CN112994263B - High-precision synchronous operation control system, method and storage medium - Google Patents
High-precision synchronous operation control system, method and storage medium Download PDFInfo
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- CN112994263B CN112994263B CN202110472249.2A CN202110472249A CN112994263B CN 112994263 B CN112994263 B CN 112994263B CN 202110472249 A CN202110472249 A CN 202110472249A CN 112994263 B CN112994263 B CN 112994263B
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
- H02J50/10—Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
- H02J50/80—Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04J—MULTIPLEX COMMUNICATION
- H04J3/00—Time-division multiplex systems
- H04J3/02—Details
- H04J3/06—Synchronising arrangements
- H04J3/0602—Systems characterised by the synchronising information used
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04J—MULTIPLEX COMMUNICATION
- H04J3/00—Time-division multiplex systems
- H04J3/02—Details
- H04J3/06—Synchronising arrangements
- H04J3/0635—Clock or time synchronisation in a network
- H04J3/0638—Clock or time synchronisation among nodes; Internode synchronisation
Abstract
The invention discloses a high-precision synchronous operation control system, which comprises an in-vivo electronic device and an in-vitro electronic device, wherein the in-vivo electronic device and the in-vitro electronic device are in wireless connection; when synchronous operation needs to be executed, the in-vitro electronic device changes the output voltage of the in-vitro electronic device; after the internal electronic device senses the sudden change of the output voltage, the internal electronic device and the external electronic device simultaneously execute synchronous operation. According to the invention, the sudden change of the output voltage of the in-vitro electronic device is transmitted as the synchronous signal, so that an additional chip for transmitting the synchronous signal in the electronic device can be omitted, the power consumption can be reduced, the size of the in-vivo electronic device is reduced when the in-vivo electronic device is arranged in a patient body, the minimally invasive operation can be realized, the injury to the patient is reduced, and the synchronization precision of an evoked event and a physiological signal in evoked potential examination can be met.
Description
Technical Field
The invention relates to the technical field of electric communication, in particular to a high-precision synchronous operation control system/device between an extracorporeal device and an intracorporeal device.
Background
Neuroelectrophysiology examination methods have been widely used in modern medicine for diagnosis, intra-operative monitoring, and prognosis evaluation of neurological diseases as an important means for examining the function of the nervous system. For example, Somatosensory Evoked Potentials (SEPs), characteristic of reversal of the central sulcus of SEPs, can be used to effectively assess functional brain regions, and the magnitude of SEPs can also be used to effectively assess the effectiveness of physiological stimuli. Such physiological electrical signals require acquisition of physiological electrical signals generated by stimulation, and are configured to determine the response of a human body to the stimulation (the response time of the physiological electrical signals generally requires less than 5 ms).
However, the conventional synchronous operation control device has the following problems:
1. the external electronic device and the internal electronic device are both provided with chips for transmitting synchronous signals, the synchronous signals are simultaneously transmitted to the external electronic device and the internal electronic device through a master controller, and the external electronic device and the internal electronic device execute synchronous operation after receiving the synchronous signals.
2. The power supply of the in-vivo electronic device is supplied by a battery, so that the volume of the in-vivo electronic device is large, when the in-vivo electronic device is arranged in the skull, a part of the skull needs to be cut off to install the in-vivo electronic device, the injury to a patient is large, the service life of the battery is limited (generally, several years), secondary injury can be caused to the patient when the battery is replaced, the battery is equivalent to a 'timing bomb', and once the battery is damaged, irreparable injury can be caused to the human body.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: in order to solve the technical problem that power consumption of an in-vivo electronic device is high due to high transmission power consumption of a synchronous signal in the prior art, the invention provides a high-precision synchronous operation control system, which transmits the synchronous operation signal in a voltage change mode, has a simple structure and low power consumption, and can meet the synchronization precision of an evoked event and a physiological signal in evoked potential examination.
The technical scheme adopted by the invention for solving the technical problems is as follows: a high precision synchronous operation control system comprising: an in-vivo electronic device adapted to be disposed within a body of a patient; an in-vitro electronic device adapted to be disposed outside of a patient's body, wirelessly connected with the in-vivo electronic device; wherein, when the synchronous operation needs to be executed, the in-vitro electronic device changes the power supply voltage; after the in-vivo electronic device senses that the power supply voltage changes suddenly, the in-vivo electronic device and the in-vitro electronic device execute synchronous operation at the same time.
According to the high-precision synchronous operation control system, the sudden change of the power supply voltage of the in-vitro electronic device is transmitted as the synchronous signal, so that an additional chip for transmitting the synchronous signal in the electronic device can be omitted, the power consumption can be reduced, the volume of the in-vivo electronic device (the volume can be reduced to 1/8-1/6 of the volume of the existing device) can be reduced, the high-precision synchronous operation control system can be minimally invasive when being arranged in a patient body, the harm to the patient can be reduced, and the synchronous precision of an induced event and a physiological signal in evoked potential examination can be met.
Further, in particular, the high-precision synchronized operation control system further comprises a stimulation module configured to apply stimulation to the patient, wherein the extracorporeal electronic device alters a supply voltage when the stimulation module applies stimulation to the patient; after the in-vivo electronic device senses that the power supply voltage changes suddenly, the in-vivo electronic device and the in-vitro electronic device execute synchronous operation at the same time. The stimulation applied by the stimulation module can be in-vitro stimulation or in-vivo stimulation, synchronous operation signals are transmitted while the stimulation is applied, and the clocks of in-vivo electronic equipment and in-vitro electronic equipment can be in the same reference by synchronous operation, so that the acquired signals can be accurately aligned with the time point of the stimulation in time, and the influence of the stimulation on the electroencephalogram signals is better analyzed.
Further, specifically, the in-vitro electronic device sends a synchronization operation request to the in-vivo electronic device, after the in-vivo electronic device responds to the in-vitro electronic device, the in-vitro electronic device changes the power supply voltage again, and after the in-vivo electronic device senses that the power supply voltage changes suddenly, the in-vivo electronic device and the in-vitro electronic device perform synchronization operation simultaneously. The synchronous operation request is sent to the in-vivo electronic device before the in-vitro electronic device changes the power supply voltage, and the in-vivo electronic device changes the power supply voltage after responding, so that the condition that the system receives an interference signal to cause misjudgment of the synchronous signal can be prevented, and the accuracy of synchronous signal identification is improved.
Further, specifically, the in-vitro electronic device includes an in-vivo coil module, the in-vivo electronic device includes an in-vivo coil module, and the in-vitro coil module and the in-vivo coil module are inductively connected, wherein when the output voltage of the in-vitro coil module changes suddenly, the alternating voltage of the in-vivo coil module changes along with the change of the output voltage. The in-vivo electronic device can obtain electric energy through the wireless coupling of the in-vivo coil module and the in-vitro coil module without arranging a battery module, the volume of the in-vivo electronic device can be greatly reduced, and the safety of the in-vivo electronic device can be improved.
Further, it is specific, external coil module includes transmitting coil and external magnet, transmitting coil encircles external magnet sets up, internal coil module includes receiving coil and internal magnet, receiving coil encircles internal magnet sets up, external magnet with through the absorption connection between the internal magnet. Can adsorb internal coil module and external coil module fixedly through internal magnet and external magnet inter attraction, convert supply voltage into electromagnetic radiation through transmitting coil and launch away, receiving coil receives electromagnetic radiation and converts it into the supply voltage who is suitable for internal electron device, and receiving coil and transmitting coil's wireless coupling not only can carry out energy transmission, and transmission efficiency is higher to because the real-time of coil response can regard as synchronous signal transmission.
Further, specifically, the in vitro electronic device further comprises an in vitro controller, the in vivo electronic device further comprises an in vivo controller, the in vitro controller is electrically connected with the transmitting coil, and the in vivo controller is electrically connected with the receiving coil. When synchronous operation is required, the external controller can change the power supply voltage transmitted to the transmitting coil, so that the voltage of the transmitting coil changes suddenly, the voltage of the receiving coil changes suddenly after inductive coupling, the voltage with the sudden change is transmitted to the internal controller, the internal controller recognizes that the voltage changes suddenly (namely, a synchronous operation signal), and the internal controller and the external controller execute synchronous operation. The time of the whole transmission process of the synchronous signal is within 5ms, and the synchronous precision of the evoked event and the physiological signal in the evoked potential examination can be met.
Further, preferably, the in vivo electronic device comprises an in vivo bluetooth module, the in vivo bluetooth module is electrically connected with the in vivo controller, the in vitro electronic device comprises an in vitro bluetooth module, the in vitro bluetooth module is electrically connected with the in vitro controller, and the in vivo bluetooth module is wirelessly connected with the in vitro bluetooth module through bluetooth. The power consumption of bluetooth transmission is little, and transmission distance is long and signal transmission is stable, is difficult for receiving the interference. When the in-vitro electronic device sends a synchronous operation request to the in-vivo electronic device, the in-vivo electronic device can give a response to the in-vitro electronic device through the Bluetooth, and then the in-vitro electronic device transmits a synchronous operation signal. Meanwhile, the Bluetooth module can also carry out data transmission.
Further, in particular, the in-vivo electronic device includes a voltage detection module configured to monitor a change in the receive coil voltage signal and send the change to the in-vivo controller.
Further, specifically, the in vitro electronic device includes a power amplifier circuit, the in vitro controller transmits the voltage value to the power amplifier circuit, and the power amplifier circuit is configured to amplify the voltage value and transmit the amplified voltage value to the transmitting coil. The power amplifier circuit can amplify the tiny voltage signal output by the external controller, so that the transmitting coil can be identified conveniently.
Further, specifically, the synchronization operation includes: the in-vivo electronic device and the in-vitro electronic device zero-clear their own time stamps. The time stamps of the in-vivo electronic device and the in-vitro electronic device are cleared simultaneously, and then the physiological signals are acquired, so that the accuracy of signal data acquisition can be improved, and the method is representative when clinical analysis is carried out.
The invention also provides a high-precision synchronous operation control method, which adopts the high-precision synchronous operation control system and comprises the following steps:
s1: establishing wireless communication connection between the in-vitro electronic device and the in-vivo electronic device;
s2: the in-vivo electronic device and the in-vitro electronic device execute synchronous operation simultaneously after the in-vitro electronic device changes the power supply voltage and induces the sudden change of the power supply voltage.
According to the high-precision synchronous operation control method, the sudden change of the output voltage of the in-vitro electronic device is transmitted as the synchronous signal, so that an extra chip for transmitting the synchronous signal in the electronic device can be omitted, the power consumption can be reduced, the size of the in-vivo electronic device can be reduced, and the synchronization precision of the evoked event and the physiological signal in the evoked potential examination can be met.
Further, specifically, the method further includes:
s2-1: applying stimulation to the patient by a stimulation module;
the step S2-1 is between the steps S1 and S2. By applying stimulation and simultaneously transmitting synchronous operation signals, the clocks of the in-vivo electronic equipment and the in-vitro electronic equipment can be positioned on the same reference by synchronous operation, so that the acquired signals can be aligned with the time point of stimulation accurately in time, and the influence of stimulation on electroencephalogram signals is better analyzed.
Further, specifically, the method further includes: the in-vitro electronic device sends a synchronization operation request to the in-vivo electronic device, and the in-vivo electronic device performs the step S2 after giving a response to the in-vitro electronic device.
Further, specifically, the step S2 specifically includes: changing power supply voltage through an external controller and transmitting the power supply voltage to a transmitting coil, wherein alternating current voltage of the transmitting coil is subjected to sudden change; after the receiving coil is inductively coupled with the alternating voltage of the transmitting coil, the alternating voltage of the receiving coil also changes suddenly; the receiving coil transmits the voltage signal with the mutation to the in-vivo controller, the in-vivo controller identifies the voltage signal with the mutation as a synchronous operation signal, and the in-vivo controller and the in-vitro controller simultaneously execute synchronous operation. The power supply voltage is converted into electromagnetic radiation through the transmitting coil and transmitted, the receiving coil receives the electromagnetic radiation and converts the electromagnetic radiation into the power supply voltage suitable for the in-vivo electronic device, the wireless coupling of the in-vivo coil and the in-vitro coil can not only carry out energy transmission, but also has higher transmission efficiency, and the real-time property of coil induction can be used as synchronous signal transmission; when synchronous operation is required, the external controller can change the power supply voltage transmitted to the transmitting coil, so that the voltage of the transmitting coil changes suddenly, the voltage of the receiving coil changes suddenly after inductive coupling, the voltage with the sudden change is transmitted to the internal controller, the internal controller recognizes that the voltage changes suddenly (namely, a synchronous operation signal), and the internal controller and the external controller execute synchronous operation. The time of the whole transmission process of the synchronous signal is within 5ms, and the synchronous precision of the evoked event and the physiological signal in the evoked potential examination can be met.
Further, specifically, the method further includes: and monitoring the change of the voltage signal of the receiving coil through a voltage detection module, and sending the change to the in-vivo controller.
Further, specifically, the method further includes: and transmitting the voltage value to a power amplifier circuit through the external controller, amplifying the voltage value through the power amplifier circuit and transmitting the amplified voltage value to the transmitting coil.
Further, specifically, the in-vitro electronic device and the in-vivo electronic device are connected through bluetooth communication.
The present invention also provides a computer-readable storage medium having stored thereon computer instructions which, when executed, implement the high-precision synchronous operation control method as described above.
The high-precision synchronous operation control system and the high-precision synchronous operation control method have the advantages that the real-time property of coil voltage signal transmission is utilized, the sudden change of the power supply voltage signal is used as a transmission signal for synchronous operation, an additional chip for synchronous signal transmission arranged in an electronic device is omitted, power consumption can be reduced, the size of the electronic device in a body is reduced, when the system is arranged in the body of a patient, the system can realize minimally invasive operation, the damage to the patient is reduced, and the synchronous precision of an induced event and a physiological signal in evoked potential examination can be met; voltage induction between the transmitting coil and the receiving coil is used as signal transmission of synchronous operation, so that the method is visual and simple, and the voltage of the receiving coil part is not filtered by a system and only changes along with the voltage change of the transmitting coil without interfering with the voltage of other parts of the in-vivo electronic device; when the synchronous operation is not needed, the voltage of the transmitting coil is kept unchanged at a reference voltage, when the synchronous operation is needed, the voltage mutation of the transmitting coil is realized by improving the power supply voltage by 20% -50% on the basis of the reference voltage, the receiving coil senses the voltage mutation and transmits a signal to the in-vivo controller, and the in-vivo controller can recognize the voltage mutation as a synchronous operation signal and execute the synchronous operation. The transmitting coil and the receiving coil are used as transmission paths of synchronous operation signals while supplying power to the electronic device in the body, when the output voltage of the transmitting coil changes, the receiving coil can immediately sense the voltage change, the change is used as a transmission signal of synchronous operation, the response speed is high, and the synchronization precision of an evoked event and a physiological signal in evoked potential examination can be met.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a schematic diagram of a high precision synchronous operation control system of the present invention.
Fig. 2 is a schematic structural diagram of an in-vitro electronic device and an in-vivo electronic device according to the present invention.
Fig. 3 is a schematic structural view of an in-vivo coil module and an in-vitro coil module according to the present invention.
Fig. 4 is a waveform illustration of the abrupt voltage signal transition of the present invention.
Fig. 5 is a second construction diagram of the high-precision synchronous operation control system of the present invention.
FIG. 6 is a schematic diagram of a third construction of the high precision synchronous operation control system of the present invention.
Fig. 7 is a flowchart of a high-precision synchronous operation control method of the present invention.
Fig. 8 is another flowchart of the high-precision synchronous operation control method of the present invention.
In the figure: 1. internal electronic device, 2, external electronic device, 3, stimulation module, 11, internal coil module, 111, receiving coil, 112, internal magnet, 12, internal controller, 13, internal bluetooth module, 14, voltage detection module, 21, external coil module, 211, transmitting coil, 212, external magnet, 22, external controller, 23, external bluetooth module, 24, power amplifier circuit.
Detailed Description
The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic views illustrating only the basic structure of the present invention in a schematic manner, and thus show only the constitution related to the present invention.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the invention. Furthermore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example 1
1-3, a high precision, synchronized operation control system includes an in-vivo electronic device 1 adapted to be disposed within a patient's body; an extracorporeal electronic device 2 adapted to be arranged outside the patient's body, which is wirelessly connected to the in-vivo electronic device 1; wherein, when the synchronous operation needs to be executed, the external electronic device 2 changes the supply voltage; after the in-vivo electronic device 1 induces the sudden change of the power supply voltage, the in-vivo electronic device 1 and the in-vitro electronic device 2 simultaneously execute synchronous operation. In the present embodiment, the synchronization operation may be, but is not limited to, clearing the time stamps of the in-vivo electronic device 1 and the in-vitro electronic device 2 themselves, and may be other operations. In this embodiment, before the external electronic device 2 changes the power supply voltage, the external electronic device 2 may send a synchronization operation request to the internal electronic device 1, and after the internal electronic device 1 responds to the external electronic device 2, the external electronic device 2 changes the power supply voltage, so that interference of other factors can be eliminated, and the accuracy of synchronization signal transmission is improved. In this embodiment, the patient is not limited to a human body, but may be an animal body for scientific research.
The in-vitro electronic device 2 comprises an in-vitro coil module 21, the in-vivo electronic device 1 comprises an in-vivo coil module 11, the in-vitro coil module 21 and the in-vivo coil module 11 are in inductive connection, and when the output voltage of the in-vitro coil module 21 changes suddenly, the alternating voltage of the in-vivo coil module 11 changes along with the change of the output voltage. The in-vivo electronic device 1 can obtain electric energy through the wireless coupling of the in-vivo coil module 11 and the in-vivo coil module 21 without arranging a battery module, the volume of the in-vivo electronic device 1 can be greatly reduced to 1/8-1/6 of the volume of the existing in-vivo electronic device, and the safety of the in-vivo electronic device 1 can be improved.
The external coil module 21 comprises a transmitting coil 211 and an external magnet 212, the transmitting coil 211 is arranged around the external magnet 212, the internal coil module 11 comprises a receiving coil 111 and an internal magnet 112, the receiving coil 111 is arranged around the internal magnet 112, and the external magnet 212 is connected with the internal magnet 112 through adsorption. In this embodiment, the number of turns of the transmitting coil 211 may be 8-10 turns, and the number of turns of the receiving coil 111 may be 6-8 turns, so that not only the requirement of power supply can be satisfied, but also the volume of the in-vivo electronic device is not increased, and meanwhile, the signal transmission is more stable. Can adsorb internal coil module 11 and external coil module 21 fixedly through internal magnet 112 and external magnet 212 inter attraction, convert power supply voltage into electromagnetic radiation through transmitting coil 211 and send out, receiving coil 111 receives electromagnetic radiation and converts it into the power supply voltage who is suitable for internal electron device 1, receiving coil 111 and transmitting coil 211's wireless coupling not only can carry out energy transmission, and transmission efficiency is higher, and because the real-time of coil induction can regard as synchronous signal transmission. The voltage at the receiving coil 111 is the most direct voltage, and only changes along with the voltage change of the transmitting coil 211, and the voltage at the receiving coil 111 is not subjected to system filtering processing and is not interfered by other factors. When the synchronous operation is not required, the transmitting coil 211 and the receiving coil 111 are both maintained at a reference voltage, and when the synchronous operation is required, the output voltage of the transmitting coil 211 is changed, for example, by 20% -50% on the basis of the reference voltage, and if the output voltage is changed too little, it may be recognized as a normal voltage fluctuation, and the synchronous signal may not be accurately recognized.
The in-vitro electronic device 2 further comprises an in-vitro controller 22, the in-vivo electronic device 1 further comprises an in-vivo controller 12, the in-vitro controller 22 is electrically connected with the transmitting coil 211, and the in-vivo controller 12 is electrically connected with the receiving coil 111. In the present embodiment, the external controller 22 and the internal controller 12 are both single-chip microcomputers, but are not limited thereto, and may be other types of controllers.
Internal electronic device 1 includes internal bluetooth module 13, and internal bluetooth module 13 is connected with internal controller 12 electricity, and external electronic device 2 includes external bluetooth module 23, and external bluetooth module 23 is connected with external controller 22 electricity, and internal bluetooth module 13 passes through bluetooth wireless connection with external bluetooth module 23. Establish bluetooth connection through external bluetooth module 23 and internal bluetooth module 13, at this moment, external controller 22 and internal controller 12 can realize communication connection through the bluetooth, and when external controller 22 sent synchronous operation request to internal controller 12, internal controller 12 can give the response through the bluetooth. The bluetooth transmission has small power consumption, long transmission distance and stable signal transmission, is not easy to be interfered, and of course, in other embodiments, other wireless communication modes such as wifi and sub-1G can be adopted.
The in-vivo electronic device 1 includes a voltage detection module 14, and the voltage detection module 14 is configured to monitor the change of the voltage signal of the receiving coil 111 and send the change to the in-vivo controller 12. In this embodiment, the voltage detection module 14 may be an AD converter, and when the voltage of the receiving coil 111 changes, the voltage received by the voltage detection module 14 also changes, and detects whether the change exceeds a normal change range, and if the voltage change exceeds the normal range, the in-vivo controller 12 recognizes that the signal is a synchronous operation signal, and performs the synchronous operation.
The in-vitro electronic device 2 comprises a power amplifier circuit 24, the in-vitro controller 22 transmits the voltage value to the power amplifier circuit 24, and the power amplifier circuit 24 is configured to amplify the voltage value and transmit the amplified voltage value to the transmitting coil 211. Since the voltage signal output from the external controller 22 is relatively small, the voltage signal is amplified by the power amplifier circuit 24 and is easily received by the transmitting coil 211.
The operation of the high-precision synchronous operation control system will be described with reference to fig. 4. When synchronous operation (for example, an evoked event in evoked potential check) needs to be performed, the external controller 22 establishes communication connection with the internal controller 12 wirelessly, the external controller 22 sends a synchronous operation request to the internal controller 12, after the internal controller 12 gives a response to the external controller 22, the external controller 22 changes the power supply voltage and sends a signal to the power amplifier circuit 24, the power supply voltage of the power amplifier circuit 24 changes suddenly at time t1 and transmits the signal to the transmitting coil 211, the alternating voltage of the transmitting coil 211 changes suddenly at time t1, the receiving coil 111 senses that the alternating voltage of the transmitting coil 211 changes suddenly, the alternating voltage of the receiving coil 111 changes suddenly at time t1, the receiving coil 111 transmits the suddenly changed alternating voltage to the voltage detection module 14, the voltage detection module 14 rectifies and filters the suddenly changed alternating voltage and detects that the voltage exceeds the normal change range at time t3, the in-vivo controller 12 recognizes that the voltage after rectification and filtering still has a sudden change, determines that the voltage is a synchronous operation signal, analyzes the time point of the sudden change of the voltage, and performs a zero clearing time stamp, for example, when the voltage has a sudden change at time t3, the in-vivo controller 12 takes time t3 as the zero time of physiological signal acquisition. In this embodiment, the time difference between the time t1 and the time t3 can be controlled within 5ms, and the synchronization accuracy between the evoked event and the physiological signal in the evoked potential monitoring can be satisfied. The synchronous operation control system can align the signal acquisition time lines of the in-vivo electronic device and the in-vitro electronic device, and improve the accuracy of physiological signal acquisition.
Example 2
As shown in fig. 2-6, a high precision synchronous operation control system includes an in-vivo electronic device 1 adapted to be disposed in a patient's body such as a human brain; an extracorporeal electronic device 2 adapted to be arranged outside the patient's body, which is wirelessly connected to the in-vivo electronic device 1; a stimulation module 3, the stimulation module 3 being configured to apply stimulation (which may be in vivo or in vitro) to a patient; wherein, when the stimulation module 3 applies stimulation to the patient, the in vitro electronic device 2 changes the supply voltage; after the in-vivo electronic device 1 induces the sudden change of the power supply voltage, the in-vivo electronic device 1 and the in-vitro electronic device 2 simultaneously execute synchronous operation. In this embodiment, before the external electronic device 2 changes the supply voltage, the external electronic device 2 may send a synchronization operation request to the internal electronic device 1, and after the internal electronic device 1 responds to the external electronic device 2, the external electronic device 2 changes the supply voltage again, so that interference of other factors may be eliminated, and accuracy of synchronization signal transmission may be improved. The embodiment transmits the synchronous signals while applying stimulation, executes synchronous operation, and can enable clocks of the in-vivo electronic equipment and the in-vitro electronic equipment to be on the same reference, so that the acquired signals can be aligned with the time point of stimulation accurately in time, and the influence of stimulation on electroencephalogram signals is better analyzed.
The in-vitro electronic device 2 comprises an in-vitro coil module 21, the in-vivo electronic device 1 comprises an in-vivo coil module 11, the in-vitro coil module 21 and the in-vivo coil module 11 are in inductive connection, and when the output voltage of the in-vitro coil module 21 changes suddenly, the alternating voltage of the in-vivo coil module 11 changes along with the change of the output voltage.
The external coil module 21 comprises a transmitting coil 211 and an external magnet 212, the transmitting coil 211 is arranged around the external magnet 212, the internal coil module 11 comprises a receiving coil 111 and an internal magnet 112, the receiving coil 111 is arranged around the internal magnet 112, and the external magnet 212 is connected with the internal magnet 112 through adsorption.
The in-vitro electronic device 2 further comprises an in-vitro controller 22, the in-vivo electronic device 1 further comprises an in-vivo controller 12, the in-vitro controller 22 is electrically connected with the transmitting coil 211, and the in-vivo controller 12 is electrically connected with the receiving coil 111.
The in vivo electronic device 1 comprises an in vivo Bluetooth module 13, the in vivo Bluetooth module 13 is electrically connected with an in vivo controller 12, the in vitro electronic device 2 comprises an in vitro Bluetooth module 23, the in vitro Bluetooth module 23 is electrically connected with an in vitro controller 22, the in vivo Bluetooth module 13 is wirelessly connected with the in vitro Bluetooth module 23 through Bluetooth, and of course, in other embodiments, other wireless communication modes such as wifi, sub-1G and the like can be adopted.
The in-vivo electronic device 1 includes a voltage detection module 14, and the voltage detection module 14 is configured to monitor the change of the voltage signal of the receiving coil 111 and send the change to the in-vivo controller 12.
The in-vitro electronic device 2 comprises a power amplifier circuit 24, the in-vitro controller 22 transmits the voltage value to the power amplifier circuit 24, and the power amplifier circuit 24 is configured to amplify the voltage value and transmit the amplified voltage value to the transmitting coil 211.
The working principle and the technical effect of the corresponding parts of this embodiment and embodiment 1 are the same, and are not described herein again. Example 3
As shown in fig. 7, a high-precision synchronous operation control method using the high-precision synchronous operation control system of embodiment 1 includes the steps of:
s1: establishing wireless communication connection between the in-vitro electronic device and the in-vivo electronic device;
s2: the external electronic device changes the power supply voltage, and after the internal electronic device induces the sudden change of the power supply voltage, the internal electronic device and the external electronic device simultaneously execute synchronous operation.
Before step S2 is executed, the in-vitro electronic device sends a synchronization request to the in-vivo electronic device, and after the in-vivo electronic device gives a response to the in-vitro electronic device, step S2 is executed. The synchronization operation may be, for example, the in-vivo electronic device and the in-vitro electronic device clearing their own time stamps, but is not limited thereto, and may be other synchronization operations. The wireless communication connection may be, for example, a bluetooth connection, a WiFi connection, sub-1G, or the like. When synchronous operation needs to be executed, the external controller establishes communication connection with the internal controller through Bluetooth, the external controller sends a synchronous operation request to the internal controller, after the internal controller responds to the external controller, the external controller changes power supply voltage and transmits the power supply voltage to the transmitting coil, alternating voltage of the transmitting coil changes suddenly, after the receiving coil is inductively coupled with the alternating voltage of the transmitting coil, the alternating voltage of the receiving coil changes suddenly, the receiving coil transmits the voltage signal with the sudden change to the internal controller, the internal controller identifies the voltage signal with the sudden change as a synchronous operation signal, and the internal controller and the external controller execute synchronous operation simultaneously. In this embodiment, the voltage detection module monitors the change of the voltage signal of the receiving coil and sends the change to the internal controller, the external controller transmits the voltage value to the power amplifier circuit, and the power amplifier circuit amplifies the voltage value and sends the amplified voltage value to the transmitting coil.
In the embodiment, the real-time property of coil voltage signal transmission is utilized, the voltage change of the transmitting coil is induced in real time through the receiving coil, the voltage detection module detects whether the voltage signal of the receiving coil changes suddenly or not in real time, if the voltage signal changes suddenly and exceeds the normal change range, the internal controller identifies the signal as a synchronous operation signal, the internal controller and the external controller execute synchronous operation, the time of the transmission process of the whole synchronous signal is within 5ms, and the synchronization precision of an evoked event and a physiological signal in evoked potential check can be met.
Example 4
As shown in fig. 8, a high-precision synchronous operation control method, when the high-precision synchronous operation control system of embodiment 2 is adopted, includes the following steps:
s1: establishing wireless communication connection between the in-vitro electronic device and the in-vivo electronic device;
s2-1: applying stimulation to the patient by a stimulation module;
s2: the in-vivo electronic device and the in-vitro electronic device execute synchronous operation simultaneously after the in-vitro electronic device changes the power supply voltage and induces the sudden change of the power supply voltage.
In this embodiment, when the stimulation module applies the stimulation to the patient, it is considered that the synchronization operation needs to be performed, before performing step S2, the in-vitro electronic device may first send a synchronization operation request to the in-vivo electronic device, and after the in-vivo electronic device gives a response to the in-vitro electronic device, perform step S2. Specifically, the external controller and the internal controller are in communication connection, the external controller sends a synchronous operation request to the internal controller, the external controller changes power supply voltage and transmits the power supply voltage to the transmitting coil after the internal controller responds to the external controller, the alternating voltage of the transmitting coil changes suddenly, the alternating voltage of the receiving coil changes suddenly after the receiving coil is inductively coupled with the alternating voltage of the transmitting coil, the receiving coil transmits the voltage signal with the sudden change to the internal controller, the internal controller recognizes the voltage signal with the sudden change as a synchronous operation signal, and the internal controller and the external controller execute synchronous operation simultaneously. In this embodiment, the voltage detection module monitors the change of the voltage signal of the receiving coil and sends the change to the internal controller, the external controller transmits the voltage value to the power amplifier circuit, and the power amplifier circuit amplifies the voltage value and sends the amplified voltage value to the transmitting coil.
In the embodiment, the real-time property of coil voltage signal transmission is utilized, the voltage change of the transmitting coil is induced in real time through the receiving coil, the voltage detection module detects whether the voltage signal of the receiving coil changes suddenly or not in real time, if the voltage signal changes suddenly and exceeds the normal change range, the internal controller identifies the signal as a synchronous operation signal, the internal controller and the external controller execute synchronous operation, the time of the transmission process of the whole synchronous signal is within 5ms, and the synchronization precision of an evoked event and a physiological signal in evoked potential check can be met. In addition, the synchronous signals are transmitted while the stimulation is applied, so that the clocks of the in-vivo electronic equipment and the in-vitro electronic equipment can be in the same reference, the acquired signals can be accurately aligned with the time point of the stimulation in time, and the influence of the stimulation on the electroencephalogram signals can be better analyzed.
Example 5
A computer-readable storage medium having stored thereon computer instructions which, when executed, implement the high-precision synchronous operation control method of embodiment 3 or 4.
It should be noted that, in the above embodiments, all or part of the implementation may be realized by software, hardware, firmware or any combination thereof, and when the implementation is realized by software, all or part of the implementation may be realized in the form of a computer program product. The computer program product includes one or more computer instructions. The processes or functions according to the embodiments of the present application are generated in whole or in part when the computer instructions are loaded and executed on a computer. The computer may be a general purpose computer, a special purpose computer, a network of computers, or other programmable device. The computer instructions may be stored on a computer readable storage medium or transmitted from one computer readable storage medium to another, for example, from one website, computer, server, or data center to another website, computer, server, or data center via wire (e.g., coaxial cable, fiber optic, Digital Subscriber Line (DSL)), or wireless (e.g., infrared, wireless, microwave, etc.). The computer-readable storage medium can be any available medium that can be accessed by a computer or a data storage device, such as a server, a data center, etc., that incorporates one or more of the available media. The usable medium may be a magnetic medium (e.g., floppy Disk, hard Disk, magnetic tape), an optical medium (e.g., Digital Versatile Disk (DVD)), or a semiconductor medium (e.g., Solid State Disk (SSD)), among others.
It will be understood by those skilled in the art that all or part of the steps for implementing the above embodiments may be implemented by hardware, or may be implemented by a program instructing relevant hardware, and the program may be stored in a computer-readable storage medium, and the above-mentioned storage medium may be a read-only memory, a magnetic disk or an optical disk, etc.
In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined by the scope of the claims.
Claims (16)
1. A high precision synchronous operation control system comprising:
an in-vivo electronic device (1) adapted to be arranged in a body of a patient;
an in-vitro electronic device (2) adapted to be arranged outside the patient's body, which is wirelessly connected with the in-vivo electronic device (1);
a stimulation module (3), the stimulation module (3) being configured to apply stimulation to the patient,
wherein the extracorporeal electronic device (2) alters a supply voltage when the stimulation module (3) applies stimulation to the patient; after the in-vivo electronic device (1) induces the sudden change of the power supply voltage, the in-vivo electronic device (1) and the in-vitro electronic device (2) execute synchronous operation simultaneously.
2. The high-precision synchronous operation control system according to claim 1, characterized in that the external electronic device (2) sends a synchronous operation request to the internal electronic device (1), the external electronic device (2) changes the supply voltage after the internal electronic device (1) gives a response to the external electronic device (2), and the internal electronic device (1) and the external electronic device (2) perform synchronous operation simultaneously after the internal electronic device (1) senses the sudden change of the supply voltage.
3. The high precision synchronous operation control system according to claim 2, characterized in that the external electronic device (2) comprises an external coil module (21), the internal electronic device (1) comprises an internal coil module (11), and the external coil module (21) and the internal coil module (11) are inductively connected, wherein when the output voltage of the external coil module (21) changes suddenly, the alternating voltage of the internal coil module (11) changes along with the change of the output voltage.
4. The high-precision synchronous operation control system according to claim 3, wherein the external coil module (21) comprises a transmitting coil (211) and an external magnet (212), the transmitting coil (211) is arranged around the external magnet (212), the internal coil module (11) comprises a receiving coil (111) and an internal magnet (112), the receiving coil (111) is arranged around the internal magnet (112), and the external magnet (212) is connected with the internal magnet (112) through adsorption.
5. The high precision synchronous operation control system according to claim 4, wherein the external electronic device (2) further comprises an external controller (22), the internal electronic device (1) further comprises an internal controller (12), the external controller (22) is electrically connected with the transmitting coil (211), and the internal controller (12) is electrically connected with the receiving coil (111).
6. The high-precision synchronous operation control system according to claim 5, wherein the in-vivo electronic device (1) comprises an in-vivo Bluetooth module (13), the in-vivo Bluetooth module (13) is electrically connected with the in-vivo controller (12), the out-vitro electronic device (2) comprises an in-vitro Bluetooth module (23), the in-vitro Bluetooth module (23) is electrically connected with the out-vivo controller (22), and the in-vivo Bluetooth module (13) is wirelessly connected with the out-vitro Bluetooth module (23) through Bluetooth.
7. The high precision synchronous operation control system of claim 5, characterized in that the in-vivo electronic device (1) comprises a voltage detection module (14), the voltage detection module (14) being configured to monitor changes in the receive coil (111) voltage signal and send to the in-vivo controller (12).
8. The high precision synchronous operation control system according to claim 5, characterized in that the external electronic device (2) comprises a power amplifier circuit (24), the external controller (22) transmits a voltage value to the power amplifier circuit (24), and the power amplifier circuit (24) is configured to amplify the voltage value and transmit it to the transmitting coil (211).
9. The high precision synchronous operation control system of claim 1, wherein the synchronous operation comprises: the in-vivo electronic device (1) and the in-vitro electronic device (2) zero-clear their timestamps.
10. A high-precision synchronous operation control method employing the high-precision synchronous operation control system according to any one of claims 1 to 9, characterized by comprising the steps of:
s1: establishing wireless communication connection between the in-vitro electronic device and the in-vivo electronic device;
s2-1: applying stimulation to the patient by a stimulation module;
s2: the in-vivo electronic device and the in-vitro electronic device execute synchronous operation simultaneously after the in-vitro electronic device changes the power supply voltage and induces the sudden change of the power supply voltage.
11. The high-precision synchronous operation control method according to claim 10,
the method further comprises the following steps: the in-vitro electronic device sends a synchronization operation request to the in-vivo electronic device, and the in-vivo electronic device performs the step S2 after giving a response to the in-vitro electronic device.
12. The high-precision synchronous operation control method according to claim 11, wherein the step S2 specifically includes:
changing power supply voltage through an external controller and transmitting the power supply voltage to a transmitting coil, wherein alternating current voltage of the transmitting coil is subjected to sudden change; after the receiving coil is inductively coupled with the alternating voltage of the transmitting coil, the alternating voltage of the receiving coil also changes suddenly; the receiving coil transmits the voltage signal with the mutation to the in-vivo controller, the in-vivo controller identifies the voltage signal with the mutation as a synchronous operation signal, and the in-vivo controller and the in-vitro controller simultaneously execute synchronous operation.
13. The high precision synchronous operation control method of claim 12, further comprising:
and monitoring the change of the voltage signal of the receiving coil through a voltage detection module, and sending the change to the in-vivo controller.
14. The high precision synchronous operation control method of claim 12, further comprising:
and transmitting the voltage value to a power amplifier circuit through the external controller, amplifying the voltage value through the power amplifier circuit and transmitting the amplified voltage value to the transmitting coil.
15. The high-precision synchronous operation control method according to claim 10, wherein the in-vitro electronic device and the in-vivo electronic device are connected through bluetooth communication.
16. A computer-readable storage medium having stored thereon computer instructions, wherein the computer instructions, when executed, implement the high precision synchronous operation control method of any one of claims 10-15.
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| PCT/CN2021/109115 WO2022227312A1 (en) | 2021-04-29 | 2021-07-29 | High-precision synchronous operation control system and method, and storage medium |
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| CA2945711A1 (en) * | 2014-04-15 | 2015-10-22 | Heartware, Inc. | Improvements in transcutaneous energy transfer systems |
| WO2017156613A1 (en) * | 2016-03-18 | 2017-09-21 | Fundação Oswaldo Cruz | Modular apparatus and method for the analogous synchronisation of electroencephalograms with luminous events, oscillatory events of electrical nature, and motor behaviour events |
| WO2017184083A1 (en) * | 2016-04-22 | 2017-10-26 | Agency For Science, Technology And Research | Synchronized time-division wireless power transfer for multiple voltage applications |
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Application publication date: 20210618 Assignee: Boruikang medical technology (Shanghai) Co.,Ltd. Assignor: NEURACLE TECHNOLOGY (CHANGZHOU) CO.,LTD. Contract record no.: X2022980011241 Denomination of invention: High-precision synchronous operation control system, method and storage medium Granted publication date: 20210803 License type: Common License Record date: 20220728 |