CN113081842A

CN113081842A - Spirolactone sheet production process and production equipment thereof

Info

Publication number: CN113081842A
Application number: CN202110399846.7A
Authority: CN
Inventors: 董长军
Original assignee: Shanghai Hengshan Pharmaceutical Co ltd
Current assignee: Shanghai Hengshan Pharmaceutical Co ltd
Priority date: 2021-04-14
Filing date: 2021-04-14
Publication date: 2021-07-09
Anticipated expiration: 2041-04-14
Also published as: CN113081842B

Abstract

The invention discloses a spironolactone tablet production process and spironolactone tablet production equipment, wherein the spironolactone tablet production equipment comprises a workbench, a mixing and granulating mechanism and a drying and dispersing mechanism are arranged on the workbench, a granulating machine is arranged at one end of the workbench, a tablet press is arranged below the workbench, a feeding mechanism is arranged above the mixing and granulating mechanism, the mixing and granulating mechanism is fixed with the drying and dispersing mechanism, and the granulating machine is positioned below one end of the drying and dispersing mechanism. Mix pelletization mechanism and will mix and pelletize even as a whole, mix pelletization mechanism and after mixing the raw materials and pelletize the raw materials after mixing, dry dispersion mechanism transmits the pelletization to carrying out dispersion and drying to the pelletization in transmission process, prevent that the pelletization from gluing together, and will be stained with the pelletization dispersion of gluing together in transmission process, thereby accelerate the drying of pelletization and reduce the work burden of whole grain machine, improve the whole grain efficiency of spirolactone piece.

Description

Spirolactone sheet production process and production equipment thereof

Technical Field

The invention relates to the technical field of spironolactone sheet production, in particular to a spironolactone sheet production process and spironolactone sheet production equipment.

Background

With the continuous progress of science and technology and the continuous improvement of living standard, the amount of exercise of people is continuously reduced, and people excessively drink alcohol and ingest a large amount of high-salt diet while lacking physical exercise or physical activity, so that human diseases are endless, such as hypertension and heart failure.

Spirolactone is potassium-retaining diuretic, has potassium-retaining effect, and is mainly used for inhibiting aldosterone, and is aldosterone receptor antagonist. Aldosterone has the functions of sodium retention and water retention, so spironolactone is a medicament for expelling sodium, retaining potassium and promoting diuresis. Spironolactone is used primarily for two treatments, one for heart failure and the other for hypertension.

In the production and preparation process of the spironolactone tablets, spironolactone and some auxiliary materials are mixed together for granulation and tabletting. At present, common stirring and mixing equipment sequentially feeds materials through a feeding hole, so that raw materials are layered in the stirring and mixing equipment, the mixing time is long, and the mixing efficiency is low.

Disclosure of Invention

The invention aims to provide a spironolactone sheet production process and spironolactone sheet production equipment, which aim to solve the problems in the background technology.

In order to solve the technical problems, the invention provides the following technical scheme: the utility model provides a spironolactone piece production facility, this production facility includes the workstation, be provided with on the workstation and mix pelletization mechanism and dry dispersion mechanism, workstation one end is provided with the tablet press, is provided with the tablet press below the workstation, it is provided with feed mechanism to mix pelletization mechanism top, mixes pelletization mechanism and dry dispersion mechanism fixed, the pelletization machine is located the below of dry dispersion mechanism one end. Mix pelletization mechanism and will mix and pelletize even as a whole, mix pelletization mechanism and after mixing the raw materials and pelletize the raw materials after mixing, dry dispersion mechanism transmits the pelletization, and disperse and dry to the pelletization in transmission process, prevent that the pelletization from gluing together, and will be stained with the pelletization dispersion of gluing together in transmission process, thereby accelerate the dry work burden that reduces whole grain machine of pelletization, improve the whole grain efficiency of spironolactone piece, thereby the production efficiency of spironolactone piece has been improved.

The mixing and granulating mechanism comprises a protective box, two groups of support rings and one group of cross frames are arranged in the protective box from top to bottom, a blanking box is arranged on the upper group of support rings, a mixing box is arranged on the lower group of support rings, a granulating box is arranged on the cross frames, the upper end of the blanking box is connected with a feeding mechanism pipeline, and the lower end of the mixing box is rotatably connected with the granulating box; the drying and dispersing mechanism comprises a conveying belt, one end of the conveying belt is positioned below the cross, and the other end of the conveying belt is positioned above the granulating machine. The feed box stores the raw materials that feed mechanism put in, and put into the mixing box with the raw materials through the rotation, the feed box drives the flow of the inside air of mixing box when rotating, make the raw materials accomplish preliminary mixing at the in-process that falls down, prevent that the phenomenon of layering appears after the raw materials falls into the mixing box, the mixing box makes and mixes between the raw materials through centrifugal force, the part in the mixing box rotates the in-process pelletization case stirs the raw materials at the mixing box, accelerate the mixing rate of raw materials, after the raw materials gets into the pelletization case, the mixing box drives the pelletization roller through rotating and rotates in the pelletization case, and accomplish the pelletization to the raw materials with the pelletization board in the pelletization case each other, the conveyer belt transmits the pelletization, and make the dispersion between the pelletization through vibrations in transmission process, the conveyer belt puts into the.

Six groups of connecting plates are arranged on the blanking box, a blanking cabin is arranged at the other end of each group of connecting plates, a blanking plate is arranged below each group of blanking cabins, and the blanking plates are positioned in the mixing box; the inside lower extreme of mixing box is the recess form, and mixing box below symmetry is provided with two sets of gangplates, every group all be provided with the pelletization roller on the gangplate, gangplate and pelletization roller all are located the pelletization case. The lower feed bin and the feed box are connected to the connecting plate, the feed bin stores the raw materials, the raw materials enter the mixing box through the feed plate, the feed plate rotates in the mixing box under the drive of the feed bin, and the air flows in the mixing box is driven, various raw materials are mixed with each other under the drive of the air flow in the falling process, the lower end inside the mixing box is in a groove shape, the mixing box generates centrifugal force when rotating at high speed, the raw materials falling into the groove are mixed again under the action of the centrifugal machine, the linkage plate provides support for the rotating installation of the granulating roller, the granulating roller rotates in the granulator under the drive of the linkage plate, and the granulating roller and the granulating plate in the granulating box are matched with each other to complete the granulation of the raw materials.

A discharging through hole is formed in the middle of the lower end of the mixing box; be provided with the pelletization board in the pelletization case, the pelletization roller rotates with the pelletization board to be connected, the pelletization middle part is provided with telescopic cylinder, telescopic cylinder upper end is provided with divides the material umbrella, the upper end that divides the material umbrella is located discharging hole, the top that lies in the pelletization board on the telescopic cylinder is provided with the spacing ring. Discharging hole provides the support in entering into the pelletization case for the raw materials after mixing, divide the material umbrella to lead to the groove shutoff of ejection of compact, and disperse the raw materials in the mixing box that falls into, prevent that the raw materials from piling up at the mixing box middle part, telescopic cylinder provides power for dividing the rising and descending of material umbrella, divide the material umbrella to remove the shutoff to discharging hole under telescopic cylinder's drive, make the raw materials after the humidification mixes enter into the pelletization case, and simultaneously, divide the material umbrella to disperse the raw materials that flow in the mixing box, make the raw materials dispersion everywhere at the pelletization board, the stop ring limits the whereabouts region of raw materials, prevent to fall into the position that is close to telescopic cylinder, make the raw materials all fall on the position that the pelletization board has the pelletization hole.

Six groups of mounting grooves are formed in the upper end of the material distribution umbrella, an auxiliary plate is arranged in each group of mounting grooves, a stirring plate is arranged at the other end of each group of auxiliary plates, the lower end of each group of stirring plates is attached to the end face of a groove in the mixing box, each group of stirring plates is arc-shaped, a material distribution air bag is arranged below the edge of the material distribution umbrella, a rotating motor is arranged at the lower end of the material distribution umbrella, and the rotating motor is fixed to the upper end of the telescopic cylinder. The upper end of the material distributing umbrella is positioned in the mixing box, the auxiliary plate is used for connecting the stirring plate and the material distributing umbrella, when the raw materials need to be granulated, the material distributing umbrella descends, the stirring plate rotates in the mixing box under the driving of the material distributing umbrella, the stirring plate scrapes the raw materials in the mixing box into the granulating box, the raw materials are further prevented from being adhered in the mixing box, when the mixing box rotates, the material distributing umbrella reverses in the mixing box, namely, the rotating direction of the mixing box is opposite to that of the mixing box, so that the stirring plate blocks and stirs the raw materials in the mixing box, the raw materials climb and fall from the stirring plate under the driving of the mixing box, the mixing of the raw materials is further accelerated, when the material distributing umbrella rotates at a high speed, the material distributing air bag expands outwards under the action of a centrifugal machine, the material distributing range of the material distributing umbrella is expanded, the raw materials slide into the material distributing air bag from the material distributing umbrella, the rotary motor enables the material-distributing air bag to continuously expand and contract outwards through speed change, so that the falling area of the raw materials is continuously changed back and forth, and the raw materials are uniformly dispersed on the granulating plate.

The drying and dispersing mechanism further comprises a protective shell, the protective shell covers the conveying belt, one end of the conveying belt is located in the protective box, the other end of the conveying belt is located in the protective shell, vertical plates are arranged on two sides of the upper portion of the conveying belt and located in the protective shell, a plurality of groups of granulating plates are arranged between the vertical plates, and the granulating plates are not in contact with the conveying belt. The granulating plates are rotatably arranged on the two groups of vertical plates, the granulating plates have a certain rotating angle on the vertical plates, and the granulating plates and the conveying belt are matched with each other to disperse agglomerated granules.

The conveyer belt includes two sets of mounting panels, and is two sets of be provided with the transmission band between the mounting panel, the transmission band includes the link joint, installs the transmission belt on the link joint, the link joint is kept away from transmission belt and is provided with a plurality of vibrations boards of group on the surface, and the link joint middle part is provided with two sets of fixed plates and a set of air heater, and is two sets of be provided with a plurality of groups on the fixed plate and strike the hammer, strike hammer and vibrations board and take place the striking, a plurality of dry gas pockets of group have all been seted up on link joint and the transmission belt, be provided with a. The link joint passes through the live-rollers and installs between two sets of mounting panels, the link joint rotates under the drive of live-rollers, the link joint provides the support for the installation of transmission belt and vibrations board, the vibrations board takes place the striking with the hammer under the drive of link joint, thereby make the vibrations board vibrate, a plurality of groups vibrations board can transmit the link joint with the vibrations, and can transmit the vibrations through the link joint on the transmission belt, thereby prevent that the vibrations can be too big and lead to the pelletization split, transmission belt is the rubber material, the sawtooth rack supports the pelletization, decompose the pelletization of agglomeration through vibrations simultaneously, the hot-air blower blows off the hot-air, the hot-air carries out the drying through the pelletization of dry gas vent on to the transmission belt.

In order to achieve the above purpose, the invention also provides the following technical scheme: a spironolactone sheet production process comprises the following steps:

s1, weighing the raw materials according to the weight ratio, and adding the raw materials into a mixing and granulating mechanism for mixing;

s2, weighing other raw materials again according to the weight ratio, mixing the raw materials with the raw materials in the step S1, and granulating;

s3, drying the granulated particles;

s4, carrying out granule finishing treatment by a granule finishing machine;

s5, tabletting;

and S6, packaging.

Step S1 includes the following specific steps:

1) the feeding mechanism puts the raw materials into the blanking cabin according to the weight ratio;

2) the blanking bin rotates, the blanking plate generates rotating airflow in the mixing box, and the blanking plate simultaneously puts raw materials into the mixing box;

3) the mixing box mixes the raw materials through centrifugal force;

4) the agitation plate causes the material to tumble in the mixing tank as the mixing tank rotates.

Step S3 includes the following specific steps:

a) the conveying belt conveys the pellets;

b) the knocking hammer collides with the vibration plate to vibrate the transmission belt, and the transmission belt vibrates to granulate and disperse;

c) the conveyor belt separates the agglomerated pellets and the conveyor belt dries the pellets with hot air.

Compared with the prior art, the invention has the following beneficial effects:

1. the dry dispersion mechanism transmits the pelletization to disperse and dry the pelletization in transmission process, prevent that the pelletization from gluing together, and will be stained with the pelletization dispersion of gluing together in transmission process, thereby accelerate the dry of pelletization and reduce the work burden of whole grain machine, improve the whole grain efficiency of spironolactone piece, thereby improved the production efficiency of spironolactone piece.

2. The workbin drives the flow of the inside air of mixing box when rotating, makes the raw materials accomplish preliminary mixing at the in-process that falls down, prevents that the raw materials from appearing the phenomenon of layering behind the mixing box, and the mixing box passes through centrifugal force and mixes between the messenger raw materials, rotates the in-process at the mixing box, and the part in the pelletization case stirs the raw materials for the mixing speed of raw materials, and then improves the production efficiency of mixing efficiency and spirolactone piece.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:

FIG. 1 is a schematic representation of the steps of the production process of the present invention;

FIG. 2 is a schematic view of the overall structure of the apparatus of the present invention;

FIG. 3 is a schematic view of the internal structure of the apparatus of the present invention;

FIG. 4 is a schematic structural view of the mixing and pelletizing mechanism of the present invention;

FIG. 5 is a schematic top view of the mixing and pelletizing mechanism of the present invention coupled to a dry dispersing mechanism;

FIG. 6 is a schematic structural diagram of the region A in FIG. 4 according to the present invention;

FIG. 7 is a schematic view of the structure of the conveyor belt of the present invention;

FIG. 8 is a schematic view of the structure of the transfer belt of the present invention;

FIG. 9 is a schematic view of the blanking chamber structure of the present invention;

fig. 10 is a schematic view of the interior of the mixing box of the present invention viewed from above.

In the figure: 1. a work table; 2. a mixing and granulating mechanism; 3. a feeding mechanism; 4. a drying and dispersing mechanism; 5. a granulating machine; 6. a tablet press; 2-1, a protective box; 2-2, a blanking box; 2-3, a mixing box; 2-4, a granulation box; 2-5, a support ring; 2-6, a cross; 2-21, connecting plates; 2-22, a blanking cabin; 2-23, blanking plate; 2-31, a linkage plate; 2-32, a granulating roller; 2-41, a granulation plate; 2-42, telescopic cylinder; 2-43, a limit ring; 2-44, a material separating umbrella; 2-45, an auxiliary plate; 2-46, a stirring plate; 2-47, a rotating electrical machine; 2-48, a material separating air bag; 4-1, a protective shell; 4-2, vertical plates; 4-3, conveying belt; 4-21, granulating plate; 4-31, mounting plate; 4-32, a conveying belt; 4-33, link joint; 4-34, a vibration plate; 4-35, fixing plate; 4-36, knocking hammer; 4-37, a conveying belt; 4-38, saw tooth strip.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-10, the present invention provides the following technical solutions: the utility model provides a spironolactone piece production facility, this production facility includes workstation 1, turn right from a left side and install mixed pelletization mechanism 2 and dry dispersion mechanism 4 on the workstation 1, whole grain machine 5 is installed to 1 right-hand member below of workstation, tablet press 6 is installed to 1 below of workstation, feed mechanism 3 is installed to mixed pelletization mechanism 2 top, it is fixed with dry dispersion mechanism 4 to mix pelletization mechanism 2, dry dispersion mechanism 4 transmits the pelletization to whole grain machine 5, whole grain machine 5 is located the below of 4 one ends of dry dispersion mechanism, whole grain machine 5 transmits the pelletization after the whole grain is handled to tablet press 6 in and carries out the preforming.

The mixed granulating mechanism 2 comprises a protective box 2-1, two groups of support rings 2-5 and a group of cross frames 2-6 are arranged in the protective box 2-1 from top to bottom, a blanking box 2-2 is rotatably arranged on the group of support rings 2-5 above, a mixing box 2-3 is rotatably arranged on the group of support rings 2-5 below, a granulating box 2-4 is fixedly arranged on the cross frames 2-6, the upper end of the blanking box 2-2 is connected with a feeding mechanism 3 through a pipeline, the feeding mechanism 3 is in the prior art, the feeding mechanism 3 is used for weighing raw materials, and the raw materials are put into the blanking box 2-2 according to the weight ratio.

Further, a sliding plate (not shown) is arranged below the crosses 2-6 and used for sliding the pellets onto the conveyor belts 4-32 to prevent the pellets from being split.

Further, a gear ring (not shown in the figure) is arranged on the outer side of the blanking box 2-2, a motor (not shown in the figure) is installed on one side, located on the blanking box 2-2, of the protection box 2-1, the motor is in rotating connection with the gear ring through a gear, and the motor provides power for the rotation of the blanking box 2-2; the outer side of the mixing box 2-3 is also provided with a gear ring (not shown in the figure), one side of the protective box 2-1, which is positioned at the mixing box 2-3, is also provided with a motor (not shown in the figure), the motor is rotationally connected with the gear ring through a gear, and the motor provides power for the rotation of the mixing box 2-3.

Six groups of connecting plates 2-21 are arranged in the blanking box 2-2, the other end of each group of connecting plates 2-21 is fixed with a blanking chamber 2-22, a blanking plate 2-23 is arranged below each group of blanking chambers 2-22, the lowest end of each blanking plate 2-3 is provided with a material blocking component (not shown in the figure), the material blocking component is used for preventing raw materials from falling into the mixing box 2-3 when the raw materials are not required to be mixed, and the blanking plates 2-23 are positioned in the mixing box 2-3.

The lower end of the interior of the mixing box 2-3 is in a groove shape, a discharging through hole is formed in the middle of the lower end of the mixing box 2-3, two groups of linkage plates 2-31 are symmetrically arranged below the mixing box 2-3, the linkage plates 2-31 penetrate through the support rings 2-5, the linkage plates 2-31 are located in the granulating box 2-4, each group of linkage plates 2-31 are rotatably provided with granulating rollers 2-32, and the linkage plates 2-31 and the granulating rollers 2-32 are located in the granulating box 2-4.

The granulating box 2-4 is internally provided with a granulating plate 2-41, the granulating roller 2-32 is rotationally connected with the granulating plate 2-41, the middle part of the granulating box 2-4 is provided with a telescopic cylinder 2-42, the telescopic cylinder 2-42 is fixed on a cross 2-6, the upper end of the telescopic cylinder 2-42 is provided with a rotating motor 2-47, the upper end of the rotating motor 2-47 is provided with a material separating umbrella 2-44, the upper end of the material separating umbrella 2-44 is positioned in the discharging through hole, the telescopic cylinder 2-42 is positioned above the granulating plate 2-41 and is provided with a limiting ring 2-43, and the lower end of the limiting ring 2-43 is fixed with the granulating plate 2-41.

Six groups of mounting grooves are formed in the upper end of each material separating umbrella 2-44, an auxiliary plate 2-45 is rotatably mounted in each group of mounting grooves, a stirring plate 2-46 is rotatably mounted at the other end of each group of auxiliary plates 2-45, the lower end of each group of stirring plates 2-46 is attached to the end face of a groove in the mixing box 2-3, the stirring plates 2-46 are rotatably connected with the mixing box 2-3, the stirring plates 2-46 have a certain inclination angle in the horizontal direction, each group of stirring plates 2-46 are arc-shaped, and material separating airbags 2-48 are mounted below the edges of the material separating umbrellas 2-44.

The drying and dispersing mechanism 4 comprises a conveying belt 4-3, a mounting opening is formed in the position, corresponding to the conveying belt 4-3, on the protective box 2-1, and one end of the conveying belt 4-3 is located below the cross 2-6 through the mounting opening;

the drying and dispersing mechanism 4 further comprises a protective shell 4-1, the protective shell 4-1 covers the other end of the conveyer belt 4-3, the left end of the conveyer belt 4-3 is located in the protective box 2-1, the right end of the conveyer belt 4-3 is located in the protective shell 4-1, vertical plates 4-2 are installed on two sides above the conveyer belt 4-3 in the protective shell 4-1, a plurality of groups of whole grain plates 4-21 are rotatably installed between the two groups of vertical plates 4-2, and the whole grain plates 4-21 are not in contact with the conveyer belt 4-3.

The conveying belt 4-3 comprises two groups of mounting plates 4-31, a conveying belt 4-32 is arranged between the two groups of mounting plates 4-31 through a rotating roller, the conveying belt 4-32 comprises a chain plate 4-33 and a conveying belt 4-37 arranged on the chain plate 4-33, a plurality of groups of vibration plates 4-34 are arranged on the surface of the chain plate 4-33 far away from the conveying belt 4-37, two groups of fixing plates 4-35 and a group of hot air blower (not shown in the figure) are arranged in the middle of the chain plate 4-33, the fixing plates 4-35 and the hot air blower are both arranged on the mounting plates 4-31, and the hot air blower is positioned between the two groups of.

The upper end and the lower end of each of the two groups of fixed plates 4-35 are provided with a plurality of groups of knocking hammers 4-36 through rubber rods, the knocking hammers 4-36 are made of rubber, the knocking hammers 4-36 collide with the vibrating plates 4-34, the chain plates 4-33 and the transmission belts 4-37 are provided with a plurality of groups of drying air holes, and the transmission belts 4-37 are provided with a plurality of groups of sawtooth strips 4-38.

A spironolactone sheet production process comprises the following steps:

s3, drying the granulated particles;

s4, carrying out granule finishing treatment by a granule finishing machine;

s5, tabletting;

and S6, packaging.

Step S1 includes the following specific steps:

3) the mixing box mixes the raw materials through centrifugal force;

Step S3 includes the following specific steps:

a) the conveying belt conveys the pellets;

The working principle of the invention is as follows:

the feeding mechanism 3 correspondingly puts raw materials into six groups of blanking cabins 2-22, the motor drives the blanking boxes 2-2 to rotate, so that the blanking cabins 2-22 drive the blanking plates 2-23 to rotate, the material blocking assemblies on the blanking plates 2-23 are opened, the raw materials flow out of the blanking plates 2-23, the rotation of the blanking plates 2-23 drives the air in the mixing box 2-3 to flow, rotational flow is generated in the mixing box 2-3, and the raw materials are mixed together under the drive of the rotational flow in the falling process, so that the primary mixing of the raw materials is realized.

The raw materials fall into the mixing box 2-3, the mixing box 2-3 is driven by the motor to rotate at a high speed, so that centrifugal force is generated, the raw materials are mixed in the mixing box 2-3 under the action of the centrifugal force, meanwhile, the material distributing umbrella 2-44 is reversed to stir the raw materials in the mixing box 2-3, and the raw materials are stirred by the stirring plate 2-46 while flowing in the mixing box 2-3, so that the mixing speed of the raw materials is increased.

When granulation is required, the material separating umbrella 2-44 is driven by the telescopic cylinder 2-42 to remove the blockage of the discharging through hole, so that the raw materials in the mixing box 2-3 are scattered on the granulating plate 2-41 through the material separating umbrella 2-44, the material separating umbrella 2-44 is driven by the rotating motor 2-47 to rotate at high speed and low speed, so that the raw materials are uniformly scattered on the granulating plate 2-41 under the action of the material separating air bag 2-48, and when the material separating umbrella 2-44 rotates, the stirring plate 2-46 is driven by the material separating umbrella 2-44 to scrape the raw materials in the mixing box 2-3 into the granulating box 2-4.

The mixing box 2-3 is driven by a motor to rotate, so that the granulating rollers 2-32 rotate in the granulating box 2-4, and are matched with the granulating plates 2-41 for granulating.

The material particles falling from the granulating plates 2-41 fall on the conveying belts 4-37, the conveying belts 4-37 convey the granules and dry the granules through hot air, the conveying belts 4-37 are subjected to vibration energy transmitted by the chain plates 4-33 in the moving process and vibrate the granules, so that the granules are prevented from being stuck together and agglomerated, and meanwhile, the saw-toothed strips 4-38 on the conveying belts 4-37 are matched with the whole granulating plates 4-21 to disperse the agglomerated granules.

The granules are driven by a transmission belt 4-32 to enter a granulator 5 for granulation, then are conveyed to a tabletting machine 6 for tabletting, and finally are packaged.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art will understand that various changes, modifications and substitutions can be made without departing from the spirit and scope of the invention as defined by the appended claims. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A spironolactone sheet production facility which characterized in that: this production facility includes workstation (1), be provided with on workstation (1) and mix pelletization mechanism (2) and dry dispersion mechanism (4), workstation (1) one end is provided with whole grain machine (5), is provided with tablet press (6) below workstation (1), it is provided with feed mechanism (3) to mix pelletization mechanism (2) top, and it is fixed with dry dispersion mechanism (4) to mix pelletization mechanism (2), whole grain machine (5) are located the below of dry dispersion mechanism (4) one end.

2. The spironolactone sheet production apparatus according to claim 1, characterized in that: the mixing and granulating mechanism (2) comprises a protective box (2-1), two groups of support rings (2-5) and a group of cross frames (2-6) are arranged in the protective box (2-1) from top to bottom, a blanking box (2-2) is arranged on the upper group of support rings (2-5), a mixing box (2-3) is arranged on the lower group of support rings (2-5), a granulating box (2-4) is arranged on the cross frames (2-6), the upper end of the blanking box (2-2) is connected with the feeding mechanism (3) through a pipeline, and the lower end of the mixing box (2-3) is rotatably connected with the granulating box (2-4); the drying and dispersing mechanism (4) comprises a conveying belt (4-3), one end of the conveying belt (4-3) is positioned below the cross (2-6), and the other end of the conveying belt (4-3) is positioned above the granulating machine (5).

3. The spironolactone sheet production apparatus according to claim 2, characterized in that: six groups of connecting plates (2-21) are arranged on the blanking box (2-2), a blanking cabin (2-22) is arranged at the other end of each group of connecting plates (2-21), a blanking plate (2-23) is arranged below each group of blanking cabin (2-22), and the blanking plate (2-23) is positioned in the mixing box (2-3); the lower end of the interior of the mixing box (2-3) is groove-shaped, two groups of linkage plates (2-31) are symmetrically arranged below the mixing box (2-3), each group of linkage plates (2-31) is provided with a granulating roller (2-32), and the linkage plates (2-31) and the granulating rollers (2-32) are located in the granulating box (2-4).

4. The spironolactone sheet production apparatus according to claim 3, characterized in that: a discharging through hole is formed in the middle of the lower end of the mixing box (2-3); the granulating device is characterized in that a granulating plate (2-41) is arranged in the granulating box (2-4), the granulating roller (2-32) is rotatably connected with the granulating plate (2-41), a telescopic cylinder (2-42) is arranged in the middle of the granulating box (2-4), a material distributing umbrella (2-44) is arranged at the upper end of the telescopic cylinder (2-42), the upper end of the material distributing umbrella (2-44) is located in a discharging through hole, and a limiting ring (2-43) is arranged above the granulating plate (2-41) on the telescopic cylinder (2-42).

5. The spironolactone sheet production apparatus according to claim 4, characterized in that: six groups of mounting grooves are formed in the upper end of each material separating umbrella (2-44), an auxiliary plate (2-45) is arranged in each mounting groove, the other end of each auxiliary plate (2-45) is provided with a stirring plate (2-46), the lower end of each stirring plate (2-46) is attached to the end face of a groove in the mixing box (2-3), each stirring plate (2-46) is arc-shaped, a material separating air bag (2-48) is arranged below the edge of each material separating umbrella (2-44), a rotating motor (2-47) is arranged at the lower end of each material separating umbrella (2-44), and the rotating motor (2-47) is fixed to the upper end of the telescopic cylinder (2-42).

6. The spironolactone sheet production apparatus according to claim 5, characterized in that: the drying and dispersing mechanism (4) further comprises a protective shell (4-1), the protective shell (4-1) covers the conveying belt (4-3), one end of the conveying belt (4-3) is located in the protective box (2-1), the other end of the conveying belt (4-3) is located in the protective shell (4-1), vertical plates (4-2) are arranged on two sides above the conveying belt (4-3) located in the protective shell (4-1), a plurality of groups of whole grain plates (4-21) are arranged between the two groups of vertical plates (4-2), and the whole grain plates (4-21) are not in contact with the conveying belt (4-3).

7. The spironolactone sheet production apparatus according to claim 6, characterized in that: the conveying belt (4-3) comprises two groups of mounting plates (4-31), a conveying belt (4-32) is arranged between the two groups of mounting plates (4-31), the conveying belt (4-32) comprises chain plates (4-33) and conveying belts (4-37) mounted on the chain plates (4-33), a plurality of groups of vibration plates (4-34) are arranged on the surfaces, far away from the conveying belts (4-37), of the chain plates (4-33), two groups of fixing plates (4-35) and a group of hot air blowers are arranged in the middle of the chain plates (4-33), a plurality of groups of knocking hammers (4-36) are arranged on the two groups of fixing plates (4-35), the knocking hammers (4-36) are collided with the vibration plates (4-34), a plurality of groups of drying air holes are formed in the chain plates (4-33) and the conveying belts (4-37), the transmission belt (4-37) is provided with a plurality of groups of sawtooth strips (4-38).

8. A production process which is specially used for the spironolactone production equipment of claim 1, and is characterized in that: the production process comprises the following steps:

s3, drying the granulated particles;

s4, carrying out granule finishing treatment by a granule finishing machine;

s5, tabletting;

and S6, packaging.

9. The spironolactone tablet production process according to claim 8, characterized in that:

step S1 includes the following specific steps:

3) the mixing box mixes the raw materials through centrifugal force;

10. The spironolactone tablet production process according to claim 9, characterized in that:

step S3 includes the following specific steps:

a) the conveying belt conveys the pellets;