CN113080868A - One set is applicable to work system that toy pain threshold was measured - Google Patents
One set is applicable to work system that toy pain threshold was measured Download PDFInfo
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- CN113080868A CN113080868A CN202110386236.3A CN202110386236A CN113080868A CN 113080868 A CN113080868 A CN 113080868A CN 202110386236 A CN202110386236 A CN 202110386236A CN 113080868 A CN113080868 A CN 113080868A
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4824—Touch or pain perception evaluation
- A61B5/4827—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold
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Abstract
The invention relates to the technical field of pain medical research, in particular to a set of working system suitable for measuring pain threshold of small animals, which avoids the interference of animal stress state, random walk and excrement wetting body to the experimental process, ensures the reliability, stability and authenticity of the detection result and improves the practicability; the method comprises the following steps: an animal, a test subject for pain threshold measurement; the metal bracket and the organic glass plate comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of the animal; the micro oxygen generator is used for providing continuous sufficient oxygen for the animals and ensuring that the animals are in normal vital signs in the measurement process; the micro oxygen generator supplies oxygen to the anesthesia system, and the anesthesia system supplies anesthetic gas to a plurality of animals to ensure that the animals maintain a shallow anesthesia state in the measurement process; the pipeline is used for conveying anesthetic gas to the animal; the anesthetic flow control bracket is mounted on the anesthesia system.
Description
Technical Field
The invention relates to the technical field of pain medical research, in particular to a set of working system suitable for measuring pain threshold of small animals.
Background
In current animal pain threshold measurement (tail flick test, paw flick test), the animal is usually placed in a separate compartment on a plexiglas plate. In this case, the animal can move around in the compartment for adapting to the new environment of strangeness, and simultaneously the excrement and urine is increased to the response to the excitation, pollutes local environment, wets the animal body and includes hind paw and tail, and this can greatly influence the operation process of getting rid of the claw and getting rid of the tail experiment, is difficult to obtain reliable and stable testing result. In addition, the organic glass plate absorbs infrared heat and blocks heat conduction, so that the pain threshold detection value is prolonged, and the pain state of the animal cannot be truly reflected.
Disclosure of Invention
In order to solve the technical problems, the invention provides the working system which avoids the interference of the stress state of animals, the random walk and the excrement wetting bodies to the experimental process, ensures the reliability, the stability and the authenticity of the detection result, and improves the practicability and is suitable for the pain threshold measurement of the small animals.
The invention relates to a set of working system suitable for measuring pain threshold of small animals, which comprises:
an animal, a test subject for pain threshold measurement;
the device comprises a metal bracket and an organic glass plate, wherein the metal bracket and the organic glass plate comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of an animal;
the micro oxygen generator is used for providing continuous sufficient oxygen for the animals and ensuring that the animals are in normal vital signs in the measurement process;
the anesthesia system supplies oxygen to the anesthesia system, and supplies anesthesia gas to a plurality of animals so that the animals maintain a shallow anesthesia state in the measurement process;
a conduit for delivering anesthetic gases to an animal;
an anesthetic flow control mount mounted on the anesthesia system for controlling the amount of anesthetic delivered by the anesthesia system to the animal;
the pain measuring instrument is used for measuring the pain threshold value of the animal, and the stimulation output value is adjustable.
The working system suitable for measuring the pain threshold of the small animals further comprises a tail gas recovery treatment tank, the pipeline comprises an air outlet pipe and an air return pipe, the anesthesia system conveys anesthetic gas to the animals through the air outlet pipe, the air return pipe is used for recovering redundant anesthetic gas, and the recovered anesthetic gas is conveyed to the tail gas recovery treatment tank through the air return pipe.
The work system is suitable for measuring the pain threshold of the small animals, and the stimulation of the pain threshold measurement of the pain measuring instrument adopts an infrared radiation heat source. .
According to the working system suitable for measuring the pain threshold of the small animal, the metal bracket and the organic glass plate on the organic glass plate are processed by the opening, and the stimulation of the pain measuring instrument is directly contacted with the animal detection part.
The working system suitable for measuring the pain threshold of the small animals further comprises a constant temperature blanket, and the constant temperature blanket is placed on the metal bracket and the organic glass plate and slides relatively.
The working system is suitable for measuring the pain threshold of the small animals, and the anesthesia system is provided with an oxygen regulating meter which is used for regulating the oxygen delivery amount of the micro oxygen generator into the anesthesia system.
Compared with the prior art, the invention has the beneficial effects that: carry anesthetic gas to the animal through anesthesia system, miniature oxygenerator passes through anesthesia system simultaneously and carries oxygen to the animal, and the animal maintains shallow anesthesia state in the experimentation to can get rid of the claw or the reaction of whipping the tail to the amazing appearance of pain measuring instrument, avoided animal stress state, walk about at will and the excrement is stained with the interference of wetting the health to the experimentation, guaranteed reliability, stability and the authenticity of testing result, improved the practicality.
Drawings
FIG. 1 is a logic flow diagram of the present invention;
FIG. 2 is a schematic flow diagram of the present invention;
in the drawings, the reference numbers: 1. a micro oxygen generator; 2. an anesthesia system; 3. an anesthetic flow control mount; 4. an air outlet and air return pipe; 5. a tail gas recovery treatment tank; 6. an animal; 7. a metal bracket and an organic glass plate; 8. a pain measuring instrument; 9. a constant temperature blanket.
Detailed Description
The following detailed description of embodiments of the present invention is provided in connection with the accompanying drawings and examples. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
As shown in fig. 1 to 2, a set of working systems of the present invention suitable for pain threshold measurement of small animals includes an animal 6 as a test object for pain threshold measurement; the metal bracket and the organic glass plate 7 comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of the animal 6; the micro oxygen generator 1 is used for providing continuous sufficient oxygen for the animal 6 and ensuring that the animal 6 is in normal vital signs in the measurement process; the micro oxygen generator 1 supplies oxygen to the anesthesia system 2, the anesthesia system 2 supplies anesthesia gas to a plurality of animals 6, so that the animals 6 maintain a shallow anesthesia state in the measurement process; the conduit 4 is used for delivering anaesthetic gases to the animal 6; an anesthetic flow control support 3 is mounted on the anesthesia system 2 for controlling the amount of anesthetic delivered by the anesthesia system to the animal 6; the pain measuring instrument 8 is used for measuring the pain threshold value of the animal, and the stimulation output value of the pain measuring instrument is adjustable; carry anesthetic gas to the animal through anesthesia system, miniature oxygenerator passes through anesthesia system simultaneously and carries oxygen to animal 6, and the animal maintains shallow anesthesia state in the experimentation to can get rid of the claw or the reaction of whipping the tail to the amazing appearance of pain measuring instrument, avoided animal stress state, walk about at will and the excrement is stained with the interference of wet health to the experimentation, guaranteed reliability, stability and the authenticity of testing result, improve the practicality.
As a preference of the above embodiment, a test object for pain threshold measurement by the animal 6 is included; the metal bracket and the organic glass plate 7 comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of the animal 6; the micro oxygen generator 1 is used for providing continuous sufficient oxygen for the animal 6 and ensuring that the animal 6 is in normal vital signs in the measurement process; the micro oxygen generator 1 supplies oxygen to the anesthesia system 2, the anesthesia system 2 supplies anesthesia gas to a plurality of animals 6, so that the animals 6 maintain a shallow anesthesia state in the measurement process; the conduit 4 is used for delivering anaesthetic gases to the animal 6; an anesthetic flow control support 3 is mounted on the anesthesia system 2 for controlling the amount of anesthetic delivered by the anesthesia system to the animal 6; the pain measuring instrument 8 is used for measuring the pain threshold value of the animal, and the stimulation output value is adjustable; the system is characterized by further comprising a tail gas recovery treatment tank 5, wherein the pipeline 4 comprises an air outlet pipe and an air return pipe, the anesthesia system 2 conveys anesthetic gas to the animal 6 through the air outlet pipe, the air return pipe is used for recovering redundant anesthetic gas, and the recovered anesthetic gas is conveyed to the tail gas recovery treatment tank 5 through the air return pipe; through the arrangement, the recovery effect of anesthetic gas is improved, and the practicability is improved.
As a preference of the above embodiment, a test object for pain threshold measurement by the animal 6 is included; the metal bracket and the organic glass plate 7 comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of the animal 6; the micro oxygen generator 1 is used for providing continuous sufficient oxygen for the animal 6 and ensuring that the animal 6 is in normal vital signs in the measurement process; the micro oxygen generator 1 supplies oxygen to the anesthesia system 2, the anesthesia system 2 supplies anesthesia gas to a plurality of animals 6, so that the animals 6 maintain a shallow anesthesia state in the measurement process; the conduit 4 is used for delivering anaesthetic gases to the animal 6; an anesthetic flow control support 3 is mounted on the anesthesia system 2 for controlling the amount of anesthetic delivered by the anesthesia system to the animal 6; the pain measuring instrument 8 is used for measuring the pain threshold value of the animal, and the stimulation output value is adjustable; the stimulation of the pain threshold measurement of the pain measuring instrument 8 adopts an infrared radiation heat source; through the arrangement, the stimulation intensity can be accurately controlled through the stimulation of the radiation heat source, the pain sensation close to 'pure' can be measured, the reliability, the stability and the authenticity of a detection result are ensured, and the practicability is improved.
As a preference of the above embodiment, a test object for pain threshold measurement by the animal 6 is included; the metal bracket and the organic glass plate 7 comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of the animal 6; the micro oxygen generator 1 is used for providing continuous sufficient oxygen for the animal 6 and ensuring that the animal 6 is in normal vital signs in the measurement process; the micro oxygen generator 1 supplies oxygen to the anesthesia system 2, the anesthesia system 2 supplies anesthesia gas to a plurality of animals 6, so that the animals 6 maintain a shallow anesthesia state in the measurement process; the conduit 4 is used for delivering anaesthetic gases to the animal 6; an anesthetic flow control support 3 is mounted on the anesthesia system 2 for controlling the amount of anesthetic delivered by the anesthesia system to the animal 6; the pain measuring instrument 8 is used for measuring the pain threshold value of the animal, and the stimulation output value is adjustable; the metal bracket and the organic glass plate on the organic glass plate 7 are processed by adopting openings and are used for directly contacting the stimulation of the pain measuring instrument 8 with the detection part of the animal 6; through the arrangement, the opening of the organic glass plate is processed, so that the infrared heat source is in direct contact with the detection part, the loss of heat energy in the detection process is eliminated, the reliability, the stability and the authenticity of the detection result are ensured, and the practicability is improved.
As a preference of the above embodiment, a test object for pain threshold measurement by the animal 6 is included; the metal bracket and the organic glass plate 7 comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of the animal 6; the micro oxygen generator 1 is used for providing continuous sufficient oxygen for the animal 6 and ensuring that the animal 6 is in normal vital signs in the measurement process; the micro oxygen generator 1 supplies oxygen to the anesthesia system 2, the anesthesia system 2 supplies anesthesia gas to a plurality of animals 6, so that the animals 6 maintain a shallow anesthesia state in the measurement process; the conduit 4 is used for delivering anaesthetic gases to the animal 6; an anesthetic flow control support 3 is mounted on the anesthesia system 2 for controlling the amount of anesthetic delivered by the anesthesia system to the animal 6; the pain measuring instrument 8 is used for measuring the pain threshold value of the animal, and the stimulation output value is adjustable; the temperature control device also comprises a constant temperature blanket 9, wherein the constant temperature blanket 9 is placed on the metal bracket and the organic glass plate 7 and slides relatively; through the arrangement, the constant temperature blanket 9 continuously provides a heat source for the animal to be tested so as to keep the animal to be tested at the body temperature and maintain the normal physiological state.
As a preference of the above embodiment, a test object for pain threshold measurement by the animal 6 is included; the metal bracket and the organic glass plate 7 comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and is used for providing a place for measuring the pain threshold of the animal 6; the micro oxygen generator 1 is used for providing continuous sufficient oxygen for the animal 6 and ensuring that the animal 6 is in normal vital signs in the measurement process; the micro oxygen generator 1 supplies oxygen to the anesthesia system 2, the anesthesia system 2 supplies anesthesia gas to a plurality of animals 6, so that the animals 6 maintain a shallow anesthesia state in the measurement process; the conduit 4 is used for delivering anaesthetic gases to the animal 6; an anesthetic flow control support 3 is mounted on the anesthesia system 2 for controlling the amount of anesthetic delivered by the anesthesia system to the animal 6; the pain measuring instrument 8 is used for measuring the pain threshold value of the animal, and the stimulation output value is adjustable; the anesthesia system 2 is provided with an oxygen regulating meter which is used for regulating the oxygen delivery amount of the micro oxygen generator 1 to the anesthesia system 2; through the arrangement, normal vital signs of the animals are guaranteed, the reliability of the animal pain threshold measuring result is improved, and the practicability is improved.
The working system suitable for measuring the pain threshold of the small animal is characterized in that anesthesia gas is conveyed to the animal through the anesthesia system when the working system works, meanwhile, the micro oxygen generator conveys oxygen into the animal on the organic glass plate through the anesthesia system, the oxygen regulating meter plays a role in controlling the amount of the oxygen conveyed to the anesthesia system, the animal maintains a shallow anesthesia state in the experimental process, a paw or tail flicking reaction can occur to the stimulation of the pain measuring instrument, and the pain measuring instrument can automatically record and display a thermal stimulation output value and the paw or tail flicking reaction value of the animal.
The working system suitable for measuring the pain threshold of the small animal is provided with common mechanical mounting modes, connection modes or setting modes, and can be implemented as long as the beneficial effects of the working system can be achieved; the micro oxygen generator 1, the anesthesia system 2, the anesthetic flow control bracket 3, the pain measuring instrument 8 and the constant temperature blanket 9 which are suitable for the working system for measuring the pain threshold of the small animal are purchased from the market, and technicians in the industry only need to install and operate according to the attached operating instructions.
The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.
Claims (6)
1. One set of work system that is applicable to toy pain threshold and measures, its characterized in that includes:
an animal (6) as a test subject for pain threshold measurement;
the device comprises a metal bracket and an organic glass plate (7), wherein the metal bracket and the organic glass plate (7) comprise an organic glass plate and a metal bracket, and the organic glass plate is fixedly arranged on the metal bracket and used for providing a place for measuring the pain threshold of an animal (6);
the micro oxygen generator (1) is used for providing continuous sufficient oxygen for the animal (6) and ensuring that the animal (6) is in normal vital signs in the measurement process;
the anesthesia system (2), the said miniature oxygenerator (1) supplies oxygen to the anesthesia system (2), the anesthesia system (2) supplies anesthetic gas to several animals (6), make the animal (6) maintain the state of shallow anesthesia in the measurement process;
a conduit (4), said conduit (4) being for delivering anaesthetic gas to an animal (6);
an anesthetic flow control support (3), said anesthetic flow control support (3) being mounted on an anesthesia system (2) for controlling an amount of anesthetic delivered by the anesthesia system to an animal (6);
the pain measuring instrument (8) is used for measuring the pain threshold value of the animal, and the stimulation output value is adjustable.
2. The set of working systems suitable for measuring the pain threshold of the small animals according to claim 1, further comprising a tail gas recovery processing tank (5), wherein the pipeline (4) comprises an air outlet pipe and an air return pipe, the anesthesia system (2) conveys anesthetic gas to the animals (6) through the air outlet pipe, the air return pipe is used for recovering redundant anesthetic gas, and the recovered anesthetic gas is conveyed to the tail gas recovery processing tank (5) through the air return pipe.
3. The set of working systems for pain threshold measurement in small animals according to claim 1, characterized in that the stimulation of the pain threshold measurement of the pain measuring instrument (8) is with an infrared radiation heat source.
4. The set of working systems for pain threshold measurement in small animals according to claim 1, characterized in that the metal support and the plexiglas plate on the plexiglas plate (7) are treated with openings for direct contact of the stimuli of the pain measuring device (8) with the test site of the animal (6).
5. The set of working systems for threshold of pain measurement in small animals according to claim 1, further comprising a thermostatic blanket (9), the thermostatic blanket (9) being placed on the metal support and the plexiglas plate (7) and sliding with respect thereto.
6. The set of working systems suitable for measuring the pain threshold of the small animals according to claim 1, wherein the anesthesia system (2) is provided with an oxygen regulation meter, and the oxygen regulation meter is used for regulating the amount of oxygen delivered into the anesthesia system (2) by the micro oxygen generator (1).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110386236.3A CN113080868A (en) | 2021-04-12 | 2021-04-12 | One set is applicable to work system that toy pain threshold was measured |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110386236.3A CN113080868A (en) | 2021-04-12 | 2021-04-12 | One set is applicable to work system that toy pain threshold was measured |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1705453A (en) * | 2002-10-15 | 2005-12-07 | 詹森药业有限公司 | Animal model to evaluate visceral pain perception |
| JP2010233649A (en) * | 2009-03-30 | 2010-10-21 | Fujifilm Corp | Holder of animal being measured |
| CN104586534A (en) * | 2014-04-16 | 2015-05-06 | 复旦大学 | Simple small animal inhalation anesthesia machine |
| CN108780080A (en) * | 2016-03-04 | 2018-11-09 | 泰尔茂株式会社 | The method for selecting that the method and liquid that pain is evaluated caused by being bestowed by liquid are bestowed |
| CN111436383A (en) * | 2020-04-01 | 2020-07-24 | 金华职业技术学院 | Method for measuring cold pain behavior difference of different mice and special device thereof |
-
2021
- 2021-04-12 CN CN202110386236.3A patent/CN113080868A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1705453A (en) * | 2002-10-15 | 2005-12-07 | 詹森药业有限公司 | Animal model to evaluate visceral pain perception |
| JP2010233649A (en) * | 2009-03-30 | 2010-10-21 | Fujifilm Corp | Holder of animal being measured |
| CN104586534A (en) * | 2014-04-16 | 2015-05-06 | 复旦大学 | Simple small animal inhalation anesthesia machine |
| CN108780080A (en) * | 2016-03-04 | 2018-11-09 | 泰尔茂株式会社 | The method for selecting that the method and liquid that pain is evaluated caused by being bestowed by liquid are bestowed |
| CN111436383A (en) * | 2020-04-01 | 2020-07-24 | 金华职业技术学院 | Method for measuring cold pain behavior difference of different mice and special device thereof |
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