals corresponding to the classifications.
And S210, filtering and amplifying the electroencephalogram signals.
Because strong interference exists when the detection electrode 31 detects the electroencephalogram signal, and the detected electroencephalogram signal is very weak, the electroencephalogram signal needs to be filtered and amplified. The method is beneficial to improving the accuracy of the electroencephalogram signals and is convenient for further processing.
S220, the electroencephalogram signals are classified, and control signals corresponding to the classification are obtained.
And classifying the electroencephalogram signals according to the intensity of the electroencephalogram signals. When the strength of the electroencephalogram signal is larger than a preset threshold value, acquiring a first control signal; and when the strength of the electroencephalogram signal is smaller than the preset threshold value, acquiring a second control signal. The first control signal controls the wireless energy supply module 103 to start energy supply, and the second control signal controls the wireless energy supply module 103 to end energy supply.
The beneficial effects of the wireless closed-loop control method are as described in the beneficial effects of the wireless closed-loop control system, and are not described herein again.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A wireless closed-loop control system, comprising:
the photoelectrode module (101) is used for detecting an electroencephalogram signal;
the signal processing module (102) is used for processing and classifying the electroencephalogram signals and acquiring control signals corresponding to the classification;
a wireless energy supply module (103) for supplying electric energy to the photoelectrode module (101) according to the control signal;
the photoelectrode module (101) is also used for receiving the electric energy to enable the LED lamp (32) in the photoelectrode module (101) to emit light.
2. The wireless closed-loop control system of claim 1, wherein the photoelectrode module (101) comprises:
a detection electrode (31) for detecting the electroencephalogram signal;
a transmission interface (2) for delivering the brain electrical signal to the signal processing module (102);
the receiving coil (1) is used for receiving the electric energy provided by the wireless energy supply module (103);
an LED lamp (32) for emitting light by the electric energy.
3. Wireless closed-loop control system according to claim 2, characterized in that the probe electrode (31) and the LED lamp (32) together constitute a photoelectrode (3).
4. The wireless closed-loop control system of claim 1, wherein the signal processing module (102) comprises:
the signal processing unit (201) is used for filtering and amplifying the electroencephalogram signals;
and the signal classification unit (202) is used for classifying the electroencephalogram signals and acquiring control signals corresponding to the classification.
5. The wireless closed-loop control system of claim 4, wherein the signal classification unit (202) is specifically configured to:
judging whether the electroencephalogram signal exceeds a preset threshold value according to the intensity of the electroencephalogram signal;
when the strength of the electroencephalogram signal is larger than the preset threshold value, acquiring a first control signal;
when the electroencephalogram signal intensity is smaller than the preset threshold value, acquiring a second control signal;
wherein, the first control signal controls the wireless energy supply module (103) to start energy supply, and the second control signal controls the wireless energy supply module (103) to end energy supply.
6. The wireless closed-loop control system of claim 1, further comprising:
the wireless recording module (104) is connected with the photoelectrode module (101) and used for storing the electroencephalogram signals and forwarding the electroencephalogram signals to the signal processing module (102).
7. The wireless closed-loop control system of claim 6, further comprising:
the wireless recording module (104), the signal processing module (102) and the wireless energy supply module (103) are in wireless communication.
8. A wireless closed-loop control method applied to the wireless closed-loop control system according to claims 1-7, characterized by comprising:
detecting an electroencephalogram signal;
processing and classifying the electroencephalogram signals to obtain control signals corresponding to the classification;
and controlling the power supply according to the control signal so that the LED lamp (32) emits light.
9. The method of claim 8, wherein said processing and classifying said brain electrical signals to obtain control signals corresponding to said classification further comprises:
filtering and amplifying the electroencephalogram signals;
and classifying the electroencephalogram signals, and acquiring control signals corresponding to the classification.
10. The method of claim 9, wherein said classifying said brain electrical signal and obtaining a control signal corresponding to said classification further comprises:
judging whether the electroencephalogram signal exceeds a preset threshold value according to the intensity of the electroencephalogram signal;
when the strength of the electroencephalogram signal is larger than the preset threshold value, acquiring a first control signal;
when the electroencephalogram signal intensity is smaller than the preset threshold value, acquiring a second control signal;
wherein, the first control signal controls the wireless energy supply module (103) to start energy supply, and the second control signal controls the wireless energy supply module (103) to end energy supply.
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| US20010056290A1 (en) * | 1997-10-27 | 2001-12-27 | Fischell Robert E. | Methods for responsively treating neurological disorders |
| WO2008133625A1 (en) * | 2007-04-30 | 2008-11-06 | Medtronic, Inc. | Seizure prediction |
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