CN113081995A - Hydroxypropyl starch empty capsule and preparation method and application thereof - Google Patents
Hydroxypropyl starch empty capsule and preparation method and application thereof Download PDFInfo
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- CN113081995A CN113081995A CN202110352169.3A CN202110352169A CN113081995A CN 113081995 A CN113081995 A CN 113081995A CN 202110352169 A CN202110352169 A CN 202110352169A CN 113081995 A CN113081995 A CN 113081995A
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- hydroxypropyl starch
- parts
- portions
- grinding powder
- glue
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- 239000001341 hydroxy propyl starch Substances 0.000 title claims abstract description 55
- 235000013828 hydroxypropyl starch Nutrition 0.000 title claims abstract description 55
- 239000002775 capsule Substances 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000000843 powder Substances 0.000 claims abstract description 36
- 238000000227 grinding Methods 0.000 claims abstract description 34
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 30
- 229960001631 carbomer Drugs 0.000 claims abstract description 30
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000661 sodium alginate Substances 0.000 claims abstract description 29
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 29
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 29
- 239000008213 purified water Substances 0.000 claims abstract description 27
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 19
- 244000197580 Poria cocos Species 0.000 claims abstract description 19
- 235000013372 meat Nutrition 0.000 claims abstract description 15
- 239000004014 plasticizer Substances 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 235000001188 Peltandra virginica Nutrition 0.000 claims abstract description 5
- 239000003292 glue Substances 0.000 claims description 40
- 239000007864 aqueous solution Substances 0.000 claims description 32
- 239000000243 solution Substances 0.000 claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 238000005303 weighing Methods 0.000 claims description 16
- 229920002472 Starch Polymers 0.000 claims description 15
- 235000019698 starch Nutrition 0.000 claims description 15
- 239000008107 starch Substances 0.000 claims description 15
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 238000007598 dipping method Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 238000005520 cutting process Methods 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 238000004321 preservation Methods 0.000 claims description 2
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 abstract description 10
- 210000000936 intestine Anatomy 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract description 2
- 229940072056 alginate Drugs 0.000 abstract description 2
- 235000010443 alginic acid Nutrition 0.000 abstract description 2
- 229920000615 alginic acid Polymers 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 239000007902 hard capsule Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention provides a hydroxypropyl starch empty capsule, a preparation method and application thereof, wherein the hydroxypropyl starch empty capsule is prepared from the following raw materials in parts by weight: 800 portions of hydroxypropyl starch, 40 to 70 portions of carbomer, 40 to 70 portions of sodium alginate, 40 to 100 portions of plasticizer, 10 to 20 portions of tuckahoe grinding powder, 15 to 20 portions of red date meat grinding powder and 900 portions of purified water. The plant hollow hard capsule is prepared by adding the low-viscosity alginate serving as a raw material, and all indexes of the product meet the national standard and have the same bioequivalence and bioavailability; the poria cocos grinding powder and the red date meat grinding powder are added, so that the effects of invigorating stomach and tonifying qi are achieved, when people eat the capsule for a long time, the poria cocos and the red dates can play a health care role in intestines and stomach of a human body, damage to the intestines and stomach is reduced, personal safety of people is guaranteed, and the health care performance of the capsule is improved.
Description
Technical Field
The invention relates to the technical field of preparation of pharmaceutical excipients, and in particular relates to a hydroxypropyl starch empty capsule as well as a preparation method and application thereof.
Background
In the prior art, the medicine packaged in a capsule is generally powder or granules which have irritation to esophagus and gastric mucosa, or medicine which has bad taste, is easy to volatilize, is easy to be decomposed by saliva in oral cavity and is easy to be absorbed into trachea. The medicine is filled into capsules, so that the medicine property of the medicine is protected from being damaged, and digestive organs and respiratory tracts are protected; removal of the capsule shell may cause drug loss, drug waste, reduced efficacy, etc.; in addition, some drugs need to be dissolved and absorbed in the intestine, and the capsule protects the drug from gastric acid. Therefore, during the production of the medicine, only the capsule made of special film-forming material can be used for filling the content or the dosage into the capsule, so that the capsule is convenient to swallow.
However, the common capsules have slight irritation to the intestinal tract and stomach of human body, and after people eat the capsules for a long time, the capsules can have adverse effects on the intestinal tract, further influence the health of people and suffer from diseases.
Disclosure of Invention
The invention aims to provide a hydroxypropyl starch empty capsule, and a preparation method and application thereof.
The invention adopts the following technical scheme:
the hydroxypropyl starch empty capsule is prepared from the following raw materials in parts by weight:
800 portions of hydroxypropyl starch, 40 to 70 portions of carbomer, 40 to 70 portions of sodium alginate, 40 to 100 portions of plasticizer, 10 to 20 portions of tuckahoe grinding powder, 15 to 20 portions of red date meat grinding powder and 900 portions of purified water.
In the technical scheme, the hydroxypropyl starch empty capsule is prepared from the following raw materials in parts by weight:
855-968 parts of hydroxypropyl starch, 48-65 parts of carbomer, 46-58.5 parts of sodium alginate, 52-88 parts of plasticizer, 12.5-18.5 parts of tuckahoe grinding powder, 16.5-19 parts of red date grinding powder and 875 parts of purified water 560-.
In one embodiment of the invention, the hydroxypropyl starch empty capsule is prepared from the following raw materials in parts by weight:
948 parts of hydroxypropyl starch, 58.5 parts of carbomer, 53.5 parts of sodium alginate, 78 parts of plasticizer, 16.8 parts of poria cocos grinding powder, 17.8 parts of red date meat grinding powder and 788 parts of purified water.
In detail, in the above technical solution, the plasticizer is glycerin and/or sorbitol.
In a preferred embodiment of the present invention, the plasticizer is a mixture of 1: 1 mixture of glycerol and sorbitol.
The invention also provides a preparation method of the hydroxypropyl starch empty capsule, which comprises the following steps:
s1, weighing sodium alginate according to a proportion, adding the sodium alginate into purified water with the mass of 1.8-2.5 times of the sodium alginate, heating and stirring to prepare transparent and clear sodium alginate aqueous solution;
s2, respectively weighing hydroxypropyl starch and carbomer glue according to a proportion, adding the hydroxypropyl starch into purified water which contains 0.4-0.6 time of the plasticizer and 0.35-0.6 time of the mass of the carbomer glue according to the formula, adding the carbomer glue into purified water which contains the rest of the plasticizer and 0.5-0.75 time of the mass of the carbomer glue, heating and stirring to respectively obtain transparent and clear hydroxypropyl starch water solution and carbomer glue water solution;
s3, adding the hydroxypropyl starch aqueous solution and the carbomer glue aqueous solution prepared in the step S2 into the sodium alginate aqueous solution prepared in the step S1, and heating and stirring at 40-50 ℃ for 30-45min to obtain a mixed glue solution;
s4, weighing the poria cocos grinding powder and the red date meat grinding powder according to the proportion, adding the poria cocos grinding powder and the red date meat grinding powder into the mixed glue solution obtained in the step S3, adding the balance of purified water, uniformly stirring, placing the mixture into a water bath kettle, preserving heat, standing, and removing bubbles to obtain a mixed starch solution;
and S5, dipping the mixed starch solution in glue at the temperature of below 0 ℃, and sequentially drying and demolding to obtain the starch.
Specifically, in the above technical solution, in step S4, the temperature of the heat preservation is 65-75 ℃.
Specifically, in the above technical solution, in step S4, the standing time is 100-200 min.
Specifically, in the above technical solution, in step S1, the heating and stirring temperature is 58-65 ℃.
Specifically, in the above technical solution, in step S2, the heating and stirring temperature is 55-65 ℃.
Specifically, in the above technical solution, in step S5, the temperature of the dipping glue is controlled to be lower than-5 ℃.
Specifically, in the above technical solution, in step S5, the drying temperature is 4-8 ℃.
Specifically, in the above technical solution, step S5 further includes cutting and fitting after demolding.
The invention also provides the application of the hydroxypropyl starch hollow capsule or the preparation method of the hydroxypropyl starch hollow capsule in medicine, food and health care product capsules.
Compared with the prior art, the invention has the beneficial effects that:
1. the hydroxypropyl starch hollow capsule provided by the invention is prepared by adding low-viscosity alginate into the capsule as a raw material, each index of the prepared capsule conforms to the national standard, particularly the heavy metal content is far lower than the national specified standard, and the prepared capsule has the same bioequivalence and bioavailability;
2. when the hydroxypropyl starch hollow capsule provided by the invention is produced, the poria cocos grinding powder and the red date meat grinding powder are added, so that the functions of invigorating stomach and tonifying qi are achieved, and when people eat the capsule for a long time, the poria cocos and the red dates can play a health care role on the intestines and stomach of a human body, the damage to the intestines and stomach is reduced, the personal safety of people is guaranteed, and the health care performance of the capsule is improved.
Detailed Description
The present invention is further described in detail below with reference to specific examples so that those skilled in the art can more clearly understand the present invention.
The following examples are given for the purpose of illustration only and are not intended to limit the scope of the invention.
All other embodiments obtained by a person skilled in the art based on the specific embodiments of the present invention without any inventive step are within the scope of the present invention.
In the examples of the present invention, all the raw material components are commercially available products well known to those skilled in the art unless otherwise specified.
In the examples of the present invention, unless otherwise specified, all technical means used are conventional means well known to those skilled in the art.
Example 1
The embodiment of the invention provides a hydroxypropyl starch empty capsule and a preparation method thereof, and the preparation method specifically comprises the following steps:
s1, weighing 58g of sodium alginate, adding the sodium alginate into 100g of purified water, and placing the mixture in a water bath kettle at 62 ℃ for heating and stirring until a transparent and clear sodium alginate aqueous solution is obtained;
s2, 965g of hydroxypropyl starch is weighed and added into an aqueous solution containing 36g of glycerin and 484g of purified water, 55g of carbomer is weighed and added into an aqueous solution containing 36g of sorbitol and 36g of purified water, and the mixture is placed in a water bath kettle at 60 ℃ to be heated and stirred, so that a transparent and clear hydroxypropyl starch aqueous solution and a clear carbomer glue aqueous solution are obtained respectively;
s3, adding the hydroxypropyl starch aqueous solution and the carbomer glue aqueous solution prepared in the step S2 into the sodium alginate aqueous solution prepared in the step S1, and heating and stirring at 45 ℃ for 35min to obtain a mixed glue solution;
s4, weighing 16g of poria cocos grinding powder and 18g of red date meat grinding powder, adding the weighed materials into the mixed glue solution in the step S3, adding 130g of purified water, uniformly stirring, placing the mixture into a 70 ℃ water bath kettle, preserving heat, standing for 120min, and removing bubbles to obtain a mixed starch solution;
and S5, dipping the mixed starch solution in glue at-12 ℃, and sequentially drying and demoulding at 6 ℃, cutting and sheathing to obtain the starch.
Example 2
The embodiment of the invention provides a hydroxypropyl starch empty capsule and a preparation method thereof, and the preparation method specifically comprises the following steps:
s1, weighing 65g of sodium alginate, adding the sodium alginate into 120g of purified water, and placing the mixture in a water bath kettle at 60 ℃ for heating and stirring until a transparent and clear sodium alginate aqueous solution is obtained;
s2, weighing 838g of hydroxypropyl starch, adding the hydroxypropyl starch into an aqueous solution containing 15g of glycerol, 15g of sorbitol and 420g of purified water, weighing 45g of carbomer glue, adding the carbomer glue into an aqueous solution containing 15g of glycerol, 15g of sorbitol and 27g of purified water, and simultaneously placing the mixture in a water bath kettle at 65 ℃ for heating and stirring to respectively obtain a transparent and clear hydroxypropyl starch aqueous solution and a carbomer glue aqueous solution;
s3, adding the hydroxypropyl starch aqueous solution and the carbomer glue aqueous solution prepared in the step S2 into the sodium alginate aqueous solution prepared in the step S1, and heating and stirring at 48 ℃ for 42min to obtain a mixed glue solution;
s4, weighing 20g of poria cocos grinding powder and 15g of red date meat grinding powder, adding the weighed materials into the mixed glue solution in the step S3, adding 320g of purified water, uniformly stirring, placing the mixture into a water bath kettle at 72 ℃, preserving heat, standing for 150min, and removing bubbles to obtain a mixed starch solution;
and S5, dipping the mixed starch solution in glue at the temperature of-8 ℃, and sequentially drying and demoulding at the temperature of 6 ℃, cutting and sleeving to obtain the starch.
Example 3
The embodiment of the invention provides a hydroxypropyl starch empty capsule and a preparation method thereof, and the preparation method specifically comprises the following steps:
s1, weighing 53.5g of sodium alginate, adding the sodium alginate into 110g of purified water, and placing the mixture in a water bath kettle at 65 ℃ for heating and stirring until a transparent and clear sodium alginate aqueous solution is obtained;
s2, weighing 948g of hydroxypropyl starch, adding the hydroxypropyl starch into an aqueous solution containing 19.5g of glycerol, 19.5g of sorbitol and 473g of purified water, weighing 58.5g of carbomer glue, adding the carbomer glue into an aqueous solution containing 19.5g of glycerol, 19.5g of sorbitol and 35g of purified water, and simultaneously placing the mixture in a water bath kettle at 60 ℃ for heating and stirring to respectively obtain a transparent and clear hydroxypropyl starch aqueous solution and a carbomer glue aqueous solution;
s3, adding the hydroxypropyl starch aqueous solution and the carbomer glue aqueous solution prepared in the step S2 into the sodium alginate aqueous solution prepared in the step S1, and heating and stirring at 45 ℃ for 40min to obtain a mixed glue solution;
s4, weighing 16.8g of poria cocos grinding powder and 17.8g of red date meat grinding powder, adding the weighed materials into the mixed glue solution obtained in the step S3, adding 170g of purified water, stirring uniformly, placing the mixture into a 72-DEG C water bath kettle, preserving heat, standing for 150min, and removing bubbles to obtain a mixed starch solution;
and S5, dipping the mixed starch solution in glue at the temperature of-10 ℃, and sequentially drying and demoulding at the temperature of 7 ℃, cutting and sleeving to obtain the starch glue.
The surface roughness of the samples prepared in examples 1 to 3 of the present invention was measured using a non-contact surface shape tester; puncture tests were performed on both ends of the samples prepared in examples 1 to 3 at 25 ℃ and 50% RH using symbian beiicap, and it was determined that 1 or more samples were rejected, and the breakage rate was the rejection rate when each sample was punctured 200 times.
Powder-capsule wall adhesion rate: 100mg of talc powder having a particle size of 50 μm was added to the samples obtained in examples 1 to 3 of the present invention, the capsule body and cap were closed and no powder leakage was ensured, the capsule was held by hand and turned upside down 10 times, the talc powder was poured out after opening the capsule, the mass m (in mg) of the talc powder flowing out was weighed, the adhesion rate S was calculated to be (100-m)/100 x 100%, and the procedure was repeated 5 times to obtain an average value.
The test results are shown in table 1 below.
TABLE 1 results of Performance testing of the samples
When the hydroxypropyl starch hollow capsule provided by the embodiment 1-3 of the invention is produced, the poria cocos grinding powder and the red date meat grinding powder are added, so that the capsule has the functions of invigorating stomach and tonifying qi, and people can take the health care effect on intestines and stomach and reduce the damage to the intestines and stomach when eating the capsule for a long time.
Finally, the method of the present invention is only a preferred embodiment and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A hydroxypropyl starch empty capsule which is characterized in that,
the composition is prepared from the following raw materials in parts by weight:
800 portions of hydroxypropyl starch, 40 to 70 portions of carbomer, 40 to 70 portions of sodium alginate, 40 to 100 portions of plasticizer, 10 to 20 portions of tuckahoe grinding powder, 15 to 20 portions of red date meat grinding powder and 900 portions of purified water.
2. The hydroxypropyl starch empty capsule according to claim 1,
the composition is prepared from the following raw materials in parts by weight:
855-968 parts of hydroxypropyl starch, 48-65 parts of carbomer, 46-58.5 parts of sodium alginate, 52-88 parts of plasticizer, 12.5-18.5 parts of tuckahoe grinding powder, 16.5-19 parts of red date grinding powder and 875 parts of purified water 560-.
3. The hydroxypropyl starch empty capsule according to claim 1,
the composition is prepared from the following raw materials in parts by weight:
948 parts of hydroxypropyl starch, 58.5 parts of carbomer, 53.5 parts of sodium alginate, 78 parts of plasticizer, 16.8 parts of poria cocos grinding powder, 17.8 parts of red date meat grinding powder and 788 parts of purified water.
4. Hydroxypropyl starch empty capsules according to any one of claims 1 to 3,
the plasticizer is glycerol and/or sorbitol, and preferably the mass ratio of the plasticizer to the sorbitol is 1: 1 mixture of glycerol and sorbitol.
5. The method for preparing hydroxypropyl starch empty capsules according to any one of claims 1 to 4,
the method comprises the following steps:
s1, weighing sodium alginate according to a proportion, adding the sodium alginate into purified water with the mass of 1.8-2.5 times of the sodium alginate, heating and stirring to prepare transparent and clear sodium alginate aqueous solution;
s2, respectively weighing hydroxypropyl starch and carbomer glue according to a proportion, adding the hydroxypropyl starch into purified water which contains 0.4-0.6 time of the plasticizer and 0.35-0.6 time of the mass of the carbomer glue according to the formula, adding the carbomer glue into purified water which contains the rest of the plasticizer and 0.5-0.75 time of the mass of the carbomer glue, heating and stirring to respectively obtain transparent and clear hydroxypropyl starch water solution and carbomer glue water solution;
s3, adding the hydroxypropyl starch aqueous solution and the carbomer glue aqueous solution prepared in the step S2 into the sodium alginate aqueous solution prepared in the step S1, and heating and stirring at 40-50 ℃ for 30-45min to obtain a mixed glue solution;
s4, weighing the poria cocos grinding powder and the red date meat grinding powder according to the proportion, adding the poria cocos grinding powder and the red date meat grinding powder into the mixed glue solution obtained in the step S3, adding the balance of purified water, uniformly stirring, placing the mixture into a water bath kettle, preserving heat, standing, and removing bubbles to obtain a mixed starch solution;
and S5, dipping the mixed starch solution in glue at the temperature of below 0 ℃, and sequentially drying and demolding to obtain the starch.
6. The method for preparing hydroxypropyl starch empty capsules according to claim 5,
in the step S4, in the step S,
the temperature of the heat preservation is 65-75 ℃;
and/or the standing time is 100-200 min.
7. The method for preparing hydroxypropyl starch empty capsules according to claim 5,
in the step S1, the heating and stirring temperature is 58-65 ℃;
and/or in step S2, the heating and stirring temperature is 55-65 ℃.
8. The method for preparing hydroxypropyl starch empty capsules according to claim 5,
in the step S5, in the step S,
the temperature of the dipping glue is controlled to be lower than-5 ℃;
the drying temperature is 4-8 ℃.
9. The method for preparing hydroxypropyl starch empty capsules according to claim 5,
step S5 further includes cutting and fitting after demolding.
10. Use of a hydroxypropyl starch empty capsule according to any one of claims 1 to 4 or a method of preparation of a hydroxypropyl starch empty capsule according to any one of claims 5 to 9 in pharmaceutical, food and nutraceutical capsules.
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Application publication date: 20210709 |