CN113041218A - Calcium gluconate and sodium chloride injection and preparation method thereof - Google Patents
Calcium gluconate and sodium chloride injection and preparation method thereof Download PDFInfo
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- CN113041218A CN113041218A CN202110316973.6A CN202110316973A CN113041218A CN 113041218 A CN113041218 A CN 113041218A CN 202110316973 A CN202110316973 A CN 202110316973A CN 113041218 A CN113041218 A CN 113041218A
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- injection
- sodium chloride
- preparation
- calcium gluconate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Abstract
The invention discloses a calcium gluconate and sodium chloride injection and a preparation method thereof, belonging to the field of medicine, wherein each 1000 parts by volume of the injection contains 10 parts by weight of calcium gluconate and 9 parts by weight of sodium chloride solute, and the solvent is water for injection. The preparation method comprises adding calculated amount of calcium gluconate and sodium chloride into injectable water, dissolving and boiling, adjusting pH, adding adsorbent, keeping the solution boiling, filtering to obtain filtrate, and making into concentrated solution A; the invention adopts a large bottle formula and carries out preparation twice, namely a method of firstly carrying out concentrated preparation and then carrying out diluted preparation, so that the preparation precision is more accurate, and meanwhile, the adsorbent is adopted to carry out heating adsorption in the concentrated preparation and diluted preparation processes, so that the injection has no impurities, and the application of the injection in the field of medicine is more facilitated.
Description
Technical Field
The invention relates to the field of medicines, and in particular relates to a calcium gluconate and sodium chloride injection and a preparation method thereof.
Background
Calcium gluconate is a calcium supplement, and calcium can maintain normal excitability of nerve and muscle and promote acetylcholine secretion of nerve endings. When the serum calcium is reduced, the excitability of nerve and muscle is increased to generate convulsion, and when the blood calcium is too high, the excitability is reduced to generate weakness and the like. The calcium ion can improve permeability of cell membrane, increase compactness of capillary, reduce exudation, and has antiallergic effect. Calcium ions can promote the calcification formation of bones and teeth, and competitive antagonism exists between high-concentration calcium ions and magnesium ions, so that the calcium ion can be used for relieving magnesium poisoning; calcium ions and fluoride can generate insoluble calcium fluoride for relieving fluorosis, but in the prior art, calcium gluconate is a small-dose product, and meanwhile, the traditional preparation method only removes impurities once, so that fine impurities still exist in the product, and the exertion of the drug property is influenced.
Disclosure of Invention
The invention aims to at least solve one of the technical problems in the prior art and provides a calcium gluconate and sodium chloride injection and a preparation method thereof.
The technical solution of the invention is as follows:
a calcium gluconate and sodium chloride injection comprises 10 parts by weight of calcium gluconate and 9 parts by weight of sodium chloride as solute in every 1000 parts by volume of the injection, and the solvent is water for injection.
The invention also discloses a preparation method of the calcium gluconate and sodium chloride injection, which comprises the following steps:
the method comprises the following steps: adding calculated amounts of calcium gluconate and sodium chloride into 30-50 ml of water for injection, dissolving and boiling, adding a pH adjusting solution, adjusting the pH value, adding an adsorbent, keeping the solution in a boiling state, filtering, and taking a filtrate to obtain a concentrated solution A;
step two: adding the concentrated solution A into 1/3-2/3 volume-prepared water, stirring simultaneously, continuously adding water for injection to the volume-prepared water, then adding an adsorbent, stirring, refluxing, and filtering to obtain the calcium gluconate and sodium chloride injection.
Preferably, the adsorbent is activated carbon.
Preferably, in the first step, the pH value is adjusted to 4.7-5.
Preferably, in the first step, the solution is kept boiling for 15 min.
Preferably, in the first step, the filtration is performed by using a 0.22 μm microporous filter element.
Preferably, in the first step, the adsorbent is added in an amount of 4 w/w% based on the mass of the sodium chloride.
Preferably, in the second step, the adsorbent is added in an amount of 0.025 w/v% based on the volume of the prepared amount.
Preferably, in the second step, stirring and refluxing are carried out for 15 min.
Preferably, in the second step, the temperature of the water for injection in the second step is 45-65 ℃.
The invention has at least one of the following beneficial effects:
the concentration of the calcium gluconate and sodium chloride injection is lower than the solubility (3g/100ml, 20 ℃) of calcium gluconate in water, and the product is a non-supersaturated solution, has stable quality, does not have crystallization and has low adverse reaction; the product does not need to add a stabilizer in the production process, and only 0.9 w/v% sodium chloride solution is added at the same time, so that the product is isotonic with human bodies, the stimulation of high concentration can be reduced, the product can be directly injected into veins, the intravenous drip is directly carried out during use, secondary preparation is not needed, secondary pollution is prevented, the safety is better, and the calcium gluconate injection is usually diluted to 1% by glucose solution or sodium chloride solution for use. The calcium gluconate preparation is a first-aid shortage medicament, has a reasonable large infusion dosage form, is an unsaturated solution, has stable quality, is isotonic with human bodies, can be directly injected, has a reasonable use method, is packaged with glass bottles, plastic bottles and soft bags, can meet different market demands, better ensures the product quality, does not need to add a cosolvent, and has low adverse reaction incidence.
The preparation method of the calcium gluconate and sodium chloride injection adopts a twice preparation method, namely a method of first concentrated preparation and then diluted preparation, ensures that the solute is fully dissolved during concentration, and can better ensure that the solute is fully dissolved during diluted preparation, so that the preparation precision is more accurate.
Detailed Description
The technical solution of the present invention is further illustrated by the following specific examples.
Example 1
Adding 30 ten thousand ml of water for injection into a clean thick preparation tank, adding 1000g of calcium gluconate and 22.5kg of sodium chloride, stirring, dissolving, heating to boil, adding 2mol/L hydrochloric acid solution to adjust the pH value to 4.7, adding 4 w/w% (calculated by sodium chloride) of activated carbon, and keeping the mixture slightly boiled for 15 minutes.
Adding 3.7 ten thousand ml of water for injection into a diluting preparation tank, wherein the temperature of the water for injection is 50 ℃, inputting decarburized calcium gluconate and sodium chloride concentrated solution, stirring while adding, wherein the stirring revolution is 60 r/min, and filtering by adopting a 5-micron titanium rod during decarburizing; adding water for injection to 10 ten thousand ml, adding 0.025 w/v% (based on the configured volume) of active carbon, stirring and refluxing for more than 15 minutes, sampling to determine the content and the pH value, filtering by a 0.22 mu m microporous filter element until the visible foreign matters are qualified, filling, capping, sterilizing, lamp inspection, labeling, packaging, storing and warehousing, wherein the sterilization is carried out at the temperature of 118 ℃ for 28 minutes.
Example 2
Adding 35 ten thousand ml of water for injection into a clean thick preparation tank, adding 1000g of calcium gluconate and 22.5kg of sodium chloride, stirring, dissolving, heating to boil, adding 2mol/L hydrochloric acid solution to adjust the pH value to 4.7, adding 4 w/w% (calculated by sodium chloride) of activated carbon, and keeping the mixture slightly boiled for 15 minutes.
Adding 4.2 ten thousand ml of water for injection into a diluting preparation cylinder, wherein the temperature of the water for injection is 50 ℃, inputting decarburized calcium gluconate and sodium chloride concentrated solution, stirring while adding, wherein the stirring revolution is 55 revolutions per minute, and filtering by adopting a 5-micron titanium rod during decarburizing; adding water for injection to 10 ten thousand ml, adding 0.025 w/v% (based on the configured volume) of active carbon, stirring and refluxing for more than 15 minutes, sampling to determine the content and the pH value, filtering by a 0.22 mu m microporous filter element until the visible foreign matters are qualified, filling, capping, sterilizing, lamp inspection, labeling, packaging, storing and warehousing, wherein the sterilization is carried out at the temperature of 118 ℃ for 28 minutes.
Example 3
Adding 40 ten thousand ml of water for injection into a clean thick preparation tank, adding 1000g of calcium gluconate and 22.5kg of sodium chloride, stirring, dissolving, heating to boil, adding 2mol/L hydrochloric acid solution to adjust the pH value to 4.7, adding 4 w/w% (calculated by sodium chloride) of activated carbon, and keeping the mixture slightly boiled for 15 minutes.
Adding 4.5 milliliters of water for injection into a diluting and mixing tank, wherein the temperature of the water for injection is 50 ℃, inputting decarburized calcium gluconate and sodium chloride concentrated solution, stirring while adding, wherein the stirring revolution is 65 r/min, and filtering by adopting a 5-micron titanium rod during decarburizing; adding water for injection to 10 ten thousand ml, adding 0.025 w/v% (based on the configured volume) of active carbon, stirring and refluxing for more than 15 minutes, sampling to determine the content and the pH value, filtering by a 0.22 mu m microporous filter element until the visible foreign matters are qualified, filling, capping, sterilizing, lamp inspection, labeling, packaging, storing and warehousing, wherein the sterilization is carried out at the temperature of 118 ℃ for 28 minutes.
Example 4
50 ten thousand ml of water for injection is firstly added into a clean thick preparation tank, 1000g of calcium gluconate and 22.5kg of sodium chloride are then added, the mixture is stirred, dissolved and heated to boil, 2mol/L hydrochloric acid solution is added to adjust the pH value to 4.7, 4 w/w% (calculated by sodium chloride) of activated carbon is added, and the micro-boiling is kept for 15 minutes.
Adding 3.7 ten thousand ml of water for injection into a diluting preparation tank, wherein the temperature of the water for injection is 50 ℃, inputting decarburized calcium gluconate and sodium chloride concentrated solution, stirring while adding, wherein the stirring revolution is 55 revolutions per minute, and filtering by adopting a 5-micron titanium rod during decarburizing; adding water for injection to 10 ten thousand ml, adding 0.025 w/v% (based on the configured volume) of active carbon, stirring and refluxing for more than 15 minutes, sampling to determine the content and the pH value, filtering by a 0.22 mu m microporous filter element until the visible foreign matters are qualified, filling, capping, sterilizing, lamp inspection, labeling, packaging, storing and warehousing, wherein the sterilization is carried out at the temperature of 118 ℃ for 28 minutes.
Example 5
50 ten thousand ml of water for injection is firstly added into a clean thick preparation tank, 1000g of calcium gluconate and 22.5kg of sodium chloride are then added, the mixture is stirred, dissolved and heated to boil, 2mol/L hydrochloric acid solution is added to adjust the pH value to 4.7, 4 w/w% (calculated by sodium chloride) of activated carbon is added, and the micro-boiling is kept for 15 minutes.
Adding 3.7 ten thousand ml of water for injection into a diluting preparation cylinder, wherein the temperature of the water for injection is 60 ℃, inputting decarburized calcium gluconate and sodium chloride concentrated solution, stirring while adding, wherein the stirring revolution is 55 revolutions per minute, and filtering by adopting a 5-micron titanium rod during decarburizing; adding water for injection to 10 ten thousand ml, adding 0.025 w/v% (based on the configured volume) of active carbon, stirring and refluxing for more than 15 minutes, sampling to determine the content and the pH value, filtering by a 0.22 mu m microporous filter element until the visible foreign matters are qualified, filling, capping, sterilizing, lamp inspection, labeling, packaging, storing and warehousing, wherein the sterilization is carried out at the temperature of 118 ℃ for 28 minutes.
Comparative example 1 (Disposable preparation)
Weighing 1000g of calcium gluconate and 900g of sodium chloride, adding 9 ten thousand ml of water for injection, heating to boil and dissolve, cooling, roughly filtering, adding 30g of activated carbon for injection, heating and stirring at 60 ℃ for 15min, filtering to remove carbon, adding water for injection to 10 thousand ml, finely filtering by using a 0.22 mu m microporous filter membrane, filling and sterilizing to obtain the calcium gluconate injection.
COMPARATIVE EXAMPLE 2 (dense without boiling)
50 ten thousand ml of water for injection is firstly added into a clean thick preparation tank, 1000g of calcium gluconate and 22.5kg of sodium chloride are then added, the mixture is stirred and dissolved, 2mol/L hydrochloric acid solution is added to adjust the pH value to 4.7, 4 w/w% (calculated by sodium chloride) of activated carbon is added, and the micro-boiling is kept for 15 minutes.
Adding 3.7 ten thousand ml of water for injection into a diluting preparation tank, wherein the temperature of the water for injection is 50 ℃, inputting decarburized calcium gluconate and sodium chloride concentrated solution, stirring while adding, wherein the stirring revolution is 55 revolutions per minute, and filtering by adopting a 5-micron titanium rod during decarburizing; adding water for injection to 10 ten thousand ml, adding 0.025 w/v% (based on the configured volume) of active carbon, stirring and refluxing for more than 15 minutes, sampling to determine the content and the pH value, filtering by a 0.22 mu m microporous filter element until the visible foreign matters are qualified, filling, capping, sterilizing, lamp inspection, labeling, packaging, storing and warehousing, wherein the sterilization is carried out at the temperature of 118 ℃ for 28 minutes.
The examples and comparative examples were tested as follows:
the characteristics are as follows: the product should be a colorless clear liquid.
And (3) identification:
(1) 10ml of the product is taken and added with 1 drop of ferric trichloride test solution, and the product is dark yellow.
(2) When the product is taken and checked according to general identification test, the identification reaction of calcium salt and sodium salt and chloride should be shown.
And (4) checking:
pH value: the pH value should be 4.7-7.0 according to the examination of pH value determination.
Heavy metals: taking 50ml of the product, evaporating to about 20ml, cooling, adding 2ml of acetate buffer solution (pH3.5) and a proper amount of water to obtain 25ml, checking according to the first method of heavy metal checking method, and comparing with a control solution prepared from 1.5ml (10 mu g/ml) of standard lead solution, wherein the heavy metal content is not more than three million.
Osmolality: the osmolality of the product is 300-380 mOsmol/Kg as determined by osmolality determination method.
Bacterial endotoxin: taking the product, and examining according to "bacterial endotoxin test method", wherein the amount of endotoxin in 1ml should not exceed 0.50 EU.
Insoluble microparticles: the product is examined according to "examination method of insoluble microparticle in injection", and the content of microparticles with particle size of 10 μm and more than 10 μm in 1ml should not exceed 18, and the content of microparticles with particle size of 25 μm and more than 25 μm should not exceed 2.
Loading: taking 3 bottles of the product, and checking according to the minimum filling inspection method, wherein the single bottle filling amount should be more than 97ml, and the average filling amount should be more than 100 ml.
Visible foreign matter: after 20 bottles of the product are taken and inspected according to the inspection method of visible foreign matters, no smog-like particle column can be detected, and no obvious visible foreign matters such as metal chips, glass chips, fibers and blocks with the length or the maximum particle size of more than 2mm can be detected. If the number of detected fine visible foreign matters (such as spots, short fibers and blocks with the diameter less than 2mm, and the like) is only 1 bottle, and another 20 bottles are adopted for detection by the same method, the detection is not obtained.
Content determination:
calcium gluconate: precisely measuring 50ml (about equivalent to 0.5g of calcium gluconate) of the product, putting the product into a conical flask, adding water to dilute the product into 100ml, adding 15ml of sodium hydroxide test solution and 0.1g of calcium purpurin indicator, titrating the solution by using ethylene diamine tetraacetic acid titration solution (0.05mol/L) until the solution is changed from purple to pure blue, and correcting the titration result by using a blank test. Each 1ml of disodium ethylenediaminetetraacetate titration solution (0.05mol/L) is equivalent to 22.42mg of calcium gluconate. The calculation result is 97.0-103.0% of the marked amount.
Calculating the formula: the indicated amount% (% V × f × 22.42)/(0.5 × 1000) × 100%
V: consumption of milliliters of disodium ethylene diamine tetraacetate titration solution (0.05 mol/L);
f: and (3) a correction factor of the ethylene diamine tetraacetic acid titration solution.
Sodium chloride: a proper amount of sodium single element standard solution is precisely measured, and diluted by water to prepare solution containing 100 mu g of sodium ions in each 1ml, so as to prepare reference substance storage solution. Precisely measuring 5ml of the product, placing in a 100ml measuring flask, diluting with water to scale, shaking, precisely measuring 1ml, placing in a 50ml measuring flask, diluting with water to scale, and shaking to obtain the test solution. Precisely measuring the reference stock solutions 0.5ml, 1ml, 2ml, 3ml and 4ml, respectively placing into a 100ml measuring flask, diluting with water to scale, and shaking. Taking the solutions and the sample solution, measuring the light absorption value at the wavelength of 589nm by an atomic absorption spectrophotometry, multiplying the light absorption value by a conversion coefficient of 2.542 to obtain the sodium ion concentration, determining the sodium ion concentration of the sample according to a standard curve of a reference substance, and calculating the result to be 97.0-103.0% of the marked amount.
Example 3 examination of calcium gluconate sodium chloride injection
The calcium gluconate sodium chloride injection prepared in example 1 was tested according to the test method described in example 2, and the results are shown in table 1.
TABLE 1 insoluble microparticle detection results
Table 2 results of performance tests of example 2
As can be seen from tables 1 and 2, the osmotic pressure of the examples is more in accordance with the regulations, wherein the content of insoluble particles is lower than that of the comparative examples, which shows that the preparation method of the invention can effectively remove impurities in the solution, and the analysis of the comparative example 1 shows that the preparation method mainly adopts the steps of firstly concentrating and then diluting, and adopts the adsorbent to carry out heating adsorption, so that the solute is dissolved more fully and the precision is higher, meanwhile, the analysis of the comparative example 2 shows that the preparation method carries out heating boiling during concentration, so that the dissolution of the solute NaCl is more facilitated, the precision is higher, the theoretical calculated value is more consistent, and the osmotic pressure is closer to the osmotic pressure of a human body. Meanwhile, the performance of the invention is in accordance with the specification, the measured value of osmotic pressure can be isotonic with human body, high concentration stimulation can be reduced, the invention can be directly used for intravenous injection, the invention can be directly used for intravenous drip without secondary preparation, secondary pollution is prevented, the safety is better, and the invention is more beneficial to the direct utilization in the medical field.
The above additional technical features can be freely combined and used in superposition by those skilled in the art without conflict.
In the description of the embodiments of the present invention, it should be understood that "-" and "-" indicate the same range of two numerical values, and the range includes the endpoints. For example: "A-B" means a range of greater than or equal to A and less than or equal to B. "A to B" means a range of not less than A and not more than B.
In the description of the embodiments of the present invention, the term "and/or" herein is only one kind of association relationship describing an associated object, and means that there may be three kinds of relationships, for example, a and/or B, and may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.
The above description is only a preferred embodiment of the present invention, and the technical solutions that achieve the objects of the present invention by basically the same means are all within the protection scope of the present invention.
Claims (10)
1. A calcium gluconate sodium chloride injection is characterized in that:
each 1000 volume parts of injection contains solute of 10 weight parts of calcium gluconate and 9 weight parts of sodium chloride, and the solvent is water for injection.
2. A preparation method of calcium gluconate and sodium chloride injection is characterized by comprising the following steps: comprises the following steps:
the method comprises the following steps: adding calculated amounts of calcium gluconate and sodium chloride into 30-50 ml of water for injection, dissolving and boiling, adjusting pH value, adding adsorbent, keeping the solution boiling, filtering to obtain filtrate to obtain concentrated solution A;
step two: adding the concentrated solution A into 1/3-2/3 volume-prepared water for injection, stirring simultaneously, continuously adding the water for injection to the preparation amount, then adding an adsorbent, stirring, refluxing, and filtering to obtain the calcium gluconate and sodium chloride injection.
3. The preparation method of the calcium gluconate and sodium chloride injection as claimed in claim 2, which is characterized in that: the adsorbent is activated carbon.
4. The preparation method of the calcium gluconate and sodium chloride injection as claimed in claim 2, which is characterized in that: in the first step, the pH value is adjusted to be 4.7-5.
5. The preparation method of the calcium gluconate and sodium chloride injection as claimed in claim 2, which is characterized in that: in the first step, the solution is kept boiling for 15 min.
6. The preparation method of the calcium gluconate and sodium chloride injection as claimed in claim 2, which is characterized in that: in the first step, the filtration is carried out by adopting a 0.22 mu m micropore filter element.
7. The preparation method of the calcium gluconate and sodium chloride injection as claimed in claim 2, which is characterized in that: in the first step, the adsorbent is added to account for 4w/w percent of the mass of the sodium chloride.
8. The calcium gluconate and sodium chloride injection as claimed in claim 2, wherein the injection is prepared by the following steps: in the second step, the adsorbent is added to account for 0.025 w/v% of the configured volume.
9. The preparation method of the calcium gluconate and sodium chloride injection as claimed in claim 2, which is characterized in that: and in the second step, stirring and refluxing for 15 min.
10. The preparation method of the calcium gluconate and sodium chloride injection as claimed in claim 2, which is characterized in that: in the second step, the temperature of the water for injection is 45-65 ℃.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115444816A (en) * | 2022-10-12 | 2022-12-09 | 安徽丰原药业股份有限公司淮海药厂 | Calcium gluconate and sodium chloride injection and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490770A (en) * | 2014-12-11 | 2015-04-08 | 回音必集团(江西)东亚制药有限公司 | Calcium gluconate sodium chloride injection solution and preparation method thereof |
| CN107397756A (en) * | 2017-09-15 | 2017-11-28 | 南通荣成医药化工有限公司 | A kind of glucose injection |
| CN108066360A (en) * | 2016-11-14 | 2018-05-25 | 华仁药业股份有限公司 | A kind of compound sodium acetate ringer's injection and preparation method thereof |
| US10130646B1 (en) * | 2017-07-25 | 2018-11-20 | HQ Specialty Pharma Corporation | Calcium gluconate solutions in flexible containers |
-
2021
- 2021-03-23 CN CN202110316973.6A patent/CN113041218A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490770A (en) * | 2014-12-11 | 2015-04-08 | 回音必集团(江西)东亚制药有限公司 | Calcium gluconate sodium chloride injection solution and preparation method thereof |
| CN108066360A (en) * | 2016-11-14 | 2018-05-25 | 华仁药业股份有限公司 | A kind of compound sodium acetate ringer's injection and preparation method thereof |
| US10130646B1 (en) * | 2017-07-25 | 2018-11-20 | HQ Specialty Pharma Corporation | Calcium gluconate solutions in flexible containers |
| CN107397756A (en) * | 2017-09-15 | 2017-11-28 | 南通荣成医药化工有限公司 | A kind of glucose injection |
Non-Patent Citations (3)
| Title |
|---|
| 凌沛学 主编: "《药物制剂技术》", 31 May 2007, 中国轻工业出版社 * |
| 周小雅 主编: "《药物制剂技术（第2版）》", 31 January 2012 * |
| 国家药典委员会 编: "《中华人民共和国药典2020年版（二部）》", 31 May 2020 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115444816A (en) * | 2022-10-12 | 2022-12-09 | 安徽丰原药业股份有限公司淮海药厂 | Calcium gluconate and sodium chloride injection and preparation method thereof |
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