CN113041252A - Alpha-GPC formula process technology with excellent moisture absorption resistance - Google Patents
Alpha-GPC formula process technology with excellent moisture absorption resistance Download PDFInfo
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- CN113041252A CN113041252A CN202110300873.4A CN202110300873A CN113041252A CN 113041252 A CN113041252 A CN 113041252A CN 202110300873 A CN202110300873 A CN 202110300873A CN 113041252 A CN113041252 A CN 113041252A
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- gpc
- alpha
- moisture absorption
- auxiliary materials
- excellent moisture
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- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 title claims abstract description 82
- 238000000034 method Methods 0.000 title claims abstract description 36
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 33
- 230000008569 process Effects 0.000 title claims abstract description 24
- 238000005516 engineering process Methods 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 128
- 238000002156 mixing Methods 0.000 claims abstract description 38
- 239000000843 powder Substances 0.000 claims abstract description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 132
- 239000000377 silicon dioxide Substances 0.000 claims description 66
- 235000012239 silicon dioxide Nutrition 0.000 claims description 49
- 238000003756 stirring Methods 0.000 claims description 40
- 238000001035 drying Methods 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 19
- 238000009472 formulation Methods 0.000 claims description 18
- 108010082495 Dietary Plant Proteins Proteins 0.000 claims description 17
- 229920002472 Starch Polymers 0.000 claims description 16
- 235000019698 starch Nutrition 0.000 claims description 16
- 239000008107 starch Substances 0.000 claims description 16
- 238000005303 weighing Methods 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000391 magnesium silicate Substances 0.000 claims description 3
- 229910052919 magnesium silicate Inorganic materials 0.000 claims description 3
- 235000019792 magnesium silicate Nutrition 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- 235000012222 talc Nutrition 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 238000003860 storage Methods 0.000 abstract description 2
- 238000012805 post-processing Methods 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 41
- 235000018102 proteins Nutrition 0.000 description 21
- 108090000623 proteins and genes Proteins 0.000 description 21
- 102000004169 proteins and genes Human genes 0.000 description 21
- 238000010008 shearing Methods 0.000 description 16
- 238000007873 sieving Methods 0.000 description 16
- 108010084695 Pea Proteins Proteins 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- 235000019702 pea protein Nutrition 0.000 description 10
- 235000013305 food Nutrition 0.000 description 9
- 229920000294 Resistant starch Polymers 0.000 description 8
- 238000009835 boiling Methods 0.000 description 8
- 235000021254 resistant starch Nutrition 0.000 description 8
- 229920001353 Dextrin Polymers 0.000 description 7
- 239000004375 Dextrin Substances 0.000 description 7
- 238000001816 cooling Methods 0.000 description 7
- 235000019425 dextrin Nutrition 0.000 description 7
- 239000007791 liquid phase Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 4
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 4
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000003918 potentiometric titration Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 108010064851 Plant Proteins Proteins 0.000 description 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
- 229960004373 acetylcholine Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008499 blood brain barrier function Effects 0.000 description 2
- 210000001218 blood-brain barrier Anatomy 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 235000021118 plant-derived protein Nutrition 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- ADOHEWVFRZKRHE-UHFFFAOYSA-N 2-acetyloxyethyl(trimethyl)azanium Chemical compound CC(=O)OCC[N+](C)(C)C.CC(=O)OCC[N+](C)(C)C ADOHEWVFRZKRHE-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000008777 Glycerylphosphorylcholine Substances 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 230000003930 cognitive ability Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000105 evaporative light scattering detection Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 125000001924 fatty-acyl group Chemical group 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000013016 learning Effects 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000007087 memory ability Effects 0.000 description 1
- 230000003446 memory effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- -1 phospholipid compounds Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/015—Inorganic compounds
-
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A23L29/045—Organic compounds containing nitrogen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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Abstract
The invention relates to the technical field of Alpha-GPC, in particular to an Alpha-GPC formula process technology with excellent moisture absorption resistance, which is obtained by mixing and post-processing auxiliary materials and Alpha-GPC; the dosage of the Alpha-GPC accounts for 40-65 wt% of the total amount of the auxiliary materials and the Alpha-GPC; the auxiliary material is selected from plant source auxiliary materials and/or inorganic powder. The method mainly uses plant base as auxiliary material, so that the product is more natural and healthy, has better moisture absorption resistance and fluidity, and has low initial moisture content, low burning residue content and long storage time at normal temperature.
Description
Technical Field
The invention relates to the technical field of Alpha-GPC, in particular to an Alpha-GPC formula process technology with excellent moisture absorption resistance.
Background
Alpha-glycerophosphatidylcholine (L-a-glycerophosphorylcholine, Alpha-GPC) is also known as choline glycerophosphate, glycerophosphoglyceride, glycerolecithin. It is a product of phosphatidylcholine, i.e. two fatty acyl groups on lecithin molecule are completely hydrolyzed, a water-soluble phospholipid precursor and biosynthetic precursors of neurotransmitters acetylcholine (acetylcholine) and Phosphatidylcholine (PC) naturally existing in human body, and is also a unique cell protective agent, which can support the fluidity and integrity of cell membrane. Alpha-GPC plays an important role in vivo through the production of certain hormones and neurotransmitters, such as acetylcholine and human growth hormone, and thus supports the functions of the brain and nervous system, and thus has important medical applications in neurological and psychiatric disorders of the human brain. The most important physiological function of Alpha-GPC is that it can cross the blood-brain barrier, providing a source of choline for the synthesis of acetylcholine, which can help the brain to complete learning, memory and cognitive activities and control shallow sleep and muscle activity, and phosphatidylcholine, and that entering the blood-brain barrier can promote the synthesis of phospholipids in the brain, thereby providing more phospholipid compounds for signaling within the central nerve. The long-term experimental research and clinical application show that Alpha-GPC can not only improve the memory and cognitive ability of people, but also has obvious curative effect on cerebral circulation deterioration and senile dementia, so the Alpha-GPC is called as the brain anti-aging nutrient. In addition, it can resist muscular atrophy and protect blood vessel. Thus, Alpha-GPC has important value in both the health and pharmaceutical industries.
L-Alpha-GPC molecular formula is C8H20NO6P, Alpha-GPC with molecular weight of 257.22 and high purity is generally colorless transparent viscous liquid or white solid powder or granule, and also exists in crystal form, and the melting point of the crystal is generally 142-152 ℃. The whole molecule can be divided into three parts of a glycerol group, a phosphate group and a hydrophilic choline group, and generally exists in an inner salt form and a hydrochloride form. Alpha-GPC has strong polarity and strong hygroscopicity in air, and is easily soluble in polar solvents such as water, methanol, and ethanol. In order to facilitate the use of Alpha-GPC in solid formulations, it is necessary to address the drawback of its extreme moisture absorption. At present, several methods for solving the problem of Alpha-GPC moisture absorption exist, wherein 50% of silicon dioxide is mainly used for adsorbing Alpha-GPC, or 43.5-48.5% of calcium hydrogen phosphate and the like are used, and the methods have great defects: tests show that Alpha-GPC prepared by the methods has poor dispersibility and is not beneficial to the use of a formula; the content of the residues on ignition is high, the bioavailability is low, and the residues are not easy to be absorbed and utilized by human bodies; meanwhile, the auxiliary materials used by the two formula components can not be absorbed and metabolized by human bodies, and the health concept is not met.
Disclosure of Invention
On the basis of the common general knowledge in the field, the above-mentioned preferred conditions can be combined arbitrarily without departing from the concept and the protection scope of the invention.
In order to solve the technical problems, the invention provides an alpha-GPC formula process technology with excellent moisture absorption resistance, which is obtained by mixing and post-treating auxiliary materials and alpha-GPC; the dosage of the alpha-GPC accounts for 40-65 wt% of the total amount of the auxiliary materials and the alpha-GPC; the auxiliary material is selected from plant source auxiliary materials and/or inorganic powder.
As a preferable technical scheme, the dosage of the alpha-GPC in the invention is 50-60 wt% of the total amount of the auxiliary material and the alpha-GPC.
As a preferable technical solution, the plant-derived auxiliary material in the present invention is at least one selected from starch and plant protein.
As a preferred technical solution, the mass ratio of starch to vegetable protein in the present invention is 1: (0.1-10).
As a preferable technical scheme, the mass ratio of the inorganic powder to the plant-derived auxiliary material in the invention is 1: (1-5).
In a preferred embodiment of the present invention, the inorganic powder is at least one selected from the group consisting of silicon dioxide, magnesium stearate, magnesium silicate, and talc.
As a preferred technical solution, the α -GPC formulation process with excellent moisture absorption resistance of the present invention at least comprises the following steps:
(1) weighing part of the auxiliary materials, pouring the auxiliary materials into a wet granulator, and starting stirring;
(2) adding alpha-GPC, continuing stirring, and collecting a mixed material;
(3) drying and discharging the mixed material to obtain a dried material;
(4) adding the dried material into a pulverizer to be pulverized and sieved;
(5) adding the rest adjuvants, and mixing with a mixer.
As a preferable technical scheme, in the step (1) of the invention, the addition amount of part of auxiliary materials is 10-99 wt% of the total auxiliary materials.
As a preferable technical scheme, in the step (3) of the invention, the air inlet temperature is 80-100 ℃, the air outlet temperature is 70-90 ℃, the temperature in the pot is 75-95 ℃ and the time is 5-15 min.
As a preferable technical scheme, in the step (4) of the present invention, the screen for sieving is 10-50 mesh.
Compared with the prior art, the invention has the following remarkable advantages and effects:
the invention provides an alpha-GPC formula process technology with excellent moisture absorption resistance, which mainly takes plant base as auxiliary material, so that the product is natural and healthy, has good moisture absorption resistance and fluidity, and has low initial moisture content, low burning residue content and long normal-temperature storage time; the wet granulator is used for mixing the samples, the mixing is completed in one step, the process is simple, the cost is low, the auxiliary materials and the raw materials can be effectively mixed, and the observation is not high in requirements on personnel and equipment; the auxiliary materials used in the process method are low in price, the alpha-GPC is used as the raw material, one or two of silicon dioxide, vegetable protein and starch are used as the auxiliary materials, the obtained product is good in fluidity and strong in moisture absorption resistance, and meanwhile, other technical indexes of the product, such as heavy metal, microorganisms and the like, are lower than the food hygiene standard, and the product can be safely used as an additive of medicines, health products, foods and cosmetics.
Detailed Description
The technical solutions of the present invention are described in detail below with reference to examples, but the present invention is not limited to the scope of the examples.
The invention provides an alpha-GPC (alpha-GPC) formula process technology with excellent moisture absorption resistance, which is obtained by mixing and post-treating auxiliary materials and alpha-GPC; the dosage of the alpha-GPC accounts for 40-65 wt% of the total amount of the auxiliary materials and the alpha-GPC; the auxiliary material is selected from plant source auxiliary materials and/or inorganic powder.
In some preferred embodiments, the amount of alpha-GPC is 50 to 60 wt% of the total amount of adjuvant, alpha-GPC; more preferably, the alpha-GPC is used in an amount of 55 wt% based on the total amount of the auxiliary material and alpha-GPC.
In some embodiments, the plant-derived adjuvant is selected from the group consisting of starch, plant protein.
In some embodiments, the mass ratio between the starch and the vegetable protein is 1: (0.1-10); preferably, the mass ratio of the starch to the vegetable protein is 1: (0.2-8); the mass ratio of the starch to the vegetable protein is 1: 1.
in some embodiments, the vegetable protein is selected from at least one of pea protein, rice protein, oat protein, walnut protein; preferably, the vegetable protein is at least one selected from pea protein, rice protein and oat protein; further preferably, the vegetable protein is selected from pea protein.
In some embodiments, the mass ratio of the inorganic powder to the plant-derived adjuvant is 1: (1-5); preferably, the mass ratio of the inorganic powder to the plant-derived auxiliary materials is 1: (2-4); the mass ratio of the inorganic powder to the plant source auxiliary materials is 1: 3.
in some embodiments, the inorganic powder is selected from at least one of silicon dioxide, magnesium stearate, magnesium silicate, talc; preferably, the inorganic powder is selected from at least one of silicon dioxide and magnesium stearate; more preferably, the inorganic powder is selected from silica.
In some embodiments, the particle size of the inorganic powder is 100-300 μm; preferably, the particle size of the inorganic powder is 200 μm.
In some embodiments, the α -GPC formulation technology with excellent resistance to hygroscopicity comprises at least the steps of:
(1) weighing part of the auxiliary materials, pouring the auxiliary materials into a wet granulator, and starting stirring;
(2) adding alpha-GPC, continuing stirring, and collecting a mixed material;
(3) drying and discharging the mixed material to obtain a dried material;
(4) adding the dried material into a pulverizer to be pulverized and sieved;
(5) adding the rest adjuvants, and mixing with a mixer.
In some embodiments, in step (1), a portion of the adjuvants is added in an amount of 10 to 99 wt% of the total adjuvants.
In some preferred embodiments, in the step (1), part of the auxiliary materials is added in an amount of 85 wt% of the total auxiliary materials.
In some embodiments, in the step (1), when stirring is started, the stirring frequency is 30 to 50Hz, the shearing frequency is 30 to 50Hz, and the time is 30 to 60s, preferably, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In some embodiments, in step (2), α -GPC is slowly poured into the wet granulator, and the stirring shear is turned on, with a stirring frequency of 30 to 50Hz, a shear frequency of 30 to 50Hz, and a time of 20 to 80s, preferably, with a stirring frequency of 50Hz, a shear frequency of 50Hz, and a time of 50 s.
In some embodiments, in the step (3), the air inlet temperature during drying is 80-100 ℃, the air outlet temperature is 70-90 ℃, the temperature in the pot is 75-95 ℃, and the time is 5-15 min.
In some preferred embodiments, in the step (3), the inlet air temperature during drying is 85 ℃, the outlet air temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10 min.
In some embodiments, in the step (3), a boiling drying device is used for drying.
In some embodiments, in step (4), the mesh when screened is 10-50 mesh; preferably, the screen mesh during sieving is 12 meshes.
In some embodiments, in the step (5), the material which has passed through the vibrating screen and the rest auxiliary materials are all added into a mixer to be mixed, and the mixing time is 30-90 min; preferably, the mixing time is 60 min.
The invention provides a process technology of an alpha-GPC formula with excellent moisture absorption resistance, and the inventor finds that the moisture absorption of the alpha-GPC can be obviously improved by using plant-based auxiliary materials, the protein and the starch are used as the auxiliary materials, the protein and the starch can well wrap the alpha-GPC, the sample can have good dispersibility, meanwhile, the GPC can be better absorbed and utilized by a human body, the preparation method is simple and easy to implement, the operation time is short, the obtained product has the advantages of good moisture absorption resistance and good fluidity, the inventor speculates that the plant-derived auxiliary materials are used for replacing a large amount of silicon dioxide and calcium hydrophosphate, the inorganic powder such as the silicon dioxide and the like are mixed with the plant source to the alpha-GPC to obtain granular powder wrapping the alpha-GPC, the silicon dioxide is used for absorbing the alpha-GPC, and the plant-derived auxiliary materials such as the protein and the, the hygroscopicity of alpha-GPC can be obviously improved, and the plant-based material is embedded in the surface of the alpha-GPC, so that the friction force among particles can be reduced, and the flowability among the coated alpha-GPC can be improved. In addition, the alpha-GPC prepared by the preparation method can slowly release the alpha-GPC under acidic conditions, and has high bioavailability.
Best mode and details of the present invention are described below by way of examples, and experimental methods not specifying specific conditions in the following examples are selected in accordance with conventional methods and conditions, or in accordance with commercial specifications. The reagents and starting materials used in the present invention are commercially available.
The GPC content in the product was determined by HPLC in the examples (99% Alpha-GPC was used to quantify the GPC content in the product using an ELSD detector). And (2) measuring the GPC content by combining a potentiometric titration method with an HPLC method, carrying out potentiometric titration on the Alpha-GPC sample by adopting a perchloric acid standard solution, then finding a potentiometric jump point by using a two-stage differential quotient method, and determining the volume of the perchloric acid standard solution consumed by the potentiometric titration end point, thereby obtaining the Alpha-GPC content.
Example 1
An alpha-GPC formulation process technology with excellent moisture absorption resistance, comprising at least the steps of:
(1) weighing silicon dioxide and plant-based auxiliary materials with the total amount of the auxiliary materials being 42%, pouring the silicon dioxide and the plant-based auxiliary materials into a wet granulator, and mixing uniformly in advance. Wherein the proportion of the silicon dioxide and the plant-based auxiliary materials is 1: 3, the ratio of starch to protein is 1: 1.
(2) adding 55% alpha-GPC, pouring into a food processor, stirring, and mixing.
(3) And drying the materials by using boiling drying, and cooling to room temperature to obtain the dried materials.
(4) Crushing the materials by a crusher, and sieving the crushed materials by a sieve of 20 meshes;
(5) further, 3% of silica was added to the sample, and the total mixing was performed by a mixer.
The auxiliary materials comprise 45% of silicon dioxide and plant-based auxiliary materials; wherein the plant-based auxiliary materials are starch and protein; wherein, the silicon dioxide accounting for 3 percent of the total amount of the silicon dioxide and the plant-based auxiliary materials is added in the step (5), and the rest is poured into a wet granulator in the step (1) and is mixed uniformly in advance.
The vegetable protein is selected from pea protein. The particle size of the silica is 200 μm.
In the step (1), when stirring is started, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In the step (2), the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 50 s.
In the step (3), the air inlet temperature is 85 ℃, the air outlet temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10min during drying.
In the step (3), the screen mesh during sieving is 12 meshes.
In the step (5), the mixing time is 60 min.
The GPC content was measured by liquid phase. By observing the hygroscopicity of the sample under the conditions of constant humidity and constant temperature (RH is 75 percent, T is 25 ℃), the sample still has certain fluidity after being placed for 48 hours in an open manner; when the sample is stored in an indoor environment, after the sample is placed in an open air for one week, the fluidity of the sample is not obviously different from that of the sample which is just prepared.
Example 2
An alpha-GPC formulation process technology with excellent moisture absorption resistance, comprising at least the steps of:
(1) weighing silicon dioxide and starch with the total amount of the auxiliary materials being 40%, pouring the silicon dioxide and the starch into a wet granulator, and mixing uniformly in advance. Wherein the proportion of the silicon dioxide and the plant-based auxiliary materials is 1: 2.
(2) adding 55% alpha-GPC, pouring into a food processor, stirring, and mixing.
(3) And drying the materials by using boiling drying, and cooling to room temperature to obtain the dried materials.
(4) Crushing the materials by a crusher, and sieving the crushed materials by a sieve of 20 meshes;
(5) further, 5% of silica was added to the sample, and the total mixing was performed by a mixer.
The auxiliary materials comprise 45% of silicon dioxide and plant-based auxiliary materials; wherein the plant-based auxiliary material is starch; wherein, the silicon dioxide accounting for 5 percent of the total amount of the silicon dioxide and the plant-based auxiliary materials is added in the step (5), and the rest is poured into a wet granulator in the step (1) and is mixed uniformly in advance.
The vegetable protein is selected from pea protein. The particle size of the silica is 200 μm.
In the step (1), when stirring is started, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In the step (2), the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 50 s.
In the step (3), the air inlet temperature is 85 ℃, the air outlet temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10min during drying.
In the step (3), the screen mesh during sieving is 12 meshes.
In the step (5), the mixing time is 60 min.
By observing the hygroscopicity of the sample under the conditions of constant humidity and constant temperature (RH is 75 percent, T is 25 ℃), the sample still has certain fluidity after being placed for 48 hours in an open manner; when the sample is stored in an indoor environment, after the sample is placed in an open air for one week, the fluidity of the sample is not obviously different from that of the sample which is just prepared.
Example 3
An alpha-GPC formulation process technology with excellent moisture absorption resistance, comprising at least the steps of:
(1) weighing silicon dioxide and protein with the total amount of the auxiliary materials being 40%, pouring the silicon dioxide and the protein into a wet granulator, and mixing uniformly in advance. Wherein the ratio of silica to protein is 1: 2.
(2) adding 55% alpha-GPC, pouring into a food processor, stirring, and mixing.
(3) And drying the materials by using boiling drying, and cooling to room temperature to obtain the dried materials.
(4) Crushing the materials by a crusher, and sieving the crushed materials by a sieve of 20 meshes;
(5) further, 3% of silica was added to the sample, and the total mixing was performed by a mixer.
The auxiliary materials comprise 43% of silicon dioxide and plant-based auxiliary materials; wherein the plant-based auxiliary material is protein; wherein, the silicon dioxide accounting for 3 percent of the total amount of the silicon dioxide and the plant-based auxiliary materials is added in the step (5), and the rest is poured into a wet granulator in the step (1) and is mixed uniformly in advance.
The vegetable protein is selected from pea protein. The particle size of the silica is 200 μm.
In the step (1), when stirring is started, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In the step (2), the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 50 s.
In the step (3), the air inlet temperature is 85 ℃, the air outlet temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10min during drying.
In the step (3), the screen mesh during sieving is 12 meshes.
In the step (5), the mixing time is 60 min.
The alpha-GPC content was measured by using a liquid phase. By observing the hygroscopicity of the sample under the conditions of constant humidity and constant temperature (RH is 75 percent, T is 25 ℃), the sample still has certain fluidity after being placed for 48 hours in an open manner; when the sample is stored in an indoor environment, after the sample is placed in an open air for one week, the fluidity of the sample is not obviously different from that of the sample which is just prepared.
Example 4
An alpha-GPC formulation process technology with excellent moisture absorption resistance, comprising at least the steps of:
(1) weighing silicon dioxide and resistant dextrin with the total amount of the auxiliary materials being 40%, pouring the silicon dioxide and the resistant dextrin into a wet granulator, and mixing uniformly in advance. Wherein the ratio of silica to resistant dextrin is 1: 2.
(2) adding 55% alpha-GPC, pouring into a food processor, stirring, and mixing.
(3) And drying the materials by using boiling drying, and cooling to room temperature to obtain the dried materials.
(4) Crushing the materials by a crusher, and sieving the crushed materials by a sieve of 20 meshes;
(5) further, 3% of silica was added to the sample, and the total mixing was performed by a mixer.
The auxiliary materials comprise 43% of silicon dioxide and plant-based auxiliary materials; wherein the plant-based auxiliary material is protein; wherein, the silicon dioxide accounting for 3 percent of the total amount of the silicon dioxide and the plant-based auxiliary materials is added in the step (5), and the rest is poured into a wet granulator in the step (1) and is mixed uniformly in advance.
The vegetable protein is selected from pea protein. The particle size of the silica is 200 μm.
In the step (1), when stirring is started, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In the step (2), the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 50 s.
In the step (3), the air inlet temperature is 85 ℃, the air outlet temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10min during drying.
In the step (3), the screen mesh during sieving is 12 meshes.
In the step (5), the mixing time is 60 min.
The alpha-GPC content was measured by using a liquid phase. By observing the hygroscopicity of the sample under the conditions of constant humidity and constant temperature (RH is 75 percent, T is 25 ℃), the sample is converted into a pool of water after being placed for 48 hours in an open manner; when the samples were stored in an indoor environment, the samples were completely soaked after one week of open standing.
Example 5
An alpha-GPC formulation process technology with excellent moisture absorption resistance, comprising at least the steps of:
(1) weighing silicon dioxide, protein and resistant dextrin with the total amount of the auxiliary materials being 40%, pouring the silicon dioxide, the protein and the resistant dextrin into a wet granulator, and mixing uniformly in advance. Wherein the proportion of the silicon dioxide and the plant-based auxiliary materials is 1: 3, the ratio of the protein to the resistant dextrin is 1: 1.
(2) adding 55% alpha-GPC, pouring into a food processor, stirring, and mixing.
(3) And drying the materials by using boiling drying, and cooling to room temperature to obtain the dried materials.
(4) Crushing the materials by a crusher, and sieving the crushed materials by a sieve of 20 meshes;
(5) further, 5% of silica was added to the sample, and the total mixing was performed by a mixer.
The auxiliary materials comprise 45% of silicon dioxide and plant-based auxiliary materials; wherein the plant-based auxiliary materials are protein and resistant dextrin; wherein, the silicon dioxide accounting for 5 percent of the total amount of the silicon dioxide and the plant-based auxiliary materials is added in the step (5), and the rest is poured into a wet granulator in the step (1) and is mixed uniformly in advance.
The vegetable protein is selected from pea protein. The particle size of the silica is 200 μm.
In the step (1), when stirring is started, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In the step (2), the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 50 s.
In the step (3), the air inlet temperature is 85 ℃, the air outlet temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10min during drying.
In the step (3), the screen mesh during sieving is 12 meshes.
In the step (5), the mixing time is 60 min.
The alpha-GPC content was measured by using a liquid phase. By observing the hygroscopicity of the sample under the conditions of constant humidity and constant temperature (RH is 75 percent, T is 25 ℃), the sample is converted into a pool of water after being placed for 48 hours in an open manner; when the samples were stored in an indoor environment, the samples were completely soaked after one week of open standing.
Example 6
An alpha-GPC formulation process technology with excellent moisture absorption resistance, comprising at least the steps of:
(1) weighing silicon dioxide, protein and resistant starch with the total amount of the auxiliary materials being 40%, pouring the silicon dioxide, the protein and the resistant starch into a wet granulator, and mixing uniformly in advance. Wherein the proportion of the silicon dioxide and the plant-based auxiliary materials is 1: 3, the ratio of protein to resistant starch is 1: 1.
(2) adding 55% alpha-GPC, pouring into a food processor, stirring, and mixing.
(3) And drying the materials by using boiling drying, and cooling to room temperature to obtain the dried materials.
(4) Crushing the materials by a crusher, and sieving the crushed materials by a sieve of 20 meshes;
(5) further, 5% of silica was added to the sample, and the total mixing was performed by a mixer.
The auxiliary materials comprise 45% of silicon dioxide and plant-based auxiliary materials; wherein the plant-based auxiliary materials are protein and resistant starch; wherein, the silicon dioxide accounting for 5 percent of the total amount of the silicon dioxide and the plant-based auxiliary materials is added in the step (5), and the rest is poured into a wet granulator in the step (1) and is mixed uniformly in advance.
The vegetable protein is selected from pea protein. The particle size of the silica is 200 μm.
In the step (1), when stirring is started, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In the step (2), the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 50 s.
In the step (3), the air inlet temperature is 85 ℃, the air outlet temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10min during drying.
In the step (3), the screen mesh during sieving is 12 meshes.
In the step (5), the mixing time is 60 min.
The alpha-GPC content was measured by using a liquid phase. By observing the hygroscopicity of the sample under the conditions of constant humidity and constant temperature (RH is 75 percent, T is 25 ℃), the sample is converted into a pool of water after being placed for 48 hours in an open manner; when the samples were stored in an indoor environment, the samples were completely soaked after one week of open standing.
Example 7
An alpha-GPC formulation process technology with excellent moisture absorption resistance, comprising at least the steps of:
(1) weighing silicon dioxide and resistant starch with the total amount of the auxiliary materials being 40%, pouring the silicon dioxide and the resistant starch into a wet granulator, and mixing uniformly in advance. Wherein the ratio of silicon dioxide to resistant starch is 1: 2.
(2) adding 55% alpha-GPC, pouring into a food processor, stirring, and mixing.
(3) And drying the materials by using boiling drying, and cooling to room temperature to obtain the dried materials.
(4) Crushing the materials by a crusher, and sieving the crushed materials by a sieve of 20 meshes;
(5) further, 5% of silica was added to the sample, and the total mixing was performed by a mixer.
The auxiliary materials comprise 45% of silicon dioxide and plant-based auxiliary materials; wherein the plant-based auxiliary material is resistant starch; wherein, the silicon dioxide accounting for 5 percent of the total amount of the silicon dioxide and the plant-based auxiliary materials is added in the step (5), and the rest is poured into a wet granulator in the step (1) and is mixed uniformly in advance.
The vegetable protein is selected from pea protein. The particle size of the silica is 200 μm.
In the step (1), when stirring is started, the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 40 s.
In the step (2), the stirring frequency is 50Hz, the shearing frequency is 50Hz, and the time is 50 s.
In the step (3), the air inlet temperature is 85 ℃, the air outlet temperature is 75 ℃, the temperature in the pot is 80 ℃ and the time is 10min during drying.
In the step (3), the screen mesh during sieving is 12 meshes.
In the step (5), the mixing time is 60 min.
The alpha-GPC content was measured by using a liquid phase. By observing the hygroscopicity of the sample under the conditions of constant humidity and constant temperature (RH is 75 percent, T is 25 ℃), the sample is converted into a pool of water after being placed for 48 hours in an open manner; when the samples were stored in an indoor environment, the samples were completely soaked after one week of open standing.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. An alpha-GPC formula process technology with excellent moisture absorption resistance is characterized in that auxiliary materials and alpha-GPC are mixed and post-processed to obtain the alpha-GPC composition; the dosage of the alpha-GPC accounts for 40-65 wt% of the total amount of the auxiliary materials and the alpha-GPC; the auxiliary material is selected from plant source auxiliary materials and/or inorganic powder.
2. The technique of α -GPC formulation with excellent moisture absorption and absorption properties as claimed in claim 1, wherein said α -GPC is used in an amount of 50 to 60 wt% based on the total amount of the auxiliary material and α -GPC.
3. The α -GPC formulation process technology with excellent moisture absorption resistance according to claim 1, wherein the plant-derived excipient is at least one selected from starch and vegetable protein.
4. The technique of α -GPC formulation with excellent moisture absorption resistance according to claim 3, wherein the mass ratio between starch and vegetable protein is 1: (0.1-10).
5. The α -GPC formulation process technology with excellent moisture absorption resistance according to claim 1, wherein the mass ratio of the inorganic powder to the plant-derived auxiliary material is 1: (1-5).
6. The α -GPC formulation technology with excellent moisture absorption resistance according to claim 1, wherein the inorganic powder is at least one selected from the group consisting of silicon dioxide, magnesium stearate, magnesium silicate, and talc.
7. An Alpha-GPC formulation technology with excellent moisture absorption resistance as claimed in any of claims 1 to 6, characterized by the steps of at least:
(1) weighing part of the auxiliary materials, pouring the auxiliary materials into a wet granulator, and starting stirring;
(2) adding alpha-GPC, continuing stirring, and collecting a mixed material;
(3) drying and discharging the mixed material to obtain a dried material;
(4) adding the dried material into a pulverizer to be pulverized and sieved;
(5) adding the rest adjuvants, and mixing with a mixer.
8. The α -GPC formulation process technique with excellent moisture absorption resistance according to claim 7, wherein in the step (1), a part of the excipients is added in an amount of 10 to 99 wt% based on the total excipients.
9. The process of claim 7, wherein in the step (3), the inlet air temperature is 80-100 ℃, the outlet air temperature is 70-90 ℃, the temperature in the pot is 75-95 ℃, and the time is 5-15 min.
10. The α -GPC formulation process technique with excellent moisture absorption resistance according to claim 7, wherein in the step (4), the screen mesh when passing through the screen is 10 to 50 mesh.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020132219A1 (en) * | 2000-12-28 | 2002-09-19 | Mccleary Larry | Composition and method for modulating nutrient partitioning |
| CN101945648A (en) * | 2008-02-15 | 2011-01-12 | 西梯茜生命工学股份有限公司 | Pharmaceutical formulation containing choline alfoscerate |
| US20120244583A1 (en) * | 2011-03-24 | 2012-09-27 | Yuanfa Liu | Method for Preparing High Purity L-alpha Glycerylphosphorylcholine |
| CN105658208A (en) * | 2013-12-17 | 2016-06-08 | 株式会社大熊制药 | Film coated tablet containing choline alfoscerate and process for preparing the same |
| CN112137971A (en) * | 2019-06-28 | 2020-12-29 | 北京万全德众医药生物技术有限公司 | Orally disintegrating tablet of choline alfoscerate and preparation method thereof |
-
2021
- 2021-03-22 CN CN202110300873.4A patent/CN113041252A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020132219A1 (en) * | 2000-12-28 | 2002-09-19 | Mccleary Larry | Composition and method for modulating nutrient partitioning |
| CN101945648A (en) * | 2008-02-15 | 2011-01-12 | 西梯茜生命工学股份有限公司 | Pharmaceutical formulation containing choline alfoscerate |
| US20120244583A1 (en) * | 2011-03-24 | 2012-09-27 | Yuanfa Liu | Method for Preparing High Purity L-alpha Glycerylphosphorylcholine |
| CN105658208A (en) * | 2013-12-17 | 2016-06-08 | 株式会社大熊制药 | Film coated tablet containing choline alfoscerate and process for preparing the same |
| CN112137971A (en) * | 2019-06-28 | 2020-12-29 | 北京万全德众医药生物技术有限公司 | Orally disintegrating tablet of choline alfoscerate and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 关志宇: "《药物制剂辅料与包装材料》", 31 January 2017, 中国医药科技出版社 * |
| 刘雅敏: "《药物制剂常用辅料》", 31 January 1994, 天津科技翻译出版公司出版 * |
| 吴清: "《物理药剂学》", 30 November 2018, 中国中医药出版社 * |
| 费家骍: "《大豆加工与综合利用》", 31 March 1990, 广西科学技术出版社 * |
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Application publication date: 20210629 |